DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment zip and Myh15

DIOPT Version :10

Sequence 1:NP_523860.2 Gene:zip / 38001 FlyBaseID:FBgn0287873 Length:2056 Species:Drosophila melanogaster
Sequence 2:NP_001159682.1 Gene:Myh15 / 667772 MGIID:3643515 Length:1925 Species:Mus musculus


Alignment Length:1979 Identity:678/1979 - (34%)
Similarity:1113/1979 - (56%) Gaps:103/1979 - (5%)


- Green bases have known domain annotations that are detailed below.


  Fly    62 VERNQ----FNDPATQAEWTQKRLVWVPHENQGFVAASIKREHGDEVEVELAET--GKRVMILRD 120
            :.||:    |..||    :..|:..|||.....::.|.:| |.||:.:| :.||  |:.:.|..|
Mouse    13 LRRNKADPLFQPPA----FDGKKKCWVPDGKNAYIEAEVK-ESGDDGQV-IVETRDGEIMRIKED 71

  Fly   121 DIQKMNPPKFDKVEDMAELTCLNEASVLHNIKDRYYSGLIYTYSGLFCVVVNPYKKLPIYTEKIM 185
            .:|:|||.:.:.:||::.|..||||||||.::.||...:||||||:|||.:||||.||:|.:::|
Mouse    72 KLQQMNPEELEMIEDLSMLLYLNEASVLHTLRRRYDHWMIYTYSGIFCVAINPYKWLPVYQKEVM 136

  Fly   186 ERYKGIKRHEVPPHVFAITDSAYRNMLGDREDQSILCTGESGAGKTENTKKVIQFLAYVAA-SKP 249
            ..||..:|.|||||:||:.:.|:::||.:.|:|||:.|||||:|||.|||.:||:.|.:|| |:|
Mouse   137 AAYKRKRRSEVPPHIFAVANRAFQDMLRNGENQSIVFTGESGSGKTVNTKLIIQYFATMAAISEP 201

  Fly   250 KGSGAVPHPAVLINFSVNTNKYIKVKIMAQNQNQTIEVVNGLKMVEVNSNCQEGELEQQLLQANP 314
            |.                                                 :.|.||.|:::.||
Mouse   202 KK-------------------------------------------------KLGNLEDQIVKMNP 217

  Fly   315 ILEAFGNAKTVKNDNSSRFGKFIRINFDASGFISGANIETYLLEKSRAIRQAKDERTFHIFYQLL 379
            :|||||||||.||||||||||.|||:|.|.|.:|.|:|:.|.|||||.:.|...||.:|||||:|
Mouse   218 LLEAFGNAKTQKNDNSSRFGKLIRIHFGARGTLSFADIQIYFLEKSRVVYQQPGERNYHIFYQIL 282

  Fly   380 AGATPEQREKFILDDVKSYAFLSNGSLPVPGVDDYAEFQATVKSMNIMGMTSEDFNSIFRIVSAV 444
            :|....:....:..:...:...|.|.:.|..:||..||.||.|:::::|...::....:::|.|:
Mouse   283 SGNQELRNMLLVSTNPSDFHICSCGVVAVESLDDAKEFLATEKAIDVLGFLPDEKFGCYKLVGAI 347

  Fly   445 LLFGSMKFRQERNNDQATLPDNTVAQKIAHLLGLSVTDMTRAFLTPRIKVGRDFVTKAQTKEQVE 509
            :.||::||::....:|........|.|.|.|:|:..:::.:..:.||||||.::||::|..:||.
Mouse   348 MHFGNLKFKRNLREEQLEADGTENADKAAFLMGIHASELLKGLIYPRIKVGNEYVTRSQNLQQVT 412

  Fly   510 FAVEAIAKACYERMFKWLVNRINRSLDRTKRQGASFIGILDMAGFEIFELNSFEQLCINYTNEKL 574
            :||.|::::.|||||:|||.|:|:.|| .|.....|:||||..||||.:.||.||||||:|||||
Mouse   413 YAVGALSQSIYERMFQWLVARMNQVLD-AKLTSHFFVGILDTTGFEILDYNSLEQLCINFTNEKL 476

  Fly   575 QQLFNHTMFILEQEEYQREGIEWKFIDFGLDLQPTIDLIDKPGGIMALLDEECWFPKATDKTFVD 639
            ||.||..:||||||||::||::|..||:|||:|..||.|:||.||.::|:|||..|||||:.|..
Mouse   477 QQFFNQQLFILEQEEYRKEGLDWLSIDYGLDVQACIDFIEKPMGIFSILEEECMLPKATDQMFKT 541

  Fly   640 KLV------SAHSMHPKFMKTDFRGVADFAIVHYAGRVDYSAAKWLMKNMDPLNENIVSLLQGSQ 698
            ||.      ||:...|...:.:|.  ..|.:.||||.|.|:.:.|:.||...|||.:|:|||.|.
Mouse   542 KLFDHHFGKSAYFQTPTSPEKNFE--VHFELAHYAGVVPYNISGWIGKNKGLLNETVVALLQKSS 604

