DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment zip and myh11b

DIOPT Version :9

Sequence 1:	NP_523860.2	Gene:	zip / 38001	FlyBaseID:	FBgn0265434	Length:	2056	Species:	Drosophila melanogaster
Sequence 2:	XP_017210292.1	Gene:	myh11b / 566080	ZFINID:	ZDB-GENE-101124-2	Length:	2005	Species:	Danio rerio

Alignment Length:	2032	Identity:	1076/2032 - (52%)
Similarity:	1478/2032 - (72%)	Gaps:	65/2032 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly    53 NDPELKYLSVERNQFNDPATQAEWTQKRLVWVPHENQGFVAASIKREHGDEVEVELAETGKRVMI 117
            ||...|:|.::....|....||:|:.:::||:|.|..||.:||||.|.|:||.||| :.|::|.:
Zfish     6 NDDSNKFLFLDSEFKNSGVAQADWSTRKMVWIPSERDGFQSASIKEETGNEVVVEL-DNGQKVTV 69

  Fly   118 LRDDIQKMNPPKFDKVEDMAELTCLNEASVLHNIKDRYYSGLIYTYSGLFCVVVNPYKKLPIYTE 182
            .:|||||||||||:||||||.||||||||||||:::||:||||||||||||||:||||.||||:|
Zfish    70 SKDDIQKMNPPKFNKVEDMAALTCLNEASVLHNLRERYFSGLIYTYSGLFCVVINPYKMLPIYSE 134

  Fly   183 KIMERYKGIKRHEVPPHVFAITDSAYRNMLGDREDQSILCTGESGAGKTENTKKVIQFLAYVAAS 247
            ||:|.|||.||||||||::::||:||||||.:|||||||||||||||||||||||||:||.||:|
Zfish   135 KIIEMYKGKKRHEVPPHIYSVTDNAYRNMLQEREDQSILCTGESGAGKTENTKKVIQYLAVVASS 199

  Fly   248 KPKGSGAVPHPAVLINFSVNTNKYIKVKIMAQNQNQTIEVVNGLKMVEVNSNCQEGELEQQLLQA 312
            . ||....         :.:|:.      .|.|:.|.            .|....||||:|||||
Zfish   200 H-KGKKEA---------TSDTSS------SAPNKQQK------------GSQLAFGELEKQLLQA 236

  Fly   313 NPILEAFGNAKTVKNDNSSRFGKFIRINFDASGFISGANIETYLLEKSRAIRQAKDERTFHIFYQ 377
            ||||||||||||:||||||||||||:||||.:|:|.|||||||||||||.|||||.||:|||||.
Zfish   237 NPILEAFGNAKTIKNDNSSRFGKFIKINFDNTGYIVGANIETYLLEKSRCIRQAKIERSFHIFYY 301

  Fly   378 LLAGATPEQREKFILDDVKSYAFLSNGSLPVPGVDDYAEFQATVKSMNIMGMTSEDFNSIFRIVS 442
            ::|||..:.||:.:|:|..:|.||..|.:.|....|....:.|:::|.::|...|:...:|:|.|
Zfish   302 MVAGAKDKMREELLLEDFANYRFLVAGHVQVQNQQDDEMLEETLEAMEVLGFNEEERIGMFKICS 366

  Fly   443 AVLLFGSMKFRQERNNDQATLPDNTVAQKIAHLLGLSVTDMTRAFLTPRIKVGRDFVTKAQTKEQ 507
            .||..|:::|:.|:|.:||::||||.|||:.||.|::|||.|:|.|||:|||||:.|.|||||||
Zfish   367 TVLQLGNIEFKAEKNQEQASMPDNTAAQKVCHLQGINVTDFTKAMLTPKIKVGRELVQKAQTKEQ 431

  Fly   508 VEFAVEAIAKACYERMFKWLVNRINRSLDRTKRQGASFIGILDMAGFEIFELNSFEQLCINYTNE 572
            .:|||||:|||.|:|:|:|::.|:|::||:|||||||||||||:|||||||.|||||||||||||
Zfish   432 ADFAVEALAKAMYDRLFRWILGRVNKALDKTKRQGASFIGILDIAGFEIFEDNSFEQLCINYTNE 496

