DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment zip and MYH3

DIOPT Version :9

Sequence 1:NP_523860.2 Gene:zip / 38001 FlyBaseID:FBgn0265434 Length:2056 Species:Drosophila melanogaster
Sequence 2:NP_002461.2 Gene:MYH3 / 4621 HGNCID:7573 Length:1940 Species:Homo sapiens


Alignment Length:1998 Identity:776/1998 - (38%)
Similarity:1195/1998 - (59%) Gaps:107/1998 - (5%)


- Green bases have known domain annotations that are detailed below.


  Fly    55 PELKYLSVERNQFNDPATQAEWTQKRLVWVPHENQGFVAASIKREHGDEVEVELAETGKRVMILR 119
            |.|:....||.:    |....:..|...:|....:.:....||.....:|.|| .|..:.:::..
Human    15 PFLRKSEKERIE----AQNQPFDAKTYCFVVDSKEEYAKGKIKSSQDGKVTVE-TEDNRTLVVKP 74

  Fly   120 DDIQKMNPPKFDKVEDMAELTCLNEASVLHNIKDRYYSGLIYTYSGLFCVVVNPYKKLPIYTEKI 184
            :|:..|||||||::||||.||.|||.:||:|:||||.|.:||||||||||.|||||.||:|..::
Human    75 EDVYAMNPPKFDRIEDMAMLTHLNEPAVLYNLKDRYTSWMIYTYSGLFCVTVNPYKWLPVYNPEV 139

  Fly   185 MERYKGIKRHEVPPHVFAITDSAYRNMLGDREDQSILCTGESGAGKTENTKKVIQFLAYVAA--- 246
            :|.|:|.||.|.|||:|:|:|:||:.||.|||:||||.|||||||||.|||:|||:.|.:||   
Human   140 VEGYRGKKRQEAPPHIFSISDNAYQFMLTDRENQSILITGESGAGKTVNTKRVIQYFATIAATGD 204

  Fly   247 -SKPKGSGAVPHPAVLINFSVNTNKYIKVKIMAQNQNQTIEVVNGLKMVEVNSNCQEGELEQQLL 310
             :|.|.|                                       ||        :|.||.|::
Human   205 LAKKKDS---------------------------------------KM--------KGTLEDQII 222

  Fly   311 QANPILEAFGNAKTVKNDNSSRFGKFIRINFDASGFISGANIETYLLEKSRAIRQAKDERTFHIF 375
            .|||:||||||||||:|||||||||||||:|..:|.::.|:||||||||||...|.|.||::|||
Human   223 SANPLLEAFGNAKTVRNDNSSRFGKFIRIHFGTTGKLASADIETYLLEKSRVTFQLKAERSYHIF 287

  Fly   376 YQLLAGATPEQREKFIL-DDVKSYAFLSNGSLPVPGVDDYAEFQATVKSMNIMGMTSEDFNSIFR 439
            ||:|:...||..|..:: .:...|.|:|.|.:.|..:||..|..||..:::|:|.|.|:.:.:::
Human   288 YQILSNKKPELIELLLITTNPYDYPFISQGEILVASIDDAEELLATDSAIDILGFTPEEKSGLYK 352

  Fly   440 IVSAVLLFGSMKFRQERNNDQATLPDNT-VAQKIAHLLGLSVTDMTRAFLTPRIKVGRDFVTKAQ 503
            :..||:.:|:|||:|::..:||. ||.| ||.|.|:|:||:.:|:.:|...||:|||.::|||.|
Human   353 LTGAVMHYGNMKFKQKQREEQAE-PDGTEVADKTAYLMGLNSSDLLKALCFPRVKVGNEYVTKGQ 416

  Fly   504 TKEQVEFAVEAIAKACYERMFKWLVNRINRSLDRTKRQGASFIGILDMAGFEIFELNSFEQLCIN 568
            |.:||..||.|::|:.||::|.|:|.|||:.|| ||.....|||:||:|||||||.||.||||||
Human   417 TVDQVHHAVNALSKSVYEKLFLWMVTRINQQLD-TKLPRQHFIGVLDIAGFEIFEYNSLEQLCIN 480

