DRSC/TRiP Functional Genomics Resources

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Protein Alignment zip and myo18aa

DIOPT Version :9

Sequence 1:NP_523860.2 Gene:zip / 38001 FlyBaseID:FBgn0265434 Length:2056 Species:Drosophila melanogaster
Sequence 2:XP_009303852.2 Gene:myo18aa / 566880 ZFINID:ZDB-GENE-080425-5 Length:2508 Species:Danio rerio


Alignment Length:2360 Identity:577/2360 - (24%)
Similarity:1034/2360 - (43%) Gaps:530/2360 - (22%)


- Green bases have known domain annotations that are detailed below.


  Fly    10 SKSALHPKSEYP--VSNIHYPKAANYRQT-RNYLEIAAKMSEE----VDRNDP--------ELKY 59
            ||.:..|..:.|  :|.|...:.:....| .|:..:....|.|    ....||        |...
Zfish   319 SKPSAAPAGKLPSQISTITNQQGSQVMPTPENHKHLEQNFSAERPPAKAAEDPVAILQAAHEAAC 383

  Fly    60 LSVERNQFNDPATQAEWTQKRLVWVPHENQGFVAASIKREHGD----EVEVELAETGKRVMILRD 120
            ||..:.: ...|.:..|.....||:.|::...:|..:|.:.|.    :|::.|...|..:.:..|
Zfish   384 LSKVKTE-EQLAAEKAWYNTEKVWLVHKDGFSLATQLKTDTGSLPEGKVKIRLEHDGTLLEVDED 447

  Fly   121 DIQKMNPPKFDKVEDMAELTCLNEASVLHNIKDRYYSGLIYTYSGLFCVVVNPYKKLPIYTEKIM 185
            |::|.||..:|:|||::.|..|||:|:||:::.||...||:||:|...:::||.....:|:||:|
Zfish   448 DVEKANPLSYDRVEDLSSLLYLNESSILHSLRQRYGGNLIHTYAGPNLLLINPLCSPAMYSEKVM 512

  Fly   186 ERYKGIKRHEVPPHVFAITDSAYRNMLGDREDQSILCTGESGAGKTENTKKVIQFLAYVAASKPK 250
            :.:||.:|.|..||:||:..|||..:|..|:||:|:..|.||:|||.||:.::|:|..:|||..|
Zfish   513 QMFKGCRREETAPHIFAVAQSAYHQLLTTRQDQTIVLLGRSGSGKTTNTQHLLQYLVTIAASSGK 577

  Fly   251 GSGAVPHPAVLINFSVNTNKYIKVKIMAQNQNQTIEVVNGLKMVEVNSNCQEGELEQQLLQANPI 315
            ...|....||.                                                    .:
Zfish   578 VYSAEKWQAVY----------------------------------------------------TV 590

  Fly   316 LEAFGNAKTVKNDNSSRFGKFIRINFDASGFISGANIETYLLEKSRAIRQAKDERTFHIFYQLLA 380
            ||||||..|..|.|:|||...:.::||.:|.::.|:::|.||||.|..|:.:.|.:|::||.|:|
Zfish   591 LEAFGNCSTAMNGNASRFSHIVSLDFDQAGQVASASVQTMLLEKFRVTRRPEGESSFNVFYYLMA 655

  Fly   381 GATPEQREKFILDDVKSYAFLSNGSLPVPGVDD-------YAEFQATVKSMNIMGMTSEDFNSIF 438
            ||....:.:...:.:...:  :.|..|...:||       :.:.||   :|.::|::.|:..:::
Zfish   656 GADAALKTELHFNHLAENS--TFGLHPPSKLDDKQKATQQFTKLQA---AMKVLGVSPEELKTVW 715

  Fly   439 RIVSAVLLFGSMKFRQERNNDQA---TLPDNTVAQKIAHLLGLSVTDMTRAFLTPR--------- 491
            .|:.|:...|:....:|  .|.|   ....:..|||.|:|||.|:.:::.|...|:         
Zfish   716 LILGAIYHLGAAGATKE--TDAAGRKQFARHEWAQKAAYLLGCSLEELSSAIFKPQGKGTLPRSA 778

