DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment zip and myh10

DIOPT Version :9

Sequence 1:	NP_523860.2	Gene:	zip / 38001	FlyBaseID:	FBgn0265434	Length:	2056	Species:	Drosophila melanogaster
Sequence 2:	XP_009300420.1	Gene:	myh10 / 555454	ZFINID:	ZDB-GENE-030616-162	Length:	2014	Species:	Danio rerio

Alignment Length:	2033	Identity:	1230/2033 - (60%)
Similarity:	1566/2033 - (77%)	Gaps:	62/2033 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly    45 KMSEEVDRNDPELKYLSVERNQFNDPATQAEWTQKRLVWVPHENQGFVAASIKREHGDEVEVELA 109
            :|::...:.||| :||.|:|....:|.|||:||.|:|||||.|..||.||||:.|.|:||.||||
Zfish     3 EMAQRSGQEDPE-RYLFVDRAVVYNPTTQADWTAKKLVWVPSERHGFEAASIREERGEEVLVELA 66

  Fly   110 ETGKRVMILRDDIQKMNPPKFDKVEDMAELTCLNEASVLHNIKDRYYSGLIYTYSGLFCVVVNPY 174
            |.||:.|:.:|||||||||||.|||||||||||||||||||:|||||||||||||||||||:|||
Zfish    67 ENGKKAMVNKDDIQKMNPPKFSKVEDMAELTCLNEASVLHNLKDRYYSGLIYTYSGLFCVVINPY 131

  Fly   175 KKLPIYTEKIMERYKGIKRHEVPPHVFAITDSAYRNMLGDREDQSILCTGESGAGKTENTKKVIQ 239
            |.||||:|.|:|.|:|.||||:|||::||::||||.||.||||||||||||||||||||||||||
Zfish   132 KNLPIYSENIIEMYRGKKRHEMPPHIYAISESAYRCMLQDREDQSILCTGESGAGKTENTKKVIQ 196

  Fly   240 FLAYVAASKPKGSGAVPHPAVLINFSVNTNKYIKVKIMAQNQNQTIEVVNGLKMVEVNSNCQEGE 304
            :||:||:|.   .|...|     |....:.|.:|::             ||:...        ||
Zfish   197 YLAHVASSH---KGRKDH-----NIPPESPKAVKLQ-------------NGILFY--------GE 232

  Fly   305 LEQQLLQANPILEAFGNAKTVKNDNSSRFGKFIRINFDASGFISGANIETYLLEKSRAIRQAKDE 369
            ||:||||||||||:||||||||||||||||||||||||.:|:|.|||||||||||||||||||||
Zfish   233 LERQLLQANPILESFGNAKTVKNDNSSRFGKFIRINFDVTGYIVGANIETYLLEKSRAIRQAKDE 297

  Fly   370 RTFHIFYQLLAGATPEQREKFILDDVKSYAFLSNGSLPVPGVDDYAEFQATVKSMNIMGMTSEDF 434
            ||||:||||||||....|...:|:...||.|||||::|:||..|...||.|:::|:||....|:.
Zfish   298 RTFHVFYQLLAGAGEHLRSDLLLEGFNSYRFLSNGNIPIPGQQDKDNFQETMEAMHIMSFNHEEI 362

  Fly   435 NSIFRIVSAVLLFGSMKFRQERNNDQATLPDNTVAQKIAHLLGLSVTDMTRAFLTPRIKVGRDFV 499
            .|:.::|||||.||::.|::|||.|||::|:||.|||:.||||::|.:.|||.|:||||||||:|
Zfish   363 LSMLKVVSAVLQFGNIVFKKERNTDQASMPENTAAQKLCHLLGMNVMEFTRAILSPRIKVGRDYV 427

  Fly   500 TKAQTKEQVEFAVEAIAKACYERMFKWLVNRINRSLDRTKRQGASFIGILDMAGFEIFELNSFEQ 564
            .|||||||.:|||||:|||.|||:|:|||:|||::||||||||||||||||:||||||:||||||
Zfish   428 QKAQTKEQADFAVEALAKATYERLFRWLVHRINKALDRTKRQGASFIGILDIAGFEIFQLNSFEQ 492