  Fly   569 YTNEKLQQLFNHTMFILEQEEYQREGIEWKFIDFGLDLQPTIDLIDKPGGIMALLDEECWFPKAT 633
            :|||||||.|||.||:||||||::|||||.|||||:||...|:||:||.||.::|:|||.|||||
Human   481 FTNEKLQQFFNHHMFVLEQEEYKKEGIEWTFIDFGMDLAACIELIEKPMGIFSILEEECMFPKAT 545

  Fly   634 DKTFVDKLVSAH------SMHPKFMKTDFRGVADFAIVHYAGRVDYSAAKWLMKNMDPLNENIVS 692
            |.:|.:||...|      ...||.:|.  |..|.|:::||||.||||.:.||.||.|||||.:|.
Human   546 DTSFKNKLYDQHLGKSNNFQKPKVVKG--RAEAHFSLIHYAGTVDYSVSGWLEKNKDPLNETVVG 608

  Fly   693 LLQGSQDPFVVNIWKDAEIVGMAQQALTDTQFG----ARTRKGMFRTVSHLYKEQLAKLMDTLRN 753
            |.|.|.:..:.:::        |..|..|...|    |:.:...|:|||.|::|.|.|||..||.
Human   609 LYQKSSNRLLAHLY--------ATFATADADSGKKKVAKKKGSSFQTVSALFRENLNKLMSNLRT 665

  Fly   754 TNPNFVRCIIPNHEKRAGKIDAPLVLDQLRCNGVLEGIRICRQGFPNRIPFQEFRQRYELLTPNV 818
            |:|:||||||||..|..|.::..|||.|||||||||||||||:||||||.:.:|:|||.:|..:.
Human   666 THPHFVRCIIPNETKTPGAMEHSLVLHQLRCNGVLEGIRICRKGFPNRILYGDFKQRYRVLNASA 730

  Fly   819 IPKG-FMDGKKACEKMIQALELDSNLYRVGQSKIFFRAGVLAHLEEERDFKISDLIVNFQAFCRG 882
            ||:| |:|.||||||::.::::|...|:.|.:|:||:||:|..|||.||.:::.||...||.|||
Human   731 IPEGQFIDSKKACEKLLASIDIDHTQYKFGHTKVFFKAGLLGTLEEMRDDRLAKLITRTQAVCRG 795

  Fly   883 FLARRNYQKRLQQLNAIRIIQRNCAAYLKLRNWQWWRLYTKVKPLLEVTKQEEKLVQKEDELKQV 947
            ||.|..:||.:|:..:|..||.|..:::.:::|.|.:|:.|:||||:..:.|:::...::|.::.
Human   796 FLMRVEFQKMVQRRESIFCIQYNIRSFMNVKHWPWMKLFFKIKPLLKSAETEKEMATMKEEFQKT 860

  Fly   948 REKLDTLAKNTQEYERKYQQALVEKTTLAEQLQAEIELCAEAEESRSRLMARKQELEDMMQELET 1012
            :::|.......:|.|.|....:.||..|..|:|||.|...:|||...:|:..|.:||..::|:..
Human   861 KDELAKSEAKRKELEEKLVTLVQEKNDLQLQVQAESENLLDAEERCDQLIKAKFQLEAKIKEVTE 925

  Fly  1013 RIEEEEERVLALGGEKKKLELNIQDLEEQLEEEEAARQKLQLEKVQLDAKIKKYEEDLALTDDQN 1077
            |.|:|||....|..:|:|||....:|::.:::.|....|::.||...:.|:|...|:|:..|:..
Human   926 RAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEELSGLDETI 990

