DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment zip and MYO1D

DIOPT Version :9

Sequence 1:	NP_523860.2	Gene:	zip / 38001	FlyBaseID:	FBgn0265434	Length:	2056	Species:	Drosophila melanogaster
Sequence 2:	NP_056009.1	Gene:	MYO1D / 4642	HGNCID:	7598	Length:	1006	Species:	Homo sapiens

Alignment Length:	917	Identity:	301/917 - (32%)
Similarity:	469/917 - (51%)	Gaps:	136/917 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly   105 EVELAETGKRVMILRDDIQKMNPPKFDKVEDMAELTCLNEASVLHNIKDRYYSGLIYTYSGLFCV 169
            |.|..|.||...:|.|.:   :.|:|                 :.|::.|:..|.|||:.|...|
Human     3 EQESLEFGKADFVLMDTV---SMPEF-----------------MANLRLRFEKGRIYTFIGEVVV 47

  Fly   170 VVNPYKKLPIYTEKIMERYKGIKRHEVPPHVFAITDSAYRNMLGDREDQSILCTGESGAGKTENT 234
            .|||||.|.||....:|:|||.:.:|.|||:|||.|:||:.|....:|..|:.:|||||||||.:
Human    48 SVNPYKLLNIYGRDTIEQYKGRELYERPPHLFAIADAAYKAMKRRSKDTCIVISGESGAGKTEAS 112

  Fly   235 KKVIQFLAYVAASKPKGSGAVPHPAVLINFSVNTNKYIKVKIMAQNQNQTIEVVNGLKMVEVNSN 299
            |.::|::|           |:.:|:
Human   113 KYIMQYIA-----------AITNPS---------------------------------------- 126

  Fly   300 CQEGELEQ---QLLQANPILEAFGNAKTVKNDNSSRFGKFIRINFDASGFISGANIETYLLEKSR 361
             |..|:|:   .||::|.:|||||||||.:|||||||||::.||||..|...|.:|..|||||||
Human   127 -QRAEVERVKNMLLKSNCVLEAFGNAKTNRNDNSSRFGKYMDINFDFKGDPIGGHINNYLLEKSR 190

  Fly   362 AIRQAKDERTFHIFYQLLAGATPEQ-REKFILDDVKSYAFLSNGSLPVPGVDDYAEFQATVKSMN 425
            .|.|...||:||.|||||.|.:.:. |...:...:.||.::..|:.....::|.|||:....:|.
Human   191 VIVQQPGERSFHSFYQLLQGGSEQMLRSLHLQKSLSSYNYIHVGAQLKSSINDAAEFRVVADAMK 255

  Fly   426 IMGMTSEDFNSIFRIVSAVLLFGSMKFRQERNNDQATLPDNTVAQKIAHLLGLSVTDMTRAFLTP 490
            ::|...|:..::::|::|:|..|::||..:  .|...:.:..|...||.||......:.:|.|..
Human   256 VIGFKPEEIQTVYKILAAILHLGNLKFVVD--GDTPLIENGKVVSIIAELLSTKTDMVEKALLYR 318

  Fly   491 RIKVGRDFVTKAQTKEQVEFAVEAIAKACYERMFKWLVNRIN-----RSLDRTKRQGASFIGILD 550
            .:..|||.:.|..|:::..:..:|.|||.|||:|.|:|.|||     ::.|.|.....:.||:||
Human   319 TVATGRDIIDKQHTEQEASYGRDAFAKAIYERLFCWIVTRINDIIEVKNYDTTIHGKNTVIGVLD 383

  Fly   551 MAGFEIFELNSFEQLCINYTNEKLQQLFNHTMFILEQEEYQREGIEWKFIDFGLDLQPTIDLIDK 615
            :.|||||:.|||||.||||.||||||||...:...||||||||||.||.||: .:.|..:||:::
Human   384 IYGFEIFDNNSFEQFCINYCNEKLQQLFIQLVLKQEQEEYQREGIPWKHIDY-FNNQIIVDLVEQ 447

  Fly   616 P-GGIMALLDEECW-FPKATDKTFVDKLVS-----AHSMHPKFMKTD--FRGVADFAIVHYAGRV 671
            . .||:|:||:.|. ..|.||:.|::.|.|     ||....|...:|  .....||.|.||||.|
Human   448 QHKGIIAILDDACMNVGKVTDEMFLEALNSKLGKHAHFSSRKLCASDKILEFDRDFRIRHYAGDV 512

  Fly   672 DYSAAKWLMKNMDPLNENIVSLLQGSQDPFVVNIWKDAEIVGMAQQALTDTQFGARTRKGMFRTV 736
            .||...::.||.|.|.::...|:..|.:|.:.|:|.:.::      ::|:.     |::.:  |.
Human   513 VYSVIGFIDKNKDTLFQDFKRLMYNSSNPVLKNMWPEGKL------SITEV-----TKRPL--TA 564

  Fly   737 SHLYKEQLAKLMDTLRNTNPNFVRCIIPNHEKRAGKIDAPLVLDQLRCN------GVLEGIRICR 795
            :.|:|..:..|:|.|.:..|.:||||.||.:|      :|.:.|..||.      |:||.:|:.|
Human   565 ATLFKNSMIALVDNLASKEPYYVRCIKPNDKK------SPQIFDDERCRHQVEYLGLLENVRVRR 623

  Fly   796 QGFPNRIPFQEFRQRYELLTPNVIPK-GFMDGKKACEKMIQALELDSNLYRVGQSKIFFRA-GVL 858
            .||..|..:::|..||::::....|. .....|:|.:|:|:......:: ..|::|||.|. ..|
Human   624 AGFAFRQTYEKFLHRYKMISEFTWPNHDLPSDKEAVKKLIERCGFQDDV-AYGKTKIFIRTPRTL 687

  Fly   859 AHLEEERDFKISDLIVNFQAFCRGFLARRNYQKRLQQLNAIRIIQRNCAAYLKLRNW--QWWRLY 921
            ..|||.|...:..:::..|...||.|||..|::....|..||..:|     .|::::  :..|.:
Human   688 FTLEELRAQMLIRIVLFLQKVWRGTLARMRYKRTKAALTIIRYYRR-----YKVKSYIHEVARRF 747

  Fly   922 TKVKPLLEVTKQEE-----KLVQKEDELKQV---REKLDTLAKNTQEYERKYQQALVEKTTLAEQ 978
            ..||.:.:..|..:     |::::.:|..|.   |.:...|.|:....:....:|.|....:.:.
Human   748 HGVKTMRDYGKHVKWPSPPKVLRRFEEALQTIFNRWRASQLIKSIPASDLPQVRAKVAAVEMLKG 812

  Fly   979 LQAEIEL 985
            .:|::.|
Human   813 QRADLGL 819

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
zip	NP_523860.2	Myosin_N	80..117	CDD:280832	5/11 (45%)
		Myosin_head	133..854	CDD:278492	260/745 (35%)
		MYSc_Myh2_insects_mollusks	145..854	CDD:276876	260/733 (35%)
		Myosin_tail_1	931..2011	CDD:279860	11/63 (17%)
		Prefoldin	1431..1515	CDD:298833
		FAM76	<1847..1926	CDD:292665
MYO1D	NP_056009.1	MYSc	4..694	CDD:214580	273/784 (35%)
		MYSc_Myo1	24..682	CDD:276829	261/749 (35%)
		Actin-binding. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00782	572..594		9/21 (43%)
		Myosin_TH1	803..997	CDD:283635	3/17 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910