Protein Alignment zip and myo1b

DIOPT Version :10

• Sequence 1: NP_523860.2
• Gene: zip / 38001
• FlyBaseID: FBgn0287873
• Length: 2056
• Species: Drosophila melanogaster
• Sequence 2: XP_003199241.2
• Gene: myo1b / 541515
• ZFINID: ZDB-GENE-030131-695
• Length: 1165
• Species: Danio rerio
• Alignment Length: 1232
• Identity: 363/1232 - (29%)
• Similarity: 562/1232 - (45%)
• Gaps: 256/1232 - (20%)

  Fly   133 VEDMAELTCLNEASVLHNIKDRYYSGLIYTYSGLFCVVVNPYKKLPIYTEKIMERYKGIKRHEVP 197
            |.||..|..|:|.|.:.|:|.|:....||||.|...:.:||||.|.||:.:.:|.|:....:|:.
Zfish    14 VGDMVLLEPLSEESFIENLKKRFDHNEIYTYIGSVVISMNPYKSLSIYSAEKVEEYRNRNFYELS 78

  Fly   198 PHVFAITDSAYRNMLGDREDQSILCTGESGAGKTENTKKVIQFLAYVAASKPKGSGAVPHPAVLI 262
            ||::|:.|.|||::....:||.||.||||||||||.:|.|   ::||||...||.
Zfish    79 PHIYALADEAYRSLRHQDKDQCILITGESGAGKTEASKFV---MSYVAAVCGKGQ---------- 130

  Fly   263 NFSVNTNKYIKVKIMAQNQNQTIEVVNGLKMVEVNSNCQEGELEQQLLQANPILEAFGNAKTVKN 327
                                            |||      ::::||||:||:||||||||||:|
Zfish   131 --------------------------------EVN------KVKEQLLQSNPVLEAFGNAKTVRN 157

  Fly   328 DNSSRFGKFIRINFDASGFISGANIETYLLEKSRAIRQAKDERTFHIFYQLLAGATPEQREKFIL 392
            ||||||||::.|.||..|...|..|..|||||||.::|.:.||.||||||||:||:.:..:|..|
Zfish   158 DNSSRFGKYMDIEFDFKGDPLGGVISNYLLEKSRVVKQPRGERNFHIFYQLLSGASDDMLKKLKL 222

  Fly   393 D-DVKSYAFLSNGSLPVPGVDDYAEFQATVKSMNIMGMTSEDFNSIFRIVSAVLLFGSMKFRQE- 455
            | |...|.:||..|..|.|:||.|.|:....:|.|:|...::..||..:::|||..|:::|:.|
Zfish   223 DRDFSKYNYLSLDSATVNGLDDAASFRTVRNAMQIVGFMEDEVQSILELIAAVLKLGNIEFKPES 287

  Fly   456 RNN--DQATLPDNTVAQKIAHLLGLSVTDMTRAFLTPRIKVGRDFVTKAQTKEQVEFAVEAIAKA 518
            |.|  |::.:.|....:::..|||:..:.:.|||....::...:.|:......|..:|.:|:||.
Zfish   288 RVNGFDESRVKDKNDLKEMCELLGIEQSVLERAFSFRTVEAKMEKVSTTLNVAQAYYARDALAKN 352

  Fly   519 CYERMFKWLVNRINRSLDRTKRQGASFIGILDMAGFEIFELNSFEQLCINYTNEKLQQLFNHTMF 583
            .|.|:|.|||||||.|:....:.....:|:||:.||||||.|||||..|||.||||||:|.....
Zfish   353 LYSRLFTWLVNRINESIKAQTKTRKKVMGVLDIYGFEIFEDNSFEQFIINYCNEKLQQIFIELTL 417

  Fly   584 ILEQEEYQREGIEWKFIDFGLDLQPTIDLID-KPGGIMALLDEECWFP-KATDKTFVDKLVSAHS 646
            ..|||||.||||||..|:: .:.....|||: ...||:|:|||||..| ..||:||:|||.:..:
Zfish   418 REEQEEYIREGIEWTNIEY-FNNAIICDLIENNKNGILAMLDEECLRPGTVTDETFLDKLNTVCA 481

  Fly   647 MHPKF---MKTDFRGVAD-------FAIVHYAGRVDYSAAKWLMKNMDPL-----------NENI 690
            .|..|   :..:.:.:.|       |.|.||||:|.|....::.||.|.|           |.|:
Zfish   482 EHQHFESRLSKNSKFLTDHSLPHNCFRIQHYAGKVLYRVEGFVDKNNDLLYRDLSQAMYKANHNL 546

