DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment zip and MYH1

DIOPT Version :9

Sequence 1:NP_523860.2 Gene:zip / 38001 FlyBaseID:FBgn0265434 Length:2056 Species:Drosophila melanogaster
Sequence 2:NP_005954.3 Gene:MYH1 / 4619 HGNCID:7567 Length:1939 Species:Homo sapiens


Alignment Length:1971 Identity:768/1971 - (38%)
Similarity:1199/1971 - (60%) Gaps:83/1971 - (4%)


- Green bases have known domain annotations that are detailed below.


  Fly    63 ERNQFNDPATQAEWTQKRLVWVPHENQGFVAASIKREHGDEVEVELAETGKRVMILRDDIQKMNP 127
            ||.:..  |....:..|..|:|....:.||.|:::...|.:|..: .|.|..|.:..|.:..|||
Human    21 ERERIE--AQNKPFDAKTSVFVVDPKESFVKATVQSREGGKVTAK-TEAGATVTVKDDQVFPMNP 82

  Fly   128 PKFDKVEDMAELTCLNEASVLHNIKDRYYSGLIYTYSGLFCVVVNPYKKLPIYTEKIMERYKGIK 192
            ||:||:||||.:|.|:|.:||:|:|:||.:.:||||||||||.|||||.||:|..:::..|:|.|
Human    83 PKYDKIEDMAMMTHLHEPAVLYNLKERYAAWMIYTYSGLFCVTVNPYKWLPVYNAEVVTAYRGKK 147

  Fly   193 RHEVPPHVFAITDSAYRNMLGDREDQSILCTGESGAGKTENTKKVIQFLAYVAASKPKGSGAVPH 257
            |.|.|||:|:|:|:||:.||.|||:||||.|||||||||.|||:|||:.|               
Human   148 RQEAPPHIFSISDNAYQFMLTDRENQSILITGESGAGKTVNTKRVIQYFA--------------- 197

  Fly   258 PAVLINFSVNTNKYIKVKIMAQNQNQTIEVVNGLKMVEVNSNCQEGELEQQLLQANPILEAFGNA 322
                                      ||.|....|..||.|...:|.||.|::.|||:|||||||
Human   198 --------------------------TIAVTGEKKKEEVTSGKMQGTLEDQIISANPLLEAFGNA 236

  Fly   323 KTVKNDNSSRFGKFIRINFDASGFISGANIETYLLEKSRAIRQAKDERTFHIFYQLLAGATPEQR 387
            |||:|||||||||||||:|..:|.::.|:||||||||||...|.|.||::|||||:::...|:..
Human   237 KTVRNDNSSRFGKFIRIHFGTTGKLASADIETYLLEKSRVTFQLKAERSYHIFYQIMSNKKPDLI 301

  Fly   388 EKFIL-DDVKSYAFLSNGSLPVPGVDDYAEFQATVKSMNIMGMTSEDFNSIFRIVSAVLLFGSMK 451
            |..:: .:...|||:|.|.:.||.:||..|..||..::.|:|.||::..||:::..||:.:|:||
Human   302 EMLLITTNPYDYAFVSQGEITVPSIDDQEELMATDSAIEILGFTSDERVSIYKLTGAVMHYGNMK 366

  Fly   452 FRQERNNDQATLPDNT-VAQKIAHLLGLSVTDMTRAFLTPRIKVGRDFVTKAQTKEQVEFAVEAI 515
            |:|::..:||. ||.| ||.|.|:|..|:..|:.:|...||:|||.::|||.||.:||..||.|:
Human   367 FKQKQREEQAE-PDGTEVADKAAYLQNLNSADLLKALCYPRVKVGNEYVTKGQTVQQVYNAVGAL 430

