DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment zip and MYH2

DIOPT Version :9

Sequence 1:	NP_523860.2	Gene:	zip / 38001	FlyBaseID:	FBgn0265434	Length:	2056	Species:	Drosophila melanogaster
Sequence 2:	NP_001093582.1	Gene:	MYH2 / 4620	HGNCID:	7572	Length:	1941	Species:	Homo sapiens

Alignment Length:	1967	Identity:	768/1967 - (39%)
Similarity:	1202/1967 - (61%)	Gaps:	73/1967 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly    63 ERNQFNDPATQAEWTQKRLVWVPHENQGFVAASIKREHGDEVEVELAETGKRVMILRDDIQKMNP 127
            ||.:..  |....:..|..|:|....:.||..:|:...|.:|.|: .|.|..:.:..|.:..|||
Human    21 ERERIE--AQNRPFDAKTSVFVAEPKESFVKGTIQSREGGKVTVK-TEGGATLTVKDDQVFPMNP 82

  Fly   128 PKFDKVEDMAELTCLNEASVLHNIKDRYYSGLIYTYSGLFCVVVNPYKKLPIYTEKIMERYKGIK 192
            ||:||:||||.:|.|:|.:||:|:|:||.:.:||||||||||.|||||.||:|..:::..|:|.|
Human    83 PKYDKIEDMAMMTHLHEPAVLYNLKERYAAWMIYTYSGLFCVTVNPYKWLPVYKPEVVTAYRGKK 147

  Fly   193 RHEVPPHVFAITDSAYRNMLGDREDQSILCTGESGAGKTENTKKVIQFLAYVAASKPKGSGAVPH 257
            |.|.|||:|:|:|:||:.||.|||:||||.|||||||||.|||:|||:.|
Human   148 RQEAPPHIFSISDNAYQFMLTDRENQSILITGESGAGKTVNTKRVIQYFA--------------- 197

  Fly   258 PAVLINFSVNTNKYIKVKIMAQNQNQTIEVVNGLKMVEVNSNCQEGELEQQLLQANPILEAFGNA 322
                                      ||.|....|..|:.|...:|.||.|::.|||:|||||||
Human   198 --------------------------TIAVTGEKKKEEITSGKIQGTLEDQIISANPLLEAFGNA 236

  Fly   323 KTVKNDNSSRFGKFIRINFDASGFISGANIETYLLEKSRAIRQAKDERTFHIFYQLLAGATPEQR 387
            |||:|||||||||||||:|..:|.::.|:||||||||||.:.|.|.||::|||||:.:...||..
Human   237 KTVRNDNSSRFGKFIRIHFGTTGKLASADIETYLLEKSRVVFQLKAERSYHIFYQITSNKKPELI 301

  Fly   388 EKFIL-DDVKSYAFLSNGSLPVPGVDDYAEFQATVKSMNIMGMTSEDFNSIFRIVSAVLLFGSMK 451
            |..:: .:...|.|:|.|.:.|..:||..|..||..:::|:|.|:|:..||:::..||:.:|::|
Human   302 EMLLITTNPYDYPFVSQGEISVASIDDQEELMATDSAIDILGFTNEEKVSIYKLTGAVMHYGNLK 366

  Fly   452 FRQERNNDQATLPDNT-VAQKIAHLLGLSVTDMTRAFLTPRIKVGRDFVTKAQTKEQVEFAVEAI 515
            |:|::..:||. ||.| ||.|.|:|..|:..|:.:|...||:|||.::|||.||.|||..||.|:
Human   367 FKQKQREEQAE-PDGTEVADKAAYLQSLNSADLLKALCYPRVKVGNEYVTKGQTVEQVSNAVGAL 430

  Fly   516 AKACYERMFKWLVNRINRSLDRTKRQGASFIGILDMAGFEIFELNSFEQLCINYTNEKLQQLFNH 580
            |||.||:||.|:|.|||:.|| ||:....|||:||:||||||:.||.||||||:|||||||.|||
Human   431 AKAVYEKMFLWMVARINQQLD-TKQPRQYFIGVLDIAGFEIFDFNSLEQLCINFTNEKLQQFFNH 494

  Fly   581 TMFILEQEEYQREGIEWKFIDFGLDLQPTIDLIDKPGGIMALLDEECWFPKATDKTFVDKLV--- 642
            .||:||||||::|||||.|||||:||...|:||:||.||.::|:|||.||||||.:|.:||.
Human   495 HMFVLEQEEYKKEGIEWTFIDFGMDLAACIELIEKPMGIFSILEEECMFPKATDTSFKNKLYDQH 559

  Fly   643 ---SAHSMHPKFMKTDFRGVADFAIVHYAGRVDYSAAKWLMKNMDPLNENIVSLLQGSQDPFVVN 704
               ||:...||.:|.  :..|.||::||||.|||:...||.||.|||||.:|.|.|.|....:..
Human   560 LGKSANFQKPKVVKG--KAEAHFALIHYAGVVDYNITGWLEKNKDPLNETVVGLYQKSAMKTLAQ 622