  Fly  1078 QKLLKEKKLLEERANDLSQTLAEEEEKAKHLAKLKAKHEATISELEERLHKDQQQRQESDRSKRK 1142
            .||.:|||.|:|........|..||:|...|.|.|:|.|..:.:||..|.::::.|.:.:|:|||
Human   991 AKLTREKKALQEAHQQALDDLQAEEDKVNSLNKTKSKLEQQVEDLESSLEQEKKLRVDLERNKRK 1055

  Fly  1143 IETE-------VADL---KEQLNERRVQVDEMQAQLAKREEELTQTLLRIDEESATKATAQKAQR 1197
            :|.:       :.||   |:||:||          |.|::.|..|...::::|.......||..:
Human  1056 LEGDLKLAQESILDLENDKQQLDER----------LKKKDFEYCQLQSKVEDEQTLGLQFQKKIK 1110

  Fly  1198 ELESQLAEIQEDLEAEKAARAKAEKVRRDLSEELEALKNELLDSLDTTAAQQELRSKREQELATL 1262
            ||::::.|::|::|||:|.|||.||.|.|.:.|||.|...|.::...|:.|.||..|||.|...|
Human  1111 ELQARIEELEEEIEAERATRAKTEKQRSDYARELEELSERLEEAGGVTSTQIELNKKREAEFLKL 1175

  Fly  1263 KKSLEEETVNHEGVLADMRHKHSQELNSINDQLENLRKAKTVLEKAKGTLEAENADLATELRSVN 1327
            ::.|||.|:.||.::|.:|.||:..:..:.:|::||::.|..|||.|...:.|..||::.:.||:
Human  1176 RRDLEEATLQHEAMVAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLEIDDLSSSMESVS 1240

  Fly  1328 SSRQENDRRRKQAESQIAELQVKLAEIERARSELQEKCTKLQQEAENITNQLEEAELKASAAVKS 1392
            .|:...::..:..|.|::|.:.|..||:|:.|||..:.::||.||..::.||||.|...|...:|
Human  1241 KSKANLEKICRTLEDQLSEARGKNEEIQRSLSELTTQKSRLQTEAGELSRQLEEKESIVSQLSRS 1305

  Fly  1393 ASNMESQLTEAQQLLEEETRQKLGLSSKLRQIESEKEALQEQLEEDDEAKRNYERKLAEVTTQMQ 1457
            ......|..|.::.||||.:.|..|:..|:....:.:.|:||.||:.|.|...:|.|::..:::.
Human  1306 KQAFTQQTEELKRQLEEENKAKNALAHALQSSRHDCDLLREQYEEEQEGKAELQRALSKANSEVA 1370

  Fly  1458 EIKKKAEEDA-DLAKELEEGKKRLNKDIEALERQVKELIAQNDRLDKSKKKIQSELEDATIELEA 1521
            :.:.|.|.|| ...:||||.||:|.:.::..|.||:.:.|:...|:|:|:::|.|:||..:::|.
Human  1371 QWRTKYETDAIQRTEELEEAKKKLAQRLQDSEEQVEAVNAKCASLEKTKQRLQGEVEDLMVDVER 1435

  Fly  1522 QRTKVLELEKKQKNFDKILAEEKAISEQIAQERDTAEREAREKETKVLSVSRELDEAFDKIEDLE 1586
            ..:....|:|||:||||:|||.|...|:...|.:.:.:|:|...|::..:....:||.|::|.::
Human  1436 ANSLAAALDKKQRNFDKVLAEWKTKCEESQAELEASLKESRSLSTELFKLKNAYEEALDQLETVK 1500

  Fly  1587 NKRKTLQNELDDLANTQGTADKNVHELEKAKRALESQLAELKAQNEELEDDLQLTEDAKLRLEVN 1651
            .:.|.|:.|:.||........|.:|||||:::.:|.:.|:::...||.|..|:..|...||:::.
Human  1501 RENKNLEQEIADLTEQIAENGKTIHELEKSRKQIELEKADIQLALEEAEAALEHEEAKILRIQLE 1565