  Fly   516 AKACYERMFKWLVNRINRSLDRTKRQGASFIGILDMAGFEIFELNSFEQLCINYTNEKLQQLFNH 580
            |||.|::||.|:|.|||:.|| ||:....|||:||:||||||:.||.||||||:|||||||.|||
Human   431 AKAVYDKMFLWMVTRINQQLD-TKQPRQYFIGVLDIAGFEIFDFNSLEQLCINFTNEKLQQFFNH 494

  Fly   581 TMFILEQEEYQREGIEWKFIDFGLDLQPTIDLIDKPGGIMALLDEECWFPKATDKTFVDKLVSAH 645
            .||:||||||::|||||.|||||:||...|:||:||.||.::|:|||.||||||.:|.:||...|
Human   495 HMFVLEQEEYKKEGIEWTFIDFGMDLAACIELIEKPMGIFSILEEECMFPKATDTSFKNKLYEQH 559

  Fly   646 ------SMHPKFMKTDFRGVADFAIVHYAGRVDYSAAKWLMKNMDPLNENIVSLLQGSQDP---- 700
                  ...||..|.  :..|.|:::||||.|||:.|.||.||.|||||.:|.|.|.|...    
Human   560 LGKSNNFQKPKPAKG--KPEAHFSLIHYAGTVDYNIAGWLDKNKDPLNETVVGLYQKSAMKTLAL 622

  Fly   701 -FVVNIWKDAEIVGMAQQALTDTQFGARTRKGMFRTVSHLYKEQLAKLMDTLRNTNPNFVRCIIP 764
             ||.....:||..|..:        |.:.:...|:|||.|::|.|.|||..||:|:|:|||||||
Human   623 LFVGATGAEAEAGGGKK--------GGKKKGSSFQTVSALFRENLNKLMTNLRSTHPHFVRCIIP 679

  Fly   765 NHEKRAGKIDAPLVLDQLRCNGVLEGIRICRQGFPNRIPFQEFRQRYELLTPNVIPKG-FMDGKK 828
            |..|..|.::..|||.|||||||||||||||:|||:||.:.:|:|||::|..:.||:| |:|.||
Human   680 NETKTPGAMEHELVLHQLRCNGVLEGIRICRKGFPSRILYADFKQRYKVLNASAIPEGQFIDSKK 744

  Fly   829 ACEKMIQALELDSNLYRVGQSKIFFRAGVLAHLEEERDFKISDLIVNFQAFCRGFLARRNYQKRL 893
            |.||::.::::|...|:.|.:|:||:||:|..|||.||.|::.||...||.|||||||..|||.:
Human   745 ASEKLLGSIDIDHTQYKFGHTKVFFKAGLLGLLEEMRDEKLAQLITRTQAMCRGFLARVEYQKMV 809

  Fly   894 QQLNAIRIIQRNCAAYLKLRNWQWWRLYTKVKPLLEVTKQEEKLVQKEDELKQVREKLDTLAKNT 958
            ::..:|..||.|..|::.:::|.|.:||.|:||||:..:.|:::...::|.::.:|:|.......
Human   810 ERRESIFCIQYNVRAFMNVKHWPWMKLYFKIKPLLKSAETEKEMANMKEEFEKTKEELAKTEAKR 874

  Fly   959 QEYERKYQQALVEKTTLAEQLQAEIELCAEAEESRSRLMARKQELEDMMQELETRIEEEEERVLA 1023
            :|.|.|....:.||..|..|:|||.:..|:|||...:|:..|.:||..::|:..|.|:|||....
Human   875 KELEEKMVTLMQEKNDLQLQVQAEADSLADAEERCDQLIKTKIQLEAKIKEVTERAEDEEEINAE 939

  Fly  1024 LGGEKKKLELNIQDLEEQLEEEEAARQKLQLEKVQLDAKIKKYEEDLALTDDQNQKLLKEKKLLE 1088
            |..:|:|||....:|::.:::.|....|::.||...:.|:|...|::|..|:...||.||||.|:
Human   940 LTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQ 1004