  Fly   573 KLQQLFNHTMFILEQEEYQREGIEWKFIDFGLDLQPTIDLIDKPG---GIMALLDEECWFPKATD 634
            ||||||||||||||||||::|||||.||||||||||.|:||::|.   ||:||||||||||||||
Zfish   497 KLQQLFNHTMFILEQEEYKKEGIEWSFIDFGLDLQPCIELIERPNNPPGILALLDEECWFPKATD 561

  Fly   635 KTFVDKLVSAHSMHPKFMK-TDFRGVADFAIVHYAGRVDYSAAKWLMKNMDPLNENIVSLLQGSQ 698
            .:||:||.:.||.|.||.| .:.:....|.:.||||:|||:|..||.|||||||:|:.:||..|.
Zfish   562 VSFVEKLTNTHSSHCKFSKPKNLKEKTFFTVQHYAGKVDYNAMSWLTKNMDPLNDNVTALLSNSS 626

  Fly   699 DPFVVNIWKDAE-IVG---MAQQALTDTQFGA--RTRKGMFRTVSHLYKEQLAKLMDTLRNTNPN 757
            ..|:.:||||.: :||   ||:.|.:|:...|  :::|||||||..||||.|.|||.||.||.||
Zfish   627 SAFIQDIWKDVDRVVGLETMAKMAKSDSSAPAASKSKKGMFRTVGQLYKESLGKLMTTLHNTQPN 691

  Fly   758 FVRCIIPNHEKRAGKIDAPLVLDQLRCNGVLEGIRICRQGFPNRIPFQEFRQRYELLTPNVIPKG 822
            ||||||||||||||||||.||||||.|||||||||||||||||||.|.|||||||:|....||||
Zfish   692 FVRCIIPNHEKRAGKIDAHLVLDQLSCNGVLEGIRICRQGFPNRIVFHEFRQRYEVLAAGSIPKG 756

  Fly   823 FMDGKKACEKMIQALELDSNLYRVGQSKIFFRAGVLAHLEEERDFKISDLIVNFQAFCRGFLARR 887
            |||||::|..||:.|:||.||||:|.||||||.||||.||||||.|::|:|:.|||..||||.|:
Zfish   757 FMDGKQSCTLMIKHLDLDPNLYRIGLSKIFFRTGVLAQLEEERDLKLTDIIIAFQAQARGFLGRK 821

  Fly   888 NYQKRLQQLNAIRIIQRNCAAYLKLRNWQWWRLYTKVKPLLEVTKQEEKLVQKEDELKQVREKLD 952
            .:..:.:||.|::::|||||.||.|||||||||:|||||||:||:|||::.|.|:||::.:|...
Zfish   822 AFSNKQKQLTAMKVLQRNCAVYLTLRNWQWWRLFTKVKPLLQVTRQEEEMNQIEEELQKAKEIAQ 886

  Fly   953 TLAKNTQEYERKYQQALVEKTTLAEQLQAEIELCAEAEESRSRLMARKQELEDMMQELETRIEEE 1017
            ......:|..:|:.|.:.|:..|..:||.|.||.||:||.|.||..:|||||:::.|:|.|:|||
Zfish   887 KSETELKEITQKHDQVVEERNKLQAKLQEEAELYAESEEVRIRLETKKQELEEVLHEMEARLEEE 951

  Fly  1018 EERVLALGGEKKKLELNIQDLEEQLEEEEAARQKLQLEKVQLDAKIKKYEEDLALTDDQNQKLLK 1082
            |||..|...||..|:..:::||..|.|::|.|||||||....|.||||.|||:.:.:||..||.|
Zfish   952 EERSQAFQQEKGNLQQKLKELENHLAEQDATRQKLQLESGAADGKIKKLEEDVLIMEDQKNKLQK 1016

  Fly  1083 EKKLLEERANDLSQTLAEEEEKAKHLAKLKAKHEATISELEERLHKDQQQRQESDRSKRKIETEV 1147
            ||:.||||..|.|..|||||||:|:|.|||||||:.||:||.|:.|:::.||:.:::|||:|||.
Zfish  1017 EKQQLEERLADFSSNLAEEEEKSKNLTKLKAKHESMISDLEVRMKKEEKSRQDVEKAKRKLETEH 1081

