DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment zip and Myh13

DIOPT Version :9

Sequence 1:NP_523860.2 Gene:zip / 38001 FlyBaseID:FBgn0265434 Length:2056 Species:Drosophila melanogaster
Sequence 2:NP_001074719.1 Gene:Myh13 / 544791 MGIID:1339967 Length:1938 Species:Mus musculus


Alignment Length:1976 Identity:737/1976 - (37%)
Similarity:1172/1976 - (59%) Gaps:76/1976 - (3%)


- Green bases have known domain annotations that are detailed below.


  Fly    55 PELKYLSVERNQFNDPATQAEWTQKRLVWVPHENQGFVAASIKREHGDEVEVELAETGKRVMILR 119
            ||.:.:..:...|:         .|:..:...:.:.:|...|:....|:|.|:..: .:.:.:..
Mouse    20 PEKERIEAQNRPFD---------SKKACFAVDDKEMYVKGMIQSRENDKVIVKTLD-DRELTLNS 74

  Fly   120 DDIQKMNPPKFDKVEDMAELTCLNEASVLHNIKDRYYSGLIYTYSGLFCVVVNPYKKLPIYTEKI 184
            |.:..||||||||:||||.:|.|:|.:||:|:|:||.:.:||||||||||.|||||.||:|..::
Mouse    75 DQVFPMNPPKFDKIEDMAMMTHLHEPAVLYNLKERYAAWMIYTYSGLFCVTVNPYKWLPVYNPEV 139

  Fly   185 MERYKGIKRHEVPPHVFAITDSAYRNMLGDREDQSILCTGESGAGKTENTKKVIQFLAYVAASKP 249
            :..|:|.||.|.|||:|:|:|:||:.||.||::||||.|||||||||.|||:|||:.|.:|    
Mouse   140 VAAYRGKKRQEAPPHIFSISDNAYQFMLTDRDNQSILITGESGAGKTVNTKRVIQYFATIA---- 200

  Fly   250 KGSGAVPHPAVLINFSVNTNKYIKVKIMAQNQNQTIEVVNGLKMVEVNSNCQEGELEQQLLQANP 314
                                                  |.|.|..|......:|.||.|::||||
Mouse   201 --------------------------------------VTGDKKKEQQPGKMQGTLEDQIIQANP 227

  Fly   315 ILEAFGNAKTVKNDNSSRFGKFIRINFDASGFISGANIETYLLEKSRAIRQAKDERTFHIFYQLL 379
            :||||||||||:|||||||||||||:|.|:|.::.|:||||||||||...|...||::|||||::
Mouse   228 LLEAFGNAKTVRNDNSSRFGKFIRIHFGATGKLASADIETYLLEKSRVTFQLSSERSYHIFYQIM 292

  Fly   380 AGATPEQREKFILD-DVKSYAFLSNGSLPVPGVDDYAEFQATVKSMNIMGMTSEDFNSIFRIVSA 443
            :...||..:..::. :...:.|:|.|.:.|..:||..|..||..:::|:|.:.|:...|:::..|
Mouse   293 SNKKPELIDLLLISTNPFDFPFVSQGEVTVASIDDSEELLATDNAIDILGFSPEEKVGIYKLTGA 357

  Fly   444 VLLFGSMKFRQERNNDQATLPDNT-VAQKIAHLLGLSVTDMTRAFLTPRIKVGRDFVTKAQTKEQ 507
            |:.:|:|||:|::..:||. ||.| ||.|..:|:||:..:|.:....||:|||.::|||.|..:|
Mouse   358 VMHYGNMKFKQKQREEQAE-PDGTEVADKAGYLMGLNSAEMLKGLCCPRVKVGNEYVTKGQNVQQ 421

  Fly   508 VEFAVEAIAKACYERMFKWLVNRINRSLDRTKRQGASFIGILDMAGFEIFELNSFEQLCINYTNE 572
            |..:|.|:|||.||:||.|:|.|||:.|| ||:....|||:||:||||||:.||.||||||:|||
Mouse   422 VTNSVGALAKAVYEKMFLWMVTRINQQLD-TKQPRQYFIGVLDIAGFEIFDFNSLEQLCINFTNE 485

