DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment zip and Myh7b

DIOPT Version :10

Sequence 1:NP_523860.2 Gene:zip / 38001 FlyBaseID:FBgn0287873 Length:2056 Species:Drosophila melanogaster
Sequence 2:XP_017174700.1 Gene:Myh7b / 668940 MGIID:3710243 Length:1947 Species:Mus musculus


Alignment Length:1959 Identity:767/1959 - (39%)
Similarity:1174/1959 - (59%) Gaps:77/1959 - (3%)


- Green bases have known domain annotations that are detailed below.


  Fly    76 WTQKRLVWVPHENQGFVAASIKRE-HGDEVEVELAETGKRVMILRD-DIQKMNPPKFDKVEDMAE 138
            |..|:.||||.|...:|.|.:|.| .|.:|.||..:  ::|:.:|: ::|.||||:||.:||||.
Mouse    29 WDGKKRVWVPDEQDAYVEAEVKTEATGGKVTVETKD--QKVLTVRETEMQPMNPPRFDLLEDMAM 91

  Fly   139 LTCLNEASVLHNIKDRYYSGLIYTYSGLFCVVVNPYKKLPIYTEKIMERYKGIKRHEVPPHVFAI 203
            :|.||||:||||::.||...:||||||||||.:||||.||:||..::..|||.:|.|.|||::|:
Mouse    92 MTHLNEAAVLHNLRQRYARWMIYTYSGLFCVTINPYKWLPVYTAAVVAAYKGKRRSEAPPHIYAV 156

  Fly   204 TDSAYRNMLGDREDQSILCTGESGAGKTENTKKVIQFLAYVAASKPKGSGAVPHPAVLINFSVNT 268
            .|:||.:||.:||:||:|.|||||||||.|||:|||:.|.|||   .|.|    |..        
Mouse   157 ADNAYNDMLRNRENQSMLITGESGAGKTVNTKRVIQYFAIVAA---LGDG----PGK-------- 206

  Fly   269 NKYIKVKIMAQNQNQTIEVVNGLKMVEVNSNCQEGELEQQLLQANPILEAFGNAKTVKNDNSSRF 333
                |.:.:|....                    |.||.|:::|||.:||||||||::|||||||
Mouse   207 ----KAQFLATKTG--------------------GTLEDQIIEANPAMEAFGNAKTLRNDNSSRF 247

  Fly   334 GKFIRINFDASGFISGANIETYLLEKSRAIRQAKDERTFHIFYQLLAGATPEQREKFILD-DVKS 397
            ||||||:|..:|.::.|:|::|||||||.|.|...||.:|::||:|:|..||.::..:|. :...
Mouse   248 GKFIRIHFGPTGKLASADIDSYLLEKSRVIFQLPGERGYHVYYQILSGKKPELQDMLLLSMNPYD 312

  Fly   398 YAFLSNGSLPVPGVDDYAEFQATVKSMNIMGMTSEDFNSIFRIVSAVLLFGSMKFRQERNNDQAT 462
            |.|.|.|...|..:||..|..||..:|:|:|.:.::..:.::||.|:|.||:|||:|::..:||.
Mouse   313 YHFCSQGVTTVDNMDDGEELIATDHAMDILGFSVDEKCACYKIVGALLHFGNMKFKQKQREEQAE 377

  Fly   463 LPDNTVAQKIAHLLGLSVTDMTRAFLTPRIKVGRDFVTKAQTKEQVEFAVEAIAKACYERMFKWL 527
            ......|.|.|:|:|:|..|:.:..|.||::||.::|||.|:.|||.|||.|:|||.|:|:|:||
Mouse   378 ADGTESADKAAYLMGVSSGDLLKGLLHPRVRVGNEYVTKGQSVEQVVFAVGALAKATYDRLFRWL 442

  Fly   528 VNRINRSLDRTKRQGASFIGILDMAGFEIFELNSFEQLCINYTNEKLQQLFNHTMFILEQEEYQR 592
            |:|||::|| ||.....|||:||:|||||||.|||||||||:|||||||.||..||:||||||:|
Mouse   443 VSRINQTLD-TKLPRQFFIGVLDIAGFEIFEFNSFEQLCINFTNEKLQQFFNQHMFVLEQEEYKR 506

  Fly   593 EGIEWKFIDFGLDLQPTIDLIDKPGGIMALLDEECWFPKATDKTFVDKLVSAHS-MHPKFM---- 652
            |||:|.||||||||||.||||:||.||:::|:|||.||||:|.:|..||...|| ..|.|.    
Mouse   507 EGIDWVFIDFGLDLQPCIDLIEKPLGILSILEEECMFPKASDASFRAKLYDNHSGKSPNFQQPRP 571

  Fly   653 --KTDFRGVADFAIVHYAGRVDYSAAKWLMKNMDPLNENIVSLLQGSQDPFVVNIWKDAEIVGMA 715
              |..::  |.|.:|||||.|.||...||.||.|||||.:|.:.|.||:..:..::::     .|
Mouse   572 DKKRKYQ--AHFEVVHYAGVVPYSIVGWLEKNKDPLNETVVPIFQKSQNRLLATLYEN-----YA 629

