DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment zip and Mhcl

DIOPT Version :9

Sequence 1:NP_523860.2 Gene:zip / 38001 FlyBaseID:FBgn0265434 Length:2056 Species:Drosophila melanogaster
Sequence 2:NP_732109.2 Gene:Mhcl / 41955 FlyBaseID:FBgn0026059 Length:2194 Species:Drosophila melanogaster


Alignment Length:1939 Identity:513/1939 - (26%)
Similarity:843/1939 - (43%) Gaps:456/1939 - (23%)


- Green bases have known domain annotations that are detailed below.


  Fly    71 ATQAEWTQKRLVWVPHENQGFVA------ASIKREHGDEVEVELAETGKRVMILRDDIQKMNPPK 129
            |..|:.:|...||:.|.. ||.|      ||..|:..:::.:.|...|:::.:..||::|.|.|.
  Fly   496 ADVADASQPERVWLVHRG-GFTAAIRLPTASSGRDEENKLSLRLLHNGEQLTVDEDDVEKQNSPA 559

  Fly   130 FDKVEDMAELTCLNEASVLHNIKDRYYSGLIYTYSGLFCVVVNPYKKLPIYTEKIMERYKGIKRH 194
            .|.|||:.||..||||||||.::.||.|.||:|.:|...:||||...|.:|:||::..::|.|..
  Fly   560 LDLVEDICELKYLNEASVLHCLRQRYASNLIHTKAGPTLLVVNPMAPLSLYSEKVVSMFRGCKTE 624

  Fly   195 EVPPHVFAITDSAYRNMLGDREDQSILCTGESGAGKTENTKKVIQFLAYVAASKPKGSGAVPHPA 259
            ::||||:::..:|||:::..|.|||::..|.||:||:.:.|..:.:||..|.:            
  Fly   625 DMPPHVYSLAQTAYRSLVETRRDQSLIFMGRSGSGKSTSFKHALNYLALAAGA------------ 677

  Fly   260 VLINFSVNTNKYIKVKIMAQNQNQTIEVVNGLKMVEVNSNCQEGELEQQLLQANPILEAFGNAKT 324
              .|..:|..|                         ||:.|             .|||||||.||
  Fly   678 --YNNFINAEK-------------------------VNALC-------------TILEAFGNTKT 702

  Fly   325 VKNDNSSRFGKFIRINFDASGFISGANIETYLLEKSRAIRQAKDERTFHIFYQLLAGATPEQREK 389
            ..|.|::|..:.:.::||.:|.|:.|:::..|.|:.||.|:...|.:|||..:|||||....:::
  Fly   703 CLNSNATRMTQLLSLDFDQTGQIASASLQVLLPERQRAGRRLGHEHSFHIMTRLLAGAAGLLQKE 767

  Fly   390 FILDDV---KSYAFLSNGSLPVPGVDD----YAEFQATVKSMNIMGMTSEDFNSIFRIVSAVLLF 447
            ..|:::   .|:.|:|...    .::|    ..:|..||::...:.:.::....|:.|::|:...
  Fly   768 LHLENITSEDSHPFISLSQ----KLEDRHRAANDFMRTVQAFETLNIDAKAVRGIWSILAAIYHL 828

  Fly   448 GSMKFRQERNNDQA--TLPDNTVAQKIAHLLGLSVTDMTRA---FLTPRIKVGRDFVTKAQTKEQ 507
            |.....:......|  ...:.|.|:|.:.|||:::.|::.|   ...|....|....:|:.|.:.
  Fly   829 GIAGVTKLGTGSTARTQFANPTAARKASGLLGVNLEDLSSAAFGLTQPNAPNGGLSPSKSPTSDT 893

  Fly   508 -VEFA---VEAIAKACYERMFKWLVNRINRSLDRTKRQGASFIGILDMAGFEIFELN-------- 560
             .|:|   :||:....|......:|..|||.:..:....|| |.::|..||:    |        
  Fly   894 GHEWAWECLEALVIGLYSEALAAVVALINRQICTSSHTIAS-IMLIDTPGFQ----NPASCGQQV 953

  Fly   561 --SFEQLCINYTNEKLQQLFNHTMFILEQEEYQREGIEWKFIDFGLDLQ------PTIDLIDKP- 616
              :...|..||..|:||.||:||..:..::.|.:|     .::..:||.      |.|.||||. 
  Fly   954 GATLADLRHNYLQERLQMLFHHTTLVAPRDRYAQE-----LVEIEMDLASECHPGPLISLIDKAP 1013

  Fly   617 -----------------GGIMALLDEECWFPKATDKTFVDKLVS------AHSMHPKFMKTDFRG 658
                             .|::.|||||..:|.:.|.||:::|.|      .||:..|     ..|
  Fly  1014 QNHVVRSSQRDLREHDRRGMLWLLDEEAIYPNSNDDTFLERLFSHYGDREHHSLLRK-----CAG 1073

