DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment zip and MYO15A

DIOPT Version :9

Sequence 1:NP_523860.2 Gene:zip / 38001 FlyBaseID:FBgn0265434 Length:2056 Species:Drosophila melanogaster
Sequence 2:XP_016880204.1 Gene:MYO15A / 51168 HGNCID:7594 Length:3531 Species:Homo sapiens


Alignment Length:1003 Identity:332/1003 - (33%)
Similarity:497/1003 - (49%) Gaps:169/1003 - (16%)


- Green bases have known domain annotations that are detailed below.


  Fly    16 PKSEYPVSNIH----YPKAANYRQTR--NYLEIAAKMSE--EVDRNDPELKYLSVERNQFNDPAT 72
            |::..|::.|.    .||....||..  .:..:..::.:  ...|..|..  |..:.....||..
Human  1085 PQAAAPLAPIRAPEPLPKGGERRQAAPGRFAVVMPRVQKLSSFQRVGPAT--LKPQVQPIQDPKP 1147

  Fly    73 QA---EWTQKRLVWVPHENQGFVAASIKREHGDEVEVELAETGKRVMILRDDIQKMNPPKF---- 130
            :|   .|:   .:|:..:..|    ...|.|.......|. .|...:.||...:::.||.:    
Human  1148 RACSLRWS---CLWLRADAYG----PWPRVHTHPQSCHLG-PGAACLSLRGSWEEVGPPSWRNKM 1204

  Fly   131 -----------------DKVEDMAELTCLNEASVLHNIKDRYYSGLIYTYSGLFCVVVNPYKKLP 178
                             |.||||.:|..|.|.:||.|:|.|:...|||||.|...|.||||:...
Human  1205 HSIRNLPSMRFREQHGEDGVEDMTQLEDLQETTVLSNLKIRFERNLIYTYIGSILVSVNPYQMFG 1269

  Fly   179 IYTEKIMERYKGIKRHEVPPHVFAITDSAYRNMLGDREDQSILCTGESGAGKTENTKKVIQFLAY 243
            ||..:.:::|.|....|.|||:||:.:.|:..||..:::|.|:.:||||:||||.||.::::|| 
Human  1270 IYGPEQVQQYNGRALGENPPHLFAVANLAFAKMLDAKQNQCIIISGESGSGKTEATKLILRYLA- 1333

  Fly   244 VAASKPKGSGAVPHPAVLINFSVNTNKYIKVKIMAQNQNQTI--EVVNGLKMVEVNSNCQEGELE 306
                                              |.||.:.:  :|:                  
Human  1334 ----------------------------------AMNQKREVMQQVI------------------ 1346

  Fly   307 QQLLQANPILEAFGNAKTVKNDNSSRFGKFIRINFDASGFISGANIETYLLEKSRAIRQAKDERT 371
             |:|:|.|:||:|||||||:||||||||||:.| |...|.||||....|||||||.:.|||:||.
Human  1347 -QILEATPLLESFGNAKTVRNDNSSRFGKFVEI-FLEGGVISGAITSQYLLEKSRIVFQAKNERN 1409

  Fly   372 FHIFYQLLAGATPEQREKFILDDVKSYAFLS-NGSLPVPGVDDYAEFQATVKSMNIMGMTSEDFN 435
            :||||:||||...:.|:.|.|.:.::|.:|: .|:..:.|..|..:|:..:.:|.::|.:|||.:
Human  1410 YHIFYELLAGLPAQLRQAFSLQEAETYYYLNQGGNCEIAGKSDADDFRRLLAAMEVLGFSSEDQD 1474

  Fly   436 SIFRIVSAVLLFGSMKFRQERNNDQ--ATLPDNTVAQKIAHLLGLSVTDMTRAFLTPRIKVGRDF 498
            |||||::::|..|::.|.:...:.|  |::......|.:|.||.:|...:.:|......:..|:.
Human  1475 SIFRILASILHLGNVYFEKYETDAQEVASVVSAREIQAVAELLQISPEGLQKAITFKVTETMREK 1539

