DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment zip and Myo18a

DIOPT Version :9

Sequence 1:NP_523860.2 Gene:zip / 38001 FlyBaseID:FBgn0265434 Length:2056 Species:Drosophila melanogaster
Sequence 2:XP_036012684.1 Gene:Myo18a / 360013 MGIID:2667185 Length:2493 Species:Mus musculus


Alignment Length:2243 Identity:564/2243 - (25%)
Similarity:1007/2243 - (44%) Gaps:482/2243 - (21%)


- Green bases have known domain annotations that are detailed below.


  Fly    71 ATQAEWTQKRLVWVPHENQGFVAASIKREH----GDEVEVELAETGKRVMILRDDIQKMNPPKFD 131
            |.:..|.:...||:.|.:...:|:.:|.|.    ..:..|:|...|..:.:..|||:|.|.|..|
Mouse   389 AAEEAWYETEKVWLVHRDGFSLASQLKSEELSLPEGKARVKLDHDGAILDVDEDDIEKANAPSCD 453

  Fly   132 KVEDMAELTCLNEASVLHNIKDRYYSGLIYTYSGLFCVVVNPYKKLPIYTEKIMERYKGIKRHEV 196
            ::||:|.|..|||:||||.::.||.:.|::||:|...:|::......:|:||:|..:||.:|.::
Mouse   454 RLEDLASLVYLNESSVLHTLRQRYGASLLHTYAGPSLLVLSTRGAPAVYSEKVMHMFKGCRREDM 518

  Fly   197 PPHVFAITDSAYRNMLGDREDQSILCTGESGAGKTENTKKVIQFLAYVAASKPKGSGAVPHPAVL 261
            .||::|:..:|||.||..|:||||:..|.||:|||.:.:.::|:||.:|.:              
Mouse   519 APHIYAVAQTAYRAMLMSRQDQSIVLLGSSGSGKTTSFQHLVQYLATIAGT-------------- 569

  Fly   262 INFSVNTNKYIKVKIMAQNQNQTIEVVNGLKMVEVNSNCQEGELEQQLLQANPILEAFGNAKTVK 326
                                       :|.|:..|       |..|.|   :.:||||||:.|:.
Mouse   570 ---------------------------SGTKVFSV-------EKWQAL---STLLEAFGNSPTIM 597

  Fly   327 NDNSSRFGKFIRINFDASGFISGANIETYLLEKSRAIRQAKDERTFHIFYQLLAGATPEQREKFI 391
            |.:::||.:.:.::||.:|.::.|:|:|.||||.|..|:...|.||::||.|||......|.:..
Mouse   598 NGSATRFSQILSLDFDQAGQVASASIQTMLLEKLRVARRPASEATFNVFYYLLACGDATLRTELH 662

  Fly   392 L-----DDVKSYAFLSNGSLPVPGVDDYAEFQATVKSMNIMGMTSEDFNSIFRIVSAVLLFGSMK 451
            |     ::|.....||...........:::.||   :|.::.::.|:..:.:.|::::...|:..
Mouse   663 LNHLAENNVFGIVPLSKPEEKQKAAQQFSKLQA---AMKVLAISPEEQKTCWLILASIYHLGAAG 724

  Fly   452 FRQE--RNNDQAT------LPDNTVAQKIAHLLGLSVTDMTRAFLTPRIKVG------------R 496
            ..:|  ...|:|.      ...:..|||.|:|||.|:.:::.|....::|.|            .
Mouse   725 ATKEPLEEQDEAAEAGRKQFARHEWAQKAAYLLGCSLEELSSAIFKHQLKGGTLQRSTSFRQGPE 789

  Fly   497 DFVTKAQTKEQVEFAVEAIAKACYERMFKWLVNRINRSLDRTKRQGASFIGILDMAGFEIFELN- 560
            :......||......:|.:|...|..:|..|::.:||:|..::....|.: |:|..||:..|.. 
Mouse   790 ESGLGEGTKLSALECLEGMASGLYSELFTLLISLVNRALKSSQHSLCSMM-IVDTPGFQNPEWGG 853

