DRSC/TRiP Functional Genomics Resources

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Protein Alignment zip and MYH11

DIOPT Version :9

Sequence 1:NP_523860.2 Gene:zip / 38001 FlyBaseID:FBgn0265434 Length:2056 Species:Drosophila melanogaster
Sequence 2:NP_001035203.1 Gene:MYH11 / 4629 HGNCID:7569 Length:1979 Species:Homo sapiens


Alignment Length:2021 Identity:1200/2021 - (59%)
Similarity:1540/2021 - (76%) Gaps:62/2021 - (3%)


- Green bases have known domain annotations that are detailed below.


  Fly    46 MSEEVDRNDPELKYLSVERNQFNDPATQAEWTQKRLVWVPHENQGFVAASIKREHGDEVEVELAE 110
            |:::...:|.| |:|.|::|..|.|..||:|..|||||||.|.|||.|||||.|.||||.|||.|
Human     1 MAQKGQLSDDE-KFLFVDKNFINSPVAQADWAAKRLVWVPSEKQGFEAASIKEEKGDEVVVELVE 64

  Fly   111 TGKRVMILRDDIQKMNPPKFDKVEDMAELTCLNEASVLHNIKDRYYSGLIYTYSGLFCVVVNPYK 175
            .||:|.:.:|||||||||||.|||||||||||||||||||:::||:|||||||||||||||||||
Human    65 NGKKVTVGKDDIQKMNPPKFSKVEDMAELTCLNEASVLHNLRERYFSGLIYTYSGLFCVVVNPYK 129

  Fly   176 KLPIYTEKIMERYKGIKRHEVPPHVFAITDSAYRNMLGDREDQSILCTGESGAGKTENTKKVIQF 240
            .||||:|||::.|||.||||:|||::||.|:|||:||.||||||||||||||||||||||||||:
Human   130 HLPIYSEKIVDMYKGKKRHEMPPHIYAIADTAYRSMLQDREDQSILCTGESGAGKTENTKKVIQY 194

  Fly   241 LAYVAASKPKGSGAVPHPAVLINFSVNTNKYIKVKIMAQNQNQTIEVVNGLKMVEVNSNCQEGEL 305
            ||.||:|. ||                              .:...:..|       .:...|||
Human   195 LAVVASSH-KG------------------------------KKDTSITQG-------PSFAYGEL 221

  Fly   306 EQQLLQANPILEAFGNAKTVKNDNSSRFGKFIRINFDASGFISGANIETYLLEKSRAIRQAKDER 370
            |:|||||||||||||||||||||||||||||||||||.:|:|.||||||||||||||||||:|||
Human   222 EKQLLQANPILEAFGNAKTVKNDNSSRFGKFIRINFDVTGYIVGANIETYLLEKSRAIRQARDER 286

  Fly   371 TFHIFYQLLAGATPEQREKFILDDVKSYAFLSNGSLPVPGVDDYAEFQATVKSMNIMGMTSEDFN 435
            ||||||.::|||..:.|...:|:...:|.|||||.:|:|...|...||.||::|.|||.:.|:..
Human   287 TFHIFYYMIAGAKEKMRSDLLLEGFNNYTFLSNGFVPIPAAQDDEMFQETVEAMAIMGFSEEEQL 351

  Fly   436 SIFRIVSAVLLFGSMKFRQERNNDQATLPDNTVAQKIAHLLGLSVTDMTRAFLTPRIKVGRDFVT 500
            ||.::||:||..|::.|::|||.|||::||||.|||:.||:|::|||.||:.||||||||||.|.
Human   352 SILKVVSSVLQLGNIVFKKERNTDQASMPDNTAAQKVCHLMGINVTDFTRSILTPRIKVGRDVVQ 416

  Fly   501 KAQTKEQVEFAVEAIAKACYERMFKWLVNRINRSLDRTKRQGASFIGILDMAGFEIFELNSFEQL 565
            |||||||.:|||||:|||.|||:|:|::.|:|::||:|.||||||:||||:|||||||:||||||
Human   417 KAQTKEQADFAVEALAKATYERLFRWILTRVNKALDKTHRQGASFLGILDIAGFEIFEVNSFEQL 481

  Fly   566 CINYTNEKLQQLFNHTMFILEQEEYQREGIEWKFIDFGLDLQPTIDLIDKPG---GIMALLDEEC 627
            ||||||||||||||||||||||||||||||||.||||||||||.|:||::|.   |::|||||||
Human   482 CINYTNEKLQQLFNHTMFILEQEEYQREGIEWNFIDFGLDLQPCIELIERPNNPPGVLALLDEEC 546

  Fly   628 WFPKATDKTFVDKLVSAHSMHPKFMK-TDFRGVADFAIVHYAGRVDYSAAKWLMKNMDPLNENIV 691
            ||||||||:||:||.:....||||.| ...:...:|:|:||||:|||:|:.||.|||||||:|:.
Human   547 WFPKATDKSFVEKLCTEQGSHPKFQKPKQLKDKTEFSIIHYAGKVDYNASAWLTKNMDPLNDNVT 611

