DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment zip and MYH6

DIOPT Version :9

Sequence 1:NP_523860.2 Gene:zip / 38001 FlyBaseID:FBgn0265434 Length:2056 Species:Drosophila melanogaster
Sequence 2:NP_002462.2 Gene:MYH6 / 4624 HGNCID:7576 Length:1939 Species:Homo sapiens


Alignment Length:1949 Identity:761/1949 - (39%)
Similarity:1180/1949 - (60%) Gaps:72/1949 - (3%)


- Green bases have known domain annotations that are detailed below.


  Fly    83 WVPHENQGFVAASIKREHGDEVEVELAETGKRVMILRDDIQKMNPPKFDKVEDMAELTCLNEASV 147
            :||.:.:.||.|.|....|.:|..| .|.||.|.:..|.:.:.|||||||:||||.||.|:|.:|
Human    38 FVPDDKEEFVKAKILSREGGKVIAE-TENGKTVTVK
EDQVLQQNPPKFDKIEDMAMLTFLHEPAV 101

  Fly   148 LHNIKDRYYSGLIYTYSGLFCVVVNPYKKLPIYTEKIMERYKGIKRHEVPPHVFAITDSAYRNML 212
            |.|:|:||.:.:||||||||||.|||||.||:|..:::..|:|.||.|.|||:|:|:|:||:.||
Human   102 LFNLKERYAAWMIYTYSGLFCVTVNPYKWLPVYNAEVVAAYRGKKRSEAPPHIFSISDNAYQYML 166

  Fly   213 GDREDQSILCTGESGAGKTENTKKVIQFLAYVAASKPKGSGAVPHPAVLINFSVNTNKYIKVKIM 277
            .|||:||||.|||||||||.|||:|||:.|.:||...:|.                         
Human   167 TDRENQSILITGESGAGKTVNTKRVIQYFASIAAIGDRGK------------------------- 206

  Fly   278 AQNQNQTIEVVNGLKMVEVNSNCQEGELEQQLLQANPILEAFGNAKTVKNDNSSRFGKFIRINFD 342
                             :.|:|..:|.||.|::||||.||||||||||:|||||||||||||:|.
Human   207 -----------------KDNANANKGTLEDQIIQANPALEAFGNAKTVRNDNSSRFGKFIRIHFG 254

  Fly   343 ASGFISGANIETYLLEKSRAIRQAKDERTFHIFYQLLAGATPEQREKFIL-DDVKSYAFLSNGSL 406
            |:|.::.|:||||||||||.|.|.|.||.:|||||:|:...||..:..:: ::...|||:|.|.:
Human   255 ATGKLASADIETYLLEKSRVIFQLKAERNYHIFYQILSNKKPELLDMLLVTNNPYDYAFVSQGEV 319

  Fly   407 PVPGVDDYAEFQATVKSMNIMGMTSEDFNSIFRIVSAVLLFGSMKFRQERNNDQATLPDNTV-AQ 470
            .|..:||..|..||..:.:::|.|||:...::::..|::.:|:|||:|::..:||. ||.|. |.
Human   320 SVASIDDSEELMATDSAFDVLGFTSEEKAGVYKLTGAIMHYGNMKFKQKQREEQAE-PDGTEDAD 383

  Fly   471 KIAHLLGLSVTDMTRAFLTPRIKVGRDFVTKAQTKEQVEFAVEAIAKACYERMFKWLVNRINRSL 535
            |.|:|:||:..|:.:....||:|||.::|||.|:.:||.:::.|:|||.||:||.|:|.|||.:|
Human   384 KSAYLMGLNSADLLKGLCHPRVKVGNEYVTKGQSVQQVYYSIGALAKAVYEKMFNWMVTRINATL 448

  Fly   536 DRTKRQGASFIGILDMAGFEIFELNSFEQLCINYTNEKLQQLFNHTMFILEQEEYQREGIEWKFI 600
            : ||:....|||:||:||||||:.|||||||||:|||||||.|||.||:||||||::|||||.||
Human   449 E-TKQPRQYFIGVLDIAGFEIFDFNSFEQLCINFTNEKLQQFFNHHMFVLEQEEYKKEGIEWTFI 512

  Fly   601 DFGLDLQPTIDLIDKPGGIMALLDEECWFPKATDKTFVDKLVSAH-SMHPKFMK-TDFRG--VAD 661
            |||:|||..||||:||.|||::|:|||.||||||.||..||...| .....|.| .:.:|  .|.
Human   513 DFGMDLQACIDLIEKPMGIMSILEEECMFPKATDMTFKAKLYDNHLGKSNNFQKPRNIKGKQEAH 577

  Fly   662 FAIVHYAGRVDYSAAKWLMKNMDPLNENIVSLLQGSQDPFVVNIWKDAEIVGMAQQALTDT---- 722
            |:::||||.|||:...||.||.|||||.:|:|.|.|....:..::        :..|..||    
Human   578 FSLIHYAGTVDYNILGWLEKNKDPLNETVVALYQKSSLKLMATLF--------SSYATADTGDSG 634

