DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment zip and myh4

DIOPT Version :9

Sequence 1:	NP_523860.2	Gene:	zip / 38001	FlyBaseID:	FBgn0265434	Length:	2056	Species:	Drosophila melanogaster
Sequence 2:	NP_001001244.1	Gene:	myh4 / 407946	XenbaseID:	XB-GENE-989283	Length:	1935	Species:	Xenopus tropicalis

Alignment Length:	1957	Identity:	759/1957 - (38%)
Similarity:	1185/1957 - (60%)	Gaps:	80/1957 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly    79 KRLVWVPHENQGFVAASIKREHGDEVEVELAETGKRVMILRDDIQKMNPPKFDKVEDMAELTCLN 143
            |..|:|....:.:|...:......::.|: .:.|:.|.:..:.|...|||||||:||||.:|.||
Frog    34 KNTVFVDDVKELYVKGMVTAREDGKITVK-TDDGRTVTVKENQIYPQNPPKFDKIEDMAMMTHLN 97

  Fly   144 EASVLHNIKDRYYSGLIYTYSGLFCVVVNPYKKLPIYTEKIMERYKGIKRHEVPPHVFAITDSAY 208
            |||||:|:|:||.:.:|||||||||..|||||.||:|..:::..|:|.||.|.|||:|:::|:||
Frog    98 EASVLYNLKERYAAWMIYTYSGLFCATVNPYKWLPVYNPEVVAGYRGKKRMEAPPHIFSLSDNAY 162

  Fly   209 RNMLGDREDQSILCTGESGAGKTENTKKVIQFLAYVAA--SKPKGSGAVPHPAVLINFSVNTNKY 271
            :.||.|||:||:|.|||||||||.|||:|||:.|.:||  .|.|.|
Frog   163 QAMLTDRENQSVLITGESGAGKTVNTKRVIQYFATIAALGDKKKES------------------- 208

  Fly   272 IKVKIMAQNQNQTIEVVNGLKMVEVNSNCQEGELEQQLLQANPILEAFGNAKTVKNDNSSRFGKF 336
                                      ||..:|.||.|::||||:||||||||||:||||||||||
Frog   209 --------------------------SNSLQGNLEDQIIQANPLLEAFGNAKTVRNDNSSRFGKF 247

  Fly   337 IRINFDASGFISGANIETYLLEKSRAIRQAKDERTFHIFYQLLAGATPEQREKFIL-DDVKSYAF 400
            |||:|..:|.:|.|:||||||||||...|...||::|||||:|....||..|..:| .:...|..
Frog   248 IRIHFGTTGKLSSADIETYLLEKSRVTFQLSAERSYHIFYQILTNKKPEIVEMLLLTTNPYDYPS 312

  Fly   401 LSNGSLPVPGVDDYAEFQATVKSMNIMGMTSEDFNSIFRIVSAVLLFGSMKFRQERNNDQATLPD 465
            :|.|.|.|..::|..|..||..:::::|...|:...|:::..||:..|::||:|::..:||. ||
Frog   313 ISQGELVVKSINDEEELMATDSAIDVLGFNQEEKMGIYKMTGAVMHHGNLKFKQKQREEQAE-PD 376

  Fly   466 NT-VAQKIAHLLGLSVTDMTRAFLTPRIKVGRDFVTKAQTKEQVEFAVEAIAKACYERMFKWLVN 529
            :| ||.|||:||||:..|:.:....||:|||.:||||.||..||..:|.|:.|:.:|::|.|:|.
Frog   377 STEVADKIAYLLGLNSADLLKGLCYPRVKVGNEFVTKGQTVPQVYNSVGALCKSVFEKLFLWMVT 441

  Fly   530 RINRSLDRTKRQGASFIGILDMAGFEIFELNSFEQLCINYTNEKLQQLFNHTMFILEQEEYQREG 594
            |||:.|| ||:....|||:||:||||||:.||.||||||:|||||||.|||.||:||||||::||
Frog   442 RINQQLD-TKQPRQFFIGVLDIAGFEIFDFNSLEQLCINFTNEKLQQFFNHHMFVLEQEEYKKEG 505

  Fly   595 IEWKFIDFGLDLQPTIDLIDKPGGIMALLDEECWFPKATDKTFVDKLVSAH------SMHPKFMK 653
            |:|:|||||:||...|:||:||.||.::|:|||.||||||.:|.:||...|      ...||..|
Frog   506 IDWEFIDFGMDLAACIELIEKPLGIFSILEEECMFPKATDTSFKNKLYEQHLGKCKNFEKPKPGK 570

  Fly   654 TDFRGVADFAIVHYAGRVDYSAAKWLMKNMDPLNENIVSLLQGSQDPFVVNIWKDAEIVGMAQQA 718
            .  :..|.|::|||||.|||:.:.||.||.|||||::|.|.|.|....:..::        :..|
Frog   571 G--KAEAHFSLVHYAGTVDYNISGWLEKNKDPLNESVVQLYQKSSVKLLSLLY--------SSYA 625

