DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment zip and MYH10

DIOPT Version :9

Sequence 1:NP_523860.2 Gene:zip / 38001 FlyBaseID:FBgn0265434 Length:2056 Species:Drosophila melanogaster
Sequence 2:XP_011522177.1 Gene:MYH10 / 4628 HGNCID:7568 Length:2037 Species:Homo sapiens


Alignment Length:2024 Identity:1233/2024 - (60%)
Similarity:1566/2024 - (77%) Gaps:67/2024 - (3%)


- Green bases have known domain annotations that are detailed below.


  Fly    31 ANYRQTRN--YLEIAAKMSEEVDRNDPELKYLSVERNQFNDPATQAEWTQKRLVWVPHENQGFVA 93
            ||.|.:|.  :..:...|::.....||| :||.|:|....:|||||:||.|:|||:|.|..||.|
Human    14 ANERHSRGNCFWIVPFTMAQRTGLEDPE-RYLFVDRAVIYNPATQADWTAKKLVWIPSERHGFEA 77

  Fly    94 ASIKREHGDEVEVELAETGKRVMILRDDIQKMNPPKFDKVEDMAELTCLNEASVLHNIKDRYYSG 158
            ||||.|.||||.|||||.||:.|:.:|||||||||||.|||||||||||||||||||:|||||||
Human    78 ASIKEERGDEVMVELAENGKKAMVNKDDIQKMNPPKFSKVEDMAELTCLNEASVLHNLKDRYYSG 142

  Fly   159 LIYTYSGLFCVVVNPYKKLPIYTEKIMERYKGIKRHEVPPHVFAITDSAYRNMLGDREDQSILCT 223
            ||||||||||||:||||.||||:|.|:|.|:|.||||:|||::||::||||.||.||||||||||
Human   143 LIYTYSGLFCVVINPYKNLPIYSENIIEMYRGKKRHEMPPHIYAISESAYRCMLQDREDQSILCT 207

  Fly   224 GESGAGKTENTKKVIQFLAYVAASKPKGSGAVPHPAVLINFSVNTNKYIKVKIMAQNQNQTIEVV 288
            ||||||||||||||||:||:||:|.   .|...|     |....:.|.:|               
Human   208 GESGAGKTENTKKVIQYLAHVASSH---KGRKDH-----NIPQESPKPVK--------------- 249

  Fly   289 NGLKMVEVNSNCQEGELEQQLLQANPILEAFGNAKTVKNDNSSRFGKFIRINFDASGFISGANIE 353
                        .:||||:||||||||||:||||||||||||||||||||||||.:|:|.|||||
Human   250 ------------HQGELERQLLQANPILESFGNAKTVKNDNSSRFGKFIRINFDVTGYIVGANIE 302

  Fly   354 TYLLEKSRAIRQAKDERTFHIFYQLLAGATPEQREKFILDDVKSYAFLSNGSLPVPGVDDYAEFQ 418
            |||||||||:||||||||||||||||:||....:...:|:...:|.|||||.:|:||..|...||
Human   303 TYLLEKSRAVRQAKDERTFHIFYQLLSGAGEHLKSDLLLEGFNNYRFLSNGYIPIPGQQDKDNFQ 367

  Fly   419 ATVKSMNIMGMTSEDFNSIFRIVSAVLLFGSMKFRQERNNDQATLPDNTVAQKIAHLLGLSVTDM 483
            .|:::|:|||.:.|:..|:.::||:||.||::.|::|||.|||::|:||||||:.||||::|.:.
Human   368 ETMEAMHIMGFSHEEILSMLKVVSSVLQFGNISFKKERNTDQASMPENTVAQKLCHLLGMNVMEF 432

  Fly   484 TRAFLTPRIKVGRDFVTKAQTKEQVEFAVEAIAKACYERMFKWLVNRINRSLDRTKRQGASFIGI 548
            |||.||||||||||:|.|||||||.:|||||:|||.|||:|:|||:|||::||||||||||||||
Human   433 TRAILTPRIKVGRDYVQKAQTKEQADFAVEALAKATYERLFRWLVHRINKALDRTKRQGASFIGI 497

