Protein Alignment zip and myh3

DIOPT Version :10

• Sequence 1: NP_523860.2
• Gene: zip / 38001
• FlyBaseID: FBgn0287873
• Length: 2056
• Species: Drosophila melanogaster
• Sequence 2: NP_001006915.1
• Gene: myh3 / 448762
• XenbaseID: XB-GENE-989276
• Length: 1935
• Species: Xenopus tropicalis
• Alignment Length: 1950
• Identity: 748/1950 - (38%)
• Similarity: 1186/1950 - (60%)
• Gaps: 81/1950 - (4%)

  Fly    82 VWVPHENQGFVAASIKREHGDEVEVELAETGKRVMILRDDIQKMNPPKFDKVEDMAELTCLNEAS 146
            ::|....:.:|..:::.:.|.:..|: .|.|:.|.:..|.|..||||||||:||||.:|.|||.|
 Frog    38 MFVVDTKESYVKGTLQSKEGGKATVK-TEAGQTVTVKDDQIFPMNPPKFDKIEDMAMMTHLNEPS 101

  Fly   147 VLHNIKDRYYSGLIYTYSGLFCVVVNPYKKLPIYTEKIMERYKGIKRHEVPPHVFAITDSAYRNM 211
            ||:|:|:||.:.:||||||||||.|||||.||:|..:::..|:|.||.|.|||:|:|:|:||:.|
 Frog   102 VLYNLKERYAAWMIYTYSGLFCVTVNPYKWLPVYNPEVVNAYRGKKRQEAPPHIFSISDNAYQFM 166

  Fly   212 LGDREDQSILCTGESGAGKTENTKKVIQFLAYVAASKPKGSGAVPHPAVLINFSVNTNKYIKVKI 276
            |.|||:||||.|||||||||.|||:|||:.|.:||:..|
 Frog   167 LTDRENQSILITGESGAGKTVNTKRVIQYFATIAAAPDK-------------------------- 205

  Fly   277 MAQNQNQTIEVVNGLKMVEVNSNCQEGELEQQLLQANPILEAFGNAKTVKNDNSSRFGKFIRINF 341
                           |..||...  :|.||.|::||||:||||||||||:|||||||||||||:|
 Frog   206 ---------------KKEEVAKT--KGTLEDQIIQANPLLEAFGNAKTVRNDNSSRFGKFIRIHF 253

  Fly   342 DASGFISGANIETYLLEKSRAIRQAKDERTFHIFYQLLAGATPEQREKFIL-DDVKSYAFLSNGS 405
            ..:|.::.|:||||||||||...|.|.||::|||||:::...||..|..:: .:...:.|:|.|.
 Frog   254 GTTGKLASADIETYLLEKSRVTFQLKAERSYHIFYQIMSNKKPELIEMLLITTNPYDFPFVSQGE 318

  Fly   406 LPVPGVDDYAEFQATVKSMNIMGMTSEDFNSIFRIVSAVLLFGSMKFRQERNNDQATLPDNT-VA 469
            :.|..:||..|..||..:::|:|..:::..||:::..||:.:|:|:|:|::..:||. ||.| ||
 Frog   319 ISVASIDDTEELMATDSAIDILGFNADEKVSIYKLTGAVMHYGNMRFKQKQREEQAE-PDGTEVA 382

  Fly   470 QKIAHLLGLSVTDMTRAFLTPRIKVGRDFVTKAQTKEQVEFAVEAIAKACYERMFKWLVNRINRS 534
            .|.|:|:.|:..|:.:|...||:|||.::|||.||.:||..:|.|:.||.||:||.|:|.|||..
 Frog   383 DKAAYLMCLNSADLLKALCYPRVKVGNEYVTKGQTVQQVYNSVGALGKAVYEKMFLWMVTRINEM 447

  Fly   535 LDRTKRQGASFIGILDMAGFEIFELNSFEQLCINYTNEKLQQLFNHTMFILEQEEYQREGIEWKF 599
            || ||:....|||:||:||||||:.||.||||||:|||||||.|||.||:||||||::|||||:|
 Frog   448 LD-TKQPRQYFIGVLDIAGFEIFDFNSLEQLCINFTNEKLQQFFNHHMFVLEQEEYKKEGIEWEF 511

  Fly   600 IDFGLDLQPTIDLIDKPGGIMALLDEECWFPKATDKTFVDKLVSAH------SMHPKFMKTDFRG 658
            ||||:||...|:||:||.||.::|:|||.||||||.:|.:||...|      ...||..|.  :.
 Frog   512 IDFGMDLAACIELIEKPMGIFSILEEECMFPKATDTSFKNKLYDQHLGKSNNFQKPKPAKG--KA 574

  Fly   659 VADFAIVHYAGRVDYSAAKWLMKNMDPLNENIVSLLQGSQD---PFVVNIWKDAEIVGMAQQALT 720
            .|.|::|||||.|||:.:.||.||.||||:.::.|.|.|..   .::.:.:..:|..|..:
 Frog   575 EAHFSLVHYAGTVDYNISGWLEKNKDPLNDTVIGLFQKSSMKTLAYLFSSYAASEAEGAKK---- 635