  Fly  1148 ADLKEQLNERRVQVDEMQAQLAKREEELTQTLLRIDEESATKATAQKAQRELESQLAEIQEDLEA 1212
            :||:||:...:..:.|::.|.|:.|.|:.:....::.||..|:.|.|...|:|..|:|:|::|||
Zfish  1082 SDLQEQMKNLQTLIAELKTQQARSEMEIQELQASVEAESTQKSNALKKIHEMEGLLSELQDELEA 1146

  Fly  1213 EKAARAKAEKVRRDLSEELEALKNELLDSLDTTAAQQELRSKREQELATLKKSLEEETVNHEGVL 1277
            |:.|..|:||.|::|.|||.||:.||.|||||||.|||||:|||||:|.|||.:|:|..:||..:
Zfish  1147 EQGAGRKSEKARKELEEELSALRTELEDSLDTTAVQQELRAKREQEVAMLKKLIEDEGRSHEAQV 1211

  Fly  1278 ADMRHKHSQELNSINDQLENLRKAKTVLEKAKGTLEAENADLATELRSVNSSRQENDRRRKQAES 1342
            .:::.||:|.::.::.||:..::||..|||||..||.|..||...|||:.:::|:.::::|:.|:
Zfish  1212 HELKQKHAQAVDELSQQLDQSKRAKATLEKAKQALEKEVGDLNGNLRSLGNAKQDLEQKKKKVET 1276

  Fly  1343 QIAELQVKLAEIERARSELQEKCTKLQQEAENITNQLEEAELKASAAVKSASNMESQLTEAQQLL 1407
            |:|:||.:..|.||.|.||.:..:||..|..|:.:.|.|||.|.....|...::.|||.:||:||
Zfish  1277 QLADLQTRFNESERKREELGDAVSKLNTEYNNVNSILNEAESKNIKLSKDVVSLNSQLQDAQELL 1341

  Fly  1408 EEETRQKLGLSSKLRQIESEKEALQEQLEEDDEAKRNYERKLAEVTTQMQEIKKKAEEDADLAKE 1472
            .|||||||..|::|||:|.|:..|.||::|:.||:||.||.::.:.||:.|.||:.:|.:...:.
Zfish  1342 AEETRQKLNFSTRLRQMEDERNGLLEQIDEETEARRNVERHVSSLNTQLSEAKKRLDEYSSNFQM 1406

  Fly  1473 LEEGKKRLNKDIEALERQVKELIAQNDRLDKSKKKIQSELEDATIELEAQRTKVLELEKKQKNFD 1537
            |||.||||.:|:||.:.:::|..|..|:.:|:|..:|.||:|..::|:.||..|..:||||:.||
Zfish  1407 LEESKKRLQRDLEATKGELEEKTASYDKSEKTKNHLQQELDDVLLDLDNQRQLVSNMEKKQRKFD 1471

  Fly  1538 KILAEEKAISEQIAQERDTAEREAREKETKVLSVSRELDEAFDKIEDLENKRKTLQNELDDLANT 1602
            ::||:||.:|.:.:||||.||.||||||||.|:::|.|:|....:.:||...|||:.:::||.::
Zfish  1472 QMLADEKTLSSKYSQERDCAEAEAREKETKCLALTRALEECQGSLRELEKLNKTLRTDMEDLISS 1536

  Fly  1603 QGTADKNVHELEKAKRALESQLAELKAQNEELEDDLQLTEDAKLRLEVNMQALRSQFERDLLAKE 1667
            :.  :||.|||||.|||||:|:.|:..|.|||||:||..|||||.||||||||:.|.:||:..:|
Zfish  1537 KD--NKNAHELEKTKRALEAQVEEMTIQMEELEDELQAAEDAKLHLEVNMQALKVQIQRDIQGRE 1599

  Fly  1668 EGAEEKRRGLVKQLRDLETELDEERKQRTAAVASKKKLEGDLKEIETTMEMHNKVKEDALKHAKK 1732
            |.:||||:.|:||:|:||.||::|:|.||:..|:||||||||:::|..::::::.:::|:|..:|
Zfish  1600 EQSEEKRKQLLKQVRELEAELEDEQKMRTSLAAAKKKLEGDLQDLEDQVDVNSRARDEAVKQLRK 1664

