DRSC/TRiP Functional Genomics Resources

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Protein Alignment zip and MYO5B

DIOPT Version :9

Sequence 1:NP_523860.2 Gene:zip / 38001 FlyBaseID:FBgn0265434 Length:2056 Species:Drosophila melanogaster
Sequence 2:NP_001073936.1 Gene:MYO5B / 4645 HGNCID:7603 Length:1848 Species:Homo sapiens


Alignment Length:1751 Identity:499/1751 - (28%)
Similarity:805/1751 - (45%) Gaps:354/1751 - (20%)


- Green bases have known domain annotations that are detailed below.


  Fly    76 WTQKRLVWVPHENQGFVAASIKREH--GDEVEVELAETGKRVMILRDDIQK------MNPPKFDK 132
            ::|...||:|..::.:.:|.:.:::  ||: .::|....:.::....|:|:      .||.....
Human     7 YSQCTRVWIPDPDEVWRSAELTKDYKEGDK-SLQLRLEDETILEYPIDVQRNQLPFLRNPDILVG 70

  Fly   133 VEDMAELTCLNEASVLHNIKDRYY-SGLIYTYSGLFCVVVNPYKKLPIYTEKIMERYKGIKRHEV 196
            ..|:..|:.|:|.:||||:|.|:. |..||||.|:..|.:|||::||||.:.::..|.|....::
Human    71 ENDLTALSYLHEPAVLHNLKVRFLESNHIYTYCGIVLVAINPYEQLPIYGQDVIYTYSGQNMGDM 135

  Fly   197 PPHVFAITDSAYRNMLGDREDQSILCTGESGAGKTENTKKVIQFLAYVAASKPKGSGAVPHPAVL 261
            .||:||:.:.||:.|..|.::|||:.:||||||||.:.|..:::.|.|..|              
Human   136 DPHIFAVAEEAYKQMARDEKNQSIIVSGESGAGKTVSAKYAMRYFATVGGS-------------- 186

  Fly   262 INFSVNTNKYIKVKIMAQNQNQTIEVVNGLKMVEVNSNCQEGELEQQLLQANPILEAFGNAKTVK 326
                                                  ..|..:|:::|.::||:||.|||||.:
Human   187 --------------------------------------ASETNIEEKVLASSPIMEAIGNAKTTR 213

  Fly   327 NDNSSRFGKFIRINFDASGFISGANIETYLLEKSRAIRQAKDERTFHIFYQLLAGATPEQREKFI 391
            |||||||||:|:|.||....|.|||:.||||||||.:.||.|||.:||||||.|.|...:.::..
Human   214 NDNSSRFGKYIQIGFDKRYHIIGANMRTYLLEKSRVVFQADDERNYHIFYQLCAAAGLPEFKELA 278

  Fly   392 LDDVKSYAFLS-NGSLPVPGVDDYAEFQATVKSMNIMGMTSEDFNSIFRIVSAVLLFGSMKFRQE 455
            |...:.:.:.| .|...:.||||..:|:.|.::..::|:......|||:|::::|..||:..:.|
Human   279 LTSAEDFFYTSQGGDTSIEGVDDAEDFEKTRQAFTLLGVKESHQMSIFKIIASILHLGSVAIQAE 343

  Fly   456 RNNDQATL-PDNTVAQKIAHLLGLSVTDMTRAFLTPRIKVGRDFVTKAQTKEQVEFAVEAIAKAC 519
            |:.|..:: |.:........|||:..:.|.......::....:...|..:.:||..|..|:||..
Human   344 RDGDSCSISPQDVYLSNFCRLLGVEHSQMEHWLCHRKLVTTSETYVKTMSLQQVINARNALAKHI 408

  Fly   520 YERMFKWLVNRINRSLDRTKRQGASFIGILDMAGFEIFELNSFEQLCINYTNEKLQQLFNHTMFI 584
            |.::|.|:|..||::|..:.:| .||||:||:.|||.||:|||||.||||.||||||.||..:|.
Human   409 YAQLFGWIVEHINKALHTSLKQ-HSFIGVLDIYGFETFEVNSFEQFCINYANEKLQQQFNSHVFK 472

  Fly   585 LEQEEYQREGIEWKFIDFGLDLQPTIDLIDKPGGIMALLDEECWFPKATDKTFVDKLVSAHSMHP 649
            ||||||.:|.|.|..||| .|.||.||||:...||:.||||||..||.||:.:..||...||...
Human   473 LEQEEYMKEQIPWTLIDF-YDNQPCIDLIEAKLGILDLLDEECKVPKGTDQNWAQKLYDRHSSSQ 536