  Fly   719 LTDTQF---GARTRKG-MFRTVSHLYKEQLAKLMDTLRNTNPNFVRCIIPNHEKRAGKIDAPLVL 779
            .||...   |.:.:|| .|:|||.|::|.|.|||..||:|:|:||||:|||..|..|.:|..|::
Frog   626 ATDGDAGGKGGKKKKGSSFQTVSGLFRENLNKLMTNLRSTHPHFVRCLIPNETKTPGIMDNHLLI 690

  Fly   780 DQLRCNGVLEGIRICRQGFPNRIPFQEFRQRYELLTPNVIPKG-FMDGKKACEKMIQALELDSNL 843
            .|||||||||||||||:|||:||.:.:|:|||::|..:.||:| |:|.||||||::.::::|...
Frog   691 HQLRCNGVLEGIRICRKGFPSRILYGDFKQRYKVLNASAIPEGQFIDSKKACEKLLGSIDVDHTQ 755

  Fly   844 YRVGQSKIFFRAGVLAHLEEERDFKISDLIVNFQAFCRGFLARRNYQKRLQQLNAIRIIQRNCAA 908
            |:.|.:|:||:||:|..|||.||.|::.||...||.|||:|.|..:.|.:::..||.:||.|..:
Frog   756 YKFGHTKVFFKAGLLGTLEEMRDEKLAQLITRTQALCRGYLMRLEFTKMMERREAIYVIQYNLRS 820

  Fly   909 YLKLRNWQWWRLYTKVKPLLEVTKQEEKLVQKEDELKQVREKLDTLAKNTQEYERKYQQALVEKT 973
            ::.:::|.|.:||.|:||||:..:.|:::...::|.::.:|.|.......:|.|.|....|.||.
Frog   821 FMNVKHWPWMKLYFKIKPLLKSAETEKEMANMKEEFEKTKEALVKAEARKKELEEKMVAMLQEKN 885

  Fly   974 TLAEQLQAEIELCAEAEESRSRLMARKQELEDMMQELETRIEEEEERVLALGGEKKKLELNIQDL 1038
            .|..|:|:|.|..|::||....|:..|.:||..::||..|:|:|||....|..:|:|||....:|
Frog   886 DLVLQVQSESETLADSEERCEGLIKVKIQLESKIKELTERLEDEEESNAELTAKKRKLEDECSEL 950

  Fly  1039 EEQLEEEEAARQKLQLEKVQLDAKIKKYEEDLALTDDQNQKLLKEKKLLEERANDLSQTLAEEEE 1103
            ::.:::.|....|::.||...:.|:|...|::|:.|:...||.||||.|:|........|..||:
Frog   951 KKDIDDLELTLAKVEKEKHATENKVKNLTEEMAVLDENISKLSKEKKALQEAHQQTLDDLQAEED 1015

  Fly  1104 KAKHLAKLKAKHEATISELEERLHKDQQQRQESDRSKRKIETEVADLKEQLNERRVQVDEMQAQL 1168
            |...|:|.|.|.|..:.:||..|.::::.|.:.:|:|||:|.::...:|.:.:......:.:.:|
Frog  1016 KVSSLSKAKTKLEQQVDDLEGSLEQEKKLRLDLERAKRKLEGDLKLTQETVMDLENDKQQTEEKL 1080

  Fly  1169 AKREEELTQTLLRIDEESATKATAQKAQRELESQLAEIQEDLEAEKAARAKAEKVRRDLSEELEA 1233
            .|::.|::|...:|::|.:.....||..:||::::.|::|::|||:|||||.||.|.|||.|||.
Frog  1081 KKKDFEISQLQGKIEDEQSLGTQLQKKIKELQARIEEVEEEIEAERAARAKVEKQRADLSRELEE 1145

  Fly  1234 LKNELLDSLDTTAAQQELRSKREQELATLKKSLEEETVNHEGVLADMRHKHSQELNSINDQLENL 1298
            :...|.::...|:||.|:..|||.|...|::.|||.|:.||.....:|.||:..:..:.:|::||
Frog  1146 ISERLEEAGGATSAQIEMNKKREAEFQKLRRDLEEATLQHEATAGALRKKHADSVAELGEQIDNL 1210

  Fly  1299 RKAKTVLEKAKGTLEAENADLATELRSVNSSRQENDRRRKQAESQIAELQVKLAEIERARSELQE 1363
            ::.|..|||.|..|:.|..|||:.|.:|:.|:...::..:..|.|::|::.|..|.:|..::|..
Frog  1211 QRVKQKLEKEKSELKMEIDDLASNLENVSKSKANLEKVNRVIEDQLSEVKAKDDEHQRLLNDLST 1275

  Fly  1364 KCTKLQQEAENITNQLEEAELKASAAVKSASNMESQLTEAQQLLEEETRQKLGLSSKLRQIESEK 1428
            :..:||.|...::.||||.|...|...:.......|:.|.::.|||||:.|..|:..|:....:.
Frog  1276 QKARLQTETGELSRQLEERESLISQLSRGKQGFTQQVEELKRQLEEETKAKNALAHALQSARHDC 1340