  Fly   561 -----SFEQLCINYTNEKLQQLFNHTMFILEQEEYQREGIEWKFIDFGLDLQPTID--------- 611
                 |||:||.||..::||:||:...|:.|.|.|:.:.||..|.    ||:|..|         
Mouse   854 SARGASFEELCHNYAQDRLQRLFHERTFLQELERYKEDNIELAFD----DLEPVADDSVAAVDQA 914

  Fly   612 --LI------DKPGGIMALLDEECWFPKATDKTFVDKLVSAHSMHPKFMKTDFRGVA-------- 660
              |:      |:..|::.||:||...|.||:...:|:|.|.:.  |:  :.|.:|.:        
Mouse   915 SHLVRSLAHADEARGLLWLLEEEALVPGATEDALLDRLFSYYG--PQ--EGDKKGQSPLLRSSKP 975

  Fly   661 -DFAIVHYAGR--VDYSAAKWL-MKNMDPLNENIVSLLQGSQDPFVVNIW------------KDA 709
             .|.:.|..|.  |:|:.|.|| ....:|..:|...|||.||...:.|::            ..|
Mouse   976 RHFLLGHSHGTNWVEYNVAGWLNYTKQNPATQNAPRLLQDSQKKIISNLFLGRAGSATVLSGSIA 1040

  Fly   710 EIVGMAQQAL--------TDTQFGARTRKGMFRTVSHLYKEQLAKLMDTLRNTNPNFVRCIIPNH 766
            .:.|.:|.||        |.|...|..:|   :::....|.|:..|:||::.:..:||.|.:|..
Mouse  1041 GLEGGSQLALRRATSMRKTFTTGMAAVKK---KSLCIQIKLQVDALIDTIKRSKMHFVHCFLPVA 1102

  Fly   767 EKRAG-----------------------------KIDAPLVLDQLRCNGVLEGIRICRQGFPNRI 802
            |...|                             ::|..|:..|||.:.:|:.:|:.|||:|:.:
Mouse  1103 EGWPGEPRSASSRRVSSSSELDLPPGDPCEAGLLQLDVSLLRAQLRGSRLLDAMRMYRQGYPDHM 1167

  Fly   803 PFQEFRQRYELLTPNVIPKG-----FMDGKKACEKMIQALELDSNLYRVGQSKIFFRAGVLAHLE 862
            .|.|||:|:::|.|::..|.     .:|.|:|.|:::::|:|:.:...:|.|::|||||.||.||
Mouse  1168 VFSEFRRRFDVLAPHLTKKHGRNYIVVDEKRAVEELLESLDLEKSSCCLGLSRVFFRAGTLARLE 1232

  Fly   863 EERDFKISDLIVNFQAFCRGFLARRNYQKRLQQLNAIRIIQRNCAAYLKLRNWQWWRLYTKVKPL 927
            |:||.:.|..:..|||.|||:|||::::||..|..|||.:|:|......:::|.||:|:|.|:||
Mouse  1233 EQRDEQTSRHLTLFQAACRGYLARQHFKKRKIQDLAIRCVQKNIKKNKGVKDWPWWKLFTTVRPL 1297

  Fly   928 LEVTKQEEKLVQKEDELKQVREKLDTLAKNTQEYERKYQQALVEKTTLAEQLQAEIELCAEAEES 992
            ::|...||::..|::|::|:|.||:.:.|...|......:.....:.|..:|..|    ....||
Mouse  1298 IQVQLSEEQIRNKDEEIQQLRSKLEKVEKERNELRLSSDRLETRISELTSELTDE----RNTGES 1358

  Fly   993 RSRLM----ARKQELEDMMQELETRIEEEEERVLALGGEKKKLELNIQ--------DLEEQLEEE 1045
            .|:|:    |.:...|..|:||:|:.:       ||..:.:.:|:.:.        ::..:::::
Mouse  1359 ASQLLDAETAERLRTEKEMKELQTQYD-------ALKKQMEVMEMEVMEARLIRAAEINGEVDDD 1416