  Fly   650 KFMKTDFRGVADFAIVHYAGRVDYSAAKWLMKNMDPLNENIVSLLQGSQDPFVVNIWKD------ 708
            .|.|......| |.|||:|.:|:|.:..:|.||.|.:.|..:::|:.|:.|.|.:::.|      
Human   537 HFQKPRMSNTA-FIIVHFADKVEYLSDGFLEKNRDTVYEEQINILKASKFPLVADLFHDDKDPVP 600

  Fly   709 AEIVGMAQQALTDTQFGAR-----TRKGMFRTVSHLYKEQLAKLMDTLRNTNPNFVRCIIPNHEK 768
            |...|....:....: .||     :.|...:||.|.::..|..||:||..|.|::||||.||.||
Human   601 ATTPGKGSSSKISVR-SARPPMKVSNKEHKKTVGHQFRTSLHLLMETLNATTPHYVRCIKPNDEK 664

  Fly   769 RAGKIDAPLVLDQLRCNGVLEGIRICRQGFPNRIPFQEFRQRYELLTPNVIPKGFM---DGKKAC 830
            .....|....:.|||..||||.|||...|:|:|..:.:|..||.:|    :.|..:   |.|..|
Human   665 LPFHFDPKRAVQQLRACGVLETIRISAAGYPSRWAYHDFFNRYRVL----VKKRELANTDKKAIC 725

  Fly   831 EKMIQALELDSNLYRVGQSKIFFRAGVLAHLEEERDFKISDLIVNFQAFCRGFLARRNYQKRLQQ 895
            ..:::.|..|.:.::.|::|||||||.:|:||:.|..|.....:..|...||:|.:..|. ||: 
Human   726 RSVLENLIKDPDKFQFGRTKIFFRAGQVAYLEKLRADKFRTATIMIQKTVRGWLQKVKYH-RLK- 788

  Fly   896 LNAIRIIQRNCAAYLKLRNWQWWRLYTKVKPLLEVTKQEEKLVQKEDELKQVREKLDTLAKNTQE 960
             .|...:||.|..:|..|..:..|   :::..: |.::..::.:.....::||.....:...|:.
Human   789 -GATLTLQRYCRGHLARRLAEHLR---RIRAAV-VLQKHYRMQRARQAYQRVRRAAVVIQAFTRA 848

  Fly   961 --YERKYQQALVE--KTTLAEQLQAEIELCAEAEESRSRLMARK--QELEDMMQELETRIEEEEE 1019
              ..|.|:|.|:|  .||:.:.::.              .|||:  |.|.|....::...     
Human   849 MFVRRTYRQVLMEHKATTIQKHVRG--------------WMARRHFQRLRDAAIVIQCAF----- 894

  Fly  1020 RVLALGGEKKKLELNIQDLEEQLEEEEAARQKLQLEK--VQLDAKIKKYEEDLALTDDQNQKLLK 1082
            |:|....|.|.|.:      |....|...|..:.:|.  |||..||          |:||    |
Human   895 RMLKARRELKALRI------EARSAEHLKRLNVGMENKVVQLQRKI----------DEQN----K 939

  Fly  1083 EKKLLEERANDLSQTLAEEEEKAKHLAKLKAKHEATISELEERLHKDQQQRQESDRSKRKIETEV 1147
            |.|.|.|:.:..:.|...|.|:.|                :|.:|  .||....|.|.| ::.||
Human   940 EFKTLSEQLSVTTSTYTMEVERLK----------------KELVH--YQQSPGEDTSLR-LQEEV 985

  Fly  1148 ADLKEQLNERRVQVDEMQAQLAKREEELTQTLLRIDEESATKATAQKAQRELESQLAEIQEDLEA 1212
            ..|:.:|            |.|..|.::.:     |..|..|       .||..::|    |||.
Human   986 ESLRTEL------------QRAHSERKILE-----DAHSREK-------DELRKRVA----DLEQ 1022

  Fly  1213 EKAARAKAEKVRRDLSEELEALKNELLDSLDTTAAQQELRSKREQELATLKKSLEEETVNHEGVL 1277
            |.|.          |.:|.|.|.|::|.......||..::..      .:||.||||...::.::
Human  1023 ENAL----------LKDEKEQLNNQILCQSKDEFAQNSVKEN------LMKKELEEERSRYQNLV 1071