  Fly   691 VSLLQGSQDPFVVNIWKDAEIVGMAQQALTDTQFGARTRKGMFRTVSHLYKEQLAKLMDTLRNTN 755
            :.||....:|..||:.:..                         |....::..:..||..|...|
Zfish   547 IKLLFPEGNPAKVNLKRPP-------------------------TAGFQFRASVGTLMKNLLTKN 586

  Fly   756 PNFVRCIIPNHEKRAGKIDAPLVLDQLRCNGVLEGIRICRQGFPNRIPFQEFRQRYELLTPNVIP 820
            ||::|||.||.:|.|......||..|:|..|::|.:|:.|.|:..|..::...:||::|.....|
Zfish   587 PNYIRCIKPNDKKAAHIFTDSLVCHQVRYLGLMENVRVRRAGYAFRQAYEPCLERYKMLCKQTWP 651

  Fly   821 KGFMDGKKACEKMIQALELDSNLYRVGQSKIFFR-AGVLAHLEEERDFKISDLIVNFQAFCRGFL 884
            ......::..|.::..|::.:..:..|:||||.| ...|..|||:|...:.||....|...||:.
Zfish   652 HWKGPAREGVEVLLSDLQVPAEEFAYGRSKIFIRNPRTLFFLEEKRRQCLEDLAALIQKIYRGWK 716

  Fly   885 ARRNY-------------------QKRLQQLNAIRIIQRNCAAYLKLRNWQWWRLYTKVKPLLEV 930
            .|.::                   ||:.|::....::.::.     :|.|       |.:.||..
Zfish   717 CRTHFLLLKKSQVVVAAWYRRFAQQKKYQKIRCSALVVQSF-----IRGW-------KARKLLRE 769

  Fly   931 TKQEEKLVQKEDELK------QVREKLDTLAKNTQEYERKYQQALVEKTTLAEQLQAEI-----E 984
            .|.:::..:....:.      |.|.:|..|.|   |...|:..:::....|..:.:.|:     |
Zfish   770 LKHKKRCEEAVTTISAYWHGTQARWELRRLKK---EAWNKHAVSVIWAAWLGTKARRELQKLKHE 831

  Fly   985 LCAEAEESRSRLMA------RKQELEDMMQE--------------LETRIEEEEERVLALGGEKK 1029
            .|  ::::.|.:.|      .::||:.:.:|              |..::..|..:.......||
Zfish   832 AC--SKQAVSVIWACWQGTKARRELKRLKEEARRKHAIAVIWAYWLGLKVRREYRKFFRANAGKK 894

  Fly  1030 KLELNIQDLEEQLEEEEAARQKLQLEKVQLDAKIKKYEEDLALT-------------------DD 1075
            ..:..||.:                        |:||...|..|                   |.
Zfish   895 IYDFTIQRI------------------------IQKYYLGLKKTMPSMSPIDKSWSTCPYGFLDG 935

  Fly  1076 QNQKL-----LKEKKLLEERANDLSQTLAEEEEKAKHLAK-LKAKHEATISELEERLHKDQQQRQ 1134
            .:|:|     |...|....:..:..:...||:..|..|.| .||.:.:::|:..:..:.:..:..
Zfish   936 THQELRRIFHLWRCKKYRSQFTEEKKATYEEKLAASELFKDKKALYPSSVSQPFKGDYVEITKNP 1000

  Fly  1135 ESDRSKRKIETEV--ADLKEQLNERR---------------VQVDEMQAQLAKREEEL------- 1175
            :..:....:|.:|  ||:..::|...               |..|:...|: |....|
Zfish  1001 KYQKLNSLVEDKVLLADVVSKINRANGKGTPRIFLLTKKCLVLADQKTGQV-KASVPLPDLSSVF 1064

  Fly  1176 --TQT----LLRIDEESATKATAQKAQRELES-QLAEIQEDLEAEKAARAKAEKVRRDLSEE 1230
              ||.    .|:: .|.||  :|.|....|.| :|.||...|....||.|:..:::.|:|:|
Zfish  1065 VSTQNDGFFALKL-REGAT--SAAKGDYLLSSDRLIEIITKLYCTGAASAERNQIKIDISDE 1123

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
zip	NP_523860.2	Myosin_N	79..122	CDD:460670
		MYSc_Myh2_insects_mollusks	145..854	CDD:276876	266/735 (36%)
		Myosin_tail_1	931..2011	CDD:460256	71/387 (18%)
myo1b	XP_003199241.2	MYSc_Myo1	26..685	CDD:276829	266/735 (36%)
		IQCD	740..775	CDD:467745	9/46 (20%)
		Myosin_TH1	967..1162	CDD:461801	36/161 (22%)