DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment zip and MYO5C

DIOPT Version :9

Sequence 1:NP_523860.2 Gene:zip / 38001 FlyBaseID:FBgn0265434 Length:2056 Species:Drosophila melanogaster
Sequence 2:NP_061198.2 Gene:MYO5C / 55930 HGNCID:7604 Length:1742 Species:Homo sapiens


Alignment Length:1885 Identity:516/1885 - (27%)
Similarity:874/1885 - (46%) Gaps:304/1885 - (16%)


- Green bases have known domain annotations that are detailed below.


  Fly    76 WTQKRLVWVPHENQGFVAASIKREH--GDEVEVELAETGKRV--MILRDDIQKM-NPPKFDKVED 135
            :||...||:|...:.:.:|.|.:::  ||:|...|.|.|..:  .:..:.:..: ||.......|
Human     7 YTQYNRVWIPDPEEVWKSAEIAKDYRVGDKVLRLLLEDGTELDYSVNPESLPPLRNPDILVGEND 71

  Fly   136 MAELTCLNEASVLHNIKDRY-YSGLIYTYSGLFCVVVNPYKKLPIYTEKIMERYKGIKRHEVPPH 199
            :..|:.|:|.:||||::.|: .|.|||||||:..|.:||||:||||.:.|:..|.|....::.||
Human    72 LTALSYLHEPAVLHNLRIRFAESKLIYTYSGIILVAMNPYKQLPIYGDAIIHAYSGQNMGDMDPH 136

  Fly   200 VFAITDSAYRNMLGDREDQSILCTGESGAGKTENTKKVIQFLAYVAASKPKGSGAVPHPAVLINF 264
            :||:.:.||:.|..:..:|||:.:||||||||.:.:..:::.|.|:.|   ||.|          
Human   137 IFAVAEEAYKQMARNNRNQSIIVSGESGAGKTVSARYAMRYFATVSKS---GSNA---------- 188

  Fly   265 SVNTNKYIKVKIMAQNQNQTIEVVNGLKMVEVNSNCQEGELEQQLLQANPILEAFGNAKTVKNDN 329
                                                   .:|.::|.:|||.||.|||||.:|||
Human   189 ---------------------------------------HVEDKVLASNPITEAVGNAKTTRNDN 214

  Fly   330 SSRFGKFIRINFDASGFISGANIETYLLEKSRAIRQAKDERTFHIFYQLLAGATPEQREKFILDD 394
            ||||||:..|:||....|.|||:.||||||||.:.|:::||.:||||||.|.|...:.:...|..
Human   215 SSRFGKYTEISFDEQNQIIGANMSTYLLEKSRVVFQSENERNYHIFYQLCASAQQSEFKHLKLGS 279

  Fly   395 VKSYAFL-SNGSLPVPGVDDYAEFQATVKSMNIMGMTSEDFN-SIFRIVSAVLLFGSMKFRQERN 457
            .:.:.:. ..|:..:.||:|.||...|.|:..::|. .|||. .:|:|::|:|..|:::.....|
Human   280 AEEFNYTRMGGNTVIEGVNDRAEMVETQKTFTLLGF-KEDFQMDVFKILAAILHLGNVQITAVGN 343

  Fly   458 NDQATLPDNTVAQKIAHLLGLSVTDMTRAFLTPRIKVGRDFVTKAQTKEQVEFAVEAIAKACYER 522
            ...:...|::..:....||||....:.:.....:|....:.|.|..|:.|...|.:|:||..|..
Human   344 ERSSVSEDDSHLKVFCELLGLESGRVAQWLCNRKIVTSSETVVKPMTRPQAVNARDALAKKIYAH 408

  Fly   523 MFKWLVNRINRSLDRTKRQGASFIGILDMAGFEIFELNSFEQLCINYTNEKLQQLFNHTMFILEQ 587
            :|.::|.|||::|..:.:| .:|||:||:.|||.|::|||||.||||.||||||.||..:|.|||
Human   409 LFDFIVERINQALQFSGKQ-HTFIGVLDIYGFETFDVNSFEQFCINYANEKLQQQFNMHVFKLEQ 472

  Fly   588 EEYQREGIEWKFIDFGLDLQPTIDLIDKPGGIMALLDEECWFPKATDKTFVDKLVSAH-SMHPKF 651
            |||.:|.|.|..||| .|.||.||||:...||:.||||||..|..||:.::.||.:.. :.:|.|
Human   473 EEYMKEDIPWTLIDF-YDNQPVIDLIEAKMGILELLDEECLLPHGTDENWLQKLYNNFVNRNPLF 536

  Fly   652 MKTDFRGVADFAIVHYAGRVDYSAAKWLMKNMDPLNENIVSLLQGSQDPFVVNIWKDAE------ 710
            .|......: |.|.|:|.:|:|....:|.||.|.:.:.:|.:|:.|:.....|.:::..      
Human   537 EKPRMSNTS-FVIQHFADKVEYKCEGFLEKNRDTVYDMLVEILRASKFHLCANFFQENPTPPSPF 600

