DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment zip and myh3

DIOPT Version :9

Sequence 1:	NP_523860.2	Gene:	zip / 38001	FlyBaseID:	FBgn0265434	Length:	2056	Species:	Drosophila melanogaster
Sequence 2:	NP_001006915.1	Gene:	myh3 / 448762	XenbaseID:	XB-GENE-989276	Length:	1935	Species:	Xenopus tropicalis

Alignment Length:	1950	Identity:	748/1950 - (38%)
Similarity:	1186/1950 - (60%)	Gaps:	81/1950 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly    82 VWVPHENQGFVAASIKREHGDEVEVELAETGKRVMILRDDIQKMNPPKFDKVEDMAELTCLNEAS 146
            ::|....:.:|..:::.:.|.:..|: .|.|:.|.:..|.|..||||||||:||||.:|.|||.|
Frog    38 MFVVDTKESYVKGTLQSKEGGKATVK-TEAGQTVTVKDDQIFPMNPPKFDKIEDMAMMTHLNEPS 101

  Fly   147 VLHNIKDRYYSGLIYTYSGLFCVVVNPYKKLPIYTEKIMERYKGIKRHEVPPHVFAITDSAYRNM 211
            ||:|:|:||.:.:||||||||||.|||||.||:|..:::..|:|.||.|.|||:|:|:|:||:.|
Frog   102 VLYNLKERYAAWMIYTYSGLFCVTVNPYKWLPVYNPEVVNAYRGKKRQEAPPHIFSISDNAYQFM 166

  Fly   212 LGDREDQSILCTGESGAGKTENTKKVIQFLAYVAASKPKGSGAVPHPAVLINFSVNTNKYIKVKI 276
            |.|||:||||.|||||||||.|||:|||:.|.:||:..|
Frog   167 LTDRENQSILITGESGAGKTVNTKRVIQYFATIAAAPDK-------------------------- 205

  Fly   277 MAQNQNQTIEVVNGLKMVEVNSNCQEGELEQQLLQANPILEAFGNAKTVKNDNSSRFGKFIRINF 341
                           |..||...  :|.||.|::||||:||||||||||:|||||||||||||:|
Frog   206 ---------------KKEEVAKT--KGTLEDQIIQANPLLEAFGNAKTVRNDNSSRFGKFIRIHF 253

  Fly   342 DASGFISGANIETYLLEKSRAIRQAKDERTFHIFYQLLAGATPEQREKFIL-DDVKSYAFLSNGS 405
            ..:|.::.|:||||||||||...|.|.||::|||||:::...||..|..:: .:...:.|:|.|.
Frog   254 GTTGKLASADIETYLLEKSRVTFQLKAERSYHIFYQIMSNKKPELIEMLLITTNPYDFPFVSQGE 318

  Fly   406 LPVPGVDDYAEFQATVKSMNIMGMTSEDFNSIFRIVSAVLLFGSMKFRQERNNDQATLPDNT-VA 469
            :.|..:||..|..||..:::|:|..:::..||:::..||:.:|:|:|:|::..:||. ||.| ||
Frog   319 ISVASIDDTEELMATDSAIDILGFNADEKVSIYKLTGAVMHYGNMRFKQKQREEQAE-PDGTEVA 382

  Fly   470 QKIAHLLGLSVTDMTRAFLTPRIKVGRDFVTKAQTKEQVEFAVEAIAKACYERMFKWLVNRINRS 534
            .|.|:|:.|:..|:.:|...||:|||.::|||.||.:||..:|.|:.||.||:||.|:|.|||..
Frog   383 DKAAYLMCLNSADLLKALCYPRVKVGNEYVTKGQTVQQVYNSVGALGKAVYEKMFLWMVTRINEM 447

  Fly   535 LDRTKRQGASFIGILDMAGFEIFELNSFEQLCINYTNEKLQQLFNHTMFILEQEEYQREGIEWKF 599
            || ||:....|||:||:||||||:.||.||||||:|||||||.|||.||:||||||::|||||:|
Frog   448 LD-TKQPRQYFIGVLDIAGFEIFDFNSLEQLCINFTNEKLQQFFNHHMFVLEQEEYKKEGIEWEF 511

  Fly   600 IDFGLDLQPTIDLIDKPGGIMALLDEECWFPKATDKTFVDKLVSAH------SMHPKFMKTDFRG 658
            ||||:||...|:||:||.||.::|:|||.||||||.:|.:||...|      ...||..|.  :.
Frog   512 IDFGMDLAACIELIEKPMGIFSILEEECMFPKATDTSFKNKLYDQHLGKSNNFQKPKPAKG--KA 574

  Fly   659 VADFAIVHYAGRVDYSAAKWLMKNMDPLNENIVSLLQGSQD---PFVVNIWKDAEIVGMAQQALT 720
            .|.|::|||||.|||:.:.||.||.||||:.::.|.|.|..   .::.:.:..:|..|..:
Frog   575 EAHFSLVHYAGTVDYNISGWLEKNKDPLNDTVIGLFQKSSMKTLAYLFSSYAASEAEGAKK---- 635