  Fly  1046 EAARQ-KLQLEKV--QLDAKIKKYEEDLALTDDQNQKLLKEKKLLEERANDLSQTLAEEEEKAKH 1107
            :|..: :|:.|:.  ::|...|:.:::|   :|:.:...:.::.||.|..||.   |:.:|..:.
Mouse  1417 DAGGEWRLKYERAVREVDFTKKRLQQEL---EDKMEVEQQSRRQLERRLGDLQ---ADSDESQRA 1475

  Fly  1108 LAKLKAKHEATISELEE-RLHKDQQQ--RQESDRSKRKIETEVADLKEQLNERRVQVDEMQAQLA 1169
            |.:||.|.:...:||:: :||.:.||  ..|.::.:|:.::|::...|:....::|.:::|.:..
Mouse  1476 LQQLKKKCQRLTAELQDTKLHLEGQQVRNHELEKKQRRFDSELSQAHEETQREKLQREKLQREKD 1540

  Fly  1170 KREEELTQTLLRIDEESATKATAQKAQRELESQLAEIQEDLEAEKAARAKAEKVRRDLSEELEAL 1234
            ....|......:::|:....|...:....||::|.:|......::|:.||.:|..|||..:::..
Mouse  1541 MLLAEAFSLKQQMEEKDLDIAGFTQKVVSLEAELQDISSQESKDEASLAKVKKQLRDLEAKVKDQ 1605

  Fly  1235 KNELLDSLDTTAAQQELRSKREQELATLKKSLEEETVNHEGVLADMRHKHSQELNSINDQLENLR 1299
            :.||         .::..|.:..|.|.|:..:|.|.         ||..||:|:.|.::::|..|
Mouse  1606 EEEL---------DEQAGSIQMLEQAKLRLEMEMER---------MRQTHSKEMESRDEEVEEAR 1652

  Fly  1300 KA-KTVLEKAKGTLEAENADLATELRSVNSSRQENDRRRKQAESQIAEL--QVKLAEIE---RAR 1358
            :: :..|::.:..||.|..|           :|:..|.:::.||:::.|  ||...:.|   |.|
Mouse  1653 QSCQKKLKQMEVQLEEEYED-----------KQKALREKRELESKLSTLSDQVNQRDFESEKRLR 1706

  Fly  1359 SELQEKCTKL------------------QQEAENITNQLEEAELKASAAVKSASNMESQLTEAQQ 1405
            .:|  |.||.                  ::|...:.|||||:|...:||||:...||.::.:...
Mouse  1707 KDL--KRTKALLADAQIMLDHLKNNAPSKREIAQLKNQLEESEFTCAAAVKARKAMEVEMEDLHL 1769

  Fly  1406 LLEEETRQKLGLSSKLRQIESEKEALQEQLEED----DEAKRNYERKLAEVTTQMQEIKKKAEED 1466
            .:::..:.|..|..:|.:::.||..:|.:||||    :|..:.::..:|:.:..|.::.      
Mouse  1770 QIDDIAKAKTALEEQLSRLQREKNEIQNRLEEDQEDMNELMKKHKAAVAQASRDMAQMN------ 1828

  Fly  1467 ADLAKELEEG---KKRLNKDIEALERQVKELIAQNDRLDKSKKKIQSELEDATIELEAQRTKVLE 1528
             ||..::||.   |:.|.:.::||:.||:.|  :...:|||   :.|..|....|||.:    ||
Mouse  1829 -DLQAQIEESNKEKQELQEKLQALQSQVEFL--EQSMVDKS---LVSRQEAKIRELETR----LE 1883

  Fly  1529 LEKKQ-KNFDKILAEEKAISEQIAQERD-TAEREAREKETKVLSVSRELDEAFDKIEDLENKR-- 1589
            .||.| |..:.:.:..|...|::.:||| .|..|.||||                    :|||  
Mouse  1884 FEKTQVKRLENLASRLKETMEKLTEERDQRAAAENREKE--------------------QNKRLQ 1928

  Fly  1590 ---KTLQNELDDLANTQGTADKNVHELEKAKRALESQLAELKAQNEELEDDLQLTEDAKLRLEVN 1651
               :..:.|:.:||..:..|.:..||       ||..|..|:|.|:.|:.||:|.          
Mouse  1929 RQLRDTKEEMSELARKEAEASRKKHE-------LEMDLESLEAANQSLQADLKLA---------- 1976