  Fly  1733 LQAQVKDALRDAEEAKAAKEELQALSKEAERKVKALEAEVLQLTEDLASSERARRAAETERDELA 1797
            :|.|:||..|:.|:|:|:.:|:.:.::|:|||.:|:|||:|.|.|:|||:|:||:.||.||||:|
Zfish  1665 IQTQMKDYQRELEDARASHKEVLSDARESERKARAMEAEILHLHEELASAEKARKHAERERDEIA 1729

  Fly  1798 EEIANNANKGSLMIDEKRRLEARIATLEEELEEEQSNSEVLLDRSRKAQLQIEQLTTELANEKSN 1862
            .|:|:.:...|...|||||||::|..|||||::||:.:|.|.:|.|::..:::|||.||..|:||
Zfish  1730 GEMASGSFGKSGTSDEKRRLESKIQHLEEELDDEQATTETLNERLRRSVQEVDQLTNELHTERSN 1794

  Fly  1863 SQKNENGRALLERQNKELKAKLAEIETAQRTKVKATIATLEAKIANLEEQLENEGKERLLQQKAN 1927
            :|:.|:|...:|||||||:|||.|:|...::|.::|:|.||:|:...|:||::|.:||....||.
Zfish  1795 AQRMESGWQQMERQNKELRAKLLEMEGQVKSKQRSTVAALESKLQQTEDQLDHESRERQAIAKAM 1859

  Fly  1928 RKMDKKIKELTMNIEDERRHVDQHKEQMDKLNSRIKLLKRNLDETEEELQKEKTQKRKYQRECED 1992
            |:.|||:|||...:||||:.::|:|:|.:|.|.|.:.||..::|::||.|:....:||.|:|..:
Zfish  1860 RQKDKKLKELMNQVEDERKQMEQYKDQAEKANLRARQLKMQMEESDEESQRATAARRKLQKELNE 1924

  Fly  1993 MIESQEAMNREINSLKTKLRRTGGIGLSSSRLTGTPSSKRAGG------------------GGGG 2039
            .||:.:|::||::||::||||    |..||  ..||..:.|||                  ||..
Zfish  1925 AIEANDALSREVSSLRSKLRR----GSDSS--FSTPLRRSAGGSFRQARRTMMETSEIPEDGGPS 1983

  Fly  2040 DDSSVQDESLDGEDSAN 2056
            ..|..|...|..|..:|
Zfish  1984 ATSVCQPGELQMESISN 2000

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
zip	NP_523860.2	Myosin_N	80..117	CDD:280832	19/36 (53%)
		Myosin_head	133..854	CDD:278492	467/730 (64%)
		MYSc_Myh2_insects_mollusks	145..854	CDD:276876	456/718 (64%)
		Myosin_tail_1	931..2011	CDD:279860	501/1079 (46%)
		Prefoldin	1431..1515	CDD:298833	34/83 (41%)
		FAM76	<1847..1926	CDD:292665	35/78 (45%)
myh11b	XP_017210292.1	Myosin_N	33..70	CDD:280832	19/37 (51%)
		Myosin_head	85..788	CDD:278492	467/730 (64%)
		MYSc_class_II	97..788	CDD:276951	456/718 (64%)
		Myosin_tail_1	865..1943	CDD:279860	501/1079 (46%)
		FAM76	<1020..1099	CDD:292665	41/78 (53%)
		BAR	<1156..>1305	CDD:299863	70/148 (47%)
		RILP-like	<1760..1872	CDD:304877	51/111 (46%)
		COG7	1824..>1943	CDD:287200	48/118 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	1148	1.000	Domainoid score	I16
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	2314	1.000	Inparanoid score	I32
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D40305at33208
OrthoFinder	1	1.000	-	-		FOG0000014
OrthoInspector	1	1.000	-	-		otm24342
orthoMCL	1	0.900	-	-		OOG6_100110
Panther	1	1.100	-	-	O	PTHR45615
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X58
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	10	9.970