  Fly   565 LCINYTNEKLQQLFNHTMFILEQEEYQREGIEWKFIDFGLDLQPTIDLIDKPG---GIMALLDEE 626
            |||||||||||||||||||||||||||||||||.||||||||||.||||::|.   |::||||||
Zfish   493 LCINYTNEKLQQLFNHTMFILEQEEYQREGIEWSFIDFGLDLQPCIDLIERPANPPGVLALLDEE 557

  Fly   627 CWFPKATDKTFVDKLVSAHSMHPKFMK-TDFRGVADFAIVHYAGRVDYSAAKWLMKNMDPLNENI 690
            ||||||||||||||||.....|.||.| ...:..|||.|:||||||||.|.:||||||||||:|:
Zfish   558 CWFPKATDKTFVDKLVQEQGTHGKFQKPRQLKDKADFCIIHYAGRVDYKADEWLMKNMDPLNDNV 622

  Fly   691 VSLLQGSQDPFVVNIWKDA-----------------------EIVGMAQQA-LTDTQFGA--RTR 729
            .:||..|.|.||..:|||.                       .|||:.|.| :.:|.|||  :|:
Zfish   623 ATLLHQSTDKFVAELWKDEIQNFQRASFYDVSSLHESPGEVDRIVGLDQVAGMNETAFGAAYKTK 687

  Fly   730 KGMFRTVSHLYKEQLAKLMDTLRNTNPNFVRCIIPNHEKRAGKIDAPLVLDQLRCNGVLEGIRIC 794
            |||||||..||||.|.|||.|||||||||||||||||||||||::..||||||||||||||||||
Zfish   688 KGMFRTVGQLYKESLTKLMATLRNTNPNFVRCIIPNHEKRAGKLEPHLVLDQLRCNGVLEGIRIC 752

  Fly   795 RQGFPNRIPFQEFRQRYELLTPNVIPKGFMDGKKACEKMIQALELDSNLYRVGQSKIFFRAGVLA 859
            ||||||||.|||||||||:||||.|||||||||:|||:||:|||||.||||:||||||||.||||
Zfish   753 RQGFPNRIVFQEFRQRYEILTPNAIPKGFMDGKQACERMIRALELDPNLYRIGQSKIFFRTGVLA 817

  Fly   860 HLEEERDFKISDLIVNFQAFCRGFLARRNYQKRLQQLNAIRIIQRNCAAYLKLRNWQWWRLYTKV 924
            |||||||.||:|:|:.||:.|||:|||:.:.|:.|||:|::::|||||||||||:||||||:|||
Zfish   818 HLEEERDLKITDIIIYFQSVCRGYLARKAFAKKQQQLSALKVLQRNCAAYLKLRHWQWWRLFTKV 882

  Fly   925 KPLLEVTKQEEKLVQKEDELKQVREKLDTLAKNTQEYERKYQQALVEKTTLAEQLQAEIELCAEA 989
            ||||:||:|||::..|::||.:|:|:...:.....|.|||:||.|.||..||||||||.||.|||
Zfish   883 KPLLQVTRQEEEMQAKDEELIKVKERQVKVENELVEMERKHQQLLEEKNILAEQLQAETELFAEA 947

  Fly   990 EESRSRLMARKQELEDMMQELETRIEEEEERVLALGGEKKKLELNIQDLEEQLEEEEAARQKLQL 1054
            ||.|:||:|:|||||:::.:||:|:||||||..:|..||||::.:||||||||:|||||||||||
Zfish   948 EEMRARLVAKKQELEEILHDLESRVEEEEERNQSLQNEKKKMQSHIQDLEEQLDEEEAARQKLQL 1012

  Fly  1055 EKVQLDAKIKKYEEDLALTDDQNQKLLKEKKLLEERANDLSQTLAEEEEKAKHLAKLKAKHEATI 1119
            |||..:|||||.|||:.|.:|||.|.||||||||:|..:::..|||||||||:|.|:|.|.|..:
Zfish  1013 EKVTAEAKIKKMEEDILLLEDQNSKFLKEKKLLEDRVGEMTSQLAEEEEKAKNLGKVKNKQEMMM 1077