  Fly   692 SLLQGSQDPFVVNIWKDAE-IVGMAQQA-LTDTQF--GARTRKGMFRTVSHLYKEQLAKLMDTLR 752
            |||..|.|.||.::|||.: |||:.|.| :|::..  .::|:|||||||..||||||.|||.|||
Human   612 SLLNASSDKFVADLWKDVDRIVGLDQMAKMTESSLPSASKTKKGMFRTVGQLYKEQLGKLMTTLR 676

  Fly   753 NTNPNFVRCIIPNHEKRAGKIDAPLVLDQLRCNGVLEGIRICRQGFPNRIPFQEFRQRYELLTPN 817
            ||.||||||||||||||:||:||.|||:||||||||||||||||||||||.|||||||||:|..|
Human   677 NTTPNFVRCIIPNHEKRSGKLDAFLVLEQLRCNGVLEGIRICRQGFPNRIVFQEFRQRYEILAAN 741

  Fly   818 VIPKGFMDGKKACEKMIQALELDSNLYRVGQSKIFFRAGVLAHLEEERDFKISDLIVNFQAFCRG 882
            .|||||||||:||..||:|||||.||||:||||||||.|||||||||||.||:|:|:.|||.|||
Human   742 AIPKGFMDGKQACILMIKALELDPNLYRIGQSKIFFRTGVLAHLEEERDLKITDVIMAFQAMCRG 806

  Fly   883 FLARRNYQKRLQQLNAIRIIQRNCAAYLKLRNWQWWRLYTKVKPLLEVTKQEEKLVQKEDELKQV 947
            :|||:.:.||.|||.|:::|||||||||||||||||||:|||||||:||:|||::..|||||::.
Human   807 YLARKAFAKRQQQLTAMKVIQRNCAAYLKLRNWQWWRLFTKVKPLLQVTRQEEEMQAKEDELQKT 871

  Fly   948 REKLDTLAKNTQEYERKYQQALVEKTTLAEQLQAEIELCAEAEESRSRLMARKQELEDMMQELET 1012
            :|:........:|.|:|:.|...||..|.||||||.||.|||||.|.||.|:|||||:::.|:|.
Human   872 KERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEEILHEMEA 936

  Fly  1013 RIEEEEERVLALGGEKKKLELNIQDLEEQLEEEEAARQKLQLEKVQLDAKIKKYEEDLALTDDQN 1077
            |:||||:|...|..|:||:...:.|||||||||||||||||||||..:|||||.|:::.:.||||
Human   937 RLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQN 1001

  Fly  1078 QKLLKEKKLLEERANDLSQTLAEEEEKAKHLAKLKAKHEATISELEERLHKDQQQRQESDRSKRK 1142
            .||.||:||||||.:||:..|||||||||:|.|||.|||:.|||||.||.|:::.|||.::.|||
Human  1002 NKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRK 1066

  Fly  1143 IETEVADLKEQLNERRVQVDEMQAQLAKREEELTQTLLRIDEESATKATAQKAQRELESQLAEIQ 1207
            :|.:.:|..||:.:.:.|:.|::.||||:||||...|.|:|:|.|.|..|.|..||||..::::|
Human  1067 LEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQ 1131

  Fly  1208 EDLEAEKAARAKAEKVRRDLSEELEALKNELLDSLDTTAAQQELRSKREQELATLKKSLEEETVN 1272
            |||::|:|||.||||.:|||.|||||||.||.|:||:||.|||||:|||||:..|||:|:|||.:
Human  1132 EDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRS 1196

  Fly  1273 HEGVLADMRHKHSQELNSINDQLENLRKAKTVLEKAKGTLEAENADLATELRSVNSSRQENDRRR 1337
            ||..:.:||.||:|.:..:.:|||..::||..|:|.|.|||.||||||.|||.:..::||.:.::
Human  1197 HEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKK 1261

  Fly  1338 KQAESQIAELQVKLAEIERARSELQEKCTKLQQEAENITNQLEEAELKASAAVKSASNMESQLTE 1402
            |:.|:|:.|||.|.::.||||:||.:|..|||.|.|::|..|.|||.||....|..:::.|||.:
Human  1262 KKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQD 1326

  Fly  1403 AQQLLEEETRQKLGLSSKLRQIESEKEALQEQLEEDDEAKRNYERKLAEVTTQMQEIKKKAEEDA 1467
            .|:||:|||||||.:|:||||:|.|:.:||:||:|:.|||:|.||.::.:..|:.:.|||.::.|
Human  1327 TQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFA 1391