  Fly   549 LDMAGFEIFELNSFEQLCINYTNEKLQQLFNHTMFILEQEEYQREGIEWKFIDFGLDLQPTIDLI 613
            ||:||||||||||||||||||||||||||||||||||||||||||||||.||||||||||.||||
Human   498 LDIAGFEIFELNSFEQLCINYTNEKLQQLFNHTMFILEQEEYQREGIEWNFIDFGLDLQPCIDLI 562

  Fly   614 DKPG---GIMALLDEECWFPKATDKTFVDKLVSAHSMHPKFMK-TDFRGVADFAIVHYAGRVDYS 674
            ::|.   |::||||||||||||||||||:|||.....|.||.| ...:..|||.|:||||:|||.
Human   563 ERPANPPGVLALLDEECWFPKATDKTFVEKLVQEQGSHSKFQKPRQLKDKADFCIIHYAGKVDYK 627

  Fly   675 AAKWLMKNMDPLNENIVSLLQGSQDPFVVNIWKDA----------------------EIVGMAQ- 716
            |.:||||||||||:|:.:||..|.|.||..:|||.                      .|||:.| 
Human   628 ADEWLMKNMDPLNDNVATLLHQSSDRFVAELWKDEIQNIQRASFYDSVSGLHEPPVDRIVGLDQV 692

  Fly   717 QALTDTQFGA--RTRKGMFRTVSHLYKEQLAKLMDTLRNTNPNFVRCIIPNHEKRAGKIDAPLVL 779
            ..:|:|.||:  :|:|||||||..||||.|.|||.|||||||||||||||||||||||:|..|||
Human   693 TGMTETAFGSAYKTKKGMFRTVGQLYKESLTKLMATLRNTNPNFVRCIIPNHEKRAGKLDPHLVL 757

  Fly   780 DQLRCNGVLEGIRICRQGFPNRIPFQEFRQRYELLTPNVIPKGFMDGKKACEKMIQALELDSNLY 844
            |||||||||||||||||||||||.|||||||||:||||.|||||||||:|||:||:|||||.|||
Human   758 DQLRCNGVLEGIRICRQGFPNRIVFQEFRQRYEILTPNAIPKGFMDGKQACERMIRALELDPNLY 822

  Fly   845 RVGQSKIFFRAGVLAHLEEERDFKISDLIVNFQAFCRGFLARRNYQKRLQQLNAIRIIQRNCAAY 909
            |:||||||||||||||||||||.||:|:|:.|||.|||:|||:.:.|:.|||:|::::|||||||
Human   823 RIGQSKIFFRAGVLAHLEEERDLKITDIIIFFQAVCRGYLARKAFAKKQQQLSALKVLQRNCAAY 887

  Fly   910 LKLRNWQWWRLYTKVKPLLEVTKQEEKLVQKEDELKQVREKLDTLAKNTQEYERKYQQALVEKTT 974
            ||||:|||||::|||||||:||:|||:|..|::||.:|:||...:....:|.|||:||.|.||..
Human   888 LKLRHWQWWRVFTKVKPLLQVTRQEEELQAKDEELLKVKEKQTKVEGELEEMERKHQQLLEEKNI 952

  Fly   975 LAEQLQAEIELCAEAEESRSRLMARKQELEDMMQELETRIEEEEERVLALGGEKKKLELNIQDLE 1039
            ||||||||.||.|||||.|:||.|:|||||:::.:||:|:||||||...|..||||::.:|||||
Human   953 LAEQLQAETELFAEAEEMRARLAAKKQELEEILHDLESRVEEEEERNQILQNEKKKMQAHIQDLE 1017

  Fly  1040 EQLEEEEAARQKLQLEKVQLDAKIKKYEEDLALTDDQNQKLLKEKKLLEERANDLSQTLAEEEEK 1104
            |||:|||.||||||||||..:|||||.||::.|.:|||.|.:|||||:|:|..:.|..|||||||
Human  1018 EQLDEEEGARQKLQLEKVTAEAKIKKMEEEILLLEDQNSKFIKEKKLMEDRIAECSSQLAEEEEK 1082

