DRSC/TRiP Functional Genomics Resources

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Protein Alignment zip and myo5c

DIOPT Version :10

Sequence 1:NP_523860.2 Gene:zip / 38001 FlyBaseID:FBgn0287873 Length:2056 Species:Drosophila melanogaster
Sequence 2:XP_691143.2 Gene:myo5c / 562676 ZFINID:ZDB-GENE-131127-196 Length:1746 Species:Danio rerio


Alignment Length:1980 Identity:522/1980 - (26%)
Similarity:852/1980 - (43%) Gaps:476/1980 - (24%)


- Green bases have known domain annotations that are detailed below.


  Fly    76 WTQKRLVWVPHENQGFVAASIKREH--GD-EVEVEL---------AETGKRVMILRDDIQKMNPP 128
            :|:...||:|.....:.:|.|..:.  || |:|::|         .|.|:::..||      ||.
Zfish     7 YTKYNRVWIPDAEHVWKSAEILTDFKPGDSELELQLEDGTELHYPLEGGEKLPPLR------NPD 65

  Fly   129 KFDKVEDMAELTCLNEASVLHNIKDRYY-SGLIYTYSGLFCVVVNPYKKLPIYTEKIMERYKGIK 192
            ......|:..|:.|:|.:||||:|.|:. |.:||||.|:..|.|||||:||||.:.::..|.|..
Zfish    66 ILVGENDLTALSYLHEPAVLHNLKVRFVESKIIYTYCGIILVAVNPYKQLPIYGDAVIHAYSGQN 130

  Fly   193 RHEVPPHVFAITDSAYRNMLGDREDQSILCTGESGAGKTENTKKVIQFLAYVAASKPKGSGAVPH 257
            ..::.||:||:.:.||:.|..:.::|||:.:||||||||.:.:..:::.|.|:.|..|       
Zfish   131 MGDLDPHIFAVAEEAYKQMARNNKNQSIIVSGESGAGKTVSARYAMRYFAMVSKSGSK------- 188

  Fly   258 PAVLINFSVNTNKYIKVKIMAQNQNQTIEVVNGLKMVEVNSNCQEGELEQQLLQANPILEAFGNA 322
                                                         ..:|.::|.:|||.||.|||
Zfish   189 ---------------------------------------------TRVEDKVLASNPITEAIGNA 208

  Fly   323 KTVKNDNSSRFGKFIRINFDASGFISGANIETYLLEKSRAIRQAKDERTFHIFYQLLAGAT-PEQ 386
            ||.:|||||||||:..|:||....|.|||:.||||||||.:.|:::||.:|||||:.|.|. ||.
Zfish   209 KTTRNDNSSRFGKYTEISFDKRYQIIGANMRTYLLEKSRVVFQSENERNYHIFYQMCACANQPEF 273

  Fly   387 R-------EKFILDDVKSYAFLSNGSLPVPGVDDYAEFQATVKSMNIMGMTSEDFNSIFRIVSAV 444
            :       |||      :|..| .|.:.:.||||.|:...|.::.|::|:.......:|::::|:
Zfish   274 KGLRLLGAEKF------NYTRL-GGEIEIEGVDDRADMAETRRTFNLLGLKENFQTDVFKVLAAI 331

  Fly   445 LLFGSMKFRQERNNDQATLPDNT-VAQKIAH------LLGLSVTDMTRAFLTPRIKVGRDFVTKA 502
            |..|::..:       |..|:.: :..:..|      |:|:|..:|:|.....||.:..:.|.|.
Zfish   332 LHLGNVIIK-------AKDPEKSFIGSRDPHLAIFCDLMGVSTENMSRWLCHRRIVLSTETVVKP 389

  Fly   503 QTKEQVEFAVEAIAKACYERMFKWLVNRINRSLDRTKRQGASFIGILDMAGFEIFELNSFEQLCI 567
            |.:|:...|.:|:||..|..:|.|::::||.:|....:| .||||:||:.|||.||:|||||.||
Zfish   390 QPRERAVNARDALAKHIYAHLFNWVIHKINHALMVPGKQ-HSFIGVLDIYGFETFEINSFEQFCI 453

  Fly   568 NYTNEKLQQLFNHTMFILEQEEYQREGIEWKFIDFGLDLQPTIDLIDKPGGIMALLDEECWFPKA 632
            ||.||||||.||..:|.||||||.:|.|.|..||| .|.||.||||:...||:.||||||.||:.
Zfish   454 NYANEKLQQQFNLHVFKLEQEEYMKEDIPWTLIDF-YDNQPVIDLIEAKMGILDLLDEECLFPQG 517