  Fly  1468 DLAKELEEGKKRLNKDIEALERQVKELIAQNDRLDKSKKKIQSELEDATIELEAQRTKVLELEKK 1532
            ...:.|||||||..|:||.|.:|.:|..|..|:|:|:|.::|.||:|..::|:.||..|..||||
Human  1392 STVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKK 1456

  Fly  1533 QKNFDKILAEEKAISEQIAQERDTAEREAREKETKVLSVSRELDEAFDKIEDLENKRKTLQNELD 1597
            |:.||::|||||.||.:.|.|||.||.||||||||.||::|.|:||.:..|:||...|.|:.|::
Human  1457 QRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEME 1521

  Fly  1598 DLANTQGTADKNVHELEKAKRALESQLAELKAQNEELEDDLQLTEDAKLRLEVNMQALRSQFERD 1662
            ||.:::....||||||||:|||||:|:.|:|.|.|||||:||.|||||||||||||||:.|||||
Human  1522 DLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERD 1586

  Fly  1663 LLAKEEGAEEKRRGLVKQLRDLETELDEERKQRTAAVASKKKLEGDLKEIETTMEMHNKVKEDAL 1727
            |.|::|..|||||.|.:||.:.||||::|||||..|.|:|||||||||::|...:...|.:|:|:
Human  1587 LQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAI 1651

  Fly  1728 KHAKKLQAQVKDALRDAEEAKAAKEELQALSKEAERKVKALEAEVLQLTEDLASSERARRAAETE 1792
            |..:|||||:||..|:.|:|:|:::|:.|.:||.|:|.|:|||:::||.||||::||||:.|:.|
Human  1652 KQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLE 1716

  Fly  1793 RDELAEEIANNANKGSLMIDEKRRLEARIATLEEELEEEQSNSEVLLDRSRKAQLQIEQLTTELA 1857
            ::|||||:|::.:..:.:.|||||||||||.|||||||||.|.|.:.||.|||..|.|||:.|||
Human  1717 KEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELA 1781

  Fly  1858 NEKSNSQKNENGRALLERQNKELKAKLAEIETAQRTKVKATIATLEAKIANLEEQLENEGKERLL 1922
            .|:|.:||||:.|..||||||||::||.|:|.|.::|.|:|||.||||||.||||:|.|.:|:..
Human  1782 TERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQA 1846

  Fly  1923 QQKANRKMDKKIKELTMNIEDERRHVDQHKEQMDKLNSRIKLLKRNLDETEEELQKEKTQKRKYQ 1987
            ..|:.::.|||:||:.:.:||||:..:|:|||.:|.|:|:|.|||.|:|.|||.|:....:||.|
Human  1847 ATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQ 1911

  Fly  1988 RECEDMIESQEAMNREINSLKTKLRRTGGIGLSSSRLTGTPSSKRAGG-------GGGGDDSSVQ 2045
            ||.::..||.|||.||:|:||:||||        ...|....|:|:||       .|..:::..:
Human  1912 RELDEATESNEAMGREVNALKSKLRR--------GNETSFVPSRRSGGRRVIENADGSEEETDTR 1968

  Fly  2046 DESLDG 2051
            |...:|
Human  1969 DADFNG 1974

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
zipNP_523860.2 Myosin_N 80..117 CDD:280832 27/36 (75%)
Myosin_head 133..854 CDD:278492 488/728 (67%)
MYSc_Myh2_insects_mollusks 145..854 CDD:276876 476/716 (66%)
Myosin_tail_1 931..2011 CDD:279860 589/1079 (55%)
Prefoldin 1431..1515 CDD:298833 37/83 (45%)
FAM76 <1847..1926 CDD:292665 45/78 (58%)
MYH11NP_001035203.1 Myosin_N 34..71 CDD:280832 27/36 (75%)
Myosin_head 87..778 CDD:278492 488/728 (67%)
MYSc_class_II 99..778 CDD:276951 476/716 (66%)
Actin-binding. /evidence=ECO:0000250 668..690 18/21 (86%)
Actin-binding. /evidence=ECO:0000250 769..783 11/13 (85%)
Myosin_tail_1 855..1935 CDD:279860 589/1079 (55%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 865..889 7/23 (30%)
FAM76 <997..1089 CDD:292665 52/91 (57%)
V_Alix_like <1027..1299 CDD:187408 145/271 (54%)
crotonase-like 1073..>1131 CDD:304874 25/57 (44%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1751..1807 35/55 (64%)
DUF2570 1787..>1874 CDD:305162 46/86 (53%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1873..1979 44/110 (40%)
C-terminal 1942..1979 7/33 (21%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 1156 1.000 Domainoid score I16
eggNOG 1 0.900 - - E2759_KOG0161
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 2373 1.000 Inparanoid score I35
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D40305at33208
OrthoFinder 1 1.000 - - FOG0000014
OrthoInspector 1 1.000 - - otm42309
orthoMCL 1 0.900 - - OOG6_100110
Panther 1 1.100 - - O PTHR45615
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X58
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
1211.830

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