DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment zip and myo18ab

DIOPT Version :9

Sequence 1:NP_523860.2 Gene:zip / 38001 FlyBaseID:FBgn0265434 Length:2056 Species:Drosophila melanogaster
Sequence 2:XP_021322097.1 Gene:myo18ab / 559005 ZFINID:ZDB-GENE-080423-1 Length:2267 Species:Danio rerio


Alignment Length:1979 Identity:526/1979 - (26%)
Similarity:918/1979 - (46%) Gaps:443/1979 - (22%)


- Green bases have known domain annotations that are detailed below.


  Fly    42 IAAKM---SEEVDRNDPELKYLSVERNQFNDPATQAE--------WTQKRLVWVPHENQGFVAAS 95
            :.|:|   ||:|: .|| :..|..:......|..:.|        |.....||:.|::...:|..
Zfish   513 VCARMTCWSEQVE-EDP-VAILKADHAAAAHPKVKTEEQIAAEQAWYGSEKVWLVHKDGFSLATV 575

  Fly    96 IKREHGD----EVEVELAETGKRVMILRDDIQKMNPPKFDKVEDMAELTCLNEASVLHNIKDRYY 156
            :|.|.|.    :|:::|...|..:.:..||::|.|||.||:.||:|.|..|||:||:|:::.||.
Zfish   576 VKTEAGSLPEGKVKIKLEHDGTVLDVDEDDVEKANPPSFDRCEDLAALLYLNESSVMHSLRQRYG 640

  Fly   157 SGLIYTYSGLFCVVVNPYKKLPIYTEKIMERYKGIKRHEVPPHVFAITDSAYRNMLGDREDQSIL 221
            ..||:|::|...|:|||.....:|:||:|..:||.:|.:..||::|:..|||||:|..|:||||:
Zfish   641 GNLIHTHAGPNMVIVNPISAPSMYSEKVMHMFKGCRREDTAPHIYAVAQSAYRNLLTTRQDQSIV 705

  Fly   222 CTGESGAGKTENTKKVIQFLAYVAASKPKGSGAVPHPAVLINFSVNTNKYIKVKIMAQNQNQTIE 286
            ..|:||:|||.|.:.::|:|..:|.|    :|                     ||....:.|.:.
Zfish   706 LLGKSGSGKTTNCQHLVQYLVSIAGS----TG---------------------KIFTAEKWQAVY 745

  Fly   287 VVNGLKMVEVNSNCQEGELEQQLLQANPILEAFGNAKTVKNDNSSRFGKFIRINFDASGFISGAN 351
            .                           |||||||:.|..|:|:|||.:.:.::||.:|.::.|:
Zfish   746 T---------------------------ILEAFGNSATSMNNNASRFSQIVSLDFDQAGQVASAS 783

  Fly   352 IETYLLEKSRAIRQAKDERTFHIFYQLLAGATPEQREKFILDD-VKSYAFLSNGSLPVPGVDD-- 413
            |:|.||||.|.:::.:.|.||::||.::|||....|.:...:. .::.||   |.:|....:|  
Zfish   784 IQTMLLEKLRVVKRPETESTFNVFYYMMAGADSTLRTELHFNHFAENSAF---GIVPQSKPEDKQ 845

  Fly   414 -----YAEFQATVKSMNIMGMTSEDFNSIFRIVSAVLLFGSMKFRQERNND--QATLPDNTVAQK 471
                 :.:.||   :|.::|::|::..:::.|:.|:...|:....:...::  :.....:..|||
Zfish   846 KASQQFTKLQA---AMKVLGISSDEQKALWLILGAIYHLGAAGATKAEADEAGRKQFARHEWAQK 907

  Fly   472 IAHLLGLSVTDMTRAFLTPRIK-----------------VGRDFVTKAQTKEQVEFAVEAIAKAC 519
            .|:|||.::.:::.|....:.|                 .|.:...|....|    .:||:|...
Zfish   908 AAYLLGCTLEELSSAIFKHQPKGTLQRSTSFRQGPDDAGTGDNSGPKITALE----CLEAMAAGL 968

  Fly   520 YERMFKWLVNRINRSLDRTKRQGASFIGILDMAGFEIFEL------NSFEQLCINYTNEKLQQLF 578
            |..:|..:::.:||:|..::....|.: |:|..||:..:|      .:||:||.||..|:||.||
Zfish   969 YSELFTLVISLVNRALKSSQHSLCSLL-IVDTPGFQNPKLAKRERGATFEELCHNYAQERLQTLF 1032

  Fly   579 NHTMFILEQEEYQREGIEWKFIDF---------GLD------LQPTIDLIDKPGGIMALLDEECW 628
            :...|:.|.|.|:.|.||....|.         .:|      |..|:...|:..|::.|::||..
Zfish  1033 HERTFVQELERYKEENIELALDDIESSTSLSVAAIDQASSQALVRTLARTDEARGLLWLMEEEAL 1097

