Protein Alignment zip and Myo15a

DIOPT Version :10

• Sequence 1: NP_523860.2
• Gene: zip / 38001
• FlyBaseID: FBgn0287873
• Length: 2056
• Species: Drosophila melanogaster
• Sequence 2: NP_001414755.1
• Gene: Myo15a / 501699
• RGDID: 1561873
• Length: 3512
• Species: Rattus norvegicus
• Alignment Length: 1054
• Identity: 348/1054 - (33%)
• Similarity: 518/1054 - (49%)
• Gaps: 197/1054 - (18%)

  Fly     8 LKSKSALHPKSEYPV-----SNIHYPK-------------AANYRQTRNYLEIAAKMSEEVDRND 54
            :..:.||.|.:.||:     |...:|:             .|..|...:.|:...::.::..|..
  Rat  1035 VSERKALRPSASYPLVTCKQSRATWPQWHRWKTVSRTPAPLAPTRAPGSLLKAGKQLRDKPGRFA 1099

  Fly    55 ---PELKYLS---------------VERNQFNDPATQA---EWTQKRLVWVPHENQG-------F 91
               |:::.||               .:::..:.|||||   .|.:   :|.|.:...       .
  Rat  1100 VVMPQVRGLSSFQQKGSAPLQPPEHSDQDPEHGPATQACSLRWPR---LWSPADTHSPWPRIHTL 1161

  Fly    92 VAASIKREHGDEVEVE---LAETGKR-----VMILRD--DIQKMNPPKFDKVEDMAELTCLNEAS 146
            .:.|..|.||.:.:..   ..:||.|     :..:|:  .::.....:.|.||||.:|..|.|.:
  Rat  1162 SSPSPLRGHGGDCQSPKDLWKKTGSRSWQNKMHSIRNLPSVRSREQHREDGVEDMTQLEDLQETT 1226

  Fly   147 VLHNIKDRYYSGLIYTYSGLFCVVVNPYKKLPIYTEKIMERYKGIKRHEVPPHVFAITDSAYRNM 211
            ||.|:|.|:...|||||.|...|.||||:...||..:.:::|.|....|.|||:|||.:.|:..|
  Rat  1227 VLTNLKTRFERNLIYTYIGSILVSVNPYRMFAIYGPEQVQQYSGRALGENPPHLFAIANLAFAKM 1291

  Fly   212 LGDREDQSILCTGESGAGKTENTKKVIQFLAYVAASKPKGSGAVPHPAVLINFSVNTNKYIKVKI 276
            |..:::|.::.:||||:||||.||.:::.||
  Rat  1292 LDAKQNQCVIISGESGSGKTEATKLLLRCLA---------------------------------- 1322

  Fly   277 MAQNQNQTIEVVNGLKMVEVNSNCQEGELEQQLLQANPILEAFGNAKTVKNDNSSRFGKFIRINF 341
             |.||.:  :|:..:|                :|:|.|:||||||||||:||||||||||:.| |
  Rat  1323 -AMNQRR--DVMQQIK----------------ILEATPLLEAFGNAKTVRNDNSSRFGKFVEI-F 1367

  Fly   342 DASGFISGANIETYLLEKSRAIRQAKDERTFHIFYQLLAGATPEQREKFILDDVKSYAFLS-NGS 405
            ...|.|.||....|||||||.:.|||:||.:||||:||||...:.|:.|.|.:.::|.:|: .|:
  Rat  1368 LEGGVICGAITSQYLLEKSRIVFQAKNERNYHIFYELLAGLPAQLRQAFSLQEAETYYYLNQGGN 1432

  Fly   406 LPVPGVDDYAEFQATVKSMNIMGMTSEDFNSIFRIVSAVLLFGSMKFRQERNNDQ--ATLPDNTV 468
            ..:.|..|..:|:..:.:|.::|.||||.:|||||::::|..|::.|.:...:.|  |::.....
  Rat  1433 CEIAGKSDADDFRRLLAAMEVLGFTSEDQDSIFRILASILHLGNVYFEKHETDAQEVASVVSARE 1497