  Fly   573 KLQQLFNHTMFILEQEEYQREGIEWKFIDFGLDLQPTIDLIDKPGGIMALLDEECWFPKATDKTF 637
            ||||.|||.||:||||||::|||||:|||||:||...|:||:||.||.::|:|||.||||||.:|
Mouse   486 KLQQFFNHHMFVLEQEEYKKEGIEWEFIDFGMDLAACIELIEKPMGIFSILEEECMFPKATDTSF 550

  Fly   638 VDKLVSAH-SMHPKFMK---TDFRGVADFAIVHYAGRVDYSAAKWLMKNMDPLNENIVSLLQGSQ 698
            .:||...| .....|.|   |..:..|.|::|||||.|||:.|.||.||.|||||.:|.|.|.|.
Mouse   551 KNKLYDQHLGKSNNFQKPKPTKGKAEAHFSLVHYAGTVDYNIAGWLDKNKDPLNETVVGLYQKSS 615

  Fly   699 ---DPFVVNIWKDAEIVGMAQQALTDTQFGARTRKGMFRTVSHLYKEQLAKLMDTLRNTNPNFVR 760
               ..|:.:.:..||....|     ..:.|.:.:...|:|||.:::|.|.|||..||:|:|:|||
Mouse   616 LKLLSFLFSNYAGAEAGDSA-----GGKKGGKKKGSSFQTVSAVFRENLNKLMTNLRSTHPHFVR 675

  Fly   761 CIIPNHEKRAGKIDAPLVLDQLRCNGVLEGIRICRQGFPNRIPFQEFRQRYELLTPNVIPKG-FM 824
            |:|||..|..|.:|..||:.|||||||||||||||:|||:||.:.:|:|||.:|..:.||:| |:
Mouse   676 CLIPNETKTPGVMDHYLVMHQLRCNGVLEGIRICRKGFPSRILYADFKQRYRILNASAIPEGQFI 740

  Fly   825 DGKKACEKMIQALELDSNLYRVGQSKIFFRAGVLAHLEEERDFKISDLIVNFQAFCRGFLARRNY 889
            |.|.|.||::.::::|...:|.|.:|:||:||:|..|||.||.|:..|:...||.|||:|.|..:
Mouse   741 DSKNASEKLLNSIDVDREQFRFGHTKVFFKAGLLGLLEEMRDEKLVTLMTRTQAVCRGYLMRVEF 805

  Fly   890 QKRLQQLNAIRIIQRNCAAYLKLRNWQWWRLYTKVKPLLEVTKQEEKLVQKEDELKQVREKLDTL 954
            :|.:::..:|..||.|..:::.:::|.|..|:.|:||||:..:.|:::...:::.::.:|.|...
Mouse   806 KKMMERRESIFCIQYNVRSFMNVKHWPWMNLFFKIKPLLKSAEAEKEMATMKEDFERAKEDLARS 870

  Fly   955 AKNTQEYERKYQQALVEKTTLAEQLQAEIELCAEAEESRSRLMARKQELEDMMQELETRIEEEEE 1019
            ....:|.|.|....|.||..|..|:|:|.|...:|||....|:..|.:||..::||..|:|||||
Mouse   871 EARRKELEEKMVSLLQEKNDLQLQVQSETENLMDAEERCEGLIKSKIQLEAKVKELNERLEEEEE 935

  Fly  1020 RVLALGGEKKKLELNIQDLEEQLEEEEAARQKLQLEKVQLDAKIKKYEEDLALTDDQNQKLLKEK 1084
            ....|..:|:.||.....|:..:::.|....|::.||...:.|:|...|::...::...||.|||
Mouse   936 MNSELVAKKRNLEDKCSSLKRDIDDLELTLTKVEKEKHATENKVKNLSEEMTALEETISKLTKEK 1000