  Fly  1105 AKHLAKLKAKHEATISELEERLHKDQQQRQESDRSKRKIETEVADLKEQLNERRVQVDEMQAQLA 1169
            ||:|||::.|.|..||:|||||.|:::.|||.:::|||::.|..||::|:.|.:.|:||::.|||
Human  1083 AKNLAKIRNKQEVMISDLEERLKKEEKTRQELEKAKRKLDGETTDLQDQIAELQAQIDELKLQLA 1147

  Fly  1170 KREEELTQTLLRIDEESATKATAQKAQRELESQLAEIQEDLEAEKAARAKAEKVRRDLSEELEAL 1234
            |:||||...|.|.|:|:..|..|.|..|||::|:||:|||.|:|||:|.||||.:||||||||||
Human  1148 KKEEELQGALARGDDETLHKNNALKVVRELQAQIAELQEDFESEKASRNKAEKQKRDLSEELEAL 1212

  Fly  1235 KNELLDSLDTTAAQQELRSKREQELATLKKSLEEETVNHEGVLADMRHKHSQELNSINDQLENLR 1299
            |.||.|:|||||||||||:|||||:|.|||:|||||.|||..:.|||.:|:..|..:::|||..:
Human  1213 KTELEDTLDTTAAQQELRTKREQEVAELKKALEEETKNHEAQIQDMRQRHATALEELSEQLEQAK 1277

  Fly  1300 KAKTVLEKAKGTLEAENADLATELRSVNSSRQENDRRRKQAESQIAELQVKLAEIERARSELQEK 1364
            :.|..|||.|..||.:|.:||.|::.:...:.|::.:||:.::|:.||..|::|.:|.|.||.||
Human  1278 RFKANLEKNKQGLETDNKELACEVKVLQQVKAESEHKRKKLDAQVQELHAKVSEGDRLRVELAEK 1342

  Fly  1365 CTKLQQEAENITNQLEEAELKASAAVKSASNMESQLTEAQQLLEEETRQKLGLSSKLRQIESEKE 1429
            .:|||.|.:|::..|||||.|.....|.|:::||||.:.|:||:|||||||.|||::||:|.||.
Human  1343 ASKLQNELDNVSTLLEEAEKKGIKFAKDAASLESQLQDTQELLQEETRQKLNLSSRIRQLEEEKN 1407

  Fly  1430 ALQEQLEEDDEAKRNYERKLAEVTTQMQEIKKKAEEDADLAKELEEGKKRLNKDIEALERQVKEL 1494
            :||||.||::||::|.|:::..:.:|:.:.|||.::|....:.|||.||:|.||.|||.::::|.
Human  1408 SLQEQQEEEEEARKNLEKQVLALQSQLADTKKKVDDDLGTIESLEEAKKKLLKDAEALSQRLEEK 1472

  Fly  1495 IAQNDRLDKSKKKIQSELEDATIELEAQRTKVLELEKKQKNFDKILAEEKAISEQIAQERDTAER 1559
            ....|:|:|:|.::|.||:|.|::|:.||.....||||||.||::|||||:||.:.|:|||.||.
Human  1473 ALAYDKLEKTKNRLQQELDDLTVDLDHQRQVASNLEKKQKKFDQLLAEEKSISARYAEERDRAEA 1537

  Fly  1560 EAREKETKVLSVSRELDEAFDKIEDLENKRKTLQNELDDLANTQGTADKNVHELEKAKRALESQL 1624
            ||||||||.||::|.|:||.:..|:.|.:.|.|:.:::||.:::....||||||||:|||||.|:
Human  1538 EAREKETKALSLARALEEALEAKEEFERQNKQLRADMEDLMSSKDDVGKNVHELEKSKRALEQQV 1602

  Fly  1625 AELKAQNEELEDDLQLTEDAKLRLEVNMQALRSQFERDLLAKEEGAEEKRRGLVKQLRDLETELD 1689
            .|::.|.|||||:||.||||||||||||||:::||||||..::|..|||:|.|:||:|:||.||:
Human  1603 EEMRTQLEELEDELQATEDAKLRLEVNMQAMKAQFERDLQTRDEQNEEKKRLLIKQVRELEAELE 1667