  Fly  1278 ADMRHKHSQELNSINDQLENLRKAKTVLEKAKGTLEAENADLATELRSVNSSRQENDRRRKQAES 1342
                    :|.:.:..:.:|||...|::::..|                   .:.|...:...||
Human  1072 --------KEYSQLEQRYDNLRDEMTIIKQTPG-------------------HRRNPSNQSSLES 1109

  Fly  1343 QIAELQVKLAEIERARSELQEKCTKLQQEAENITNQLEEAELKASAAVKSASNMESQLTEAQQLL 1407
            ......:..:||               .:.|:...|:||..|:     |:|.:|...|.      
Human  1110 DSNYPSISTSEI---------------GDTEDALQQVEEIGLE-----KAAMDMTVFLK------ 1148

  Fly  1408 EEETRQKLGLSSKLRQIESEKEALQEQLE--EDDEAKRNYERKLAEVTTQMQEIKKKAEEDADLA 1470
                     |..::|::|.|::.||.|||  |..::|:        |..:..:.....:.:||||
Human  1149 ---------LQKRVRELEQERKKLQVQLEKREQQDSKK--------VQAEPPQTDIDLDPNADLA 1196

  Fly  1471 ------KELEEGKKRLNKDIEALERQVKELIAQNDRLDKSKKK---IQSELEDATIELEAQRTKV 1526
                  :|||...|:|..|:..|.:.|.:...||:....|...   :.::|:.|..|||.::.:|
Human  1197 YNSLKRQELESENKKLKNDLNELRKAVADQATQNNSSHGSPDSYSLLLNQLKLAHEELEVRKEEV 1261

  Fly  1527 LELEKKQKNFDKILAEEKAISEQIAQERDTAEREAREKETKVLSVSRELDEAFDKIEDLENKRKT 1591
            |.|..:     .:.|:::.::.:.|:....|.......|       :.:|:. |.||......:|
Human  1262 LILRTQ-----IVSADQRRLAGRNAEPNINARSSWPNSE-------KHVDQE-DAIEAYHGVCQT 1313

  Fly  1592 LQNELDD--LANTQGTADKNVHELEKAKRALESQLAELKAQNEELEDDLQLTEDAKLRLEVNMQA 1654
             .::.:|  ..|..|........|::..|.||   |:|:||:.|.|::::       .|:..::|
Human  1314 -NSKTEDWGYLNEDGELGLAYQGLKQVARLLE---AQLQAQSLEHEEEVE-------HLKAQLEA 1367

  Fly  1655 LRSQFERD--------LLAKEEGAEEKRRGLVKQLRDLETELDEERKQRTAAVASKKKLEGDLKE 1711
            |:.:.::.        ||:.|...|   .|:.:::..|..|                  ..||||
Human  1368 LKEEMDKQQQTFCQTLLLSPEAQVE---FGVQQEISRLTNE------------------NLDLKE 1411

  Fly  1712 IETTMEMHNKVKEDALKHAKKLQAQVKDALRDAEEAKAAKEELQALSKEAERKVKALEAEV 1772
            :...:|          |:.:||:.|:|..::.|::.:||    |||: ::|||...|..:|
Human  1412 LVEKLE----------KNERKLKKQLKIYMKKAQDLEAA----QALA-QSERKRHELNRQV 1457

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
zipNP_523860.2 Myosin_N 80..117 CDD:280832 7/38 (18%)
Myosin_head 133..854 CDD:278492 274/737 (37%)
MYSc_Myh2_insects_mollusks 145..854 CDD:276876 270/725 (37%)
Myosin_tail_1 931..2011 CDD:279860 189/871 (22%)
Prefoldin 1431..1515 CDD:298833 24/94 (26%)
FAM76 <1847..1926 CDD:292665
MYO5BNP_001073936.1 Requires for interaction with LIMA1. /evidence=ECO:0000269|PubMed:29880681 21..40 3/19 (16%)
MYSc 64..760 CDD:214580 283/755 (37%)
MYSc_Myo5 83..749 CDD:276831 270/725 (37%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 596..630 5/34 (15%)
Actin-binding. /evidence=ECO:0000255 640..662 12/21 (57%)
IQ 860..881 CDD:197470 6/34 (18%)
CCDC144C 895..1172 CDD:291576 94/421 (22%)
RILP-like <980..1080 CDD:304877 34/152 (22%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1093..1123 6/63 (10%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1166..1192 6/33 (18%)
Myo5b_CBD 1474..1845 CDD:271261
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0000014
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.910

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