  Fly  1085 KLLEERANDLSQTLAEEEEKAKHLAKLKAKHEATISELEERLHKDQQQRQESDRSKRKIETEVAD 1149
            |.|:|........|..||:|...|.|:..|.|....:||..|.::::.|.:.:|.|||:|.::..
Mouse  1001 KSLQEAHQQTLDDLQVEEDKVNGLIKINVKLEQQTDDLEGSLEQEKKLRADLERVKRKLEGDLKM 1065

  Fly  1150 LKEQLNERRVQVDEMQAQLAKREEELTQTLLRIDEESATKATAQKAQRELESQLAEIQEDLEAEK 1214
            .:|.:.:......:::.:|.|:|.|::|...|||:|.......||..:||:::..|::|::|||.
Mouse  1066 SQESIMDLENDTQQLEEKLKKKEFEMSQLQTRIDDEQVLSLQLQKKIKELQARTEELEEEIEAEH 1130

  Fly  1215 AARAKAEKVRRDLSEELEALKNELLDSLDTTAAQQELRSKREQELATLKKSLEEETVNHEGVLAD 1279
            ..|||.||.|.||:.|||.:...|.::...|:||.|:..|||.|...|::.|||.|:.||...|.
Mouse  1131 TVRAKIEKQRSDLARELEEISERLEEASGATSAQIEMNKKRESEFQKLRRDLEEATLQHEATAAT 1195

  Fly  1280 MRHKHSQELNSINDQLENLRKAKTVLEKAKGTLEAENADLATELRSVNSSRQENDRRRKQAESQI 1344
            :|.||:..:..:.:|::||::.|..|||.|..|:.|..|:|:.:.:|:.|:...:|..:..|.|.
Mouse  1196 LRKKHADTVAELGEQIDNLQRVKQKLEKEKSELKMEIDDMASNIETVSKSKSNMERMCRSVEDQF 1260

  Fly  1345 AELQVKLAEIERARSELQEKCTKLQQEAENITNQLEEAELKASAAVKSASNMESQLTEAQQLLEE 1409
            .|::.|..:..:...:|..:..:||.:...:::|:||.|...|...||...:..||.|.::.|||
Mouse  1261 NEIKAKDDQQTQLIHDLNMQKARLQTQNGELSHQVEEKESLVSQLTKSKQALTQQLEELKRQLEE 1325

  Fly  1410 ETRQKLGLSSKLRQIESEKEALQEQLEEDDEAKRNYERKLAEVTTQMQEIKKKAEEDA-DLAKEL 1473
            ||:.|..|:..|:....:.:.|:||.||:.|.|...:|.|::..:::.:.:.|.|.|| ...:||
Mouse  1326 ETKAKNALAHALQSSRHDCDLLREQYEEEQEGKAELQRALSKANSEVAQWRTKYETDAIQRTEEL 1390

  Fly  1474 EEGKKRLNKDIEALERQVKELIAQNDRLDKSKKKIQSELEDATIELEAQRTKVLELEKKQKNFDK 1538
            ||.||:|.:.::..|...:...::...|:|:|:::|.|::|..::||...|....|:|||:||||
Mouse  1391 EEAKKKLAQRLQEAEENTEASNSKCASLEKTKQRLQGEVDDLMLDLERANTACATLDKKQRNFDK 1455

  Fly  1539 ILAEEKAISEQIAQERDTAEREAREKETKVLSVSRELDEAFDKIEDLENKRKTLQNELDDLANTQ 1603
            :|||.|...::...|.:.|::|:|...|::..:....:|..|::|.|..:.|.||.|:.||....
Mouse  1456 VLAEWKQKLDESQAELEAAQKESRSLSTEIFKMRNAYEEVVDQLETLRRENKNLQEEISDLTEQI 1520