  Fly  1652 MQALRSQFERDLLAKEEGAEEKRRGLVKQLRDLETELDEERKQRTAAVASKKKLEGDLKEIETTM 1716
            :..::|:.:|.:..|:|..|:.:|...:.:..:::.||.|.:.|..|:..|||:||||.|||..:
Human  1566 LTQVKSEIDRKIAEKDEEIEQLKRNYQRTVETMQSALDAEVRSRNEAIRLKKKMEGDLNEIEIQL 1630

  Fly  1717 EMHNKVKEDALKHAKKLQAQVKDALRDAEEAKAAKEELQALSKEAERKVKALEAEVLQLTEDLAS 1781
            ...|:...:.|||.:.:|.|:||.....::|...:|:|:......||:...|:|||.:|...|..
Human  1631 SHANRQAAETLKHLRSVQGQLKDTQLHLDDALRGQEDLKEQLAIVERRANLLQAEVEELRATLEQ 1695

  Fly  1782 SERARRAAETERDELAEEIANNANKGSLMIDEKRRLEARIATLEEELEEEQSNSEVLLDRSRKAQ 1846
            :||||:.||.|..:..|.:.....:.:.:|..|::||..:..|:.|:|:...::....::::||.
Human  1696 TERARKLAEQELLDSNERVQLLHTQNTSLIHTKKKLETDLMQLQSEVEDASRDARNAEEKAKKAI 1760

  Fly  1847 LQIEQLTTELANEKSNSQKNENGRALLERQNKELKAKLAEIETAQRTKVKATIATLEAKIANLEE 1911
            .....:..||..|:..|...|..:..||:..|:|:.:|.|.|.......|..|..||.:|..||.
Human  1761 TDAAMMAEELKKEQDTSAHLERMKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQKLETRIRELEF 1825

  Fly  1912 QLENEGKERLLQQKANRKMDKKIKELTMNIEDERRHVDQHKEQMDKLNSRIKLLKRNLDETEEEL 1976
            :||.|.|:.....|..||.::::||||...|::|::|.:.::.:|||..::|..||..:|.:|:.
Human  1826 ELEGEQKKNTESVKGLRKYERRVKELTYQSEEDRKNVLRLQDLVDKLQVKVKSYKRQAEEADEQA 1890

  Fly  1977 QKEKTQKRKYQRECEDMIESQEAMNREINSLKTKLRRTGGIGLSSSRL 2024
            ....|:.||.|.|.|:..|..:....::|.|:.|.|     ..:|||:
Human  1891 NAHLTKFRKAQHELEEAEERADIAESQVNKLRAKTR-----DFTSSRM 1933

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
zipNP_523860.2 Myosin_N 80..117 CDD:280832 7/36 (19%)
Myosin_head 133..854 CDD:278492 372/737 (50%)
MYSc_Myh2_insects_mollusks 145..854 CDD:276876 363/725 (50%)
Myosin_tail_1 931..2011 CDD:279860 344/1090 (32%)
Prefoldin 1431..1515 CDD:298833 30/84 (36%)
FAM76 <1847..1926 CDD:292665 23/78 (29%)
MYH3NP_002461.2 Myosin_N 36..73 CDD:280832 7/37 (19%)
Myosin_head 88..767 CDD:278492 372/737 (50%)
MYSc_Myh3 100..767 CDD:276878 363/725 (50%)
Actin-binding 656..678 15/21 (71%)
Actin-binding 758..772 6/13 (46%)
GrpE 843..>962 CDD:295646 34/118 (29%)
Myosin_tail_1 847..1924 CDD:279860 344/1086 (32%)
BAR <956..1063 CDD:299863 34/106 (32%)
MIT_CorA-like <1296..>1408 CDD:294313 35/111 (32%)
COG6 1373..>1506 CDD:303003 45/132 (34%)
TMPIT 1739..>1850 CDD:285135 30/110 (27%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG0161
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D47111at2759
OrthoFinder 1 1.000 - - FOG0000014
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100110
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X58
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
65.720

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