  Fly   699 DPFVVNIWKDAEIVGMAQQALTDTQFGART-RKG-MFRTVSHLYKEQLAKLMDTLRNTNPNFVRC 761
            :..:.|::....|.|.|      :|||.:| :|| .|..::.|:||.:.|||..|::|.|:||||
Mouse   605 NKVLANLFTKDIIAGSA------SQFGEKTHKKGTSFHLITSLHKENINKLMTDLKSTAPHFVRC 663

  Fly   762 IIPNHEKRAGKIDAPLVLDQLRCNGVLEGIRICRQGFPNRIPFQEFRQRYELLTPNVIPKG-FMD 825
            |.||..|..|.:|..|||.||||||||||||:|.:.||:.:.:.:|:|||.:|.|.:..|. |:.
Mouse   664 INPNKNKIPGVMDPFLVLQQLRCNGVLEGIRVCCEAFPSWMLYDDFKQRYWILNPRIFSKSKFVS 728

  Fly   826 GKKACEKMIQALELDSNLYRVGQSKIFFRAGVLAHLEEERDFKISDLIVNFQAFCRGFLARRNYQ 890
            .:||.|:::..||:|...|:.|.:|:||:|.:|..|||.||.|||.:...|||..||.|.|..:|
Mouse   729 SRKATEEVLDFLEIDHPHYQCGVTKVFFKAFILDQLEERRDEKISKVFTLFQARARGKLMRITFQ 793

  Fly   891 KRLQQLNAIRIIQRNCAAYLKLRNWQWWRLYTKVKPLLEVTKQEEKLVQKEDELKQVREKLDTLA 955
            |.|::.:|:.:||.|..|::.::|..|..|:.|:|||.:.....|::...::|..|:::.|::..
Mouse   794 KILEERDALALIQENIRAFIAVKNCPWMGLFFKIKPLAKSVGAGEEIAGLKEECAQLQKALESSE 858

  Fly   956 KNTQEYERKYQQALVEKTTLAEQLQAEIELCAEAEESRSRLMARKQELEDMMQELETRIEEEEER 1020
            ...:|.:.|....:.||..|..|||||.|..|.:||....|:..|.|||..::||..::|||||.
Mouse   859 SQREELKTKQVSLVQEKNDLRLQLQAEQETLANSEEQCESLIKSKVELEVKIKELSRQVEEEEEI 923

  Fly  1021 VLALGGEKKKLELNIQDLEEQLEEEEAARQKLQLEKVQLDAKIKKYEEDLALTDDQNQKLLKEKK 1085
            ...|....:|||....:|::::.:.||...|.:..|...:.|::...|::...:::..||.:..|
Mouse   924 NSELTARGRKLEDECSELKKEIYDLEAILAKSEKGKCAAEHKVRNLTEEVHSLNEEVSKLSRVVK 988

  Fly  1086 LLEERANDLSQTLAEEEEKAKHLAKLKAKHEATISELEERLHKDQQQRQESDRSKRKIETEVADL 1150
            ..:|......:.|..||||..:::|...|....|..||..|.::::.|.:.:|.|||::.|:...
Mouse   989 DAQETQQQTQEQLHIEEEKLSNMSKANLKLAQQIDVLEGDLERERKARMKCEREKRKLQDELKMN 1053

  Fly  1151 KEQLNERRVQVDEMQAQLAKREEELTQTLLRIDEESATKATAQKAQRELESQLAEIQEDLEAEKA 1215
            :|..........::..||.|:|.|:.|...:::.|....:..||..:||::.:..::|:||:|:.
Mouse  1054 QEGAENLESSRQKLAEQLRKKEFEMGQMNSKVENEKNQVSQLQKMVKELQTHILNLKEELESERT 1118

  Fly  1216 ARAKAEKVRRDLSEELEALKNELLDSLDTTAAQQELRSKREQELATLKKSLEEETVNHEGVLADM 1280
            .|||.|:.:.||.::||.|...|.::..|:.||.|:..::|.....|...:||.|.:.|...|.:
Mouse  1119 IRAKVEREKGDLVQDLEDLNERLEEAGGTSLAQMEITKQQEARFQKLHHDMEETTRHFEATSASL 1183

  Fly  1281 RHKHSQELNSINDQLENLRKAKTVLEKAKGTLEAENADLATELRSVNSSRQENDRRRKQAESQIA 1345
            :.:|::.|..:..|:|:|::.:.|||:.|..|:.:..||...:..:..::...::.....|.::.
Mouse  1184 KKRHAENLAELEGQVEHLQQVRLVLEQDKSDLQLQVDDLLNRVDQMARAKANAEKLCGLYERRLN 1248

  Fly  1346 ELQVKLAEIERARSELQEKCTKLQQEAENITNQLEEAELKASAAVKSASNMESQLTEAQQLLEEE 1410
            |...||.|:.:...:|..:.||||.|:.....:|||.|...|...:..||...|:.|.:..||||
Mouse  1249 EANTKLDEVTQLAHDLTTQKTKLQSESGEFFKRLEEKEALISQLSREKSNFTRQVEELRAQLEEE 1313

