Protein Alignment zip and MYO5C

DIOPT Version :10

• Sequence 1: NP_523860.2
• Gene: zip / 38001
• FlyBaseID: FBgn0287873
• Length: 2056
• Species: Drosophila melanogaster
• Sequence 2: NP_061198.2
• Gene: MYO5C / 55930
• HGNCID: 7604
• Length: 1742
• Species: Homo sapiens
• Alignment Length: 1885
• Identity: 516/1885 - (27%)
• Similarity: 874/1885 - (46%)
• Gaps: 304/1885 - (16%)

  Fly    76 WTQKRLVWVPHENQGFVAASIKREH--GDEVEVELAETGKRV--MILRDDIQKM-NPPKFDKVED 135
            :||...||:|...:.:.:|.|.:::  ||:|...|.|.|..:  .:..:.:..: ||.......|
Human     7 YTQYNRVWIPDPEEVWKSAEIAKDYRVGDKVLRLLLEDGTELDYSVNPESLPPLRNPDILVGEND 71

  Fly   136 MAELTCLNEASVLHNIKDRY-YSGLIYTYSGLFCVVVNPYKKLPIYTEKIMERYKGIKRHEVPPH 199
            :..|:.|:|.:||||::.|: .|.|||||||:..|.:||||:||||.:.|:..|.|....::.||
Human    72 LTALSYLHEPAVLHNLRIRFAESKLIYTYSGIILVAMNPYKQLPIYGDAIIHAYSGQNMGDMDPH 136

  Fly   200 VFAITDSAYRNMLGDREDQSILCTGESGAGKTENTKKVIQFLAYVAASKPKGSGAVPHPAVLINF 264
            :||:.:.||:.|..:..:|||:.:||||||||.:.:..:::.|.|:.|   ||.|
Human   137 IFAVAEEAYKQMARNNRNQSIIVSGESGAGKTVSARYAMRYFATVSKS---GSNA---------- 188

  Fly   265 SVNTNKYIKVKIMAQNQNQTIEVVNGLKMVEVNSNCQEGELEQQLLQANPILEAFGNAKTVKNDN 329
                                                   .:|.::|.:|||.||.|||||.:|||
Human   189 ---------------------------------------HVEDKVLASNPITEAVGNAKTTRNDN 214

  Fly   330 SSRFGKFIRINFDASGFISGANIETYLLEKSRAIRQAKDERTFHIFYQLLAGATPEQREKFILDD 394
            ||||||:..|:||....|.|||:.||||||||.:.|:::||.:||||||.|.|...:.:...|..
Human   215 SSRFGKYTEISFDEQNQIIGANMSTYLLEKSRVVFQSENERNYHIFYQLCASAQQSEFKHLKLGS 279

  Fly   395 VKSYAFL-SNGSLPVPGVDDYAEFQATVKSMNIMGMTSEDFN-SIFRIVSAVLLFGSMKFRQERN 457
            .:.:.:. ..|:..:.||:|.||...|.|:..::|. .|||. .:|:|::|:|..|:::.....|
Human   280 AEEFNYTRMGGNTVIEGVNDRAEMVETQKTFTLLGF-KEDFQMDVFKILAAILHLGNVQITAVGN 343

  Fly   458 NDQATLPDNTVAQKIAHLLGLSVTDMTRAFLTPRIKVGRDFVTKAQTKEQVEFAVEAIAKACYER 522
            ...:...|::..:....||||....:.:.....:|....:.|.|..|:.|...|.:|:||..|..
Human   344 ERSSVSEDDSHLKVFCELLGLESGRVAQWLCNRKIVTSSETVVKPMTRPQAVNARDALAKKIYAH 408

  Fly   523 MFKWLVNRINRSLDRTKRQGASFIGILDMAGFEIFELNSFEQLCINYTNEKLQQLFNHTMFILEQ 587
            :|.::|.|||::|..:.:| .:|||:||:.|||.|::|||||.||||.||||||.||..:|.|||
Human   409 LFDFIVERINQALQFSGKQ-HTFIGVLDIYGFETFDVNSFEQFCINYANEKLQQQFNMHVFKLEQ 472

  Fly   588 EEYQREGIEWKFIDFGLDLQPTIDLIDKPGGIMALLDEECWFPKATDKTFVDKLVSAH-SMHPKF 651
            |||.:|.|.|..||| .|.||.||||:...||:.||||||..|..||:.::.||.:.. :.:|.|
Human   473 EEYMKEDIPWTLIDF-YDNQPVIDLIEAKMGILELLDEECLLPHGTDENWLQKLYNNFVNRNPLF 536