  Fly   492 -IKVGRDFVTKAQTKEQVEFAVEAIAKACYERMFKWLVNRINRSLDRTKRQGASFIGILDMAGF- 554
             ::...:....|.:|......:|::|...|..:|..:::.|||:|..::....|.: |:|..|| 
Zfish   779 SLRPSTEDTDHAASKATAAECLESMAAGLYSELFTLIISLINRALKSSQHSLCSLL-IVDTPGFQ 842

  Fly   555 -------EIFELNSFEQLCINYTNEKLQQLFNHTMFILEQEEYQREGIEWKFIDFGLDLQP---- 608
                   :|....:||:||.||..|:||.||....|:.|.|.|:.|.||.. :|   ||:|    
Zfish   843 NPRQVKTQIQRSATFEELCHNYAQERLQTLFQERTFVKELERYKEENIEIT-LD---DLEPSPSR 903

  Fly   609 ---------------TIDLIDKPGGIMALLDEECWFPKATDKTFVDKLVSAH-------SMHPKF 651
                           |:...|:..|:..|::||...|..:::|.:.:|.|.:       :.|...
Zfish   904 SVAVIDQSSSQTLVRTLSRTDEARGLFWLMEEEVLQPGGSEETLLQRLFSYYGPAEGESTGHTVV 968

  Fly   652 MKTDFRGVADFAIVHYAGR--VDYSAAKWL-MKNMDPLNENIVSLLQGSQDPFVVNIW------- 706
            :|::  ....|.:.|..|.  |:|....|| :..::|..:|..:||..||...:..::       
Zfish   969 LKSE--NTNHFVLGHSHGTDWVEYDTYGWLNLARLNPTPQNAANLLLNSQKKSISGMFVGRSSSA 1031

  Fly   707 -----KDAEIVGMAQQAL--------TDTQFGARTRKGMFRTVSHLYKEQLAKLMDTLRNTNPNF 758
                 ..|.:.|::|.|:        |.|...|..:|   :::....|.|:..|:||:|.:..:|
Zfish  1032 AVLTGSIAGLEGVSQLAMRRATSMRKTFTTGMAAVKK---KSLCLQIKLQVDALLDTIRRSKVHF 1093

  Fly   759 VRCIIPNHE--KRAG-----------KIDAPLVLDQLRCNGVLEGIRICRQGFPNRIPFQEFRQR 810
            |.|::|..|  :.||           :||..|:..|:....:|:.:||.|||:|:.:.|.|||:|
Zfish  1094 VHCLLPRAEVLRAAGSPDESCDPGLMQIDVALLRAQIHGFKLLDSLRIYRQGYPDHMVFSEFRRR 1158

  Fly   811 YELLTPNVIPK-G----FMDGKKACEKMIQALELDSNLYRVGQSKIFFRAGVLAHLEEERDFKIS 870
            :::|.|::..| |    ..|.|:|.|:::::|||:.:.|.:|.|::|||||.:|.||.:||....
Zfish  1159 FDVLAPHLTKKLGRNYIVKDEKRAVEELLESLELEKSSYHMGLSRVFFRAGTVAKLEAQRDEHTR 1223

  Fly   871 DLIVNFQAFCRGFLARRNYQKRLQQLNAIRIIQRNCAAYLKLRNWQWWRLYTKVKPLLEVTKQEE 935
            ..|..|||.|||||:|:.::||..|..|||.:|:|......:::|.||:|:|.|:||:||...||
Zfish  1224 QNITLFQAACRGFLSRQAFKKRKIQDLAIRCVQKNIKKNRGVKDWPWWKLFTTVRPLVEVQLTEE 1288

  Fly   936 KLVQKEDELKQVREKLDTLAKNTQEYERKYQQALVEKTTLAEQLQAEI-ELCAEAEESRSRLMAR 999
            ::..|::|:..::.||:.:.|...|..           ..:::|::.| ||.||..:.|:...:.
Zfish  1289 QIRGKDEEIMHMKLKLERVEKERNELR-----------LTSDRLESRITELTAELSDERNTAEST 1342

  Fly  1000 KQELEDMMQE---LETRIEEEEERVLALGGEKKKLELNI--------QDLEEQL---EEEEAARQ 1050
            .|.||....|   ||..:::.:.:..||..:.:.:|:.|        .||..::   :::.....
Zfish  1343 SQLLETETSERLRLEKDMKDLQVKFDALKKQTESMEMEIMEARLLRASDLNGEMDDGDDDSGGEW 1407