  Fly   721 DTQFGARTRKGMFRTVSHLYKEQLAKLMDTLRNTNPNFVRCIIPNHEKRAGKIDAPLVLDQLRCN 785
                |.:.:...|:|||.|::|.|.|||..||.|:|:||||||||..|..|.::..|||.|||||
 Frog   636 ----GGKKKGSSFQTVSALFRENLNKLMSNLRTTHPHFVRCIIPNETKTPGAMEHELVLHQLRCN 696

  Fly   786 GVLEGIRICRQGFPNRIPFQEFRQRYELLTPNVIPKG-FMDGKKACEKMIQALELDSNLYRVGQS 849
            ||||||||||:|||:||.:.:|:|||::|..:.||:| |:|.|||.||::.::::|...||.|.:
 Frog   697 GVLEGIRICRKGFPSRILYGDFKQRYKILNASAIPEGQFIDSKKASEKLLGSIDVDHTQYRFGHT 761

  Fly   850 KIFFRAGVLAHLEEERDFKISDLIVNFQAFCRGFLARRNYQKRLQQLNAIRIIQRNCAAYLKLRN 914
            |:||:||:|..|||.||.:::.:|...||.|||:|.|..::|.:::..|:..||.|..:::.:::
 Frog   762 KVFFKAGLLGTLEEMRDDRLAHVITRTQAMCRGYLMRVEFKKMMERREAVFTIQYNIRSFMNVKH 826

  Fly   915 WQWWRLYTKVKPLLEVTKQEEKLVQKEDELKQVREKLDTLAKNTQEYERKYQQALVEKTTLAEQL 979
            |.|.:||.|:||||:..:.|:::...::|.::.:|.|.......:|.|.|..:.|.||..|..|:
 Frog   827 WPWMKLYFKIKPLLKSAESEKEMQNMKEEFEKTKELLAKSEAKRKELEEKMVKVLQEKNDLQLQV 891

  Fly   980 QAEIELCAEAEESRSRLMARKQELEDMMQELETRIEEEEERVLALGGEKKKLELNIQDLEEQLEE 1044
            |:|.|...:|||...:|:..|.:||..|:||..|:|:|||....|..:|:|||....:|::.:::
 Frog   892 QSESENLTDAEERCDQLIKSKIQLEAKMKELNERLEDEEESNAELTAKKRKLEDECSELKKDIDD 956

  Fly  1045 EEAARQKLQLEKVQLDAKIKKYEEDLALTDDQNQKLLKEKKLLEERANDLSQTLAEEEEKAKHLA 1109
            .|....|::.||...:.|:|...|::|:.|:...||.||||.|:|........|..||:|...|.
 Frog   957 LELTLAKVEKEKHATENKVKNLTEEMAVLDETIVKLTKEKKALQEAHQQTLDDLQAEEDKVNTLT 1021

  Fly  1110 KLKAKHEATISELEERLHKDQQQRQESDRSKRKIETEVADLKE---QLNERRVQVDEMQAQLAKR 1171
            |.|||.|..:.:||..|.::::.|.:.:|||||:|.::...:|   .|...|.|:||   :|.|:
 Frog  1022 KAKAKLEQQVDDLEGSLEQEKKLRMDLERSKRKLEGDLKLAQETIMDLENDRQQLDE---KLKKK 1083

  Fly  1172 EEELTQTLLRIDEESATKATAQKAQRELESQLAEIQEDLEAEKAARAKAEKVRRDLSEELEALKN 1236
            |.|::|...:|::|.|..|..||..:||::::.|::|::|||:||||||||.|.|||.|||.:..
 Frog  1084 EFEMSQYASKIEDEQALGAQLQKKIKELQARIEELEEEIEAERAARAKAEKQRSDLSRELEEISE 1148

  Fly  1237 ELLDSLDTTAAQQELRSKREQELATLKKSLEEETVNHEGVLADMRHKHSQELNSINDQLENLRKA 1301
            .|.::...|:||.|:..|||.|...:::.|||.|:.||...|.:|.|.:..:..:.:|::||::.
 Frog  1149 RLEEAGGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAAALRKKQADSVAELGEQIDNLQRV 1213

  Fly  1302 KTVLEKAKGTLEAENADLATELRSVNSSRQENDRRRKQAESQIAELQVKLAEIERARSELQEKCT 1366
            |..|||.|..|:.|..|||:.:.:::.::...::..:..|.|::||:.|..|.:|..::|..:..
 Frog  1214 KQKLEKEKSELKMEIDDLASNMENLSKAKANFEKICRTLEDQLSELKTKDEEHQRQINDLTAQRA 1278