  Fly   629 FPKATDKTFVDKLVSAHSMHPK---------FMKTDFRGVADFAIVHYAGR--VDYSAAKWLM-K 681
            .|..:::|.:::|.|.:|  |.         .:|:|  ....|.:.|..|.  |:|.|..||. .
Zfish  1098 QPGGSEETLLERLFSYYS--PADGESKGPALLLKSD--KPHHFLLGHSHGTDWVEYDAGGWLSHA 1158

  Fly   682 NMDPLNENIVSLLQGSQDPFVVNIWKD------------AEIVGMAQQAL--------TDTQFGA 726
            ..:|.::|...|||.||...:.:::..            |.:.|.:|.||        |.|...|
Zfish  1159 KQNPASQNAAILLQDSQKKNISSLFMGRSGGATVLSGSIAGLEGGSQLALRRATSMRKTFTTGVA 1223

  Fly   727 RTRKGMFRTVSHLYKEQLAKLMDTLRNTNPNFVRCIIPNHEKRAGKIDAP--------------- 776
            ..:|   :::....|.|:..||||:|.:..:||.|::|..|..:..:..|               
Zfish  1224 AVKK---KSLCIQVKLQVDALMDTVRRSRVHFVHCLLPKAETLSADVKVPGGESCDTGLMQLDVC 1285

  Fly   777 LVLDQLRCNGVLEGIRICRQGFPNRIPFQEFRQRYELLTPNVIPKG-----FMDGKKACEKMIQA 836
            |:..|||.:.:|:.:||.|||:|:.:.|.|||:|:::|||::..|.     ..|.|:|.|:::::
Zfish  1286 LLRAQLRGSKLLDALRIYRQGYPDHLVFSEFRRRFDVLTPHLTKKHGRNYIVTDEKRAVEELLES 1350

  Fly   837 LELDSNLYRVGQSKIFFRAGVLAHLEEERDFKISDLIVNFQAFCRGFLARRNYQKRLQQLNAIRI 901
            |||:.:.|.:|.|::||||||||.|||.||.:....:..|||.|||:|||:.::||..|..|||.
Zfish  1351 LELEKSSYHMGLSRVFFRAGVLAKLEENRDIQTRRNLTLFQAACRGYLARQAFKKRKIQDLAIRC 1415

  Fly   902 IQRNCAAYLKLRNWQWWRLYTKVKPLLEVTKQEEKLVQKEDELKQVREKLDTLAKNTQEYERKYQ 966
            ||:|......::.|.||:|:|.|:||:||...||::..|::|::.::.||:              
Zfish  1416 IQKNIKKNRGVKGWPWWKLFTTVRPLIEVQLTEEQIRGKDEEIQLLKSKLE-------------- 1466

  Fly   967 QALVEKTTLAEQLQAEIELCAEAEESRSRLMARKQELEDMMQELETRIEEEEERVLALGGEKKKL 1031
                                 :.|:.|:.|......||..:.||.:.:.:|...     ||    
Zfish  1467 ---------------------KVEKERNELRLNSDRLESKITELSSELADERNT-----GE---- 1501

  Fly  1032 ELNIQDLEEQLEEEEAARQKLQLEKVQLDAK---IKKYEEDLALTDDQNQKLLKEKKLLEERAND 1093
                 ...:.||.|.:.|.:|:.:...|.||   :||..|.:.:.       :.|.:|:  ||::
Zfish  1502 -----SASQLLESETSERLRLEKDMKDLQAKFDAMKKQTESMEME-------VMEARLI--RASE 1552

  Fly  1094 LSQTLAEEEEKAKHLAKLKAKHEATISELE---ERLHKDQQQRQE-SDRSKRKIETEVADLKEQL 1154
            |:..:.:::..    .:.:.|:|..|.|:|   :||.::...:.| ..::||::|.::.||:.. 
Zfish  1553 LNGEMDDDDTG----GEWRLKYERAIREIEFTKKRLQQEFDDKLEVEQQNKRQLERKLTDLQAD- 1612

  Fly  1155 NERRVQVDEMQAQLAKREEELT----QTLLRIDEESATKATAQKAQRELESQLAEIQEDLEAEKA 1215
            ||   :|..:..||.|:.:.||    .|.|.::.:.:.....:|.||:.:|:..:.||:::.||:
Zfish  1613 NE---EVQRVAQQLKKKCQRLTAELQDTKLHLEGQQSRNHDLEKKQRKFDSEQTQAQEEVQREKS 1674

  Fly  1216 ARAKAEKVRRDLSEELEALKNELLD-SLDTTAAQQEL-------------RSKREQELATLKKSL 1266
            .|.|..:.:..|:.|:.:|:.:|.| .|:..|...:|             .||.|..||.:||.|
Zfish  1675 QREKLSREKDMLTGEVFSLRQQLEDKDLEICAVNLKLEQMEAELQDLNSQESKDEASLAKIKKQL 1739

