Protein Alignment zip and Cgnl1

DIOPT Version :10

• Sequence 1: NP_523860.2
• Gene: zip / 38001
• FlyBaseID: FBgn0287873
• Length: 2056
• Species: Drosophila melanogaster
• Sequence 2: NP_080875.3
• Gene: Cgnl1 / 68178
• MGIID: 1915428
• Length: 1297
• Species: Mus musculus
• Alignment Length: 1146
• Identity: 270/1146 - (23%)
• Similarity: 485/1146 - (42%)
• Gaps: 348/1146 - (30%)

  Fly   925 KPLLEVTKQEEKLVQKEDELKQVREKLDTLAKNTQEYERKYQQALVEKTTLAEQLQAEIELCAEA 989
            ||.|:  .::.|::.|..:     |.....|.:.....:|.::..:...||..|.:|   :.|.:
Mouse   457 KPPLQ--NKDGKVLNKGRQ-----ESTGACAPSLPAPNKKEEEIKIATATLMLQNRA---VAATS 511

  Fly   990 EESRSRLMAR-------KQELEDMM---QELETRIEEEEERVLALGGEKKKLELNIQDLEEQLEE 1044
            :....::..:       .|...|::   |||..:..||..:.:.....|          |...:.
Mouse   512 DSGAKKISVKTFPSDSSTQATPDLLKGQQELTQQTNEETAKQILYNYLK----------EGGTDN 566

  Fly  1045 EEAARQKLQL--EKVQLDAKIKKYEEDLALTDDQ-------NQKLLKEKKLLEERANDLSQTLAE 1100
            |:|.::|:.|  ||:|   .:|......|...:|       ...||.:|..|....::|.|.|
Mouse   567 EDATKRKVNLVFEKIQ---TLKSRAAGSAQGSNQAPNSPSEGNSLLDQKNKLILEVSELQQQL-- 626

  Fly  1101 EEEKAKHLAKLKAKHEATISELEERLHKDQQQRQESDRSKRKIETEVADLKEQLNERRVQVDEMQ 1165
                     :|:.|::..|.|..||:.:|.::.:.  |.:.::| |.|.|:.:|       :|.:
Mouse   627 ---------QLEMKNQQNIKEERERMREDLEELRV--RHQSQVE-ETATLQRRL-------EESE 672

  Fly  1166 AQLAKREEELTQTLLRIDEESATKATAQKAQRELESQLAEIQEDLEAEKAARAKAEKVRRDLSEE 1230
            .:|.|..|||.|..:..::.       |...|:|:.||:|:.::|::.|.:.   ::.:..|.||
Mouse   673 GELRKSLEELFQVKMEREQH-------QTEIRDLQDQLSEMHDELDSTKRSE---DREKGALIEE 727

  Fly  1231 LEALKNELLDSLDTTAAQQELRSKREQELATLKKSLEEETVNHEGVLADMRHKHSQELNSINDQL 1295
            |...|.:|.|.|.....|::|..|||:||..||.:|:||..:|:..:..::.::..||.::.:.:
Mouse   728 LLQAKQDLQDLLIAKEEQEDLLRKRERELTALKGALKEEVSSHDQEMDKLKEQYDAELQALRESV 792

  Fly  1296 ENLRKAKTVLEKAKGTLEAENADLATELRSVNSSRQENDRRRKQAESQIAELQVKLAEIERARSE 1360
            |...|...|              ||:...|...|:.|.|.|.|..:.:..:||.::||:||..::
Mouse   793 EEATKNVEV--------------LASRSNSSEQSQAEADLREKVLKEENEKLQGRIAELERRAAQ 843

  Fly  1361 LQEKCTKLQQEAENITNQLEEAELKASAAVKSASNMESQLTEAQQLLEEETRQKLGLSSKLRQIE 1425
            ||              .|:|:.:...:.|.::....||::.:.::.|....:::       ::..
Mouse   844 LQ--------------RQMEDVKGDEAQAKETLRKCESEVQQLEEALVHARKEE-------KEAT 887

  Fly  1426 SEKEALQEQLEEDDEAKRNYERKLAEVTTQMQEIKKKAEEDADLAKELEEGKKRLNKDIEALERQ 1490
            ..:.||:::||:       ..|:|::|:.:.:|:.:|..::|:..::|    ::|..::|: ||.
Mouse   888 CARRALEKELEQ-------ARRELSQVSQEQKELLEKLRDEAEQKEQL----RKLKNEMES-ERW 940

