DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment zip and myo5ab

DIOPT Version :9

Sequence 1:NP_523860.2 Gene:zip / 38001 FlyBaseID:FBgn0265434 Length:2056 Species:Drosophila melanogaster
Sequence 2:XP_009296049.2 Gene:myo5ab / 565267 ZFINID:ZDB-GENE-050411-72 Length:1800 Species:Danio rerio


Alignment Length:1999 Identity:533/1999 - (26%)
Similarity:890/1999 - (44%) Gaps:486/1999 - (24%)


- Green bases have known domain annotations that are detailed below.


  Fly    82 VWVPHENQGFVAASIKREH-----------GDEVEVELAETGKRVMI--LRDDIQKMNPPKFDKV 133
            ||:|...:.:.:|.:.|::           .||.|:|.....|..::  ||      ||......
Zfish    13 VWIPDPAEVWRSAELSRDYRPGDPVLHLLLEDETELEYKLDLKSGVLPPLR------NPDILVGE 71

  Fly   134 EDMAELTCLNEASVLHNIKDRYY-SGLIYTYSGLFCVVVNPYKKLPIYTEKIMERYKGIKRHEVP 197
            .|:..|:.|:|.:||||::.|:. |.|||||.|:..|.:|||:.||||...|:..|.|....::.
Zfish    72 NDLTALSYLHEPAVLHNLRVRFTDSKLIYTYCGIILVAINPYESLPIYGSDIINAYSGQNMGDMD 136

  Fly   198 PHVFAITDSAYRNMLGDREDQSILCTGESGAGKTENTKKVIQFLAYVAASKPKGSGAVPHPAVLI 262
            ||:||:::.||:.|..|.::|||:.:||||||||.:.|..:::.|.|:.|.              
Zfish   137 PHIFAVSEEAYKQMARDEKNQSIIVSGESGAGKTVSAKYAMRYFATVSESS-------------- 187

  Fly   263 NFSVNTNKYIKVKIMAQNQNQTIEVVNGLKMVEVNSNCQEGELEQQLLQANPILEAFGNAKTVKN 327
                                                  .:..:|:::|.:|||:||||||||.:|
Zfish   188 --------------------------------------DDASVEEKVLASNPIMEAFGNAKTTRN 214

  Fly   328 DNSSRFGKFIRINFDASGFISGANIETYLLEKSRAIRQAKDERTFHIFYQLLAGATPEQREKFIL 392
            ||||||||:|.|.||....|.|||:.||||||||.:.||.:||.:||||||.|.|...:.:...|
Zfish   215 DNSSRFGKYIEIGFDRKHHIIGANMRTYLLEKSRVVFQASEERNYHIFYQLCACAHLPEFKPLKL 279

  Fly   393 DDVKSYAFLSNGSLPV-PGVDDYAEFQATVKSMNIMGMTSEDFNSIFRIVSAVLLFGSMKFRQER 456
            .....:.:.:.|..|| .||:|..|.|||.|:.:::|:|......:|:|:||:|..|:::.: ||
Zfish   280 GSADDFPYTNQGGSPVIVGVNDLKEMQATRKAFSLLGITEAHQMGLFQILSAILHLGNVEVK-ER 343

  Fly   457 NNDQATLPD-NTVAQKIAHLLGLSVTDMTRAFLTPRIKVGRDFVTKAQTKEQVEFAVEAIAKACY 520
            .:...::.| |........|..:|...|.......::|...:.:.|..|:.:.....:|:||..|
Zfish   344 GSSSCSISDENGHLAMFCDLTEVSNESMAHWLCHKKLKTATETLNKPVTRLEAVNGRDALAKHIY 408

  Fly   521 ERMFKWLVNRINRSLDRTKRQGASFIGILDMAGFEIFELNSFEQLCINYTNEKLQQLFNHTMFIL 585
            .::|.|:|:::|::|. |..:..||||:||:.|||.||||||||.||||.||||||.||..:|.|
Zfish   409 AKLFSWIVSQVNKALS-TSSKPHSFIGVLDIYGFETFELNSFEQFCINYANEKLQQQFNMHVFKL 472

  Fly   586 EQEEYQREGIEWKFIDFGLDLQPTIDLIDKPGGIMALLDEECWFPKATDKTFVDKLVSAH---SM 647
            |||||.:|.|.|..||| .|.||.|:||:...|::.||||||..||.:|.::..||.:.|   |.
Zfish   473 EQEEYMKEQIPWTLIDF-YDNQPCINLIEAKMGLLDLLDEECTMPKGSDDSWAQKLYNTHLKKSS 536

  Fly   648 HPKFMKTDFRGVADFAIVHYAGRVDYSAAKWLMKNMDPLNENIVSLLQGSQDPFVVNIWKDAEIV 712
            |  |.|......| |.|:|:|.:|:|....:|.||.|.:||..:::|:.|:...::.:::|.|..
Zfish   537 H--FEKPRMSNKA-FIILHFADKVEYQCDGFLEKNKDTVNEEQINVLKASKFSLLLELFQDEESP 598