  Fly   716 QQALTDTQFGA----RTRKGMFRTVSHLYKEQLAKLMDTLRNTNPNFVRCIIPNHEKRAGKIDAP 776
            ....|:.....    |.:...|:|||.|:||.|.|||..||.|.|:|||||:||..|..|.:|:.
Mouse   630 GSCSTEPPKSGVKEKRKKAASFQTVSQLHKENLNKLMTNLRATQPHFVRCIVPNENKTPGVMDSF 694

  Fly   777 LVLDQLRCNGVLEGIRICRQGFPNRIPFQEFRQRYELLTPNVIPKG-FMDGKKACEKMIQALELD 840
            |||.|||||||||||||||||||||:.:.:|||||.:|.|:.||.. |:|.:||.||::.:|::|
Mouse   695 LVLHQLRCNGVLEGIRICRQGFPNRLLYADFRQRYRILNPSAIPDDTFVDSRKATEKLLGSLDID 759

  Fly   841 SNLYRVGQSKIFFRAGVLAHLEEERDFKISDLIVNFQAFCRGFLARRNYQKRLQQLNAIRIIQRN 905
            ...|:.|.:|:||:||:|..|||.||.:::.::...||..||.|.|..||:.|...:|:..||.|
Mouse   760 HTQYQFGHTKVFFKAGLLGILEELRDQRLAKVLTLLQARSRGRLMRLEYQRMLGGRDALFTIQWN 824

  Fly   906 CAAYLKLRNWQWWRLYTKVKPLLEVTKQEEKLVQKEDELKQVREKLDTLAKNTQEYERKYQQALV 970
            ..|:..::||.|.:|:.|:||||...:.||:|.....||:.:|..|.|.....||.|........
Mouse   825 IRAFNAVKNWSWMKLFFKMKPLLRSAQAEEELAALRAELRGLRGALATAEAKRQELEETQVSVTQ 889

  Fly   971 EKTTLAEQLQAEIELCAEAEESRSRLMARKQELEDMMQELETRIEEEEERVLALGGEKKKLELNI 1035
            ||..||.|||||.:..|:|||....|:..|.:||..::||..|:|:|||....|...::|||...
Mouse   890 EKNDLALQLQAEQDNLADAEERCHLLIKSKVQLEAKVKELSERLEDEEEVNADLAARRRKLEDEC 954

  Fly  1036 QDLEEQLEEEEAARQKLQLEKVQLDAKIKKYEEDLALTDDQNQKLLKEKKLLEERANDLSQTLAE 1100
            .:|::.:::.|....|.:.||...:.|:|...|::|..|:...:|.||||.|:|........|..
Mouse   955 TELKKDIDDLELTLAKAEKEKQATENKVKNLTEEMAALDEAVVRLTKEKKALQEAHQQALGDLQA 1019

  Fly  1101 EEEKAKHLAKLKAKHEATISELEERLHKDQQQRQESDRSKRKIETEVADLKEQLNERRVQVDEMQ 1165
            ||::...|||.|.:.|..:.:||..|.::::.|.:::|:|||:|.::...:|.:.:......:::
Mouse  1020 EEDRVSALAKAKIRLEQQVEDLECSLEQEKKLRMDTERAKRKLEGDLKLTQETVTDTTQDKQQLE 1084

  Fly  1166 AQLAKREEELTQTLLRIDEESATKATAQKAQRELESQLAEIQEDLEAEKAARAKAEKVRRDLSEE 1230
            .:|.|::.||:|..||:::|.......||..:||:::..|::|:||||:||||:.||.|.:.:.|
Mouse  1085 EKLKKKDSELSQLNLRVEDEQLVGVQLQKKIKELQARAEELEEELEAERAARARVEKQRAEAARE 1149

  Fly  1231 LEALKNELLDSLDTTAAQQELRSKREQELATLKKSLEEETVNHEGVLADMRHKHSQELNSINDQL 1295
            ||.|...|.::...:|.|:|...|||.||..|::.|||..:.||..:|.:|.|.:.....:::|:
Mouse  1150 LEELSERLEEAGGASAGQREGCRKREAELGRLRRELEEAVLRHEATVAALRRKQADSAAELSEQV 1214

  Fly  1296 ENLRKAKTVLEKAKGTLEAENADLATELRSVNSSRQENDRRRKQAESQIAELQVKLAEIERARSE 1360
            ::|::.:..|||.|..|..|..||...:.::...:...::..:..|.|::|.::|:.|::|..::
Mouse  1215 DSLQRIRQKLEKEKSELRMEVDDLGASVETLARGKASAEKLCRTYEDQLSEAKIKVEELQRQLAD 1279