  Fly   633 TDKTFVDKLVSAHSMHPKFMKTDFRGVADFAIVHYAGRVDYSAAKWLMKNMDPLNENIVSLLQGS 697
            |||.::.||.:.....|.|.|..... ..|.|.|:|.:|:|....:|.||.|.|.|.:|.:::.|
Zfish   518 TDKNWLQKLYNFLGSKPLFEKPRLSN-DSFMIQHFADKVEYQCKGFLEKNRDTLYEELVDIMRAS 581

  Fly   698 QDPFVVNIWKDAEIVGMAQQALTDTQFGARTR---KGMFRTVSHLYKEQLAKLMDTLRNTNPNFV 759
            |...:...:|:.| .....:.:..|....|.:   |.:..||...::..|..||:||..|.|::|
Zfish   582 QFALLAGFFKEEE-ADSGHKIIKVTPAQPRVKASNKQLRSTVGDKFRSSLYLLMETLNATTPHYV 645

  Fly   760 RCIIPNHEKRAGKIDAPLVLDQLRCNGVLEGIRICRQGFPNRIPFQEFRQRYE-LLTPNVIPKGF 823
            |||.||.||...:.|:..|:.|||..||||.|||..|.:|:|..:.||..||. |::.:.:..| 
Zfish   646 RCIKPNEEKLPFEYDSRRVVQQLRACGVLETIRISAQSYPSRWTYVEFYSRYSILMSQSELKLG- 709

  Fly   824 MDGKKACEKMIQALELDSNLYRVGQSKIFFRAGVLAHLEEERDFKISDLIVNFQAFCRGFLARRN 888
             :.|:.|..::|.|..|||.|:.|::|||||||.:|:||:.|...:....|..|...||:..||:
Zfish   710 -EKKQTCRTVLQRLIPDSNQYKFGRTKIFFRAGQVAYLEKLRLDHLRAACVTIQKHVRGWRQRRS 773

  Fly   889 Y-------------------------QKRLQQLNAIRIIQRNCAAYLKLRNWQ------------ 916
            :                         .:.|:|..|..:|||:|..:|..|.:|            
Zfish   774 FLNIRQAALIIQLYVRGKKQIRCTVTAQALKQGWAAIVIQRHCRGFLVRRIYQLVLRAAVTIQAF 838

  Fly   917 --WWRLYTKVKPLLEVTKQEEKLVQKEDELKQVREKLDT---------LAKNTQEYERKYQQALV 970
              .|....:.|.:  |.:.:..::||......||.:..|         |:...|:..:|.::...
Zfish   839 TRGWMARKRYKKM--VAEHKALVLQKYARAWLVRRRFQTMRRLVINVQLSYRVQQLRKKVEEQNK 901

  Fly   971 EKTTLAEQLQAEIELCAEAEESRSRLMAR----KQELEDMMQELETRIEEEEERVLALGGEKKKL 1031
            |...|.|:|.:.....|:..|....|.|.    ..|:..::|..:|..||..:.:..|..:|:||
Zfish   902 ENCGLMEKLTSLSNARAQGLEKIQALEAELGKLTNEMSALVQRAKTNSEEANQAIDVLQNDKEKL 966

  Fly  1032 ELNIQDLEEQLEEEEAARQKLQLEKVQLDAKIKKYEEDLALTDDQNQKLLKEKKLLEERANDLSQ 1096
                      :||.:|..:||:...||:..:.    ||:            ::||:|:       
Zfish   967 ----------VEENKALERKLKDTTVQMQDQF----EDV------------KRKLMED------- 998

  Fly  1097 TLAEEEEKAKHLAKLKAKHEATISELEERLHKDQQQRQESDRSKRKIETEVADLKEQ---LNERR 1158
              .|.||:.:.:|:                |..:.|:::||:       |:..:||:   |.|.|
Zfish   999 --LEREERLRKVAE----------------HNSELQKEDSDK-------EIVAIKEENRRLREER 1038

  Fly  1159 VQVDEMQAQLAKREEELTQTLLRIDEESATKATAQKAQRELESQLAEIQEDLEAEK-AARAKAEK 1222
            :::.....:..|...||.:.:|::.:........:|....|:.|.||.::.|.|:. .||||...
Zfish  1039 IRLQTQVEEDVKTNTELQEQMLQLTKHVKVIPDLRKEINNLQIQRAEAEKTLRAQNLQARAKMNL 1103

  Fly  1223 VRR----DLSEE--LEALKNELLDSLDTTAAQQELRSKREQELATLKKSLEEETVNHEGVLADMR 1281
            :.|    |.:|:  ::.|..|..|:.|..|.........|:....::..|.|:...||..|..:.
Zfish  1104 ITRQLLGDATEQDLIQRLNEEASDNNDDGADLITAFDGMERAAKVMETQLREQKDAHESQLEALI 1168