  Fly   652 MKTDFRGVADFAIVHYAGRVDYSAAKWLMKNMDPLNENIVSLLQGSQDPFVVNIWKDAE------ 710
            .|......: |.|.|:|.:|:|....:|.||.|.:.:.:|.:|:.|:.....|.:::..
Human   537 EKPRMSNTS-FVIQHFADKVEYKCEGFLEKNRDTVYDMLVEILRASKFHLCANFFQENPTPPSPF 600

  Fly   711 ----IVGMAQQALTDTQFGARTRKGMFRTVSHLYKEQLAKLMDTLRNTNPNFVRCIIPNHEKRAG 771
                .|..|:|.:.......||      ||...::..|..||:||..|.|::||||.||.||...
Human   601 GSMITVKSAKQVIKPNSKHFRT------TVGSKFRSSLYLLMETLNATTPHYVRCIKPNDEKLPF 659

  Fly   772 KIDAPLVLDQLRCNGVLEGIRICRQGFPNRIPFQEFRQRYE-LLTPNVIPKGFMDGKKACEKMIQ 835
            :.|:..::.|||..||||.|||..|.:|:|..:.||..||. |:|...:  .|.|.|:.|:.::.
Human   660 EFDSKRIVQQLRACGVLETIRISAQSYPSRWTYIEFYSRYGILMTKQEL--SFSDKKEVCKVVLH 722

  Fly   836 ALELDSNLYRVGQSKIFFRAGVLAHLEEERDFKISDLIVNFQAFCRGFLARRNYQKRLQQLNAIR 900
            .|..|||.|:.|::|||||||.:|:||:.|..|:....|..|...||:|.|:.:   |::..|..
Human   723 RLIQDSNQYQFGKTKIFFRAGQVAYLEKLRLDKLRQSCVMVQKHMRGWLQRKKF---LRERRAAL 784

  Fly   901 IIQRNCAAYLKLRNWQWWRLYTKVKPLLEVTKQEEK----LVQKEDELKQVREKLDTLAKNT--- 958
            |||            |::|....|:..:.....:|.    ::||......||.....:...|
Human   785 IIQ------------QYFRGQQTVRKAITAVALKEAWAAIIIQKHCRGYLVRSLYQLIRMATITM 837

  Fly   959 QEY------ERKYQQALVEKTTLAEQLQAEIELCAEAEESRSRLMARKQELEDMMQELETRIEEE 1017
            |.|      .|:|::.|.|...:..|..|...|.....:|..|.:...| |...:|.|:.::|::
Human   838 QAYSRGFLARRRYRKMLEEHKAVILQKYARAWLARRRFQSIRRFVLNIQ-LTYRVQRLQKKLEDQ 901

  Fly  1018 E-------ERVLAL----GGEKKKLELNIQDLEEQLEEEEAARQKLQLEKVQLDAKIKKY----E 1067
            .       |::.:|    .|:.:|    ||.||.:|  |:||..:...|:     |.|:|    |
Human   902 NKENHGLVEKLTSLAALRAGDVEK----IQKLEAEL--EKAATHRRNYEE-----KGKRYRDAVE 955

  Fly  1068 EDLALTDDQNQKLLKEKKLLEERANDLSQTLAEEEEKAKHLAKLKAKHEATISELEERLHKDQQQ 1132
            |.||       ||.|....||.:...:...|.|:.|      :||.|.:....:|.:.:.|:::|
Human   956 EKLA-------KLQKHNSELETQKEQIQLKLQEKTE------ELKEKMDNLTKQLFDDVQKEERQ 1007

  Fly  1133 RQESDRS----KRKIETEVADLKEQLNERRVQVDEMQAQLAKREEELTQTLLRIDEESATKATAQ 1193
            |...::|    .:..|.::..|||::  :.::.::||.|.....|.:|...|:.:....:|....
Human  1008 RMLLEKSFELKTQDYEKQIQSLKEEI--KALKDEKMQLQHLVEGEHVTSDGLKAEVARLSKQVKT 1070

  Fly  1194 KAQRELESQLAEIQEDLEAEKAARAKAEKVRRDLSEELEALKNELLDSLDTTAAQQELRSK---- 1254
            .::.|.|.:|.:.|: ::.||..:::    :|::.|::..:..:||:|.|.    :::||:
Human  1071 ISEFEKEIELLQAQK-IDVEKHVQSQ----KREMREKMSEITKQLLESYDI----EDVRSRLSVE 1126

  Fly  1255 ------REQELATLKKSLEEETVNHEGVLADMRHKHSQELNSINDQLENLRKAKTVLEKAKGTLE 1313
                  .:.||....:.|::.|...|......:..:.:|:.::|.::.:|.:....|:|
Human  1127 DLEHLNEDGELWFAYEGLKKATRVLESHFQSQKDCYEKEIEALNFKVVHLSQEINHLQK------ 1185