  Fly  1361 LQEKCTKLQQEAENITNQLEEAELKASAAVKSASNMESQLTEAQQLLEEETRQKLGLSSKLRQIE 1425
            ...:..:||.|...:...|||.|...|...:..::....|.|.::.||||::.|..|:..::.:.
Mouse  1280 ASTQRGRLQTENGELGRLLEEKESMISQLSRGKTSAAQSLEELRRQLEEESKAKGALAHAVQALR 1344

  Fly  1426 SEKEALQEQLEEDDEAKRNYERKLAEVTTQMQEIKKKAEEDA-DLAKELEEGKKRLNKDIEALER 1489
            .:.:.|:||.||:.||:...:|.|::...::.:.:.|.|.|| ...:||||.||:|...::..|.
Mouse  1345 HDCDLLREQHEEESEAQAELQRLLSKANAEVAQWRSKYEADAIQRTEELEEAKKKLALRLQEAEE 1409

  Fly  1490 QVKELIAQNDRLDKSKKKIQSELEDATIELEAQRTKVLELEKKQKNFDKILAEEKAISEQIAQER 1554
            .|:...|:...|:|:|.::|:|.||.|:|||...:....|:|||::.::.|.|.:...|::.:|.
Mouse  1410 GVEAANAKCSSLEKAKLRLQTESEDVTLELERATSAAAALDKKQRHLERALEERRRQEEEMQREL 1474

  Fly  1555 DTAEREAREKETKVLSVSRELDEAFDKIEDLENKRKTLQNELDDLANTQGTADKNVHELEKAKRA 1619
            :.|:||||...|::..:....:||.:.:|.|:.:.|.||.|:.||.:....:.|::.||||||:|
Mouse  1475 EAAQREARGLGTELFRLRHSHEEALEALETLKRENKNLQEEISDLTDQVSLSGKSIQELEKAKKA 1539

  Fly  1620 LESQLAELKAQNEELEDDLQLTEDAKLRLEVNMQALRSQFERDLLAKEEGAEEKRRGLVKQLRDL 1684
            ||.:.:||:|..||.|..|:|.|...||:::.:..::::.:|.|..|:|.....||...:.:..|
Mouse  1540 LEGEKSELQAALEEAEGALELEETKTLRIQLELSQVKAEVDRKLAEKDEECTNLRRNHQRAVESL 1604

  Fly  1685 ETELDEERKQRTAAVASKKKLEGDLKEIETTMEMHNKVKEDALKHAKKLQAQVKD--ALRDAEEA 1747
            :..||.|.:.|..|:..|||:||||.::|..:....:...:|....:.||||:|:  |.||.|:.
Mouse  1605 QASLDAETRARNEALRLKKKMEGDLNDLELQLGHATRQAMEAQAATRLLQAQLKEEQAGRDEEQR 1669

  Fly  1748 KAA--KEELQALSKEAERKVKALEAEVLQLTEDLASSERARRAAETERDELAE--EIANNANKGS 1808
            .||  :|:.|||    ||:...|.||:.:|...|...||:||.||.|..|..|  .:.::.|.| 
Mouse  1670 LAAELREQGQAL----ERRAALLAAELEELRAALEQGERSRRLAEQELLEATERLNLLHSQNTG- 1729

  Fly  1809 LMIDEKRRLEARIATLEEELEEEQSNSEVLLDRSRKAQLQIEQLTTELANEKSNSQKNENGRALL 1873
             ::::|::||..:|.|..|:||.........::::||......:..||..|:..|...|..:..|
Mouse  1730 -LLNQKKKLEVDLAQLSGEVEEAAQERREAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKTL 1793

  Fly  1874 ERQNKELKAKLAEIETAQRTKVKATIATLEAKIANLEEQLENEGKERLLQQKANRKMDKKIKELT 1938
            |:..:||:|:|.|.|.|.....|..:..||||:..||.:|:.|.|:.....|..||.::::|||.
Mouse  1794 EQTVRELQARLEEAEQAALRGGKKQVQKLEAKVRELEAELDAEQKKHAEALKGVRKHERRVKELV 1858

  Fly  1939 MNIEDERRHVDQHKEQMDKLNSRIKLLKRNLDETEEELQKEKTQKRKYQRECEDMIESQEAMNRE 2003
            ...|::|:::.:.::.:|||.|::|..||..:|.|::......:.||.|.|.:|..|..:....:
Mouse  1859 YQTEEDRKNLARMQDLVDKLQSKVKSYKRQFEEAEQQASTNLAKYRKAQHELDDAEERADMAETQ 1923

  Fly  2004 INSLKTKLR 2012
            .|.|:.:.|
Mouse  1924 ANKLRARSR 1932

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
zipNP_523860.2 Myosin_N 79..122 CDD:460670 16/44 (36%)
MYSc_Myh2_insects_mollusks 145..854 CDD:276876 357/721 (50%)
Myosin_tail_1 931..2011 CDD:460256 345/1086 (32%)
Myh7bXP_017174700.1 Myosin_N 30..74 CDD:460670 16/45 (36%)
MYSc_Myh7b 98..773 CDD:276953 357/721 (50%)
Myosin_tail_1 853..1930 CDD:460256 345/1082 (32%)

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