DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment zip and Myo7b

DIOPT Version :9

Sequence 1:NP_523860.2 Gene:zip / 38001 FlyBaseID:FBgn0265434 Length:2056 Species:Drosophila melanogaster
Sequence 2:NP_001178870.1 Gene:Myo7b / 498834 RGDID:1561153 Length:2152 Species:Rattus norvegicus


Alignment Length:2177 Identity:545/2177 - (25%)
Similarity:897/2177 - (41%) Gaps:475/2177 - (21%)


- Green bases have known domain annotations that are detailed below.


  Fly    82 VWV--PHENQGFVAASIKREHGDEVEVELAET------GKRVMILRDD---IQKMNPPKFDKVED 135
            ||:  |..|:..||..     |...|.:|.:|      ||...|..:|   ::.|:|.....|:|
  Rat    10 VWLDPPSSNKTGVAIG-----GIVKETKLGKTLIEDDEGKEHWISAEDLSTLRPMHPNSAQGVDD 69

  Fly   136 MAELTCLNEASVLHNIKDRYYSGLIYTYSGLFCVVVNPYKKLPIYTEKIMERYKGIKRHEVPPHV 200
            |..|..||||.|:||:..||....||||:|...|.|||::.||:||.:.::.|......|:||||
  Rat    70 MIRLGDLNEAGVVHNLLIRYQQHKIYTYTGSILVAVNPFQMLPLYTLEQVQIYYSRHMGELPPHV 134

  Fly   201 FAITDSAYRNMLGDREDQSILCTGESGAGKTENTKKVIQFLAYVAASKPKGSGAVPHPAVLINFS 265
            |||.:|.|.||..::.||..:.:|||||||||.||.::||||.|:.                   
  Rat   135 FAIANSCYFNMKKNKRDQCCIISGESGAGKTETTKLILQFLATVSG------------------- 180

  Fly   266 VNTNKYIKVKIMAQNQNQTIEVVNGLKMVEVNSNCQEGELEQQLLQANPILEAFGNAKTVKNDNS 330
                                               |...:|||:|:|||||||||||||::||||
  Rat   181 -----------------------------------QHSWIEQQVLEANPILEAFGNAKTIRNDNS 210

  Fly   331 SRFGKFIRINFDASGFISGANIETYLLEKSRAIRQAKDERTFHIFYQLLAGATPEQREKFILDDV 395
            |||||:|.|:|::||.|.||:||.:||||||..|||.:||.:||||.:|.|.:.|::....|...
  Rat   211 SRFGKYIDIHFNSSGVIEGASIEHFLLEKSRVCRQAAEERNYHIFYCMLMGMSLEEKNMLGLGMP 275

  Fly   396 KSYAFLSNGS-LPVPGVDDYAEFQATVKSMNIMGMTSEDFNSIFRIVSAVLLFGSM-----KFRQ 454
            ..|.:|:.|: ....|:.|..::.....:|.|:..:..:...|.::::|:|..|::     .|..
  Rat   276 SEYHYLTMGNCTSYEGLSDAKDYAHVRSAMKILQFSDSENWDISKLLAAILHLGNVGFMAAVFEN 340

  Fly   455 ERNNDQATLPDNTVAQKIAHLLGLSVTDMTRAFLTPRIKVGRDFVTKAQTKEQVEFAVEAIAKAC 519
            ..::|....|....|.|:..:...::.|   ..:...|.:..:||::.....|.....:|..|..
  Rat   341 LDSSDVMETPAFPFAMKLLEVQHQALRD---CLIKHTIPILGEFVSRPLNIAQAADRRDAFVKGI 402

  Fly   520 YERMFKWLVNRINRSLDRTKRQGAS----FIGILDMAGFEIFELNSFEQLCINYTNEKLQQLFNH 580
            |..:|.|:|.:||.::...:.|...    .||:||:.|||.|:.|||||||||:.||.|||.|..
  Rat   403 YGHLFLWIVKKINAAIFTPQAQDPQNVRRAIGLLDIFGFENFQNNSFEQLCINFANEHLQQFFVK 467