  Fly   711 ----IVGMAQQALTDTQFGARTRKGMFRTVSHLYKEQLAKLMDTLRNTNPNFVRCIIPNHEKRAG 771
                .|..|:|.:.......||      ||...::..|..||:||..|.|::||||.||.||...
Human   601 GSMITVKSAKQVIKPNSKHFRT------TVGSKFRSSLYLLMETLNATTPHYVRCIKPNDEKLPF 659

  Fly   772 KIDAPLVLDQLRCNGVLEGIRICRQGFPNRIPFQEFRQRYE-LLTPNVIPKGFMDGKKACEKMIQ 835
            :.|:..::.|||..||||.|||..|.:|:|..:.||..||. |:|...:  .|.|.|:.|:.::.
Human   660 EFDSKRIVQQLRACGVLETIRISAQSYPSRWTYIEFYSRYGILMTKQEL--SFSDKKEVCKVVLH 722

  Fly   836 ALELDSNLYRVGQSKIFFRAGVLAHLEEERDFKISDLIVNFQAFCRGFLARRNYQKRLQQLNAIR 900
            .|..|||.|:.|::|||||||.:|:||:.|..|:....|..|...||:|.|:.:   |::..|..
Human   723 RLIQDSNQYQFGKTKIFFRAGQVAYLEKLRLDKLRQSCVMVQKHMRGWLQRKKF---LRERRAAL 784

  Fly   901 IIQRNCAAYLKLRNWQWWRLYTKVKPLLEVTKQEEK----LVQKEDELKQVREKLDTLAKNT--- 958
            |||            |::|....|:..:.....:|.    ::||......||.....:...|   
Human   785 IIQ------------QYFRGQQTVRKAITAVALKEAWAAIIIQKHCRGYLVRSLYQLIRMATITM 837

  Fly   959 QEY------ERKYQQALVEKTTLAEQLQAEIELCAEAEESRSRLMARKQELEDMMQELETRIEEE 1017
            |.|      .|:|::.|.|...:..|..|...|.....:|..|.:...| |...:|.|:.::|::
Human   838 QAYSRGFLARRRYRKMLEEHKAVILQKYARAWLARRRFQSIRRFVLNIQ-LTYRVQRLQKKLEDQ 901

  Fly  1018 E-------ERVLAL----GGEKKKLELNIQDLEEQLEEEEAARQKLQLEKVQLDAKIKKY----E 1067
            .       |::.:|    .|:.:|    ||.||.:|  |:||..:...|:     |.|:|    |
Human   902 NKENHGLVEKLTSLAALRAGDVEK----IQKLEAEL--EKAATHRRNYEE-----KGKRYRDAVE 955

  Fly  1068 EDLALTDDQNQKLLKEKKLLEERANDLSQTLAEEEEKAKHLAKLKAKHEATISELEERLHKDQQQ 1132
            |.||       ||.|....||.:...:...|.|:.|      :||.|.:....:|.:.:.|:::|
Human   956 EKLA-------KLQKHNSELETQKEQIQLKLQEKTE------ELKEKMDNLTKQLFDDVQKEERQ 1007

  Fly  1133 RQESDRS----KRKIETEVADLKEQLNERRVQVDEMQAQLAKREEELTQTLLRIDEESATKATAQ 1193
            |...::|    .:..|.::..|||::  :.::.::||.|.....|.:|...|:.:....:|....
Human  1008 RMLLEKSFELKTQDYEKQIQSLKEEI--KALKDEKMQLQHLVEGEHVTSDGLKAEVARLSKQVKT 1070

  Fly  1194 KAQRELESQLAEIQEDLEAEKAARAKAEKVRRDLSEELEALKNELLDSLDTTAAQQELRSK---- 1254
            .::.|.|.:|.:.|: ::.||..:::    :|::.|::..:..:||:|.|.    :::||:    
Human  1071 ISEFEKEIELLQAQK-IDVEKHVQSQ----KREMREKMSEITKQLLESYDI----EDVRSRLSVE 1126

  Fly  1255 ------REQELATLKKSLEEETVNHEGVLADMRHKHSQELNSINDQLENLRKAKTVLEKAKGTLE 1313
                  .:.||....:.|::.|...|......:..:.:|:.::|.::.:|.:....|:|      
Human  1127 DLEHLNEDGELWFAYEGLKKATRVLESHFQSQKDCYEKEIEALNFKVVHLSQEINHLQK------ 1185

  Fly  1314 AENADLATELRSVNSSRQENDRRRKQAESQIAELQVKLAEIERARSELQ----EKCTKLQQEAEN 1374
                 |..|...:|.|.:....|.......|.:.:.:::|:|:.:.:|:    |:..|::.:.|.
Human  1186 -----LFREENDINESIRHEVTRLTSENMMIPDFKQQISELEKQKQDLEIRLNEQAEKMKGKLEE 1245