  Fly  1089 ERANDLSQTLAEEEEKAKHLAKLKAKHEATISELEERLHKDQQQRQESDRSKRKIETEVADLKE- 1152
            |........|..||:|...|.|.|.|.|..:.:||..|.::::.|.:.:|:|||:|.::...:| 
Human  1005 EAHQQTLDDLQAEEDKVNTLTKAKIKLEQQVDDLEGSLEQEKKIRMDLERAKRKLEGDLKLAQES 1069

  Fly  1153 --QLNERRVQVDEMQAQLAKREEELTQTLLRIDEESATKATAQKAQRELESQLAEIQEDLEAEKA 1215
              .:...:.|:||   :|.|:|.|::....:|::|.|.....||..:||::::.|::|::|||:|
Human  1070 TMDIENDKQQLDE---KLKKKEFEMSGLQSKIEDEQALGMQLQKKIKELQARIEELEEEIEAERA 1131

  Fly  1216 ARAKAEKVRRDLSEELEALKNELLDSLDTTAAQQELRSKREQELATLKKSLEEETVNHEGVLADM 1280
            :||||||.|.|||.|||.:...|.::...|:||.|:..|||.|...:::.|||.|:.||...|.:
Human  1132 SRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATL 1196

  Fly  1281 RHKHSQELNSINDQLENLRKAKTVLEKAKGTLEAENADLATELRSVNSSRQENDRRRKQAESQIA 1345
            |.||:..:..:.:|::||::.|..|||.|..::.|..|||:.:.:|:.::...::..:..|.|::
Human  1197 RKKHADSVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNMETVSKAKGNLEKMCRALEDQLS 1261

  Fly  1346 ELQVKLAEIERARSELQEKCTKLQQEAENITNQLEEAELKASAAVKSASNMESQLTEAQQLLEEE 1410
            |::.|..|.:|..::|..:..:||.|:...:.||:|.:...|...:.......|:.|.::.||||
Human  1262 EIKTKEEEQQRLINDLTAQRARLQTESGEYSRQLDEKDTLVSQLSRGKQAFTQQIEELKRQLEEE 1326

  Fly  1411 TRQKLGLSSKLRQIESEKEALQEQLEEDDEAKRNYERKLAEVTTQMQEIKKKAEEDA-DLAKELE 1474
            .:.|..|:..|:....:.:.|:||.||:.|||...:|.:::..:::.:.:.|.|.|| ...:|||
Human  1327 IKAKSALAHALQSSRHDCDLLREQYEEEQEAKAELQRAMSKANSEVAQWRTKYETDAIQRTEELE 1391

  Fly  1475 EGKKRLNKDIEALERQVKELIAQNDRLDKSKKKIQSELEDATIELEAQRTKVLELEKKQKNFDKI 1539
            |.||:|.:.::..|..|:.:.|:...|:|:|:::|:|:||..|::|........|:|||:|||||
Human  1392 EAKKKLAQRLQDAEEHVEAVNAKCASLEKTKQRLQNEVEDLMIDVERTNAACAALDKKQRNFDKI 1456

  Fly  1540 LAEEKAISEQIAQERDTAEREAREKETKVLSVSRELDEAFDKIEDLENKRKTLQNELDDLANTQG 1604
            |||.|...|:...|.:.:::|:|...|::..:....:|:.|::|.|:.:.|.||.|:.||.....
Human  1457 LAEWKQKCEETHAELEASQKESRSLSTELFKIKNAYEESLDQLETLKRENKNLQQEISDLTEQIA 1521

  Fly  1605 TADKNVHELEKAKRALESQLAELKAQNEELEDDLQLTEDAKLRLEVNMQALRSQFERDLLAKEEG 1669
            ...|.:|||||.|:.:|.:.:||:|..||.|..|:..|...||:::.:..::|:.:|.:..|:|.
Human  1522 EGGKRIHELEKIKKQVEQEKSELQAALEEAEASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEE 1586