  Fly   713 GMAQQALTD--TQFGARTRKGMFR----TVSHLYKEQLAKLMDTLRNTNPNFVRCIIPNHEKRAG 771
            .......:.  .:||..|:.  ||    :|...::..|..||:||..|.|::||||.||..|...
Zfish   599 AAPNTTASSGRAKFGRSTQS--FREHKKSVGLQFRNSLHLLMETLNATTPHYVRCIKPNDVKAPF 661

  Fly   772 KIDAPLVLDQLRCNGVLEGIRICRQGFPNRIPFQEFRQRYE-LLTPNVIPKGFMDGKKACEKMIQ 835
            .:|....:.|||..||||.|||...|||:|..:|||..||: |:|...|   .:|.|..|:.:::
Zfish   662 MMDPHRAVQQLRACGVLETIRISAAGFPSRWTYQEFFSRYQVLMTKKEI---LLDRKLTCQSVLE 723

  Fly   836 ALELDSNLYRVGQSKIFFRAGVLAHLEEERDFKISDLIVNFQAFCRGFLARRNY----------- 889
            .|..:.:.|:.|::|||||||.:|:||:.|..|:....::.|...|.:|||..|           
Zfish   724 RLVQNKDKYQFGKTKIFFRAGQVAYLEKLRADKLRTACIHIQKTIRCWLARMKYLRIRQAAITLQ 788

  Fly   890 ------------------------QKR----------LQQLNAIRIIQRNCAAY----------- 909
                                    ||.          |:|..|..:|||....|           
Zfish   789 KYTRGHQARCLCKTLRRTRATVVFQKNTRMWAARRQYLRQKTAAVLIQRILRGYTARLEYKRLVC 853

  Fly   910 ----LKLRNW-----QWWRLYTKVKPL----------------LEVTKQEEKLVQ--------KE 941
                |.::.|     ..|| |.::|..                |:..|.|.:.|:        .|
Zfish   854 EHKALLIQRWVRGFLARWR-YRRIKRAVVYLQCCVRRMLARRELKKLKIEARSVEHYKKLNYGME 917

  Fly   942 DELKQVREKLDTLAKNTQEYERKYQQALVEKTTLA--EQLQAEIELCAEA-EESRSR---LMARK 1000
            :::.|::.|||...|..:|...  |...:|..::.  |:|..:::...|| ||:|.|   :.:.:
Zfish   918 NKIMQLQRKLDEQHKENRELSE--QIGAIESHSVVELEKLHVQLKTLQEAEEEARHREDLVTSLQ 980

  Fly  1001 QELEDMMQELETRIE---EEEERVLALGGEKKKLELNIQDLEEQLEEEEAARQKLQLEKVQLDAK 1062
            :||:.:.:|||...|   |..|:...|..||:::...||:.|:|:.|:..|..:...|.:|....
Zfish   981 EELDLVRRELEKNKEMVVELNEKNTMLKSEKEEMNRLIQEQEQQIREKSEATNEDVTENLQTQLN 1045

  Fly  1063 IKKYEEDLALTDDQNQKLLKEKKLLEERANDLSQTLAEEEEKAKHLAKLKAKHEATISEL----E 1123
            .:::         :.|.||.|...||||..||                   |.|..::|:    :
Zfish  1046 EERF---------RYQNLLTEHLKLEERYADL-------------------KSEKEVAEISTAGD 1082

  Fly  1124 ERLHKDQQQRQ-ESDRSKRKIETEVADLKEQLNERRVQVDEMQAQLAKREEELTQTLLRIDEESA 1187
            .|........| ||..|.....:||:.|::   |..|||....:.|.|.:..:            
Zfish  1083 SRADSGYSSSQSESIHSSMLTGSEVSSLEK---EDAVQVAADVSLLLKLQRRV------------ 1132

  Fly  1188 TKATAQKAQRELESQLAEIQEDLEAEKAARAKAEKVRRDLSEE--LEALKNELLDSLDTTAAQQE 1250
              |..:|...:::|::...:|.|..|||  .:.|..|:.|..|  .||||            :||
Zfish  1133 --AELEKENMDMQSEMDTKEEQLILEKA--KELEDCRKTLGAERDYEALK------------RQE 1181

  Fly  1251 LRS---KREQELATLKKSLEEET---VNHEG------VLADMRHKHSQELNSINDQLENLRKAKT 1303
            |.|   |.:::|..|::||.:.|   |...|      :|        ::|||.|::|| :||.:.
Zfish  1182 LESDNKKLKKDLQELRQSLSKGTGSKVTSPGGRAYNVIL--------EQLNSTNEELE-VRKEEV 1237

