Protein Alignment zip and myo6

DIOPT Version :10

• Sequence 1: NP_523860.2
• Gene: zip / 38001
• FlyBaseID: FBgn0287873
• Length: 2056
• Species: Drosophila melanogaster
• Sequence 2: XP_031758531.1
• Gene: myo6 / 493193
• XenbaseID: XB-GENE-1012303
• Length: 1300
• Species: Xenopus tropicalis
• Alignment Length: 1445
• Identity: 406/1445 - (28%)
• Similarity: 675/1445 - (46%)
• Gaps: 283/1445 - (19%)

  Fly    82 VWVPHENQGFVAASIKREHGDEVEVE-LAETGKRVMILRDDIQKMNPPKFD---KVEDMAELTCL 142
            ||.||...||....|.....|.:.:| |.:.||..:.   .|.::.|.:.|   .|||...|..|
 Frog     7 VWAPHPTDGFQLGKIVDIGPDSLTIEPLNQKGKTFLA---PINQVFPAEEDTSKHVEDNCSLMYL 68

  Fly   143 NEASVLHNIKDRYYSGLIYTYSGLFCVVVNPYKKLP-IYTEKIMERYKGIKRHEVPPHVFAITDS 206
            |||::||||:.||....||||.....:.||||..:| :||.:.:::|.|.....:||||:||.|.
 Frog    69 NEATLLHNIQVRYSKDKIYTYVANILIAVNPYFDVPKLYTSEQIKQYHGKSLGTLPPHVYAIADK 133

  Fly   207 AYRNMLGDREDQSILCTGESGAGKTENTKKVIQFLAYVAASKPKGSGAVPHPAVLINFSVNTNKY 271
            |:|:|...:..|||:.:||||||||||||.|:::|     ::..|||.
 Frog   134 AFRDMKVLKMSQSIIVSGESGAGKTENTKFVLRYL-----TESYGSGQ----------------- 176

  Fly   272 IKVKIMAQNQNQTIEVVNGLKMVEVNSNCQEGELEQQLLQANPILEAFGNAKTVKNDNSSRFGKF 336
                                            ::::::::|||:||||||||||:|:||||||||
 Frog   177 --------------------------------DIDERIVEANPLLEAFGNAKTVRNNNSSRFGKF 209

  Fly   337 IRINFDASGFISGANIETYLLEKSRAIRQAKDERTFHIFYQLLAGATPEQREKFILDDVKSYAFL 401
            :.|:|:....:.|..:..|||||||...|.:|||.:||||:|.|||..:.|:|..|....::.:|
 Frog   210 VEIHFNEKNSVVGGFVSHYLLEKSRICVQGQDERNYHIFYRLCAGAPEDIRQKLFLCSPDTFRYL 274

  Fly   402 S------------------------------NGSLPVPGVDDYAEFQATVKSMNIMGMTSEDFNS 436
            :                              :|:|..|.:||:.:|.....:|..:|:...:...
 Frog   275 NRGCTRYFASKDTDKQILQNRKSPEEDEYLKHGALKDPLLDDHGDFNRMCIAMKKIGLDDTEKLD 339

  Fly   437 IFRIVSAVLLFGSMKFRQE---------RNNDQATLPDNTVAQKIAHLLGLSVTDMTRAFLTPRI 492
            :||:|:.||..|::.|.:.         |.....:|      |..|.||||...|: :..||.|:
 Frog   340 LFRVVAGVLHLGNIDFEEAGSTSGGCTLRKKSSESL------QCCAKLLGLDQDDL-QVSLTSRV 397

  Fly   493 KV-----GRDFVTKAQTK-EQVEFAVEAIAKACYERMFKWLVNRINRSLDRTKRQGASFIGILDM 551
            .:     .:..|.|...| :|.|.|.:|:|||.|..:|..:|||:|:..  ...:.:.|||:||:
 Frog   398 MLTTAGGTKGTVIKVPLKVQQAENARDALAKAIYSHLFDHVVNRVNQCF--PFERSSFFIGVLDI 460

  Fly   552 AGFEIFELNSFEQLCINYTNEKLQQLFNHTMFILEQEEYQREGIEWKFIDFGLDLQPTIDLID-K 615
            ||||.||.|||||.||||.||||||.||..:...|||.||:||:....:.: :|.|..||||: |
 Frog   461 AGFEYFEHNSFEQFCINYCNEKLQQFFNERILKEEQELYQKEGLGVNEVHY-VDNQDCIDLIEAK 524

  Fly   616 PGGIMALLDEECWFPKATDKTFVDKLVSAHSMH-----PKFMK-TDFRGVAD---FAIVHYAGRV 671
            ..||:.:||||...|:.||:.|...:...|..|     |:..| ...|.:.|   |.:.|:||.|
 Frog   525 LVGILDILDEENRLPQPTDQHFTSAVHQKHKNHFRLTIPRKSKLAVHRNIRDDEGFIVRHFAGAV 589

  Fly   672 DYSAAKWLMKNMDPLNENIVSLLQGSQDPFVVNIWKDAEIVGMAQQALTDTQFGARTRKGMFRTV 736
            .|...:::.||.|.|:.::.||:..|:|.||..:::.|.         .......:|.|..|.:|
 Frog   590 CYETTQFVEKNNDALHMSLESLICESKDKFVRELFESAN---------NHKDLKQKTGKLSFISV 645