  Fly  1314 AENADLATELRSVNSSRQENDRRRKQAESQIAELQVKLAEIERARSELQ----EKCTKLQQEAEN 1374
                 |..|...:|.|.:....|.......|.:.:.:::|:|:.:.:|:    |:..|::.:.|.
Human  1186 -----LFREENDINESIRHEVTRLTSENMMIPDFKQQISELEKQKQDLEIRLNEQAEKMKGKLEE 1245

  Fly  1375 ITNQLEEAELKASAAVKSASNMESQLTEAQQLLEEETRQKLGLSSKLRQIESEKEALQEQLEEDD 1439
            ::|||..::        .....:.:..|||.  |..|::|..|..|:::::...:.|::|.|.:.
Human  1246 LSNQLHRSQ--------EEEGTQRKALEAQN--EIHTKEKEKLIDKIQEMQEASDHLKKQFETES 1300

  Fly  1440 EAKRNYERKLAEVTTQMQEIKKKAEEDADLAKELEEGKKRLNKDIEALERQVKELIAQNDRLDKS 1504
            |.|.|:.::.:.:|.:.::::::.:....:.|:|::..|.|:|.|.          ..||....|
Human  1301 EVKCNFRQEASRLTLENRDLEEELDMKDRVIKKLQDQVKTLSKTIG----------KANDVHSSS 1355

  Fly  1505 KKK-----IQSELEDATIELEAQRTKVLELEKKQKNFDKILAEEKAISEQIAQERDTAEREAREK 1564
            ..|     :|.:.||   |.:..:..:|:|:.:....:.|......|.....:..|:.......|
Human  1356 GPKEYLGMLQYKRED---EAKLIQNLILDLKPRGVVVNMIPGLPAHILFMCVRYADSLNDANMLK 1417

  Fly  1565 ETKVLSVSRELDEAFDKIEDLENKRKTLQNE---LDDLANTQGTADKNVHEL-EKAKRALESQLA 1625
            .....:::.......:.:||.|.....|.|.   |:.|....|..:...|.. ::.|..|
Human  1418 SLMNSTINGIKQVVKEHLEDFEMLSFWLSNTCHFLNCLKQYSGEEEFMKHNSPQQNKNCL----- 1477

  Fly  1626 ELKAQNEELEDDLQLTEDAKLR--------LEVNMQAL--RSQFERDLLAKEEGAE----EKR-- 1674
                .|.:|.:..|:..|..:|        :|.|:|.:  ....|.:.|....|.:    .||
Human  1478 ----NNFDLSEYRQILSDVAIRIYHQFIIIMEKNIQPIIVPGMLEYESLQGISGLKPTGFRKRSS 1538

  Fly  1675 ----------RGLVKQL---------RDLETELDEERKQRT-----AAVASKKKLEGDLKEIETT 1715
                      ..:::||         ..|:.||..:..::.     |...:...|..|:......
Human  1539 SIDDTDGYTMTSVLQQLSYFYTTMCQNGLDPELVRQAVKQLFFLIGAVTLNSLFLRKDMCSCRKG 1603

  Fly  1716 MEMHNKVK--EDALKHAKKLQAQVKDALRDAEEAKAAKEELQALSKEAERKVKALEAEVLQL--T 1776
            |::...:.  |:.||. |.||..:            |||.|:.||:         .|.:||:  |
Human  1604 MQIRCNISYLEEWLKD-KNLQNSL------------AKETLEPLSQ---------AAWLLQVKKT 1646

  Fly  1777 EDLASSERARRAAETERDELAEEIANNANKGSLMID-EKRRLEARIATLEEELEEEQSNSEVLLD 1840
            .|..:.|...|.....    |.:|....|..:.:.| |||...:.:..::..|...:.:|:::||
Human  1647 TDSDAKEIYERCTSLS----AVQIIKILNSYTPIDDFEKRVTPSFVRKVQALLNSREDSSQLMLD 1707

  Fly  1841  1840
            Human  1708  1707

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
zip	NP_523860.2	Myosin_N	79..122	CDD:460670	11/46 (24%)
		MYSc_Myh2_insects_mollusks	145..854	CDD:276876	268/723 (37%)
		Myosin_tail_1	931..2011	CDD:460256	206/1010 (20%)
MYO5C	NP_061198.2	MYSc_Myo5	81..741	CDD:276831	268/723 (37%)
		Actin-binding. /evidence=ECO:0000255|PROSITE-ProRule:PRU00782	632..654		12/21 (57%)
		IQ	810..828	CDD:197470	4/17 (24%)
		IQ	831..851	CDD:459869	4/19 (21%)
		SMC_prok_B	<886..>1356	CDD:274008	114/536 (21%)
		Myo5c_CBD	1369..1736	CDD:271260	72/377 (19%)