  Fly  1429 EALQEQLEEDDEAKRNYERKLAEVTTQMQEIKKKAEEDA-DLAKELEEGKKRLNKDIEALERQVK 1492
            :.|:||.||:.|||...:|.|::...::.:.:.|.|.|| ...:||||.||:|.:.::..|.||:
Frog  1341 DLLREQFEEEQEAKAELQRSLSKANGEVSQWRTKYETDAIQRTEELEEAKKKLAQRLQDAEEQVE 1405

  Fly  1493 ELIAQNDRLDKSKKKIQSELEDATIELEAQRTKVLELEKKQKNFDKILAEEKAISEQIAQERDTA 1557
            .:.::...|:|:|:::|||:||..:::|...:....|:|||:||||:|.|.|...|:...|.:.|
Frog  1406 AVNSKCASLEKTKQRLQSEVEDLMVDVERANSAAAALDKKQRNFDKVLVEWKQKYEEGQAELEAA 1470

  Fly  1558 EREAREKETKVLSVSRELDEAFDKIEDLENKRKTLQNELDDLANTQGTADKNVHELEKAKRALES 1622
            .:|:|...|::..:....:||.:.:|.|:.:.|.||.|:.||....|.:.|:|.||||||:.:|.
Frog  1471 LKESRSLSTEIFKMKNAYEEALEHVETLKRENKNLQQEISDLTEQIGESGKSVVELEKAKKQVEQ 1535

  Fly  1623 QLAELKAQNEELEDDLQLTEDAKLRLEVNMQALRSQFERDLLAKEEGAEEKRRGLVKQLRDLETE 1687
            :..:|:|..||.|..|:..|...||:::.:..::|:.:|.:..|:|..|:.:|...:.:..:::.
Frog  1536 EKNDLQAALEEAEGSLEHEEAKILRIQLELNQVKSEVDRKIAEKDEEIEQLKRNSQRSIDTMQST 1600

  Fly  1688 LDEERKQRTAAVASKKKLEGDLKEIETTMEMHNKVKEDALKHAKKLQAQVKDALRDAEEAKAAKE 1752
            ||.|.:.|..|:..|||:||||.|:|..:...|:...:|.|..:.:|.|.|:.....:||..|:|
Frog  1601 LDSEIRSRNDALRLKKKMEGDLNELEIQLGHANRQASEAQKQLRNVQGQFKETQLQLDEAIRAQE 1665

  Fly  1753 ELQALSKEAERKVKALEAEVLQLTEDLASSERARRAAETERDELAEEIANNANKGSLMIDEKRRL 1817
            :|:......||:....:||:.:....|..:||:|:.||.|..:.:|.:....::.:.:|:.|::|
Frog  1666 DLKEQVAVTERRNNLFQAEIEENRAGLEQTERSRKIAEQELLDASERLQLLHSQNTSLINSKKKL 1730

  Fly  1818 EARIATLEEELEE---EQSNSEVLLDRSRKAQLQIEQLTTELANEKSNSQKNENGRALLERQNKE 1879
            |:.|..|:.|.||   |..|:|   ::::||......:..||..|:..|...|..:..||:..|:
Frog  1731 ESDICQLQNEAEEAVQEARNAE---EKAKKAITDAALMAEELKKEQDTSAHLERMKKNLEQTVKD 1792

  Fly  1880 LKAKLAEIETAQRTKVKATIATLEAKIANLEEQLENEGKERLLQQKANRKMDKKIKELTMNIEDE 1944
            |:.:|.|.|.......|..:..||:::..||.:|:||.|..:...|..||.::::||||...|::
Frog  1793 LQHRLDEAEQLAMKGGKKQLQKLESRVRELENELDNEQKHGVEAVKGVRKYERRVKELTYQTEED 1857

  Fly  1945 RRHVDQHKEQMDKLNSRIKLLKRNLDETEEELQKEKTQKRKYQRECEDMIESQEAMNREINSLKT 2009
            ::::.:.::.:|||.|::|..||..:|.||:......:.||.|.|.|:..|..:....::|.|:|
Frog  1858 KKNILRLQDLVDKLQSKVKAYKRQAEEAEEQANTHLGRFRKVQHELEEAEERADIAESQVNKLRT 1922

  Fly  2010 KLRRTGG 2016
            |.|..||
Frog  1923 KSRDIGG 1929

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
zip	NP_523860.2	Myosin_N	80..117	CDD:280832	6/36 (17%)
		Myosin_head	133..854	CDD:278492	361/735 (49%)
		MYSc_Myh2_insects_mollusks	145..854	CDD:276876	353/723 (49%)
		Myosin_tail_1	931..2011	CDD:279860	345/1083 (32%)
		Prefoldin	1431..1515	CDD:298833	31/84 (37%)
		FAM76	<1847..1926	CDD:292665	21/78 (27%)
myh4	NP_001001244.1	Myosin_N	34..72	CDD:397036	7/38 (18%)
		MYSc_class_II	99..766	CDD:276951	353/723 (49%)
		Myosin_tail_1	846..1923	CDD:396244	344/1079 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D47111at2759
OrthoFinder	1	1.000	-	-		FOG0000014
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X58
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	3.010