  Fly  1604 GTADKNVHELEKAKRALESQLAELKAQNEELEDDLQLTEDAKLRLEVNMQALRSQFERDLLAKEE 1668
            ....||:.|:||.|:.:|.:.::|:|..||:|..|:..|...||:::.:..::|:.:|.:..|:|
Mouse  1521 AETGKNLQEVEKTKKQVEQEKSDLQAALEEVEGSLEHEESKILRVQLELSQVKSELDRKVTEKDE 1585

  Fly  1669 GAEEKRRGLVKQLRDLETELDEERKQRTAAVASKKKLEGDLKEIETTMEMHNKVKEDALKHAKKL 1733
            ..|:.:|...:.:..:::.||.|.:.|..|:..|||:||||.|:|..:...|:...:..||.:.:
Mouse  1586 EIEQIKRNSQRAVEAMQSVLDAEIRSRNDALRLKKKMEGDLNEMEIQLSHANRQVAETQKHLRTV 1650

  Fly  1734 QAQVKDALRDAEEAKAAKEELQALSKEAERKVKALEAEVLQLTEDLASSERARRAAETERDELAE 1798
            |.|:||:....::|:.:.|:|:......||:...|:.|:.::...|..:||.||.:|.|..:.::
Mouse  1651 QGQLKDSQLHLDDAQRSNEDLKEQLAIVERRNGLLQEELEEMKVALEQTERTRRLSEQELLDSSD 1715

  Fly  1799 EIANNANKGSLMIDEKRRLEARIATLEEELE---EEQSNSEVLLDRSRKAQLQIEQLTTELANEK 1860
            .:....::.:.:|:.|::|||.:|..:.|:|   :|..|:|   ::::||......:..||..|:
Mouse  1716 RVQLLHSQNTSLINTKKKLEADLAQCQAEVENSIQESRNAE---EKAKKAITDAAMMAEELKKEQ 1777

  Fly  1861 SNSQKNENGRALLERQNKELKAKLAEIETAQRTKVKATIATLEAKIANLEEQLENEGKERLLQQK 1925
            ..|...|..:..||:..|:|:.:|.|.|.......|..|..|||::..||.:|:.|.|......|
Mouse  1778 DTSAHLERMKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQKLEARVRELESELDAEQKRGAEALK 1842

  Fly  1926 ANRKMDKKIKELTMNIEDERRHVDQHKEQMDKLNSRIKLLKRNLDETEEELQKEKTQKRKYQREC 1990
            ...|.::|:||:|...|::|:::.:.::.:|||.:::|..||..:|.||:...:.::.|:.|.|.
Mouse  1843 GAHKYERKVKEMTYQAEEDRKNILRLQDLVDKLQAKVKSYKRQAEEAEEQANTQLSRCRRVQHEL 1907

  Fly  1991 EDMIESQEAMNREINSLKTKLRRTGG 2016
            |:..|..:....::|.|:.|.|..||
Mouse  1908 EEAEERADIAESQVNKLRAKSRDVGG 1933

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
zipNP_523860.2 Myosin_N 80..117 CDD:280832 5/36 (14%)
Myosin_head 133..854 CDD:278492 355/730 (49%)
MYSc_Myh2_insects_mollusks 145..854 CDD:276876 348/718 (48%)
Myosin_tail_1 931..2011 CDD:279860 329/1083 (30%)
Prefoldin 1431..1515 CDD:298833 26/84 (31%)
FAM76 <1847..1926 CDD:292665 22/78 (28%)
Myh13NP_001074719.1 Myosin_N 36..73 CDD:280832 5/37 (14%)
Myosin_head 88..770 CDD:278492 355/730 (49%)
MYSc_Myh13 100..770 CDD:276887 348/718 (48%)
Myosin_tail_1 850..1927 CDD:279860 329/1079 (30%)
DUF342 <1506..1582 CDD:302792 24/75 (32%)
TMPIT 1744..>1837 CDD:285135 29/95 (31%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D47111at2759
OrthoFinder 1 1.000 - - FOG0000014
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100110
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X58
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
54.820

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