  Fly   499 VTKAQTKEQVEFAVEAIAKACYERMFKWLVNRINRSLDRTKRQGASFIGILDMAGFEIFELNSFE 563
            :....|.|....|.:||||..|..:|.||:.|:|..:  :.||....|.|||:.|||....||||
Human  1540 IFTPLTVESAVDARDAIAKVLYALLFSWLITRVNALV--SPRQDTLSIAILDIYGFEDLSFNSFE 1602

  Fly   564 QLCINYTNEKLQQLFNHTMFILEQEEYQREGIEWKFIDFGLDLQPTIDLID-KPGGIMALLDEEC 627
            ||||||.||.||.|||..:|..|||||.||.|:|:.|.|. |.||.|:||. ||.||:.:||::|
Human  1603 QLCINYANENLQYLFNKIVFQEEQEEYIREQIDWQEITFA-DNQPCINLISLKPYGILRILDDQC 1666

  Fly   628 WFPKATDKTFVDKLVSAHSMHPKFMKTDFRGVADFAIVHYAGRVDYSAAKWLMKNMDPLNENIVS 692
            .||:|||.||:.|....|..:|.:.|... .:.:|.|.||||:|.|...|:|.||.|.:.::::.
Human  1667 CFPQATDHTFLQKCHYHHGANPLYSKPKM-PLPEFTIKHYAGKVTYQVHKFLDKNHDQVRQDVLD 1730

  Fly   693 LLQGSQDPFVVNIWKDAEIVGMAQQALTDTQFGARTRKGMFRTVSHLYK---------EQLAKLM 748
            |...|:...|.:::.     ..|.||       |..|.|...:|:.|||         :.|..|:
Human  1731 LFVRSRTRVVAHLFS-----SHAPQA-------APQRLGKSSSVTRLYKAHTVAAKFQQSLLDLV 1783

  Fly   749 DTLRNTNPNFVRCIIPNHEKRAGKIDAPLVLDQLRCNGVLEGIRICRQGFPNRIPFQEFRQRY-- 811
            :.:...||.|:||:.|||:|..|..:..:|:.|||.:||||.:||.::|||.|:|||.|..||  
Human  1784 EKMERCNPLFMRCLKPNHKKEPGLFEPDVVMAQLRYSGVLETVRIRKEGFPVRLPFQGFIDRYCC 1848

  Fly   812 -ELLTPNVIPKGFMDGKKACEKMIQAL-ELDSNLYRVGQSKIFFRAGVLAHLEEERDF------- 867
             ..|..::...|.|     |..::..| ::..|:||||.||:|.:..:...||..|:.       
Human  1849 LVALKHDLPANGDM-----CVSVLSRLCKVMPNMYRVGVSKLFLKEHLYQLLESMREHVLNLAAL 1908

  Fly   868 ----------------KISDLIVNFQAFCRGFLARRNYQKRLQQLNAIRIIQRNCAA---YLKLR 913
                            .:...|:..|:..||:|||:.||:..:.|...|.:.....:   |||||
Human  1909 TLQRCLRGFFIKRRFRSLRHKIILLQSRARGYLARQRYQQMRRSLVKFRSLVHAYVSRRRYLKLR 1973

  Fly   914 NWQWWRLYTKVKPLLEVTKQEEKLVQKE 941
              ..||...:...|.|    :|:|.::|
Human  1974 --AEWRCQVEGALLWE----QEELSKRE 1995

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
zipNP_523860.2 Myosin_N 80..117 CDD:280832 6/36 (17%)
Myosin_head 133..854 CDD:278492 281/739 (38%)
MYSc_Myh2_insects_mollusks 145..854 CDD:276876 274/727 (38%)
Myosin_tail_1 931..2011 CDD:279860 3/11 (27%)
Prefoldin 1431..1515 CDD:298833
FAM76 <1847..1926 CDD:292665
MYO15AXP_016880204.1 None
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0000014
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.910

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