  Fly  1267 ----------EEETVNHEGV--------------LADMRHKHSQELNSINDQLENLRKA-KTVLE 1306
                      |||.....|.              :..:|..||:|:.|..|::|.:|:: ...|:
Zfish  1740 RDLEAKVKDQEEELDEQAGTIQMLEQAKLRLEMEMERLRQTHSKEIESKEDEVEEIRQSCSKKLK 1804

  Fly  1307 KAKGTLEAENADLATELRSVNSSRQENDRRRKQAESQIAELQVKLAEIE---RARSELQEKCTKL 1368
            :.:..||.|..|....||         ::|..:|:...|:.||...::|   |.|.:|  |.||.
Zfish  1805 QMEVQLEEEYEDKQKVLR---------EKRDMEAKLMSAQDQVSHRDVEAEKRLRKDL--KRTKA 1858

  Fly  1369 ------------------QQEAENITNQLEEAELKASAAVKSASNMESQLTEAQQLLEEETRQKL 1415
                              ::|...:.|||||:|...:||||:..:||.::.:....:::.::.|.
Zfish  1859 LLADAQIMLDHLKNNAPSKREIAQLKNQLEESEFTCAAAVKARKSMEVEIEDLHVQMDDISKSKQ 1923

  Fly  1416 GLSSKLRQIESEKEALQEQLEED----DEAKRNYERKLAEVTTQMQEIKKKAEEDADLAKELEEG 1476
            .|..:|.:::.||..||.::|||    :|..:.::..:|:.:..:.:|       :||..:|||.
Zfish  1924 ALEEQLSRLQREKNDLQSRMEEDQEDMNELMKKHKAAVAQSSQNLAQI-------SDLQAQLEEA 1981

  Fly  1477 ---KKRLNKDIEALERQVKELIAQNDRLDKSKKKIQSELEDATIELEAQRTKVLELEKKQ-KNFD 1537
               |:.:.:.:.||:.|::  ..:...:|||   :.|..|....|||.:    ||.||.| |..:
Zfish  1982 MKEKQDVQEKLTALQSQLE--FQEQSMVDKS---LVSRQEAKIRELETK----LEFEKTQVKRLE 2037

  Fly  1538 KILAEEKAISEQIAQERD-TAEREAREKETKVLSVSRELDEAFDKIEDLENKR-----KTLQNEL 1596
            .::|..|...|::.:||| .:..|.||||                    :|||     :.::.|:
Zfish  2038 SLVARLKENLEKLTEERDQRSASENREKE--------------------QNKRLLRQIRDIKEEM 2082

  Fly  1597 DDLANTQGTADKNVHELEKAKRALESQLAELKAQNEELEDDLQLTEDAKLRLEVNMQALRSQFER 1661
            .:||..:..|.:..||       ||..:..|:|.|:.|:.||:|.                 |:|
Zfish  2083 AELAKKEAEASRKKHE-------LEMDIESLEAANQSLQADLKLA-----------------FKR 2123

  Fly  1662 --DLLA--KEEGAEEKRRGLVKQLRDLETELDEERKQRTAAVASKKKLEGDLKEIETTMEMHNKV 1722
              ||.|  ::|...:....|:..|:|:.|:..:.          |.|:||   ..:|..|:.::|
Zfish  2124 IGDLQAAIEDEMESDDNEDLINSLQDMVTKYQKR----------KNKIEG---ASDTDSEVEDRV 2175

  Fly  1723 KEDALKH-AKKLQAQVKDALRDAEEAKAAKEELQALSKEAER-----------KVKALEAEVLQL 1775
              |.:|. ..|.:...|: |.|....|:::..:....||.:.           |.....|:...|
Zfish  2176 --DGVKSWLSKNKGSAKN-LSDDGSLKSSRYAVNVDGKEGKEWEEGKEWKESGKAHPPAADAFAL 2237

  Fly  1776 TEDLASSERARRAAETERDELAEEIANNA 1804
            |:  .:.:|.::..:..|.|.....|.||
Zfish  2238 TD--LTRKRKKKKRKGARAEAPTAHATNA 2264

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
zipNP_523860.2 Myosin_N 80..117 CDD:280832 10/40 (25%)
Myosin_head 133..854 CDD:278492 231/820 (28%)
MYSc_Myh2_insects_mollusks 145..854 CDD:276876 224/808 (28%)
Myosin_tail_1 931..2011 CDD:279860 226/975 (23%)
Prefoldin 1431..1515 CDD:298833 22/90 (24%)
FAM76 <1847..1926 CDD:292665
myo18abXP_021322097.1 Atrophin-1 14..>529 CDD:331285 7/17 (41%)
Myosin_head 554..2053 CDD:332202 454/1661 (27%)
MYSc_Myo18 629..1368 CDD:276837 224/808 (28%)
SMC_N <1939..>2169 CDD:330553 75/302 (25%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG0161
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
21.810

Return to query results.
Submit another query.