  Fly   581 TMFILEQEEYQREGIEWKFIDFGLDLQPTIDLID-KPGGIMALLDEECWFPKATDKTFVDKLVSA 644
            .:|.:|||||..|.|.|.:|.: .|.||.:|::. ||..|::|||||..||:.||.|.:.||.|.
  Rat   468 HVFTMEQEEYLSENITWNYIHY-TDNQPILDMLALKPMSIISLLDEESRFPQGTDVTMLQKLNSI 531

  Fly   645 HSMHPKFMKTDFRGVAD--FAIVHYAGRVDYSAAKWLMKNMDPLNENIVSLLQGSQDPFVVNIWK 707
            |:.:..|::.  :.:.|  |.|.|:||.|.|.|..:|.||.|.|:.:|:.|:..|::.|:..|:.
  Rat   532 HANNKSFLRP--KSIHDTRFGIAHFAGDVYYQAEGFLEKNRDVLSTDILILIHSSKNKFLKEIFN 594

  Fly   708 DAEIVGMAQQAL---TDTQFGARTRKGMFR---------TVSHLYKEQLAKLMDTLRNTNPNFVR 760
                :.:.|..|   |..|...:|...:|:         |:|..:|:.|.:||..|.|..|.|||
  Rat   595 ----LDLPQTKLGHGTICQVKTKTGGQIFKPSDSTKRSVTLSSQFKQSLEQLMKILTNCQPYFVR 655

  Fly   761 CIIPNHEKRAGKIDAPLVLDQLRCNGVLEGIRICRQGFPNRIPFQEFRQRYELLTPNVIPKGFMD 825
            ||.||..|:....|..|.:.|||.:|::|.:.|.:.|||.|..|.||.||:.:|.|:.....|.:
  Rat   656 CIKPNEYKKPLLFDRELCIQQLRYSGMMETVHIRKSGFPIRYTFDEFSQRFRVLLPSPERVQFQN 720

  Fly   826 GKKACEKMIQALELDSNL-YRVGQSKIFFRAGVLAHLEEERD-------FKISDLI--------- 873
            ..:.....|..|.|.::. :::|::|||.:......||.:|.       .:|..::         
  Rat   721 KHRQMTSRIADLCLGTDKEWKMGKTKIFLKDHQDTMLEIQRSQALDGAAIRIQRVLRGHKYRKEF 785

  Fly   874 -------VNFQAFCRGFLARRNYQKRLQQLNAIRIIQRNCAAYLKLRNWQWWRLYTKVKPLLEVT 931
                   |..||..||...|:|::..|.....::.|.|   ::|.:|.:|..|            
  Rat   786 LRQKRAAVTLQAVWRGHNQRKNFKLILMGFERLQAIAR---SHLLMRQFQTMR------------ 835

  Fly   932 KQEEKLVQKEDELK--QVREKLDTLAKNTQEYERKYQQALVEKTTLAEQLQA--EIELCAEAEES 992
               :|:||.:...:  .||:::.. .:......:.:.:.:|.:.:..:|..:  .:.|..|.:..
  Rat   836 ---QKIVQLQARCRGYLVRQQVQA-KRRAVVIIQAHARGMVARKSYWQQKSSGPPVILAKEPKGQ 896

  Fly   993 RSRLMARKQELEDMMQELETRIEEEEERVL--ALGGEKKKLELNIQDLEEQLEEEEAARQKLQLE 1055
            ...|..:::.:.|.:  .:|.:.|:....|  .:||::.......:|||.:.:         :|.
  Rat   897 GVALDRKRKSIYDTV--TDTAMVEKVFGFLPAMIGGQEGPAPTRFEDLEVKTQ---------KLH 950

  Fly  1056 KVQLDAKIKKYE---EDL-----------ALTDDQN-------QKLLKEKKLLEERANDLSQTLA 1099
            :|.||. :...|   ||:           |:|..|.       ||.|:...|..|...|.|..||
  Rat   951 EVDLDT-VPMTEMPGEDVDGLAEYTFPKFAVTYFQKSASHTHIQKPLRYPLLYHENDTDHSAALA 1014