  Fly  1670 AEEKRRGLVKQLRDLETELDEERKQRTAAVASKKKLEGDLKEIETTMEMHNKVKEDALKHAKKLQ 1734
            .::.:|..::.:..:::.||.|.:.|..|:..|||:||||.|:|..:...|::..:||::.:..|
Human  1587 IDQMKRNHIRIVESMQSTLDAEIRSRNDAIRLKKKMEGDLNEMEIQLNHANRMAAEALRNYRNTQ 1651

  Fly  1735 AQVKDALRDAEEAKAAKEELQALSKEAERKVKALEAEVLQLTEDLASSERARRAAETERDELAEE 1799
            |.:||.....::|..::|:|:......||:...|:||:.:|...|..:||:|:.||.|..:.:|.
Human  1652 AILKDTQLHLDDALRSQEDLKEQLAMVERRANLLQAEIEELRATLEQTERSRKIAEQELLDASER 1716

  Fly  1800 IANNANKGSLMIDEKRRLEARIATLEEELE---EEQSNSEVLLDRSRKAQLQIEQLTTELANEKS 1861
            :.....:.:.:|:.|::||..|:.::.|:|   :|..|:|   ::::||......:..||..|:.
Human  1717 VQLLHTQNTSLINTKKKLETDISQIQGEMEDIIQEARNAE---EKAKKAITDAAMMAEELKKEQD 1778

  Fly  1862 NSQKNENGRALLERQNKELKAKLAEIETAQRTKVKATIATLEAKIANLEEQLENEGKERLLQQKA 1926
            .|...|..:..||:..|:|:.:|.|.|.......|..|..|||::..||.::|:|.|..:...|.
Human  1779 TSAHLERMKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQKLEARVRELEGEVESEQKRNVEAVKG 1843

  Fly  1927 NRKMDKKIKELTMNIEDERRHVDQHKEQMDKLNSRIKLLKRNLDETEEELQKEKTQKRKYQRECE 1991
            .||.::|:||||...|::|:::.:.::.:|||.:::|..||..:|.||:.....::.|:.|.|.|
Human  1844 LRKHERKVKELTYQTEEDRKNILRLQDLVDKLQAKVKSYKRQAEEAEEQSNVNLSKFRRIQHELE 1908

  Fly  1992 DMIESQEAMNREINSLKTKLR 2012
            :..|..:....::|.|:.|.|
Human  1909 EAEERADIAESQVNKLRVKSR 1929

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
zipNP_523860.2 Myosin_N 80..117 CDD:280832 10/36 (28%)
Myosin_head 133..854 CDD:278492 367/734 (50%)
MYSc_Myh2_insects_mollusks 145..854 CDD:276876 360/722 (50%)
Myosin_tail_1 931..2011 CDD:279860 339/1086 (31%)
Prefoldin 1431..1515 CDD:298833 29/84 (35%)
FAM76 <1847..1926 CDD:292665 22/78 (28%)
MYH1NP_005954.3 Myosin_N 36..73 CDD:280832 10/37 (27%)
Myosin_head 88..770 CDD:278492 367/734 (50%)
MYSc_Myh1_mammals 100..770 CDD:276875 360/722 (50%)
Actin-binding. /evidence=ECO:0000250 659..681 15/21 (71%)
Actin-binding. /evidence=ECO:0000250 761..775 6/13 (46%)
Myosin_tail_1 850..1927 CDD:279860 339/1082 (31%)
RILP-like 965..1098 CDD:304877 42/135 (31%)
MIT_CorA-like <1299..>1411 CDD:294313 32/111 (29%)
DUF342 <1506..1582 CDD:302792 26/75 (35%)
DUF342 <1670..1767 CDD:302792 27/99 (27%)
TMPIT 1744..>1853 CDD:285135 33/111 (30%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG0161
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D47111at2759
OrthoFinder 1 1.000 - - FOG0000014
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100110
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X58
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
65.720

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