  Fly   469 AQKIAHLLGLSVTDMTRAFLTPRIKVGRDFVTKAQTKEQVEFAV---EAIAKACYERMFKWLVNR 530
            .|.:|.||.:|...:.:|.   ..||......|..|...||.||   :||||..|..:|.||:.|
  Rat  1498 IQAVAELLQVSPEGLQKAI---TFKVTETIREKIFTPLTVESAVDARDAIAKVLYALLFGWLITR 1559

  Fly   531 INRSLDRTKRQGASFIGILDMAGFEIFELNSFEQLCINYTNEKLQQLFNHTMFILEQEEYQREGI 595
            :|..:  :.:|....|.|||:.|||....||||||||||.||.||.|||..:|..|||||.||.:
  Rat  1560 VNALV--SPKQDTLSIAILDIYGFEDLSFNSFEQLCINYANENLQYLFNKIVFQEEQEEYIREQM 1622

  Fly   596 EWKFIDFGLDLQPTIDLID-KPGGIMALLDEECWFPKATDKTFVDKLVSAHSMHPKFMKTDFRGV 659
            :|:.|.|. |.||.|:||. ||.||:.:||::|.||:|||.||:.|....|..:|.:.|... .:
  Rat  1623 DWREIAFA-DNQPCINLISLKPYGILRILDDQCCFPQATDHTFLQKCHYHHGANPLYCKPKM-PL 1685

  Fly   660 ADFAIVHYAGRVDYSAAKWLMKNMDPLNENIVSLLQGSQDPFVVNIWKDAEIVGMAQQALTDTQF 724
            .:|.|.||||:|.|...|:|.||.|.:.::::.|...|:...|.:::.       :..|.|
  Rat  1686 PEFTIKHYAGKVTYQVHKFLDKNHDQVRQDVLDLFVHSRTRVVAHLFS-------SHAAQT---- 1739

  Fly   725 GARTRKGMFRTVSHLYK---------EQLAKLMDTLRNTNPNFVRCIIPNHEKRAGKIDAPLVLD 780
             |..|.|...:::.|||         :.|..|::.:...||.||||:.|||:|..|..:..:::.
  Rat  1740 -APPRLGKSSSITRLYKAHTVAAKFQQSLLDLVEKMERCNPLFVRCLKPNHKKEPGLFEPDVMMA 1803

  Fly   781 QLRCNGVLEGIRICRQGFPNRIPFQEFRQRYELLTP---NVIPKGFMDGKKACEKMIQAL-ELDS 841
            |||.:||||.:||.::|||.|:|||.|..||..|..   ||...|.|     |..::..| .:..
  Rat  1804 QLRYSGVLETVRIRKEGFPVRLPFQVFIDRYRCLVALKLNVPADGDM-----CVSLLSRLCTVTP 1863

  Fly   842 NLYRVGQSKIFFRAGVLAHLEE----------------------ERDFK-ISDLIVNFQAFCRGF 883
            ::||||.||:|.:..:...||.                      :|.|: :...|:..|:..|||
  Rat  1864 DMYRVGVSKLFLKEHLHQLLESMRERVLNRAALTLQRYLRGFFTQRRFRSLRQKIILLQSRARGF 1928

  Fly   884 LARRNYQKRLQQLNAIRIIQR---NCAAYLKLR-------NWQWWR-----LYTKVKPL--LEVT 931
            |||:.||:..|.|...|.:..   |...|||||       ...|.|     ...:|.|:  |||.
  Rat  1929 LARQRYQQMRQSLLKFRSLVHTYVNRRRYLKLRAERRRRAQEAWLREQEELSKREVVPVRHLEVP 1993

  Fly   932 KQEEKLVQKEDELK 945
            .:...|:|....||
  Rat  1994 AEVAGLLQAAAGLK 2007

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
zip	NP_523860.2	Myosin_N	79..122	CDD:460670	10/59 (17%)
		MYSc_Myh2_insects_mollusks	145..854	CDD:276876	276/728 (38%)
		Myosin_tail_1	931..2011	CDD:460256	4/15 (27%)
Myo15a	NP_001414755.1	None