  Fly  1491 VKELIAQNDRLDKSKKKIQSELEDATIELEAQRTKVLELEKKQKNFDKILAEEKAISEQIAQERD 1555
                     .|||:.:|:|.|:.|..   ||.||..|||:|                 |:.:.::
Mouse   941 ---------HLDKTIEKLQKEMADIA---EASRTSSLELQK-----------------QLGEYKE 976

  Fly  1556 TAEREAREKETKVLSVSRELDEAFDKIEDLENKRKTLQNELDDLANTQGTADKNVHELEKAKRAL 1620
            ...||..|.:|::                   |.|.|                   |:|||:.|.
Mouse   977 KNRRELAEMQTQL-------------------KEKCL-------------------EVEKARLAA 1003

  Fly  1621 ESQLAELKAQNEELEDDLQLTEDAKLRLEVNMQALRSQFERDLLAKEEGAEEKRRGLVKQLRDLE 1685
            .....||:.:.|||:|                      ::|    .||.|..||:.|.:.|:|||
Mouse  1004 SKMQDELRLKEEELQD----------------------YQR----AEEEALTKRQLLEQSLKDLE 1042

  Fly  1686 TELDEERKQRTAAVASKKKLEGDLKEIETTMEMHNKVKEDALKHAKKLQAQVKDALRDAEEAKAA 1750
            .||                                               :.|..|:|
Mouse  1043 YEL-----------------------------------------------EAKSHLKD------- 1053

  Fly  1751 KEELQALSKEAERKVKALEAEVLQLTEDLASSERARRAAETERDELAEEIANNANKGSLMIDEKR 1815
                     :..|.:|.:|.:|.|
Mouse  1054 ---------DRSRLIKQMEDKVSQ----------------------------------------- 1068

  Fly  1816 RLEARIATLEEELEEEQSNSEVLLDRSRKAQLQIEQLTTELANEKSNSQKNENGRALLERQNKEL 1880
                    ||.|||||::|:::|.:|...::.|:||:.:||..||:..|..|..:..||||||:|
Mouse  1069 --------LEIELEEERTNADLLSERITWSREQMEQMRSELLQEKAAKQDLECDKISLERQNKDL 1125

  Fly  1881 KAKLAEIETAQRTKVKATIATLEAKIANLEEQLENEGKERLLQQKANRKMDKKIKELTMNIEDER 1945
            |:::..:|.:.|:..:..:..:||:||.||::||||.::|...|.:||::::|:|||.|.::||.
Mouse  1126 KSRIIHLEGSYRSSKEGLVVQMEARIAELEDRLENEERDRANLQLSNRRLERKVKELVMQVDDEH 1190

  Fly  1946 RHVDQHKEQMDKLNSRIKLLKRNLDETEEELQKEKTQKRKYQRECEDMIESQEAMNREINSLKTK 2010
            ..:   .:|.|:|:.|:|.:||.::|.|||:.:.::.|:|.|||.|:.:...|.:..::||||..
Mouse  1191 LSL---TDQKDQLSLRLKAMKRQVEEAEEEIDRLESSKKKLQRELEEQMGVNEQLQGQLNSLKKG 1252

  Fly  2011 LR-RTGGIGLSSSRLTGTPSSKRAGGGGGGDDSSVQDESLD 2050
            || :|    |||..|               |||...|.|.|
Mouse  1253 LRLKT----LSSKVL---------------DDSDDDDLSSD 1274

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
zip	NP_523860.2	Myosin_N	79..122	CDD:460670
		MYSc_Myh2_insects_mollusks	145..854	CDD:276876
		Myosin_tail_1	931..2011	CDD:460256	254/1098 (23%)
Cgnl1	NP_080875.3	Head	1..550		19/102 (19%)
		ZIM. /evidence=ECO:0000250	37..51
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	161..208
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	245..306
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	364..396
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	428..467		3/11 (27%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	586..608		2/21 (10%)
		Myosin_tail_1	<611..1253	CDD:460256	223/927 (24%)
		Tail	1259..1297		9/31 (29%)