  Fly  1100 E-----------EEEKAKHLAKLKAKHEATISELEERLHKD------QQQRQESDRSKRKIETEV 1147
            .           .|.:|...:.|..  .:.:.::.:||.||      |..|.....|::.|..||
  Rat  1015 VWIIILRFMGDLPEPQAYGRSSLTG--SSVMRQIHDRLDKDSVTQGPQHNRSTQVASQQNIGEEV 1077

  Fly  1148 ADLKEQLNERRVQVDE----------MQAQLAKREEELTQTLLRIDEESATKATAQ--------- 1193
            ......:::|.:...|          |:..|  |:|...|...::.|...|.:.|:         
  Rat  1078 FKFDGPISDRPMSNLEKVHFIVGYAIMRPGL--RDEIYCQICKQLSENYKTSSRARGWILLSLCL 1140

  Fly  1194 ----KAQRELESQLAEIQE------DLEAEKAARAKAEKVRRDLSE--ELEALKNE--------- 1237
                .::|.::..|..|.:      ...||:..|..|..||.:...  ||:|:|::         
  Rat  1141 GCFPPSERFMKYLLNFISQGPASYGPFCAERLQRTFANGVRAEPPTWLELQAVKSKKHIPIQVIL 1205

  Fly  1238 -----LLDSLDTTAAQQELRSKREQELATLKK---SLEEETVNHEGVLADMRHKHSQELNSINDQ 1294
                 |..|:|:.:..:|:..:..|:.....|   ||:....:....|.: ...|..:..:..:|
  Rat  1206 ATGRSLTISVDSASTSREICQQIAQKQGLRDKLGFSLQVAVYDKFWSLGN-SCDHVMDAVAQCEQ 1269

  Fly  1295 L-----ENLRKAKTVLEKAKGTL----EAENADLATE------LRSVNSSRQENDRRRKQAESQI 1344
            |     |:.|:|...:...|...    ::....::||      ||.|.|.....::.....|...
  Rat  1270 LAWERGESQRQAPWRIYFRKEFFTPWHDSREDPVSTELIYHQVLRGVWSGEYNFEKEEDLVELLA 1334

  Fly  1345 AELQVKLAEIERARS--ELQEKC--TKL--QQEAENITNQLEEAELKASAAVKSASNME--SQLT 1401
            ....|:|....::.:  ||...|  :||  .:..|...:.:..|..||......|:.:|  .|..
  Rat  1335 RHCYVQLGATVKSNAVQELLPSCVPSKLYRTKSPEKWASLVIAAHAKAPYTQSKATPLEVKEQTV 1399

  Fly  1402 EAQQL------------------------------------LEEETRQKLGLS-------SKLRQ 1423
            ||.:|                                    |:::.|..||||       ...|.
  Rat  1400 EAARLLWPLLFSRLFEVTTLSGPRLPKTQLILAINWKGMYFLDQKERTLLGLSFAEVMGLIANRD 1464

  Fly  1424 IESEKEALQEQLEEDDEAKRNYERKLAEVTT--------------QMQEIKKKAEEDADLAKELE 1474
            ....|..|...|.|:.|........:||:..              .:|:  :||.:|..|. ..:
  Rat  1465 APGGKSLLLSTLHEEYEFASPSSVAIAEMVALFLAGLKERSVFAMALQD--RKATDDVTLL-PFK 1526

  Fly  1475 EGKKRLNKDIEALERQVKELIAQNDRLDKSKKKIQSELE--DATIELEAQRTKVLEL--EKKQKN 1535
            :|...:....:.|......::.||||..|:.....:.|.  .:..:..||...:|.:  ||::..
  Rat  1527 KGDLLILTKKQGLLASENWVLGQNDRTGKTGLVPTACLYTIPSVTKPSAQLLNLLAMSPEKRKLA 1591

  Fly  1536 FDKILAEEKAISEQIAQERDTAER------EAREKET---KVLSVSRELDE--AFDKIEDLENKR 1589
            ..::.|.|..:.||:.:...|.|.      .|.||||   ..:.::|....  |:..    |..|
  Rat  1592 AQEVQASEPPLEEQLTELPYTLEEFSYQYFRAPEKETISRAAMPMARSRGHLWAYSP----EPLR 1652