  Fly  1690 EERKQRTAAVASKKKLEGDLKEIETTMEMHNKVKEDALKHAKKLQAQVKDALRDAEEAKAAKEEL 1754
            :|||||..|||||||:|.|||::|..:|..||.:::.:|..:|||||:||..|:.|||:|:::|:
Human  1668 DERKQRALAVASKKKMEIDLKDLEAQIEAANKARDEVIKQLRKLQAQMKDYQRELEEARASRDEI 1732

  Fly  1755 QALSKEAERKVKALEAEVLQLTEDLASSERARRAAETERDELAEEIANNANKGSLMIDEKRRLEA 1819
            .|.|||:|:|:|:||||:|||.|:|||||||||.||.||||||:||.|:|:..|.::||||||||
Human  1733 FAQSKESEKKLKSLEAEILQLQEELASSERARRHAEQERDELADEITNSASGKSALLDEKRRLEA 1797

  Fly  1820 RIATLEEELEEEQSNSEVLLDRSRKAQLQIEQLTTELANEKSNSQKNENGRALLERQNKELKAKL 1884
            |||.|||||||||||.|:|.||.||..||::.|..|||.|:|.:||::|.|..||||||||||||
Human  1798 RIAQLEEELEEEQSNMELLNDRFRKTTLQVDTLNAELAAERSAAQKSDNARQQLERQNKELKAKL 1862

  Fly  1885 AEIETAQRTKVKATIATLEAKIANLEEQLENEGKERLLQQKANRKMDKKIKELTMNIEDERRHVD 1949
            .|:|.|.::|.||||:.|||||..||||||.|.|||....|..|:.:||:||:.|.:||||||.|
Human  1863 QELEGAVKSKFKATISALEAKIGQLEEQLEQEAKERAAANKLVRRTEKKLKEIFMQVEDERRHAD 1927

  Fly  1950 QHKEQMDKLNSRIKLLKRNLDETEEELQKEKTQKRKYQRECEDMIESQEAMNREINSLKTKLRRT 2014
            |:||||:|.|:|:|.|||.|:|.|||..:....:||.|||.:|..|:.|.::||:::||.:|||.
Human  1928 QYKEQMEKANARMKQLKRQLEEAEEEATRANASRRKLQRELDDATEANEGLSREVSTLKNRLRRG 1992

  Fly  2015 GGIGLSSSR 2023
            |.|..||||
Human  1993 GPISFSSSR 2001

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
zipNP_523860.2 Myosin_N 80..117 CDD:280832 24/36 (67%)
Myosin_head 133..854 CDD:278492 508/749 (68%)
MYSc_Myh2_insects_mollusks 145..854 CDD:276876 496/737 (67%)
Myosin_tail_1 931..2011 CDD:279860 603/1079 (56%)
Prefoldin 1431..1515 CDD:298833 34/83 (41%)
FAM76 <1847..1926 CDD:292665 47/78 (60%)
MYH10XP_011522177.1 Myosin_N 64..102 CDD:280832 25/37 (68%)
Myosin_head 117..832 CDD:278492 508/749 (68%)
MYSc_Myh10 129..832 CDD:276952 496/737 (67%)
Myosin_tail_1 909..1989 CDD:279860 603/1079 (56%)
DUF342 <1105..1194 CDD:302792 42/88 (48%)
DUF2317 <1172..1283 CDD:302887 70/110 (64%)
COG5134 <1399..1527 CDD:227463 59/127 (46%)
GBP_C <1565..1671 CDD:303769 61/105 (58%)
coiled coil 1661..1671 CDD:293879 5/9 (56%)
DUF106 <1706..>1757 CDD:303007 29/50 (58%)
DUF2570 1834..>1928 CDD:305162 56/93 (60%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 1156 1.000 Domainoid score I16
eggNOG 1 0.900 - - E2759_KOG0161
Hieranoid 1 1.000 - -
Homologene 1 1.000 - - H55941
Inparanoid 1 1.050 2373 1.000 Inparanoid score I35
Isobase 1 0.950 - 0 Normalized mean entropy S1140
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D40305at33208
OrthoFinder 1 1.000 - - FOG0000014
OrthoInspector 1 1.000 - - otm42309
orthoMCL 1 0.900 - - OOG6_100110
Panther 1 1.100 - - O PTHR45615
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R786
SonicParanoid 1 1.000 - - X58
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
1514.810

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