  Fly   705 IWKDAEIVGMAQQALTDTQFGARTRKGMFRTVSHLYKEQLAKLMDTLRNTNPNFVRCIIPNHEKR 769
            ::..|: ....:.|....:.|.:.:...|:|||.|::|.|.|||..||:|:|:||||||||..|.
Human   623 LFSGAQ-TAEGEGAGGGAKKGGKKKGSSFQTVSALFRENLNKLMTNLRSTHPHFVRCIIPNETKT 686

  Fly   770 AGKIDAPLVLDQLRCNGVLEGIRICRQGFPNRIPFQEFRQRYELLTPNVIPKG-FMDGKKACEKM 833
            .|.::..|||.|||||||||||||||:|||:||.:.:|:|||::|..:.||:| |:|.|||.||:
Human   687 PGAMEHELVLHQLRCNGVLEGIRICRKGFPSRILYADFKQRYKVLNASAIPEGQFIDSKKASEKL 751

  Fly   834 IQALELDSNLYRVGQSKIFFRAGVLAHLEEERDFKISDLIVNFQAFCRGFLARRNYQKRLQQLNA 898
            :.::::|...|:.|.:|:||:||:|..|||.||.|::.||...||.|||||||..||:.:::..|
Human   752 LASIDIDHTQYKFGHTKVFFKAGLLGLLEEMRDDKLAQLITRTQARCRGFLARVEYQRMVERREA 816

  Fly   899 IRIIQRNCAAYLKLRNWQWWRLYTKVKPLLEVTKQEEKLVQKEDELKQVREKLDTLAKNTQEYER 963
            |..||.|..:::.:::|.|.:|:.|:||||:..:.|:::...::|.::::::|.......:|.|.
Human   817 IFCIQYNIRSFMNVKHWPWMKLFFKIKPLLKSAETEKEMATMKEEFQKIKDELAKSEAKRKELEE 881

  Fly   964 KYQQALVEKTTLAEQLQAEIELCAEAEESRSRLMARKQELEDMMQELETRIEEEEERVLALGGEK 1028
            |....|.||..|..|:|||.|..|:|||...:|:..|.:||..::|:..|.|:|||....|..:|
Human   882 KMVTLLKEKNDLQLQVQAEAEGLADAEERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKK 946

  Fly  1029 KKLELNIQDLEEQLEEEEAARQKLQLEKVQLDAKIKKYEEDLALTDDQNQKLLKEKKLLEERAND 1093
            :|||....:|::.:::.|....|::.||...:.|:|...|::|..|:...||.||||.|:|....
Human   947 RKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQ 1011

  Fly  1094 LSQTLAEEEEKAKHLAKLKAKHEATISELEERLHKDQQQRQESDRSKRKIETEVADLKEQL---- 1154
            ....|..||:|...|.|.|.|.|..:.:||..|.::::.|.:.:|:|||:|.::...:|.:
Human  1012 TLDDLQAEEDKVNTLTKAKIKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQESIMDIE 1076

  Fly  1155 NERRVQVDEMQAQLAKREEELTQTLLRIDEESATKATAQKAQRELESQLAEIQEDLEAEKAARAK 1219
            ||:: |:||   :|.|:|.|::....:|::|.|.....||..:||::::.|::|::|||:|:|||
Human  1077 NEKQ-QLDE---KLKKKEFEISNLQSKIEDEQALGIQLQKKIKELQARIEELEEEIEAERASRAK 1137

  Fly  1220 AEKVRRDLSEELEALKNELLDSLDTTAAQQELRSKREQELATLKKSLEEETVNHEGVLADMRHKH 1284
            |||.|.|||.|||.:...|.::...|:||.|:..|||.|...:::.|||.|:.||...|.:|.||
Human  1138 AEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKH 1202

  Fly  1285 SQELNSINDQLENLRKAKTVLEKAKGTLEAENADLATELRSVNSSRQENDRRRKQAESQIAELQV 1349
            :..:..:.:|::||::.|..|||.|..::.|..|||:.:.:|:.::...::..:..|.|::||:.
Human  1203 ADSVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNVETVSKAKGNLEKMCRTLEDQLSELKS 1267

  Fly  1350 KLAEIERARSELQEKCTKLQQEAENITNQLEEAELKASAAVKSASNMESQLTEAQQLLEEETRQK 1414
            |..|.:|..::|..:..:||.|:...:.||:|.|...|...:.......|:.|.::.||||.:.|
Human  1268 KEEEQQRLINDLTAQRGRLQTESGEFSRQLDEKEALVSQLSRGKQAFTQQIEELKRQLEEEIKAK 1332

  Fly  1415 LGLSSKLRQIESEKEALQEQLEEDDEAKRNYERKLAEVTTQMQEIKKKAEEDA-DLAKELEEGKK 1478
            ..|:..|:....:.:.|:||.||:.|:|...:|.|::..|::.:.:.|.|.|| ...:||||.||
Human  1333 NALAHALQSSRHDCDLLREQYEEEQESKAELQRALSKANTEVAQWRTKYETDAIQRTEELEEAKK 1397