  Fly  1411 TRQKLGLSSKLRQIESEKEALQEQLEEDDEAKRNYERKLAEVTTQMQEIKKKAEEDA-DLAKELE 1474
            :|.:..||..|:..:.:.:.|:||.||:.|.|....|.|::...:..:.:.|.|.|| ...::||
Mouse  1314 SRSQSALSHALQSAKHDYDLLREQYEEEQEVKAELHRALSKGNKETVQWRAKYEHDAMQRTEDLE 1378

  Fly  1475 EGKK----RLNKDIEALERQVKELIAQNDRLDKSKKKIQSELEDATIELEAQRTKVLELEKKQKN 1535
            |.||    ||.:..||:|  |..  |:|..|::::.::|.||.||..:|...|:....|.:||::
Mouse  1379 EAKKKLAIRLQEAAEAME--VSN--AKNASLERARHRLQLELGDALSDLGKARSVAAALGQKQQH 1439

  Fly  1536 FDKILAEEKAISEQIAQERDTAEREAREKETKVLSVSRELDEAFDKIEDLENKRKTLQNELDDLA 1600
            .||.|...|...::..:....:::|.|...::||:..:..:|:.:..|.|:.:.:.||.::..|.
Mouse  1440 SDKALTSWKQKLDETQELLQASQKETRALSSEVLTFRQACEESTEAQETLKRQNQDLQEQICSLT 1504

  Fly  1601 NTQGTADKNVHELEKAKRALESQLAELKAQNEELEDDLQLTEDAKLRLEVNMQALRSQFERDLLA 1665
            |......||:.|:||||:.:|.:..|::.:.||.|..|:..|...||.::.:...:::.||.|..
Mouse  1505 NQVREGIKNLAEVEKAKKLIEQEKTEVQVRLEETEGALERNESKILRFQLELSEAKAELERKLSE 1569

  Fly  1666 KEEGAEEKRRGLVKQLRDLETELDEERKQRTAAVASKKKLEGDLKEIETTMEMHNKVKEDALKHA 1730
            |||.||..|....:.:..|::.||.|...|..|...:||:||||||:|..:...|:......:..
Mouse  1570 KEEEAERLREKHQQAMGSLQSNLDLEASSRIEATRLRKKMEGDLKEMEIQLCAANRQVSQMTRAL 1634

  Fly  1731 KKLQAQVKDALRDAEEAKAAKEELQALSKEAERKVKALEAEVLQLTEDLASSERARRAAETERDE 1795
            .:||.|:||..:..:::....::|:.....||::...|::|:.:|......:||.|:.||.|..|
Mouse  1635 GQLQGQMKDLHQQLDDSIYQNKDLKEQVALAEQRTVLLQSELEELRTLQEQTERGRKLAEKELLE 1699

  Fly  1796 LAEEIANNANKGSLMIDEKRRLEARIATLEEELEEEQSNSEVLLDRSRKAQLQIEQLTTELANEK 1860
            ..|.|.....:.:.::.:|::|||.:|.:::|..|       :|...:||:.:.::...|.||..
Mouse  1700 ATERINLFHTQNTSLLSQKKKLEADVAQVQKEAGE-------MLQACQKAEEKAKKTAAEAANMS 1757

  Fly  1861 SNSQKNENGRALLERQNKELKAKLAE----IETAQRTKV---KATIATLEAKIANLEEQLENEGK 1918
            ...:|.::..|.|||..|.::..:.:    ::.|::|.|   |..|..||:::.:||.:||:|.:
Mouse  1758 EELKKEQDTNAHLERMRKNMEQTIKDLQKRLDEAEQTAVLGSKKQIQKLESRVRDLEGELESEVR 1822

  Fly  1919 ERLLQQKANRKMDKKIKELTMNIEDERRHVDQHKEQMDKLNSRIKLLKRNLDETEEELQKEKTQK 1983
            .....|:..|::::.|||||...|::::::.:.:...|||..:::..|:.::..|.:..:..::.
Mouse  1823 RSAEAQREARRLERGIKELTYQAEEDKKNLSRMQALSDKLQLKVQSYKQQVEAAEAQANQYLSKY 1887

  Fly  1984 RKYQRECEDMIESQEAMNREINSLKTKLR 2012
            :|.|.|..:..|..||...::|.|:.|.:
Mouse  1888 KKQQHELNEAKERAEAAESQVNKLRAKAK 1916

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
zipNP_523860.2 Myosin_N 79..122 CDD:460670 15/44 (34%)
MYSc_Myh2_insects_mollusks 145..854 CDD:276876 310/718 (43%)
Myosin_tail_1 931..2011 CDD:460256 304/1091 (28%)
Myh15NP_001159682.1 Myosin_N 28..73 CDD:460670 15/46 (33%)
MYSc_Myh15_mammals 96..757 CDD:276892 310/718 (43%)
Myosin_tail_1 838..1914 CDD:460256 304/1086 (28%)

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