  Fly  1120 SELEERLHKDQQQRQESDRSKRKIETEVADLKEQLNERRVQVDEMQAQLAKREEELTQTLLRIDE 1184
            .:|||||.|:::.|||.:::|||::.|..||::|:.|.:.|:||::.||||:||||...|.|.||
Zfish  1078 VDLEERLKKEEKTRQELEKAKRKLDAETTDLQDQIAELQAQIDELKIQLAKKEEELQAVLARGDE 1142

  Fly  1185 ESATKATAQKAQRELESQLAEIQEDLEAEKAARAKAEKVRRDLSEELEALKNELLDSLDTTAAQQ 1249
            |.|.|..|.|..|||::||||:|||||:|||||.||||::|||||||||||.||.|:||||||||
Zfish  1143 EVAQKNNALKQLRELQAQLAELQEDLESEKAARNKAEKLKRDLSEELEALKTELEDTLDTTAAQQ 1207

  Fly  1250 ELRSKREQELATLKKSLEEETVNHEGVLADMRHKHSQELNSINDQLENLRKAKTVLEKAKGTLEA 1314
            |||||||||:|.|||::::||.|||..:.:||.:|...|..|::|||..::.|..|||.|.|||:
Zfish  1208 ELRSKREQEVAELKKAIDDETRNHESQIQEMRQRHGTALEEISEQLEQAKRVKGNLEKNKQTLES 1272

  Fly  1315 ENADLATELRSVNSSRQENDRRRKQAESQIAELQVKLAEIERARSELQEKCTKLQQEAENITNQL 1379
            :|.:|..|::|:..::.|::.:||:.|:|:.|:..:.:|.|:.:.||.::..|:|.|.:|::..|
Zfish  1273 DNKELTNEVKSLQQAKSESEHKRKKLEAQLQEVMARFSEGEKVKGELADRTHKIQTELDNVSCLL 1337

  Fly  1380 EEAELKASAAVKSASNMESQLTEAQQLLEEETRQKLGLSSKLRQIESEKEALQEQLEEDDEAKRN 1444
            |:||.|.....|..|::||||.:.|:||:|||||||.|||::||:|.||..|.||.||::|:::|
Zfish  1338 EDAEKKGIKLTKDVSSLESQLQDTQELLQEETRQKLNLSSRIRQLEEEKNNLLEQQEEEEESRKN 1402

  Fly  1445 YERKLAEVTTQMQEIKKKAEEDADLAKELEEGKKRLNKDIEALERQVKELIAQNDRLDKSKKKIQ 1509
            .|::||.:..|:.|.|||.|:|....:.|||.|::|.||:|...::::|.....|:|:|:|.::|
Zfish  1403 LEKQLATLQAQLVETKKKLEDDVGALEGLEEVKRKLQKDMEVTSQKLEEKAIAFDKLEKTKNRLQ 1467

  Fly  1510 SELEDATIELEAQRTKVLELEKKQKNFDKILAEEKAISEQIAQERDTAEREAREKETKVLSVSRE 1574
            .||:|..::|:.||..|..||||||.||::|||||.||.:.|:|||.||.|||||:||.||::|.
Zfish  1468 QELDDLMVDLDHQRQIVSNLEKKQKKFDQMLAEEKTISARYAEERDRAEAEAREKDTKALSMARA 1532

  Fly  1575 LDEAFDKIEDLENKRKTLQNELDDLANTQGTADKNVHELEKAKRALESQLAELKAQNEELEDDLQ 1639
            ||||.:..|:.|...|.|:.|::||.:::....||||||||:||.||.|:.|::.|.|||||:||
Zfish  1533 LDEALEAKEEFERLNKQLRAEMEDLISSKDDVGKNVHELEKSKRTLEQQVEEMRTQLEELEDELQ 1597

  Fly  1640 LTEDAKLRLEVNMQALRSQFERDLLAKEEGAEEKRRGLVKQLRDLETELDEERKQRTAAVASKKK 1704
            .||||||||||||||:::||:|||.|::|..|||:|.||||:|::|.||::|||||..|||:|||
Zfish  1598 ATEDAKLRLEVNMQAMKAQFDRDLQARDEQNEEKKRALVKQVREMEAELEDERKQRALAVAAKKK 1662