  Fly  1652 MQALRSQFER--DLLA--KEEGAEEKRRGLVKQLRDLETELDEERKQRTAAVASKKKLEGDLKEI 1712
                   |:|  ||.|  ::|...::...|:..|:|:.|:..::          |.||||| .::
Mouse  1977 -------FKRIGDLQAAIEDEMESDENEDLINSLQDMVTKYQKK----------KNKLEGD-SDV 2023

  Fly  1713 ETTMEMHNKVKEDALKHAKKLQAQVKDALRDAEEAKAAKEELQALSKEA----ERKVKAL----- 1768
            ::  |:.::|  |.:|...........|..|....|:::..|.:|.||.    ||....|     
Mouse  2024 DS--ELEDRV--DGVKSWLSKNKGPSKAPSDDGSLKSSRTALNSLPKEGKGPEERPSSVLSSLSY 2084

  Fly  1769 ----------------EAEVLQLTEDLASSER----ARRAAETERDEL----AEE---------- 1799
                            ::.:..|:|...|.||    ||.....|.|:.    .||          
Mouse  2085 RKRLTLKDSIGGTGDQDSLLTTLSERATSPERPPRKARGGPREEPDQAQGRRCEELDDCSSIFSG 2149

  Fly  1800 IANNANKGSLMIDEKR------RLEARIATLEEELEEEQSNSEVLLDRSRKAQLQIEQLTTELAN 1858
            :.:...:|.    |||      |.....|.:.......:.:.|   ||:|.:      |:..|:.
Mouse  2150 VGSRPGRGL----EKRWGSDFDRSSTVSAPVSRASSATRGSGE---DRARSS------LSFSLSG 2201

  Fly  1859 EKSNSQKNE--------------NGRALLERQNKELKAKLAEIETAQRTKVKATIATLEAKIANL 1909
            ..|:.:::.              |..:.|.|::.:.:..|.: .........|::|..||     
Mouse  2202 SPSSRRRSTSRLDSLSSAISPSWNRASGLGRESPDSRLSLGQ-SCLDEWDDGASVALSEA----- 2260

  Fly  1910 EEQLENEGKERLL----QQKANRKMDKKIKELTMNIEDERRHVDQHKEQMDKLNSRIKLLKRNLD 1970
            ..|..:....|.|    |.:.:......:.|     ....|.|.:|           ..|..:|:
Mouse  2261 HSQFSHPSLARSLSVPPQPRGSSSASASVIE-----GSSVRPVSRH-----------SYLDPDLE 2309

  Fly  1971 ETEEELQKEKT---QKRKYQRECED----MIESQEAMNREINSLKTKLRRTGGIGLSSSRLTGTP 2028
            ....|:...|.   |:.:.:.:.||    .|:|..:...|.....:.:||:......||| :|..
Mouse  2310 AAINEVLSYKPVPFQRSRLEPDSEDDDRKSIQSARSAQLEHPERGSSIRRSASAADVSSR-SGRK 2373

  Fly  2029 S-----SKRAGGGGGGDDSSVQDESLDGEDSAN 2056
            |     |||:........||....|.....||:
Mouse  2374 SRSKHRSKRSSPSPSSSSSSSSSSSSSEGSSAH 2406

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
zipNP_523860.2 Myosin_N 80..117 CDD:280832 9/40 (23%)
Myosin_head 133..854 CDD:278492 227/834 (27%)
MYSc_Myh2_insects_mollusks 145..854 CDD:276876 220/822 (27%)
Myosin_tail_1 931..2011 CDD:279860 266/1213 (22%)
Prefoldin 1431..1515 CDD:298833 24/90 (27%)
FAM76 <1847..1926 CDD:292665 15/96 (16%)
Myo18aXP_036012684.1 PDZ_signaling 220..308 CDD:238492
COG5022 429..1950 CDD:227355 448/1670 (27%)
MYSc_Myo18 467..1224 CDD:276837 220/822 (27%)
MDN1 <1782..2121 CDD:227596 101/413 (24%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG0161
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.810

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