DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment zip and Prm

DIOPT Version :9

Sequence 1:	NP_523860.2	Gene:	zip / 38001	FlyBaseID:	FBgn0265434	Length:	2056	Species:	Drosophila melanogaster
Sequence 2:	NP_523982.2	Gene:	Prm / 39002	FlyBaseID:	FBgn0003149	Length:	879	Species:	Drosophila melanogaster

Alignment Length:	826	Identity:	224/826 - (27%)
Similarity:	410/826 - (49%)	Gaps:	22/826 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly  1199 LESQLAEIQEDLEAEKAARAKAEKVRRDLSEELEALKNELLDSLDTTAAQQELRSKREQELATLK 1263
            ||.::..:|:|||.|:..|.:.|:.:.|||.::..:...|.::......|.|...||:.||..|:
  Fly    40 LEDKIRLLQDDLEVERELRQRIEREKADLSVQVIQMSERLEEAEGGAEHQFEANRKRDAELLKLR 104

  Fly  1264 KSLEEETVNHEGVLADMRHKHSQELNSINDQLENLRKAKTVLEKAKGTLEAENADLATELRSVNS 1328
            |.||:..:..|.....::.||::.:....:|:|.|.|.|...||.|...:.|..:|.:::.|.|.
  Fly   105 KLLEDVHLESEETTLLLKKKHNEIITDFQEQVEILTKNKARAEKDKAKFQTEVYELLSQIESYNK 169

  Fly  1329 SRQENDRRRKQAESQIAELQVKLAEIERARSELQEKCTKLQQEAENITNQLEEAELKASAAVKSA 1393
            .:..:::...:.|..|:||.||:.|:.|...::....::|.||...:|..:::.:::......|.
  Fly   170 EKIVSEKHISKLEVSISELNVKIEELNRTVIDISSHRSRLSQENIELTKDVQDLKVQLDTVSFSK 234

  Fly  1394 SNMESQLTEAQQLLEEETRQKLGLSSKLRQIESEKEALQEQLEEDDEAKRNYERKLAEVTTQMQE 1458
            |.:.|||.:|::.||:|.|::..|.|.|.|:|.|.::::.||||:.||:.:.||:|.:.......
  Fly   235 SQVISQLEDARRRLEDEDRRRSLLESSLHQVEIELDSVRNQLEEESEARIDLERQLVKANADATS 299

  Fly  1459 IKKK-AEEDADLAKELEEGKKRLNKDIEALERQVKELIAQNDRLDKSKKKIQSELEDATIELEAQ 1522
            .:.| ..|.|..|:|:||.:::....|..||..::.||.:.:.|:|.|.::.||:|...|:||..
  Fly   300 WQNKWNSEVAARAEEVEEIRRKYQVRITELEEHIESLIVKVNNLEKMKTRLASEVEVLIIDLEKS 364

  Fly  1523 RTKVLELEKKQKNFDKILAEEKAISEQIAQERDTAEREAREKETKVLSVSRELDEAFDKIEDLEN 1587
            .....||.|.....:|...|.|:..::.....:|::|:.:.|...::....|||:..|....|..
  Fly   365 NNSCRELTKSVNTLEKHNVELKSRLDETIILYETSQRDLKNKHADLVRTVHELDKVKDNNNQLTR 429

  Fly  1588 KRKTLQNELDDLANTQGTADKNVHELEKAKRALESQLAELKAQNEELEDDLQLTEDAKLRLEVNM 1652
            :.|.|.::|.:........::.:||||...|.||::..||.|..:|.|...:..|....||..:.
  Fly   430 ENKKLGDDLHEAKGAINELNRRLHELELELRRLENERDELTAAYKEAEAGRKAEEQRGQRLAADF 494

  Fly  1653 QALRSQFERDLLAKEEGAEEKRRGLVKQLRDLETE-LDEERKQRTAAVASKKKLEGDLKEIETTM 1716
            ...|...||.|..|:|..|..|:....::..|... ::.|.:.:|.....||||:..:.|:|.::
  Fly   495 NQYRHDAERRLAEKDEEIEAIRKQTSIEIEQLNARVIEAETRLKTEVTRIKKKLQIQITELEMSL 559

  Fly  1717 EMHNKVKEDALKHAKK-------LQAQVKDALRDAEEAKAAKEELQALSKE---AERKVKALEAE 1771
            ::.||...|..|..||       |||..:|..|          :|||...:   |:|::..|..|
  Fly   560 DVANKTNIDLQKVIKKQSLQLTELQAHYEDVQR----------QLQATLDQYAVAQRRLAGLNGE 614

  Fly  1772 VLQLTEDLASSERARRAAETERDELAEEIANNANKGSLMIDEKRRLEARIATLEEELEEEQSNSE 1836
            :.::...|.|:.||:|..|.:.:|.|..|.........::..|.:||..::.:..:.||......
  Fly   615 LEEVRSHLDSANRAKRTVELQYEEAASRINELTTANVSLVSIKSKLEQELSVVASDYEEVSKELR 679

  Fly  1837 VLLDRSRKAQLQIEQLTTELANEKSNSQKNENGRALLERQNKELKAKLAEIETAQRTKVKATIAT 1901
            :..:|.:|.|::::.:..::..|:....|.|..:..||.:.|.|..:|.|:|.......|..|:.
  Fly   680 ISDERYQKVQVELKHVVEQVHEEQERIVKLETIKKSLEVEVKNLSIRLEEVELNAVAGSKRIISK 744

  Fly  1902 LEAKIANLEEQLENEGKERLLQQKANRKMDKKIKELTMNIEDERRHVDQHKEQMDKLNSRIKLLK 1966
            |||:|.:||.:||.|.:......|..||.::.:||:.:..|::::::...::.:||..::|.:.:
  Fly   745 LEARIRDLELELEEEKRRHAETIKILRKKERTVKEVLVQCEEDQKNLILLQDALDKSTAKINIYR 809

  Fly  1967 RNLDETEEELQKEKTQKRKYQRECEDMIESQEAMNREINSLKTKLR 2012
            |.|.|.|...|:..|:.|::|||.|...:..:.....:|.::.|.|
  Fly   810 RQLSEQEGVSQQTTTRVRRFQRELEAAEDRADTAESSLNIIRAKHR 855

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
zip	NP_523860.2	Myosin_N	80..117	CDD:280832
		Myosin_head	133..854	CDD:278492
		MYSc_Myh2_insects_mollusks	145..854	CDD:276876
		Myosin_tail_1	931..2011	CDD:279860	222/823 (27%)
		Prefoldin	1431..1515	CDD:298833	27/84 (32%)
		FAM76	<1847..1926	CDD:292665	21/78 (27%)
Prm	NP_523982.2	Myosin_tail_1	<34..853	CDD:279860	222/822 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45466223
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0161
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.740