  Fly  1705 LEGDLKEIETTMEMHNKVKEDALKHAKKLQAQVKDALRDAEEAKAAKEELQALSKEAERKVKALE 1769
            ||.|||::|..:|..||.:::|:|..:|||||:||..|:.|||:.:::|:...|||.|:|:|:||
Zfish  1663 LEMDLKDVEAQIEAANKARDEAIKQLRKLQAQMKDYQRELEEARTSRDEIFTQSKENEKKLKSLE 1727

  Fly  1770 AEVLQLTEDLASSERARRAAETERDELAEEIANNANKGSLMIDEKRRLEARIATLEEELEEEQSN 1834
            ||:|||.|||||||||||.||.||||||:||:|:|:..:.::|||||||||||.|||||||||||
Zfish  1728 AEILQLQEDLASSERARRHAEQERDELADEISNSASGKAALLDEKRRLEARIAQLEEELEEEQSN 1792

  Fly  1835 SEVLLDRSRKAQLQIEQLTTELANEKSNSQKNENGRALLERQNKELKAKLAEIETAQRTKVKATI 1899
            .|:|.||.||..:|::.|.||||.|:|.:||:||.|..||||||:||:||.|:|.:.::|.||:|
Zfish  1793 MELLNDRFRKTTMQVDTLNTELAGERSAAQKSENARQQLERQNKDLKSKLQELEGSVKSKFKASI 1857

  Fly  1900 ATLEAKIANLEEQLENEGKERLLQQKANRKMDKKIKELTMNIEDERRHVDQHKEQMDKLNSRIKL 1964
            |.|||||..||||||.|.|||....|..|:.:||:||:.|.:||||||.||:||||:|.|||:|.
Zfish  1858 AALEAKILQLEEQLEQEAKERAAANKIVRRTEKKLKEVFMQVEDERRHADQYKEQMEKANSRMKQ 1922

  Fly  1965 LKRNLDETEEELQKEKTQKRKYQRECEDMIESQEAMNREINSLKTKLRRTGGIGLSSSRLTGTPS 2029
            |||.|:|.|||..:....:||.|||.:|..|:.|.::||:|:||.:|||.|.:..|||| :|...
Zfish  1923 LKRQLEEAEEEATRANASRRKLQRELDDATEASEGLSREVNTLKNRLRRGGPVSFSSSR-SGRRQ 1986

  Fly  2030 SKRAGGGGGGD-DSSVQD 2046
            .:..|.....| ||...|
Zfish  1987 LQMEGDFSDDDADSKASD 2004

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
zip	NP_523860.2	Myosin_N	80..117	CDD:280832	23/36 (64%)
		Myosin_head	133..854	CDD:278492	512/750 (68%)
		MYSc_Myh2_insects_mollusks	145..854	CDD:276876	500/738 (68%)
		Myosin_tail_1	931..2011	CDD:279860	598/1079 (55%)
		Prefoldin	1431..1515	CDD:298833	33/83 (40%)
		FAM76	<1847..1926	CDD:292665	45/78 (58%)
myh10	XP_009300420.1	Myosin_N	37..75	CDD:280832	24/37 (65%)
		Myosin_head	90..812	CDD:278492	512/750 (68%)
		MYSc_Myh10	102..812	CDD:276952	500/738 (68%)
		Myosin_tail_1	889..1969	CDD:279860	598/1079 (55%)
		DUF342	<1085..1170	CDD:302792	43/84 (51%)
		RILP-like	<1528..1637	CDD:304877	61/108 (56%)
		GBP_C	<1641..1734	CDD:303769	49/92 (53%)
		coiled coil	1705..1714	CDD:293879	2/8 (25%)
		coiled coil	1723..1734	CDD:293879	7/10 (70%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	1148	1.000	Domainoid score	I16
eggNOG	1	0.900	-	-		E2759_KOG0161
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H55941
Inparanoid	1	1.050	2314	1.000	Inparanoid score	I32
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D40305at33208
OrthoFinder	1	1.000	-	-		FOG0000014
OrthoInspector	1	1.000	-	-		otm24342
orthoMCL	1	0.900	-	-		OOG6_100110
Panther	1	1.100	-	-	O	PTHR45615
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R786
SonicParanoid	1	1.000	-	-		X58
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	14	13.860