  Fly   721 DTQFGARTRKGMFRTVSHLYKEQLAKLMDTLRNTNPNFVRCIIPNHEKRAGKIDAPLVLDQLRCN 785
                |.:.:...|:|||.|::|.|.|||..||.|:|:||||||||..|..|.::..|||.|||||
Frog   636 ----GGKKKGSSFQTVSALFRENLNKLMSNLRTTHPHFVRCIIPNETKTPGAMEHELVLHQLRCN 696

  Fly   786 GVLEGIRICRQGFPNRIPFQEFRQRYELLTPNVIPKG-FMDGKKACEKMIQALELDSNLYRVGQS 849
            ||||||||||:|||:||.:.:|:|||::|..:.||:| |:|.|||.||::.::::|...||.|.:
Frog   697 GVLEGIRICRKGFPSRILYGDFKQRYKILNASAIPEGQFIDSKKASEKLLGSIDVDHTQYRFGHT 761

  Fly   850 KIFFRAGVLAHLEEERDFKISDLIVNFQAFCRGFLARRNYQKRLQQLNAIRIIQRNCAAYLKLRN 914
            |:||:||:|..|||.||.:::.:|...||.|||:|.|..::|.:::..|:..||.|..:::.:::
Frog   762 KVFFKAGLLGTLEEMRDDRLAHVITRTQAMCRGYLMRVEFKKMMERREAVFTIQYNIRSFMNVKH 826

  Fly   915 WQWWRLYTKVKPLLEVTKQEEKLVQKEDELKQVREKLDTLAKNTQEYERKYQQALVEKTTLAEQL 979
            |.|.:||.|:||||:..:.|:::...::|.::.:|.|.......:|.|.|..:.|.||..|..|:
Frog   827 WPWMKLYFKIKPLLKSAESEKEMQNMKEEFEKTKELLAKSEAKRKELEEKMVKVLQEKNDLQLQV 891

  Fly   980 QAEIELCAEAEESRSRLMARKQELEDMMQELETRIEEEEERVLALGGEKKKLELNIQDLEEQLEE 1044
            |:|.|...:|||...:|:..|.:||..|:||..|:|:|||....|..:|:|||....:|::.:::
Frog   892 QSESENLTDAEERCDQLIKSKIQLEAKMKELNERLEDEEESNAELTAKKRKLEDECSELKKDIDD 956

  Fly  1045 EEAARQKLQLEKVQLDAKIKKYEEDLALTDDQNQKLLKEKKLLEERANDLSQTLAEEEEKAKHLA 1109
            .|....|::.||...:.|:|...|::|:.|:...||.||||.|:|........|..||:|...|.
Frog   957 LELTLAKVEKEKHATENKVKNLTEEMAVLDETIVKLTKEKKALQEAHQQTLDDLQAEEDKVNTLT 1021

  Fly  1110 KLKAKHEATISELEERLHKDQQQRQESDRSKRKIETEVADLKE---QLNERRVQVDEMQAQLAKR 1171
            |.|||.|..:.:||..|.::::.|.:.:|||||:|.::...:|   .|...|.|:||   :|.|:
Frog  1022 KAKAKLEQQVDDLEGSLEQEKKLRMDLERSKRKLEGDLKLAQETIMDLENDRQQLDE---KLKKK 1083

  Fly  1172 EEELTQTLLRIDEESATKATAQKAQRELESQLAEIQEDLEAEKAARAKAEKVRRDLSEELEALKN 1236
            |.|::|...:|::|.|..|..||..:||::::.|::|::|||:||||||||.|.|||.|||.:..
Frog  1084 EFEMSQYASKIEDEQALGAQLQKKIKELQARIEELEEEIEAERAARAKAEKQRSDLSRELEEISE 1148

  Fly  1237 ELLDSLDTTAAQQELRSKREQELATLKKSLEEETVNHEGVLADMRHKHSQELNSINDQLENLRKA 1301
            .|.::...|:||.|:..|||.|...:::.|||.|:.||...|.:|.|.:..:..:.:|::||::.
Frog  1149 RLEEAGGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAAALRKKQADSVAELGEQIDNLQRV 1213

  Fly  1302 KTVLEKAKGTLEAENADLATELRSVNSSRQENDRRRKQAESQIAELQVKLAEIERARSELQEKCT 1366
            |..|||.|..|:.|..|||:.:.:::.::...::..:..|.|::||:.|..|.:|..::|..:..
Frog  1214 KQKLEKEKSELKMEIDDLASNMENLSKAKANFEKICRTLEDQLSELKTKDEEHQRQINDLTAQRA 1278

  Fly  1367 KLQQEAENITNQLEEAELKASAAVKSASNMESQLTEAQQLLEEETRQKLGLSSKLRQIESEKEAL 1431
            :||.|......||||.:...|...:.......|:.|.::.||||.:.|..|:..|:....:.:.|
Frog  1279 RLQTENGEYARQLEERDSLISQLSRGKQAFTQQIEELKRQLEEEIKAKNALAHGLQSARHDCDLL 1343