  Fly  1304 VLEKAKGTLEAENADLATELRSVNSSRQENDRRRKQAESQIAELQVKLAEIERARSELQEKCTKL 1368
            ::.:::  |.:..|....||.:|..|...:    :.....:.||. :..|:..|...|:|     
Zfish  1238 LILRSQ--LVSHEAFKHKELGTVGDSGDSS----RSPTLDLTELN-EDGELWMAYESLKE----- 1290

  Fly  1369 QQEAENITNQLEEAELKASAAVKSASNMESQLTEAQQLLEEETRQKLGLSSKLRQIESEKEALQE 1433
                   ||::                :.|||...:::.|:||.   .|..:|:.:::|.:..|:
Zfish  1291 -------TNRI----------------LVSQLQTQREMHEKETE---SLRVELQHLKAELDQQQQ 1329

  Fly  1434 QLEEDDEAKRNYERKLAEVTTQMQ-EIKKKAEEDADLAKELEEGKKRLNKDIEALERQVKELIAQ 1497
            .|.:..|...:     |.:...:| ||.:..:::.||.:::  ||:  :|.:..|::|:|..:  
Zfish  1330 MLSQSLELPHD-----ARIQASLQHEISRLTQQNMDLLEQM--GKQ--DKMVRKLKKQLKIYM-- 1383

  Fly  1498 NDRLDKSKKKIQSE---LEDATIE-LEAQRTKVLELEKKQKNFDKILA-----EEKAISEQIA-- 1551
                   ||..:.|   .|.::.| :.|:..:.:.:.:|:::|..:|.     |.|.....|.  
Zfish  1384 -------KKFGEPEGVHFEQSSPENMLAESGRTVSIVRKERDFQGMLEYRREDENKLFKTLITDL 1441

  Fly  1552 ----------------------QERDTAEREAREKETKVLSVSRELDEAFDKIEDLENKRKTLQN 1594
                                  :..|.|..:.|        ||..|:.:.:.|::...||...::
Zfish  1442 KPRGVAVNLVPGLPAYILFMCLRHADYANDDLR--------VSTLLNTSINSIKNTLKKRGDFES 1498

  Fly  1595 ELDDLANT----------QGTADKNVHELEKAKRALESQLAELKAQNEELEDDLQLTED----AK 1645
            ....||||          .|....:.|...:              |||....:..|:|.    :.
Zfish  1499 ISFWLANTCRFLHCLKQYSGEEGYSKHNTPR--------------QNEHCLTNFDLSEYRQVLSD 1549

  Fly  1646 LRLEVNMQALR--SQFERDLLAKEEGAEEKRRGL--VKQ--LRDLETELDEERKQRTAAVASKKK 1704
            |.:::..|.:|  ....:.::|.....:|..:|:  ||.  :|...:...||         :...
Zfish  1550 LAIQIYQQLIRVIENILQPMIAPAMLEQETIQGVMGVKPTGMRKRTSSFHEE---------NSHS 1605

  Fly  1705 LEGDLKEIE---TTMEMHNK-------------------------VKEDALKHAKKLQ-----AQ 1736
            ||..||:::   .|:..|..                         :::|....:|.||     .|
Zfish  1606 LESILKQLDGFYFTLLQHGNDAEVVRQVIKQQFYVICSVTLNNLLLRKDMCSWSKGLQIRYNVCQ 1670

  Fly  1737 VKDALRDAE-EAKAAKEELQALSKEAERKVKALEAEVLQLTEDLASSERARRAAETERDEL---- 1796
            :::.|.|.: :...|:|.|:.|       ::|  |::||:          ::.::.:.|.:    
Zfish  1671 LEEWLLDKDLQGSGARESLEPL-------IQA--AQLLQI----------KKKSQDDADAICTMC 1716

  Fly  1797 ----AEEIANNANKGSLMIDEKRRLE-ARIATLEEELEEEQSNSEVLLD 1840
                .::|....:..:.:.:.:.|:. :.|.|::..|::.:.:|::|:|
Zfish  1717 TALTTQQIVKILSLYTPVNEFEERVSISFIKTIQTLLKDRKESSQLLMD 1765

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
zipNP_523860.2 Myosin_N 80..117 CDD:280832 10/45 (22%)
Myosin_head 133..854 CDD:278492 274/733 (37%)
MYSc_Myh2_insects_mollusks 145..854 CDD:276876 270/721 (37%)
Myosin_tail_1 931..2011 CDD:279860 214/1043 (21%)
Prefoldin 1431..1515 CDD:298833 19/87 (22%)
FAM76 <1847..1926 CDD:292665
myo5abXP_009296049.2 Myosin_head 7..1324 CDD:332202 444/1488 (30%)
MYSc_Myo5 83..742 CDD:276831 270/721 (37%)
Myo5-like_CBD 1427..1800 CDD:322280 64/389 (16%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0000014
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
22.000

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