  Fly  1282 HKHSQELNSINDQLENLRKAKTVLEKAKG----TLEAEN---ADLATELRSVNSSRQENDRRRKQ 1339
            .| ::.|:..|:||:.|.:.|:.:.::.|    .|.|||   .:|..::..:|..:.|.:   .|
Zfish  1169 FK-NEHLSKENEQLQALFQEKSDINQSIGQEVTRLTAENMVIPELKQQVSELNRHKHELE---SQ 1229

  Fly  1340 AESQIAELQVKLAEIERA-----------RSELQEKCTKLQQEAENITNQLEEAELKASAAVKSA 1393
            .:.|.||:..||.|:..|           |..|||:.|:.|:..|....|:.|.:          
Zfish  1230 LQDQTAEMSAKLKELSSALHLAVEEEQSQRRRLQEELTESQRRREETDRQISELQ---------- 1284

  Fly  1394 SNMESQLTEAQQLLEEETRQKLGLSSKLRQIESEKEALQEQLEEDDEAKRNYERKLAEVTTQ--- 1455
              .|:|..:..|:.|.:.:..|.|.:.  ::.:|....:|||:..|...:..:.::..:.|.   
Zfish  1285 --EENQQLKKAQITESQAKNTLRLETS--RLTAENMDFEEQLDMKDRLIKRLQDQIKALQTHAAA 1345

  Fly  1456 --------------MQEIKKKAE---------------------------------EDADLAKEL 1473
                          |.|.||:.|                                 ..||...:.
Zfish  1346 NQKAAPAVPKEYLGMLEYKKEDEGRLIRILILELKPRGVGVNMIPGLAAHLLFMCVRHADYLNDG 1410

  Fly  1474 EEGKKRLNKDIEALERQVKELIAQNDR--------LDKS------KKKIQSELEDATIELEAQRT 1524
            .:.|..:|..|.|    |||:|.::..        |..:      .|:...|.|........|..
Zfish  1411 NKLKCLMNNIITA----VKEVITEHQENFELLSFWLSNTYHFLNCLKQYSGEEEFMKHNTPRQNK 1471

  Fly  1525 KVLELEKKQKNFDKILAEEKAISEQIA-----------------------QERDTAEREAREKET 1566
            ..|      ||||  |:|.:.|...:|                       .|.::.:..:..|.|
Zfish  1472 NCL------KNFD--LSEHRQILSDLAINIYHQFISVMEDALFPMIIPGMLEHESLQGISSMKPT 1528

  Fly  1567 KVLSVSREL---------DEAFDKIEDLENKRKTLQNELDDLANTQGTADKNVHELEKAKRALES 1622
            .:...|..:         .||| .:..:..|..|..:.:                   .::.:|.
Zfish  1529 GLRKRSSSVFEDGGDSSTSEAF-SVSSILQKLSTFNSSM-------------------CQQGMEP 1573

  Fly  1623 QLAELKAQNEELEDDLQLTEDAKLRLEVNMQALRSQFERDLLAKEEGAEEKRRGLVKQLRDLETE 1687
            ||     |.:.:.....|...:    .||...||    :||.:..:|         .|:|...:.
Zfish  1574 QL-----QGQIVRQLFYLIGSS----SVNCILLR----KDLCSCRKG---------MQIRCNISY 1616

  Fly  1688 LDEERKQRTAAVASKKKLEGDLKEIETTMEMHNKVKEDALKHAKKLQAQVKDALRDAEEAKAAKE 1752
            |:|..:::....::..:..|.|.:|...::::....|||                          
Zfish  1617 LEEWLREKDLLSSNAMETLGPLSQIAWLLQVNKTTDEDA-------------------------- 1655

  Fly  1753 ELQALSKEAERKVKALEAEVLQLTEDLASSERARRAAETERDELAEEIANNANKGSLMIDEKRRL 1817
                    ||.|.:..|...:|:.:.|.|        .|..|:.                |||..
Zfish  1656 --------AEIKQRCSELSAVQIVKILNS--------YTPIDDF----------------EKRVA 1688

  Fly  1818 EARIATLEEELEEEQSNSEVLLDRSRKAQL 1847
            .:.:..::..|:|.:.:|::::|...:.|:
Zfish  1689 PSFVRKVQALLQEREGSSQLMMDSQYRFQV 1718

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
zipNP_523860.2 Myosin_N 79..122 CDD:460670 14/54 (26%)
MYSc_Myh2_insects_mollusks 145..854 CDD:276876 273/728 (38%)
Myosin_tail_1 931..2011 CDD:460256 201/1054 (19%)
myo5cXP_691143.2 COG5022 12..1333 CDD:227355 443/1476 (30%)
MYSc_Myo5 82..739 CDD:276831 273/728 (38%)
Myo5c_CBD 1366..1740 CDD:271260 73/465 (16%)

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