  Fly  1590 KTLQNELDDLANTQGTADKNVHELEKAK-RALESQLAELKAQNE----ELEDDLQLTEDAKLRLE 1649
            :.|.              |:||:..|.: .|.:..||.||...:    :....|:|| |....|.
  Rat  1653 QPLL--------------KSVHDKAKLRDSACQIFLAILKYTGDYPSRQSWHSLELT-DQMFSLA 1702

  Fly  1650 VNMQALRSQFERDLLAKEEGAEEKRRGLVKQLRDLETELDEERKQRTAAVAS------KKKLEGD 1708
            :...||:.:....:|              |||........|||..:...:.:      |..|...
  Rat  1703 LKEPALQDELYCQIL--------------KQLTHNSIRFSEERAWQLLWLCTGLFPPGKALLPHA 1753

  Fly  1709 LKEIETTMEMHNKVKEDALKHAKKLQAQVKDALRDAEEAKAAKEELQALSKEAERKVKALEAEV- 1772
            .|.|::     .|.|..||..:::|...::...|     |.....::.  |.||:.|..|..|| 
  Rat  1754 QKFIDS-----RKKKPLALDCSRRLHRILRVGPR-----KQPPHHVEV--KAAEQNVSKLHHEVY 1806

  Fly  1773 ----LQLTEDLASSERARRAAETERDELAEEIANNANKG-----SLMIDEKRRLEARIATLEE-- 1826
                ...|.:::||.|.|        :|.|.||......     ||.|    ::..::.:|:|  
  Rat  1807 LPNDTNKTLEVSSSSRVR--------DLCEGIATRLQLASWDGCSLFI----KITDKVISLKEGD 1859

  Fly  1827 ----ELEEEQSNSEVLLDRSRKAQLQIEQLTTELANE---------KSNSQKNENGRALLERQNK 1878
                .|.:       :.|..:|.:.|.|..:|.|..:         .....|:.|...:| ..::
  Rat  1860 FFFDSLRQ-------VSDWVKKNRPQKEGASTTLPYQVFFMRKLWLNVTPGKDVNADTIL-HYHQ 1916

  Fly  1879 ELKAKLAEIETAQRTKV--------KATIATLEAKIANLEEQLENEGKERLLQQKANRKMDKKIK 1935
            ||...:.......|...        |....:..:::|::.:.|     :.|:.|...|.|..:..
  Rat  1917 ELPKYMRGFHKCSREDAIYLAGLIYKIQFGSDRSQMASVSKIL-----KELVPQNLTRLMSSEEW 1976

  Fly  1936 ELTMNIEDERRHVDQHKEQMDKLNSRIKLLKR 1967
            :.::.:|     .|:||.: ....::::.|||
  Rat  1977 KKSLLLE-----CDKHKNK-SVAEAKVEFLKR 2002

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
zipNP_523860.2 Myosin_N 80..117 CDD:280832 12/42 (29%)
Myosin_head 133..854 CDD:278492 267/746 (36%)
MYSc_Myh2_insects_mollusks 145..854 CDD:276876 260/734 (35%)
Myosin_tail_1 931..2011 CDD:279860 244/1268 (19%)
Prefoldin 1431..1515 CDD:298833 19/99 (19%)
FAM76 <1847..1926 CDD:292665 15/95 (16%)
Myo7bNP_001178870.1 MYSc 60..761 CDD:214580 270/764 (35%)
MYSc_Myo7 79..750 CDD:276832 260/734 (35%)
IQ 787..809 CDD:197470 7/21 (33%)
MyTH4 991..1194 CDD:214535 44/206 (21%)
B41 1201..1414 CDD:214604 40/213 (19%)
FERM_B-lobe 1304..1405 CDD:271216 23/100 (23%)
FERM_C1_MyoVII 1408..1504 CDD:270019 14/95 (15%)
SH3 1505..1565 CDD:302595 12/62 (19%)
MyTH4 1646..1793 CDD:214535 37/191 (19%)
B41 1802..2014 CDD:214604 43/232 (19%)
FERM_M 1912..2014 CDD:278785 18/103 (17%)
FERM_C2_MyoVII 2010..2105 CDD:270020
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
11.000

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