  Fly   659 VADFAIVHYAGR--VDYSAAKWLMKNMD-PLNENIVSLLQGSQDPFVVNIWKDAEIVGMAQQALT 720
            ...|.:.|..|.  |.|:...|:..:.: |...|.|||||.|....:..::..:...|.......
  Fly  1074 PRQFVLHHLQGTNPVLYAVDGWVRHSREHPGIRNAVSLLQDSSREEINRLYIGSLTRGSGAMVFC 1138

  Fly   721 DTQFGARTRKGMFRTVSHL-----------------YKEQLAKLMDTLRNTNPNFVRCIIPNHEK 768
            .:..|....:.: |.||.:                 .|..:..::||||.|..:||.|.:..|  
  Fly  1139 GSFAGLEGTQSL-RRVSSIRRSFTTAGVKRNSIMLQVKFTVDGIIDTLRRTGTHFVHCYLLQH-- 1200

  Fly   769 RAGK-----------------------IDAPLVLDQLRCNGVLEGIRICRQGFPNRIPFQEFRQR 810
            .|||                       ::.||:..|||.:.|||..|:.|.|||..:|..||.:|
  Fly  1201 NAGKHTKYTANGSPSSAAGQVSSEEEMVNVPLLRSQLRGSQVLEAARLHRLGFPESVPLLEFVRR 1265

  Fly   811 YELLTPNVIPKGFMDGKK--ACEKMIQALELDSNLYRVGQSKIFFRAGVLAHLEEERDFKISDLI 873
            :.||.      |.:...|  :.|:::...|||...||:|.|:|.||:|||:.||.:||..:||.|
  Fly  1266 FGLLA------GDLASNKDVSVEQILAVNELDVASYRIGPSQILFRSGVLSELEAKRDVLLSDRI 1324

  Fly   874 VNFQAFCRGFLARRNY-QKRLQQLNAIRIIQRNCAAYLKLRNWQWWRLYTKVKPLLEVTKQEEKL 937
            :..||||||:|||:.. |:|:|:| |:|.||||..|:|.:|:|.||||..:|.|||.|.:.||:|
  Fly  1325 IQLQAFCRGYLARKKMSQRRVQEL-AVRCIQRNVKAFLAVRDWPWWRLLVRVTPLLNVHRTEEQL 1388

  Fly   938 VQKEDELKQVREKLDTLAKNTQEYERKYQQALVEKTTLAEQLQAEIELCAEAEESRSRLMARKQE 1002
            ....:||..:|.||:.:                                   |..||.:.|..|:
  Fly  1389 KTANEELLMLRAKLEKI-----------------------------------ECDRSEVKAENQK 1418

  Fly  1003 LEDMMQELETRIEEEEERVLALGGEKKKLELNIQDLEEQLEEEEAARQKLQLEKVQLDAKIKKYE 1067
            ||..:.||...:.||..              ......|:||.|.|.|.||:.|......|:|..:
  Fly  1419 LEAKLSELTVDLAEERS--------------TAHIATERLEAETAERLKLEKELGDQTNKVKNLQ 1469

  Fly  1068 EDLALTDDQNQKLLKEKKLLEERANDLSQTLAEEEEKAKHLAKLKAKHEATISELE---ERLH-K 1128
            |       ..:||..|....:...|.:|:....|.|........|.|:|....|||   .||| :
  Fly  1470 E-------TTEKLEMELICAKSDLNGISEDEDAENEDGVGGGVYKLKYERVARELEFTKRRLHTQ 1527

  Fly  1129 DQQQRQESDRSKRKIETEVADLKEQLNERRVQVDEMQAQLAKREEELTQTLLRIDEESATKATAQ 1193
            .:...::....|:.:|.:::|..|::.|:|..|.:.:.:..|...|:....:.::|::|.....:
  Fly  1528 HEHDLEQLVALKKHLEMKLSDAYEEVVEQRQVVGQWKRKAQKMTNEMNDLRMLLEEQNARNNLLE 1592

  Fly  1194 KAQRELESQLAEIQEDLEAEKAARAKAEKVRRDLSEELEALKNELLDSLDTTAAQQELRSKREQE 1258
            |.||:.:::...:|:.:..|:.|:   |:..|: .:.|:|.|..|..:|..|....|.   :|::
  Fly  1593 KKQRKFDAECQSLQDAVRQERQAK---ERYGRE-KDVLQAEKFTLEQTLADTRLDLEF---KEEK 1650

  Fly  1259 LATLKKSLEEETVNHEGVLADMRHKHSQELNSINDQLENLRKAKTVLEKAKGTLEAENADLATEL 1323
            ||:|::.|||.|..                                     |..|.|.|.|    
  Fly  1651 LASLQRELEEMTFG-------------------------------------GGTEEEFAQL---- 1674