  Fly  1367 KLQQEAENITNQLEEAELKASAAVKSASNMESQLTEAQQLLEEETRQKLGLSSKLRQIESEKEAL 1431
            :||.|......||||.:...|...:.......|:.|.::.||||.:.|..|:..|:....:.:.|
 Frog  1279 RLQTENGEYARQLEERDSLISQLSRGKQAFTQQIEELKRQLEEEIKAKNALAHGLQSARHDCDLL 1343

  Fly  1432 QEQLEEDDEAKRNYERKLAEVTTQMQEIKKKAEEDA-DLAKELEEGKKRLNKDIEALERQVKELI 1495
            :||.||:.|||...:|.|::...::.:.:.|.|.|| ...:|||:.||:|.:.::..|..::.:.
 Frog  1344 REQYEEEQEAKGELQRSLSKANGEVAQWRTKYETDAIQRTEELEDAKKKLAQRLQEAEEHIEAVN 1408

  Fly  1496 AQNDRLDKSKKKIQSELEDATIELEAQRTKVLELEKKQKNFDKILAEEKAISEQIAQERDTAERE 1560
            ::...|:|:|:::|:|:||..:::|...:....|:||||||||||||.|...|:...|.:.:::|
 Frog  1409 SKCASLEKTKQRLQNEVEDLMVDVERSNSACAALDKKQKNFDKILAEWKQKFEESQAELEASQKE 1473

  Fly  1561 AREKETKVLSVSRELDEAFDKIEDLENKRKTLQNELDDLANTQGTADKNVHELEKAKRALESQLA 1625
            :|...|::..:....:|:.|.:|..:.:.|.||.|:.||........|.:||:||||:.:|.:..
 Frog  1474 SRSLSTELFKMKNAYEESLDHLETTKRENKNLQQEISDLTEQVSEVSKTLHEVEKAKKIIEQEKT 1538

  Fly  1626 ELKAQNEELEDDLQLTEDAKLRLEVNMQALRSQFERDLLAKEEGAEEKRRGLVKQLRDLETELDE 1690
            |:::..||.|..|:..|...||:::.:..::|:.:|.:..|:|..::.:|..|:.:..:::.||.
 Frog  1539 EIQSALEEAEASLEHEEGKILRIQLELNQVKSEIDRKIAEKDEEIDQLKRNHVRVVESMQSTLDA 1603

  Fly  1691 ERKQRTAAVASKKKLEGDLKEIETTMEMHNKVKEDALKHAKKLQAQVKDALRDAEEAKAAKEELQ 1755
            |.:.|..|:..|||:||||.|:|..:...|:...::.|..:.:|..:||.....:::..|:|:|:
 Frog  1604 EIRSRNDALRLKKKMEGDLNEMEIQLSHANRQASESQKQLRNVQGLLKDVQIHLDDSLRAQEDLK 1668

  Fly  1756 ALSKEAERKVKALEAEVLQLTEDLASSERARRAAETERDELAEEIANNANKGSLMIDEKRRLEAR 1820
            ......||:...::||:.::...|..:||:|:.||.|..:.:|.:....::.:.:|:.|:::|..
 Frog  1669 EQLAMVERRANLMQAEIEEMRAALEQTERSRKVAEQELLDASERVQLLHSQNTSLINTKKKMETD 1733

  Fly  1821 IATLEEELEE---EQSNSEVLLDRSRKAQLQIEQLTTELANEKSNSQKNENGRALLERQNKELKA 1882
            |..|:.|:||   |..|:|   ::::||......:..||..|:..|...|..:..|::..|:|:.
 Frog  1734 ITQLQTEVEEAIQEARNAE---EKAKKAITDAAMMAEELKKEQDTSAHLERMKKNLDQTVKDLQH 1795

  Fly  1883 KLAEIETAQRTKVKATIATLEAKIANLEEQLENEGKERLLQQKANRKMDKKIKELTMNIEDERRH 1947
            :|.|.|.......|..|..|||::..||.:::.|.|......|..||.::::|||:...|:::::
 Frog  1796 RLDEAEQLAMKGGKKQIQKLEARVRELENEVDVEQKRSTEAIKGVRKYERRVKELSYQSEEDKKN 1860

  Fly  1948 VDQHKEQMDKLNSRIKLLKRNLDETEEELQKEKTQKRKYQRECEDMIESQEAMNREINSLKTKLR 2012
            :.:.::.:|||..::|..||..:|.||:.....|:.||.|.|.|:..|..:....::|.|:.|.|
 Frog  1861 ILRLQDLVDKLQMKVKAYKRQTEEIEEQSNINLTKYRKIQHELEEAEERADIAESQVNKLRAKTR 1925

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
zip	NP_523860.2	Myosin_N	79..122	CDD:460670	8/39 (21%)
		MYSc_Myh2_insects_mollusks	145..854	CDD:276876	351/720 (49%)
		Myosin_tail_1	931..2011	CDD:460256	339/1086 (31%)
myh3	NP_001006915.1	Myosin_N	33..77	CDD:460670	8/39 (21%)
		Motor_domain	100..766	CDD:473979	351/720 (49%)
		Myosin_tail_1	846..1923	CDD:460256	339/1082 (31%)