  Fly   737 SHLYKEQLAKLMDTLRNTNPNFVRCIIPNHEKRAGKIDAPLVLDQLRCNGVLEGIRICRQGFPNR 801
            .:.:|.||..|::.||:|..:|:|||.||.:..:.:.:...:|.||:|:|::..:.:.:.|||:|
 Frog   646 GNKFKTQLNLLLEKLRSTGSSFIRCIKPNLKMTSHQFEGAQILSQLQCSGMVSVLDLMQGGFPSR 710

  Fly   802 IPFQEFRQRYELLTPNVIPKGFMDGKKACEKMIQALELDSNLYRVGQSKIFFRAGVLAHLEE--- 863
            ..|.|....|:...|..:.:  :|.:..|:.:.:||.|:.|.|:.|.:|:|||.|..|..::
 Frog   711 ASFHELYNMYKKYMPAKMSR--LDPRLFCKALFKALGLNENDYKFGLTKVFFRPGKFAEFDQIMK 773

  Fly   864 -ERDFKISDLI--VNFQAFCRGFLARRNYQKRLQ--QLNAIRI---IQRNCAAYLKL-RNWQWWR 919
             :.| .:::||  ||....|..:       |::|  .|..|::   ||...:|.:|: :..:.|.
 Frog   774 SDPD-HLAELIRRVNHWLICSRW-------KKVQWCALCVIKLKNKIQYRASACIKMQKTIRMWL 830

  Fly   920 LYTKVKPLLEVTKQEEKLVQKEDELKQV----REKLDTLAKNTQEYERKYQQALVE-KTTL--AE 977
            ...|.||.::...:.:.|.::.|:..:|    :|....::|..::.|......|.: |.|:  .|
 Frog   831 CRKKHKPRIDGMVKVQTLKKRLDKFNEVVNALKEGKAEMSKQVKDLELSIDALLSKIKNTIMTRE 895

  Fly   978 QLQAEIE-LCAEAEESRSRLMARKQELEDMMQELETRIEEEEERVLALGGEKKKLELNIQDLEEQ 1041
            |::.|.: |...:.:..:.|..||:|.|:  .|...:|:||.||      |:|:     ::.||:
 Frog   896 QIEREYDNLVKSSGQLLNSLQKRKKEEEE--AERLHKIQEEMER------ERKR-----REAEEE 947

  Fly  1042 LEEEEAARQKLQLEKVQLDAKIKKYEEDLALTDDQNQKLLK--EKKLLEERAND-LSQTLAEEEE 1103
            |..:|...::|   |.:::||.|:.||:....:::.:::..  |.:|..:|..: ..|.:.|:|.
 Frog   948 LRRKEENERRL---KAEIEAKRKQEEEERKKREEEEKRIQAEVEMQLARDREEESQQQAILEQER 1009

  Fly  1104 KAKHLAKLKAKHEATISELEERLHKDQQQRQESDRSKRKIETEVADLKEQLNERRVQVDEMQAQL 1168
            :.:.||...|:.||      |.:::|.........:...::....:.|...:..::.::||
 Frog  1010 RDRELAMRIAQSEA------ELINEDGPDSALRSDTVGVLQPSPVNYKAGEDRTKLTMEEM---- 1064

  Fly  1169 AKREEELTQTLLRIDEESATKATAQKAQRELES-QLAEIQE------DLEAEKAARA-------- 1218
               .:|:|..|.|..:..|||:.|...:.:|.. :.||:::      |:|...|.|.
 Frog  1065 ---AKEMTDILSRGGQVQATKSAASVKKHDLSKWKYAELRDAINTSCDIELLAACREEFHRRLKV 1126

  Fly  1219 ----KAEKVRRDLSEELEALKN--------------ELLDSLDTTAAQQELRSKREQ---ELATL 1262
                |::..:|:...|..|.|:              :....:...|.|||:...|:|   .:..:
 Frog  1127 YHAWKSKNKKRNADTEQRAPKSVTDYDFAPFMNNSPQQNPVVQLPARQQEIEMNRQQRYFRIPFI 1191

  Fly  1263 KKSLEEETVNHEGVLADMRHKHSQELNS-----------INDQLENLRKAKTVLEKAKGTLEAEN 1316
            :.             || ::|..|....           |..|:| |...|..:....|..:.|.
 Frog  1192 RP-------------AD-QYKDPQNKKKGWWYAHFDGPWIARQME-LHPDKPPIMLVAGKDDMEM 1241

  Fly  1317 ADLATELRSVNSSRQENDRRRKQAESQIAELQVKLAEIERARSELQEKCTKLQQEAENITNQLEE 1381
            .:|..|         |....||:.    ||:      :.|...|:.|:|..:|.    ::|.:|.
 Frog  1242 CELNLE---------ETGLTRKRG----AEI------LPRQFEEIWERCGGIQY----LSNAIES 1283

  Fly  1382 AELKASAAVKSASNM 1396
            .:.:.:.|.....|:
 Frog  1284 RQARPTYATAMLQNL 1298

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
zip	NP_523860.2	Myosin_N	79..122	CDD:460670	12/40 (30%)
		MYSc_Myh2_insects_mollusks	145..854	CDD:276876	256/764 (34%)
		Myosin_tail_1	931..2011	CDD:460256	106/524 (20%)
myo6	XP_031758531.1	Myosin_N	2..40	CDD:460670	11/32 (34%)
		MYSc_Myo6	71..761	CDD:276833	256/764 (34%)
		CBD_MYO6-like	772..916	CDD:409646	31/151 (21%)
		MYO6_MIU_linker	1001..1074	CDD:412090	16/85 (19%)
		MyUb_Myo6	1088..1128	CDD:439319	7/39 (18%)
		Myosin-VI_CBD	1183..1273	CDD:465157	23/123 (19%)