  Fly  1324 RSVNSSRQENDRRRKQAESQIAELQVKLAEIERARSELQEKCTKLQQEAENITNQL-EEAELKAS 1387
               ..|:.|.:||.|:.|.::.|:..::..:|:|:..|:.....:::||...:.|. ||.|....
  Fly  1675 ---RRSKNETERRAKEQEEELDEMAGQIQLLEQAKLRLEMTLETMRKEARRESQQRDEELEEVRG 1736

  Fly  1388 AAVKSASNMESQLTEAQQLLEEET---RQKLGLSSKLRQIESE-------KEALQEQLEEDDEAK 1442
            ...|....:|.|| |.:.  ||.|   |:|..|..:|..:|..       :|||.::|..|   .
  Fly  1737 NGYKKIKALECQL-ETEH--EERTLLLREKHELERRLSSMEDRDRVDRDAEEALNQKLRRD---L 1795

  Fly  1443 RNYERKLAEVTTQMQEIKKKAEEDADLAKELEEGKKRLNKDIEALERQVKELIAQNDRLDKSKKK 1507
            |.|:..|.:..||::.:|      ||...                    |.||.|          
  Fly  1796 RKYKALLKDAQTQLERLK------ADTPG--------------------KTLIRQ---------- 1824

  Fly  1508 IQSELEDA----TIELEAQRTKVLELEKKQKNFDKIL-----AEEKAISEQIAQERDTAEREARE 1563
            ::::||||    ::.::|::|...||.:.|..||:..     |||:|    .|..||.||.:|:.
  Fly  1825 LRNQLEDAESARSLAMKARQTAEAELTEVQAMFDESHRARNDAEERA----NAAHRDRAELQAQI 1885

  Fly  1564 KETKVLSVSRELDEAFDKIEDLENKRKTLQNELDDLANTQGTADKNVHELEKAKRALESQLAELK 1628
            :|.:     .||.|...|......:..|.|..:.:       |:..::|:|..:..|:.|:|||:
  Fly  1886 EENE-----EELGELMKKYSATVKQLNTEQINVSE-------AEFKLNEMEAERNNLKEQVAELQ 1938

  Fly  1629 AQNEELED--DLQLTEDAKLRLEVNMQALRSQFERDLLAKEEGAEEKRRGLVKQLRDLETELDEE 1691
            .:.:.:|:  |..:...:| |||:..:.|.|:.|.      |.|...|         ||.:::..
  Fly  1939 HRLDNVENLGDPSMAMMSK-RLELRTKELESRLEL------EQATRAR---------LEVQVNRH 1987

  Fly  1692 RKQRTAAVASKKKLEGDLKEIETTMEMHNKVKEDALKHAKKLQAQVKDALRDAEE----AKAAKE 1752
            ::       :.:||:.::    |..:|.....:|.:|.::|       :|||..|    ..:.::
  Fly  1988 KE-------ALEKLQNEV----TQSKMREMQAQDVIKKSQK-------SLRDMREEFHAVSSREQ 2034

  Fly  1753 ELQALSKEAERKVKALEAEVLQLTEDLASSERARRAAETERDELAEEIANNANKGSLMIDEKRRL 1817
            |.....|:.|:||:.:|:|...|..||..:  .:|.|:.::                        
  Fly  2035 ESLTRRKDLEKKVEQMESEGAALKNDLRLA--LQRIADLQQ------------------------ 2073

  Fly  1818 EARIATLEEELEEEQSNSEVLLDRSRKAQLQIEQLTTEL--ANEKSNSQKNENG 1869
                 .:|||.|||.|.|    |.|..:...|..|...|  .:.|.:||::.||
  Fly  2074 -----AMEEEGEEELSES----DESLSSVGSISDLEDRLRPVHVKRSSQQSLNG 2118

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
zipNP_523860.2 Myosin_N 80..117 CDD:280832 11/42 (26%)
Myosin_head 133..854 CDD:278492 226/821 (28%)
MYSc_Myh2_insects_mollusks 145..854 CDD:276876 218/809 (27%)
Myosin_tail_1 931..2011 CDD:279860 223/971 (23%)
Prefoldin 1431..1515 CDD:298833 17/83 (20%)
FAM76 <1847..1926 CDD:292665 8/25 (32%)
MhclNP_732109.2 PDZ_signaling 339..426 CDD:238492
MYSc 556..1317 CDD:214580 236/840 (28%)
MYSc_Myo18 575..1305 CDD:276837 218/809 (27%)
GBP_C <1540..1750 CDD:303769 58/261 (22%)
COG1340 1565..1833 CDD:224259 81/360 (23%)
coiled coil 1723..1734 CDD:293879 4/10 (40%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C45466217
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG0161
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - P PTHR45615
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
43.840

Return to query results.
Submit another query.