  Fly  1051 KLQLEKVQLDAKI--KKYEEDLALTDDQNQKLLKEKKLLEERANDLSQTLAEEEEKAKHLAKLKA 1113
            :|:.|:...|.:.  ||.::::   ||:.:...:.|:.||.:..||.   |::||..:.:.:||.
Zfish  1408 RLKYERAIRDTEFTKKKLQQEM---DDKLETEQQNKRHLERKLADLQ---ADQEESQRSVQQLKK 1466

  Fly  1114 KHEATISELEE-RLHKDQQQ--RQESDRSKRKIETEVADLKEQLNERRVQVDEMQAQLAKREEEL 1175
            |.:...:||:: :||.:.|:  ..|.:|.:||.:.:.:.::|:|.:.|.|    :.:|::..:.|
Zfish  1467 KCQRLAAELQDTKLHLENQEGRNHELERKQRKFDVDKSQVQEELQKERNQ----REKLSRERDML 1527

  Fly  1176 TQTLLRIDEESATK----ATAQKAQRELESQLAEIQEDLEAEKAARAKAEKVRRDLSEELEALKN 1236
            |..:..|.::...|    .|......:|||:|.::......::|:.||.:|..|||..:::..:.
Zfish  1528 TSEMFTIKQQLQEKDTELCTVSLKVEQLESELQDLSSQESKDEASHAKVKKQLRDLEAKVKDQEE 1592

  Fly  1237 ELLDSLDTTAAQQELRSKREQELATLKKSLEEETVNHEGVLADMRHKHSQELNSINDQLENLR-K 1300
            ||         .::..|.:..|.|.|:..:|.|.         :|..||:||:|.::::|.:| .
Zfish  1593 EL---------DEQAGSIQMLEQAKLRLEMEMER---------LRQTHSKELDSKDEEVEEIRLS 1639

  Fly  1301 AKTVLEKAKGTLEAENADLATELRSVNSSRQENDRRRKQAESQIAELQVKLAEIE---RARSELQ 1362
            ....|::.:..||.|.||....||         |:|..:::...|:.||...::|   |.|.:| 
Zfish  1640 CSKKLKQMEVQLEEEYADKQRVLR---------DKRDLESKLMTAQEQVGQKDVETEKRLRKDL- 1694

  Fly  1363 EKCTKL------------------QQEAENITNQLEEAELKASAAVKSASNMESQLTEAQQLLEE 1409
             |.||:                  ::|...:.|:|||:|...:||||:..:||.::.:....:::
Zfish  1695 -KRTKVLLADAQIMLDHMKSNVPSKREIATLKNKLEESEFACAAAVKARKSMELEIEDLHIQMDD 1758

  Fly  1410 ETRQKLGLSSKLRQIESEKEALQEQLEEDDEAKRNYERKLAEVTTQMQEIKKK-----AEEDADL 1469
            .::.|:.|..:|.:::.||..||.:.|||.|              .|.|:.||     |:...||
Zfish  1759 ISKAKMSLEEQLSRLQREKNDLQSRFEEDQE--------------DMNELMKKHKAAVAQSTRDL 1809

  Fly  1470 AKELEEGKKRLNKDIEALERQVKELIAQNDRLDKSKKKIQSEL---EDATIE---LEAQRTKVLE 1528
            |:            |..|:.||:|.:.:...:......:||:|   |.:.:|   :..|..|:.|
Zfish  1810 AQ------------ISDLQTQVEEAMKEKQEIQDKLHSLQSQLEFQEQSMVEKSLVSRQEAKIRE 1862

  Fly  1529 LEKKQKNFDKILAEEKAISEQIAQERDTAEREAREKETKVLSVSRELDEAFDKIEDLENKRKTLQ 1593
            ||.|.: :::  .:.|.:...:.:.::..|:...|::.:|...:||.|         :|||  ||
Zfish  1863 LETKLE-YER--TQTKRLESLVTRLKENLEKMTEERDQRVGCENREKD---------QNKR--LQ 1913

  Fly  1594 NELDDLANTQGTADKNVHELEKAKRALESQLAELKAQNEELEDDLQLTEDAKLRLEVNMQALRSQ 1658
            .::.|:........|...|..:.|..||..:..|:|.|:.|:.||:|   |..|:.....|:..:
Zfish  1914 RQIRDIKEEMTELSKKEAEASRKKHELEMDIESLEAANQSLQADLKL---AFKRIGDLQAAMEDE 1975