  Fly   723 -QFGARTRKGMFRTVSHLYKEQLAKLMDTLRNTNPNFVRCIIPNHEKRAGKIDAPLVLDQLRCNG 786
             ..|.:.:...|:|||.|::|.|.|||..||.|:|:||||||||..|..|.:|.|||:.||||||
Human   635 KSKGGKKKGSSFQTVSALHRENLNKLMTNLRTTHPHFVRCIIPNERKAPGVMDNPLVMHQLRCNG 699

  Fly   787 VLEGIRICRQGFPNRIPFQEFRQRYELLTPNVIPKG-FMDGKKACEKMIQALELDSNLYRVGQSK 850
            |||||||||:||||||.:.:|||||.:|.|..||:| |:|.:|..||::.:|::|.|.|:.|.:|
Human   700 VLEGIRICRKGFPNRILYGDFRQRYRILNPVAIPEGQFIDSRKGTEKLLSSLDIDHNQYKFGHTK 764

  Fly   851 IFFRAGVLAHLEEERDFKISDLIVNFQAFCRGFLARRNYQKRLQQLNAIRIIQRNCAAYLKLRNW 915
            :||:||:|..|||.||.::|.:|...||..||.|.|..::|.:::.:|:.:||.|..|::.::||
Human   765 VFFKAGLLGLLEEMRDERLSRIITRMQAQARGQLMRIEFKKIVERRDALLVIQWNIRAFMGVKNW 829

  Fly   916 QWWRLYTKVKPLLEVTKQEEKLVQKEDELKQVREKLDTLAKNTQEYERKYQQALVEKTTLAEQLQ 980
            .|.:||.|:||||:..:.|:::...::|..:::|.|:......:|.|.|....|.||..|..|:|
Human   830 PWMKLYFKIKPLLKSAETEKEMATMKEEFGRIKETLEKSEARRKELEEKMVSLLQEKNDLQLQVQ 894

  Fly   981 AEIELCAEAEESRSRLMARKQELEDMMQELETRIEEEEERVLALGGEKKKLELNIQDLEEQLEEE 1045
            ||.:...:|||...:|:..|.:||..::|:..|:|:|||....|..:|:|||....:|::.:::.
Human   895 AEQDNLNDAEERCDQLIKNKIQLEAKVKEMNERLEDEEEMNAELTAKKRKLEDECSELKKDIDDL 959

  Fly  1046 EAARQKLQLEKVQLDAKIKKYEEDLALTDDQNQKLLKEKKLLEERANDLSQTLAEEEEKAKHLAK 1110
            |....|::.||...:.|:|...|::|..|:...||.||||.|:|........|..||:|...|:|
Human   960 ELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQALDDLQVEEDKVNSLSK 1024

  Fly  1111 LKAKHEATISELEERLHKDQQQRQESDRSKRKIETEVADLKEQLNERRVQVDEMQAQLAKREEEL 1175
            .|.|.|..:.:||..|.::::.|.:.:|:|||:|.::...:|.:.:......:::.:|.|:|.::
Human  1025 SKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQESIMDLENDKLQLEEKLKKKEFDI 1089

  Fly  1176 TQTLLRIDEESATKATAQKAQRELESQLAEIQEDLEAEKAARAKAEKVRRDLSEELEALKNELLD 1240
            .|...:|::|.......||..:|.::::.|::|:||||:.||||.||:|.|||.|||.:...|.:
Human  1090 NQQNSKIEDEQVLALQLQKKLKENQARIEELEEELEAERTARAKVEKLRSDLSRELEEISERLEE 1154

  Fly  1241 SLDTTAAQQELRSKREQELATLKKSLEEETVNHEGVLADMRHKHSQELNSINDQLENLRKAKTVL 1305
            :...|:.|.|:..|||.|...:::.|||.|:.||...|.:|.||:..:..:.:|::||::.|..|
Human  1155 AGGATSVQIEMNKKREAEFQKMRRDLEEATLQHEATAAALRKKHADSVAELGEQIDNLQRVKQKL 1219

  Fly  1306 EKAKGTLEAENADLATELRSVNSSRQENDRRRKQAESQIAELQVKLAEIERARSELQEKCTKLQQ 1370
            ||.|...:.|..|:.:.:..:..::...::..:..|.|..|.:|||.|.:|:.::...:..|||.
Human  1220 EKEKSEFKLELDDVTSNMEQIIKAKANLEKVSRTLEDQANEYRVKLEEAQRSLNDFTTQRAKLQT 1284

  Fly  1371 EAENITNQLEEAELKASAAVKSASNMESQLTEAQQLLEEETRQKLGLSSKLRQIESEKEALQEQL 1435
            |...:..||||.|...|...:...:...|:.:.::.||||.:.|..|:..|:....:.:.|:||.
Human  1285 ENGELARQLEEKEALISQLTRGKLSYTQQMEDLKRQLEEEGKAKNALAHALQSARHDCDLLREQY 1349

  Fly  1436 EEDDEAKRNYERKLAEVTTQMQEIKKKAEEDA-DLAKELEEGKKRLNKDIEALERQVKELIAQND 1499
            ||:.|||...:|.|::..:::.:.:.|.|.|| ...:||||.||:|.:.::..|..|:.:.|:..
Human  1350 EEETEAKAELQRVLSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDAEEAVEAVNAKCS 1414

  Fly  1500 RLDKSKKKIQSELEDATIELEAQRTKVLELEKKQKNFDKILAEEKAISEQIAQERDTAEREAREK 1564
            .|:|:|.::|:|:||..:::|........|:|||:||||||||.|...|:...|.:::::|||..
Human  1415 SLEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQRNFDKILAEWKQKYEESQSELESSQKEARSL 1479

  Fly  1565 ETKVLSVSRELDEAFDKIEDLENKRKTLQNELDDLANTQGTADKNVHELEKAKRALESQLAELKA 1629
            .|::..:....:|:.:.:|..:.:.|.||.|:.||....|...||||||||.::.||.:..||::
Human  1480 STELFKLKNAYEESLEHLETFKRENKNLQEEISDLTEQLGEGGKNVHELEKVRKQLEVEKLELQS 1544

  Fly  1630 QNEELEDDLQLTEDAKLRLEVNMQALRSQFERDLLAKEEGAEEKRRGLVKQLRDLETELDEERKQ 1694
            ..||.|..|:..|...||.::....::::.||.|..|:|..|:.:|...:.:..|:|.||.|.:.
Human  1545 ALEEAEASLEHEEGKILRAQLEFNQIKAEIERKLAEKDEEMEQAKRNHQRVVDSLQTSLDAETRS 1609

  Fly  1695 RTAAVASKKKLEGDLKEIETTMEMHNKVKEDALKHAKKLQAQVKDALRDAEEAKAAKEELQALSK 1759
            |...:..|||:||||.|:|..:...|::..:|.|..|.||:.:||.....::|..|.::|:....
Human  1610 RNEVLRVKKKMEGDLNEMEIQLSHANRMAAEAQKQVKSLQSLLKDTQIQLDDAVRANDDLKENIA 1674

  Fly  1760 EAERKVKALEAEVLQLTEDLASSERARRAAETERDELAEEIANNANKGSLMIDEKRRLEARIATL 1824
            ..||:...|:||:.:|...:..:||:|:.||.|..|.:|.:....::.:.:|::|:::|:.:..|
Human  1675 IVERRNNLLQAELEELRAVVEQTERSRKLAEQELIETSERVQLLHSQNTSLINQKKKMESDLTQL 1739

  Fly  1825 EEELEE---EQSNSEVLLDRSRKAQLQIEQLTTELANEKSNSQKNENGRALLERQNKELKAKLAE 1886
            :.|:||   |..|:|   ::::||......:..||..|:..|...|..:..:|:..|:|:.:|.|
Human  1740 QSEVEEAVQECRNAE---EKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTIKDLQHRLDE 1801

  Fly  1887 IETAQRTKVKATIATLEAKIANLEEQLENEGKERLLQQKANRKMDKKIKELTMNIEDERRHVDQH 1951
            .|.......|..:..|||::..||.:||.|.|......|..||.:::|||||...|::::::.:.
Human  1802 AEQIALKGGKKQLQKLEARVRELEGELEAEQKRNAESVKGMRKSERRIKELTYQTEEDKKNLLRL 1866

  Fly  1952 KEQMDKLNSRIKLLKRNLDETEEELQKEKTQKRKYQRECEDMIESQEAMNREINSLKTKLRRTG 2015
            ::.:|||..::|..||..:|.||:.....::.||.|.|.::..|..:....::|.|:.|.|..|
Human  1867 QDLVDKLQLKVKAYKRQAEEAEEQANTNLSKFRKVQHELDEAEERADIAESQVNKLRAKSRDIG 1930

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
zipNP_523860.2 Myosin_N 80..117 CDD:280832 13/33 (39%)
Myosin_head 133..854 CDD:278492 368/732 (50%)
MYSc_Myh2_insects_mollusks 145..854 CDD:276876 360/720 (50%)
Myosin_tail_1 931..2011 CDD:279860 336/1083 (31%)
Prefoldin 1431..1515 CDD:298833 30/84 (36%)
FAM76 <1847..1926 CDD:292665 21/78 (27%)
MYH6NP_002462.2 Myosin_N 35..72 CDD:280832 13/34 (38%)
Myosin_head 87..768 CDD:278492 368/732 (50%)
MYSc_class_II 99..768 CDD:276951 360/720 (50%)
Actin-binding 657..679 15/21 (71%)
Actin-binding 759..773 6/13 (46%)
Myosin_tail_1 848..1925 CDD:279860 336/1079 (31%)
SPEC 881..1043 CDD:295325 56/161 (35%)
MM_CoA_mutase <1134..1295 CDD:294532 51/160 (32%)
MIT_CorA-like <1297..>1409 CDD:294313 33/111 (30%)
TMPIT 1740..>1832 CDD:285135 27/94 (29%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1826..1849 7/22 (32%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1909..1939 6/22 (27%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG0161
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D47111at2759
OrthoFinder 1 1.000 - - FOG0000014
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100110
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X58
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
65.720

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