  Fly  1479 RLNKDIEALERQVKELIAQNDRLDKSKKKIQSELEDATIELEAQRTKVLELEKKQKNFDKILAEE 1543
            :|.:.::|.|..|:.:.|:...|:|:|:::|:|:||..:::|........|:|||:||||||||.
Human  1398 KLAQRLQAAEEHVEAVNAKCASLEKTKQRLQNEVEDLMLDVERTNAACAALDKKQRNFDKILAEW 1462

  Fly  1544 KAISEQIAQERDTAEREAREKETKVLSVSRELDEAFDKIEDLENKRKTLQNELDDLANTQGTADK 1608
            |...|:...|.:.:::|||...|::..:....:|:.|::|.|:.:.|.||.|:.||........|
Human  1463 KQKCEETHAELEASQKEARSLGTELFKIKNAYEESLDQLETLKRENKNLQQEISDLTEQIAEGGK 1527

  Fly  1609 NVHELEKAKRALESQLAELKAQNEELEDDLQLTEDAKLRLEVNMQALRSQFERDLLAKEEGAEEK 1673
            .:|||||.|:.:|.:..||:|..||.|..|:..|...||:::.:..::|:.:|.:..|:|..::.
Human  1528 RIHELEKIKKQVEQEKCELQAALEEAEASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQL 1592

  Fly  1674 RRGLVKQLRDLETELDEERKQRTAAVASKKKLEGDLKEIETTMEMHNKVKEDALKHAKKLQAQVK 1738
            :|..::.:..:::.||.|.:.|..|:..|||:||||.|:|..:...|::..:||::.:..|..:|
Human  1593 KRNHIRIVESMQSTLDAEIRSRNDAIRLKKKMEGDLNEMEIQLNHANRMAAEALRNYRNTQGILK 1657

  Fly  1739 DALRDAEEAKAAKEELQALSKEAERKVKALEAEVLQLTEDLASSERARRAAETERDELAEEIANN 1803
            |.....::|..::|:|:......||:...|:||:.:|...|..:||:|:.||.|..:.:|.:...
Human  1658 DTQIHLDDALRSQEDLKEQLAMVERRANLLQAEIEELRATLEQTERSRKIAEQELLDASERVQLL 1722

  Fly  1804 ANKGSLMIDEKRRLEARIATLEEELE---EEQSNSEVLLDRSRKAQLQIEQLTTELANEKSNSQK 1865
            ..:.:.:|:.|::||..|:.::.|:|   :|..|:|   ::::||......:..||..|:..|..
Human  1723 HTQNTSLINTKKKLETDISQMQGEMEDILQEARNAE---EKAKKAITDAAMMAEELKKEQDTSAH 1784

  Fly  1866 NENGRALLERQNKELKAKLAEIETAQRTKVKATIATLEAKIANLEEQLENEGKERLLQQKANRKM 1930
            .|..:..:|:..|:|:.:|.|.|.......|..|..|||::..||.::|:|.|......|..||.
Human  1785 LERMKKNMEQTVKDLQLRLDEAEQLALKGGKKQIQKLEARVRELEGEVESEQKRNAEAVKGLRKH 1849

  Fly  1931 DKKIKELTMNIEDERRHVDQHKEQMDKLNSRIKLLKRNLDETEEELQKEKTQKRKYQRECEDMIE 1995
            ::::||||...|::|:::.:.::.:|||.:::|..||..:|.||:......:.||.|.|.|:..|
Human  1850 ERRVKELTYQTEEDRKNILRLQDLVDKLQAKVKSYKRQAEEAEEQSNTNLAKFRKLQHELEEAEE 1914

  Fly  1996 SQEAMNREINSLKTKLR 2012
            ..:....::|.|:.|.|
Human  1915 RADIAESQVNKLRVKSR 1931

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
zip	NP_523860.2	Myosin_N	80..117	CDD:280832	10/36 (28%)
		Myosin_head	133..854	CDD:278492	364/729 (50%)
		MYSc_Myh2_insects_mollusks	145..854	CDD:276876	357/717 (50%)
		Myosin_tail_1	931..2011	CDD:279860	344/1087 (32%)
		Prefoldin	1431..1515	CDD:298833	31/84 (37%)
		FAM76	<1847..1926	CDD:292665	21/78 (27%)
MYH2	NP_001093582.1	Myosin_N	36..73	CDD:280832	10/37 (27%)
		Myosin_head	88..772	CDD:278492	364/729 (50%)
		MYSc_Myh2_mammals	100..772	CDD:276877	357/717 (50%)
		Actin-binding. /evidence=ECO:0000250	661..683		15/21 (71%)
		Actin-binding. /evidence=ECO:0000250	763..777		6/13 (46%)
		Myosin_tail_1	852..1929	CDD:279860	344/1083 (32%)
		RILP-like	967..1100	CDD:304877	44/136 (32%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1128..1149		14/20 (70%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1155..1174		6/18 (33%)
		DUF342	<1672..1769	CDD:302792	27/99 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0161
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D47111at2759
OrthoFinder	1	1.000	-	-		FOG0000014
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100110
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X58
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.720