  Fly  1659 FE-----------RDLLAKEEGAEEKRRGLVKQLRDLETELDEERKQRTAAVASKKK-------- 1704
            .|           :|::.|    .:||:.......|:::|: |:|.....::.||.|        
Zfish  1976 METDDDDDLINSLQDMVTK----YQKRKNKTGDESDMDSEV-EDRVDGVKSLLSKSKGSTKTLSD 2035

  Fly  1705 ------------LEGDLKEIETTMEMHNKVKED-----------ALKHAKKLQAQVKD------- 1739
                        ...|:|:::...|....||:|           :|.:.|:  |..||       
Zfish  2036 DGPQKTTRHPNSANADVKDVKEGKEGKEDVKKDSDESRSVSVISSLSYRKR--AHQKDWNGGAGD 2098

  Fly  1740 ------ALRDAEE------AKAAK--------EEL--------QALSKEAERKVKALEAEVLQLT 1776
                  |||:..|      .:.||        ::|        ||.|:.|.|..|.|:....:.:
Zfish  2099 ETSLFSALREQPEMPDRLSLRKAKTKSTDRPGDDLDDRGSVISQAYSEAAIRARKGLDRRWTKSS 2163

  Fly  1777 -----EDLASS---ERA--RRAAETERDELAEEIANNANKGSLMIDEKRRLEARIATLEEELEEE 1831
                 |.:.||   .||  ||..:.:.|..:...:.:..:.:..||:.|......:|...:....
Zfish  2164 PEFDKESMVSSVAPSRASTRRGIDEDEDARSGVSSFSLRRSTSWIDDSRSDYGSASTSHRQRSRS 2228

  Fly  1832 QS------NSEVLLDRSRK---------------------------------------AQLQIEQ 1851
            :|      .|.:.|.||.:                                       ||::..:
Zfish  2229 RSPGSTSVGSRISLARSTRLSEFGVRLNNDDVDEDDDVDSVSVAAYSPRSQGRSLSTPAQMRSSE 2293

  Fly  1852 LTTELANEKSNSQKNENGRALLERQNKELKAKLAEIETAQRTKVKATIATLEAKIANLE------ 1910
            ...:.::.|..|.:|        ..:.:|:..:.|:.:.:..|.|.  .:||.....||      
Zfish  2294 SPVDASDIKPVSHRN--------YLDPDLEKAINEVLSFKPIKFKR--RSLEDSDEELEGGGGAG 2348

  Fly  1911 EQLENEGKERLLQQK----------------------------ANRKMDKKIKELTMNIEDERRH 1947
            |..:.:|.:.|||.|                            :.||..||.:....:......|
Zfish  2349 EDEDRKGTKSLLQDKDDKDLGLTRSALDSGRSGSSMSSFSSKSSRRKNKKKSRRSESDSSSNEGH 2413

  Fly  1948 VDQHKEQMDKLNSRIKLLKRNLDETEEELQKEKTQKRKYQRECEDMIESQEAMNREINSLKTKLR 2012
            ..:|.::.||..||             ..:|:::...|.:.|......:.....|..||:|....
Zfish  2414 SRRHSKRKDKRGSR-------------NSRKKESGSSKSESESSSSSSASTVSYRSSNSVKRTTN 2465

  Fly  2013 RTGGIGLSSSRLTGTPSSKR 2032
            :....|...|.:...|.||:
Zfish  2466 QKASDGDRESPVEERPPSKK 2485

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
zipNP_523860.2 Myosin_N 80..117 CDD:280832 9/40 (23%)
Myosin_head 133..854 CDD:278492 227/815 (28%)
MYSc_Myh2_insects_mollusks 145..854 CDD:276876 220/803 (27%)
Myosin_tail_1 931..2011 CDD:279860 276/1302 (21%)
Prefoldin 1431..1515 CDD:298833 23/91 (25%)
FAM76 <1847..1926 CDD:292665 17/112 (15%)
myo18aaXP_009303852.2 Atrophin-1 <36..373 CDD:331285 12/53 (23%)
Myosin_head 397..1944 CDD:332202 456/1705 (27%)
MYSc_Myo18 472..1207 CDD:276837 220/803 (27%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG0161
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
21.810

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