  Fly  1432 QEQLEEDDEAKRNYERKLAEVTTQMQEIKKKAEEDA-DLAKELEEGKKRLNKDIEALERQVKELI 1495
            :||.||:.|||...:|.|::...::.:.:.|.|.|| ...:|||:.||:|.:.::..|..::.:.
Frog  1344 REQYEEEQEAKGELQRSLSKANGEVAQWRTKYETDAIQRTEELEDAKKKLAQRLQEAEEHIEAVN 1408

  Fly  1496 AQNDRLDKSKKKIQSELEDATIELEAQRTKVLELEKKQKNFDKILAEEKAISEQIAQERDTAERE 1560
            ::...|:|:|:::|:|:||..:::|...:....|:||||||||||||.|...|:...|.:.:::|
Frog  1409 SKCASLEKTKQRLQNEVEDLMVDVERSNSACAALDKKQKNFDKILAEWKQKFEESQAELEASQKE 1473

  Fly  1561 AREKETKVLSVSRELDEAFDKIEDLENKRKTLQNELDDLANTQGTADKNVHELEKAKRALESQLA 1625
            :|...|::..:....:|:.|.:|..:.:.|.||.|:.||........|.:||:||||:.:|.:..
Frog  1474 SRSLSTELFKMKNAYEESLDHLETTKRENKNLQQEISDLTEQVSEVSKTLHEVEKAKKIIEQEKT 1538

  Fly  1626 ELKAQNEELEDDLQLTEDAKLRLEVNMQALRSQFERDLLAKEEGAEEKRRGLVKQLRDLETELDE 1690
            |:::..||.|..|:..|...||:::.:..::|:.:|.:..|:|..::.:|..|:.:..:::.||.
Frog  1539 EIQSALEEAEASLEHEEGKILRIQLELNQVKSEIDRKIAEKDEEIDQLKRNHVRVVESMQSTLDA 1603

  Fly  1691 ERKQRTAAVASKKKLEGDLKEIETTMEMHNKVKEDALKHAKKLQAQVKDALRDAEEAKAAKEELQ 1755
            |.:.|..|:..|||:||||.|:|..:...|:...::.|..:.:|..:||.....:::..|:|:|:
Frog  1604 EIRSRNDALRLKKKMEGDLNEMEIQLSHANRQASESQKQLRNVQGLLKDVQIHLDDSLRAQEDLK 1668

  Fly  1756 ALSKEAERKVKALEAEVLQLTEDLASSERARRAAETERDELAEEIANNANKGSLMIDEKRRLEAR 1820
            ......||:...::||:.::...|..:||:|:.||.|..:.:|.:....::.:.:|:.|:::|..
Frog  1669 EQLAMVERRANLMQAEIEEMRAALEQTERSRKVAEQELLDASERVQLLHSQNTSLINTKKKMETD 1733

  Fly  1821 IATLEEELEE---EQSNSEVLLDRSRKAQLQIEQLTTELANEKSNSQKNENGRALLERQNKELKA 1882
            |..|:.|:||   |..|:|   ::::||......:..||..|:..|...|..:..|::..|:|:.
Frog  1734 ITQLQTEVEEAIQEARNAE---EKAKKAITDAAMMAEELKKEQDTSAHLERMKKNLDQTVKDLQH 1795

  Fly  1883 KLAEIETAQRTKVKATIATLEAKIANLEEQLENEGKERLLQQKANRKMDKKIKELTMNIEDERRH 1947
            :|.|.|.......|..|..|||::..||.:::.|.|......|..||.::::|||:...|:::::
Frog  1796 RLDEAEQLAMKGGKKQIQKLEARVRELENEVDVEQKRSTEAIKGVRKYERRVKELSYQSEEDKKN 1860

  Fly  1948 VDQHKEQMDKLNSRIKLLKRNLDETEEELQKEKTQKRKYQRECEDMIESQEAMNREINSLKTKLR 2012
            :.:.::.:|||..::|..||..:|.||:.....|:.||.|.|.|:..|..:....::|.|:.|.|
Frog  1861 ILRLQDLVDKLQMKVKAYKRQTEEIEEQSNINLTKYRKIQHELEEAEERADIAESQVNKLRAKTR 1925

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
zip	NP_523860.2	Myosin_N	80..117	CDD:280832	7/34 (21%)
		Myosin_head	133..854	CDD:278492	359/732 (49%)
		MYSc_Myh2_insects_mollusks	145..854	CDD:276876	351/720 (49%)
		Myosin_tail_1	931..2011	CDD:279860	339/1086 (31%)
		Prefoldin	1431..1515	CDD:298833	27/84 (32%)
		FAM76	<1847..1926	CDD:292665	20/78 (26%)
myh3	NP_001006915.1	Myosin_N	35..73	CDD:367160	7/35 (20%)
		Motor_domain	100..766	CDD:354959	351/720 (49%)
		Myosin_tail_1	846..1923	CDD:366712	339/1082 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D47111at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010