  Fly  1375 ITNQLEEAELKASAAVKSASNMESQLTEAQQLLEEETRQKLGLSSKLRQIESEKEALQEQLEEDD 1439
            ::|||..::        .....:.:..|||.  |..|::|..|..|:::::...:.|::|.|.:.
Human  1246 LSNQLHRSQ--------EEEGTQRKALEAQN--EIHTKEKEKLIDKIQEMQEASDHLKKQFETES 1300

  Fly  1440 EAKRNYERKLAEVTTQMQEIKKKAEEDADLAKELEEGKKRLNKDIEALERQVKELIAQNDRLDKS 1504
            |.|.|:.::.:.:|.:.::::::.:....:.|:|::..|.|:|.|.          ..||....|
Human  1301 EVKCNFRQEASRLTLENRDLEEELDMKDRVIKKLQDQVKTLSKTIG----------KANDVHSSS 1355

  Fly  1505 KKK-----IQSELEDATIELEAQRTKVLELEKKQKNFDKILAEEKAISEQIAQERDTAEREAREK 1564
            ..|     :|.:.||   |.:..:..:|:|:.:....:.|......|.....:..|:.......|
Human  1356 GPKEYLGMLQYKRED---EAKLIQNLILDLKPRGVVVNMIPGLPAHILFMCVRYADSLNDANMLK 1417

  Fly  1565 ETKVLSVSRELDEAFDKIEDLENKRKTLQNE---LDDLANTQGTADKNVHEL-EKAKRALESQLA 1625
            .....:::.......:.:||.|.....|.|.   |:.|....|..:...|.. ::.|..|     
Human  1418 SLMNSTINGIKQVVKEHLEDFEMLSFWLSNTCHFLNCLKQYSGEEEFMKHNSPQQNKNCL----- 1477

  Fly  1626 ELKAQNEELEDDLQLTEDAKLR--------LEVNMQAL--RSQFERDLLAKEEGAE----EKR-- 1674
                .|.:|.:..|:..|..:|        :|.|:|.:  ....|.:.|....|.:    .||  
Human  1478 ----NNFDLSEYRQILSDVAIRIYHQFIIIMEKNIQPIIVPGMLEYESLQGISGLKPTGFRKRSS 1538

  Fly  1675 ----------RGLVKQL---------RDLETELDEERKQRT-----AAVASKKKLEGDLKEIETT 1715
                      ..:::||         ..|:.||..:..::.     |...:...|..|:......
Human  1539 SIDDTDGYTMTSVLQQLSYFYTTMCQNGLDPELVRQAVKQLFFLIGAVTLNSLFLRKDMCSCRKG 1603

  Fly  1716 MEMHNKVK--EDALKHAKKLQAQVKDALRDAEEAKAAKEELQALSKEAERKVKALEAEVLQL--T 1776
            |::...:.  |:.||. |.||..:            |||.|:.||:         .|.:||:  |
Human  1604 MQIRCNISYLEEWLKD-KNLQNSL------------AKETLEPLSQ---------AAWLLQVKKT 1646

  Fly  1777 EDLASSERARRAAETERDELAEEIANNANKGSLMID-EKRRLEARIATLEEELEEEQSNSEVLLD 1840
            .|..:.|...|.....    |.:|....|..:.:.| |||...:.:..::..|...:.:|:::||
Human  1647 TDSDAKEIYERCTSLS----AVQIIKILNSYTPIDDFEKRVTPSFVRKVQALLNSREDSSQLMLD 1707

  Fly  1841  1840
            Human  1708  1707

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
zipNP_523860.2 Myosin_N 80..117 CDD:280832 11/40 (28%)
Myosin_head 133..854 CDD:278492 272/735 (37%)
MYSc_Myh2_insects_mollusks 145..854 CDD:276876 268/723 (37%)
Myosin_tail_1 931..2011 CDD:279860 206/1010 (20%)
Prefoldin 1431..1515 CDD:298833 19/88 (22%)
FAM76 <1847..1926 CDD:292665
MYO5CNP_061198.2 Myosin_N 12..48 CDD:280832 11/35 (31%)
MYSc 62..752 CDD:214580 281/753 (37%)
MYSc_Myo5 81..741 CDD:276831 268/723 (37%)
Actin-binding. /evidence=ECO:0000255|PROSITE-ProRule:PRU00782 632..654 12/21 (57%)
IQ 810..828 CDD:197470 4/17 (24%)
COG1340 890..1150 CDD:224259 68/294 (23%)
P-loop_NTPase <910..>1163 CDD:304359 66/287 (23%)
GBP_C <927..1030 CDD:303769 32/122 (26%)
coiled coil 997..1010 CDD:293879 4/12 (33%)
coiled coil 1019..1030 CDD:293879 1/10 (10%)
Rab5-bind 1020..1345 CDD:286404 70/356 (20%)
DUF3585 1160..1326 CDD:304905 35/186 (19%)
Myo5c_CBD 1369..1736 CDD:271260 72/377 (19%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0000014
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.910

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