DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment zip and myh9a

DIOPT Version :9

Sequence 1:	NP_523860.2	Gene:	zip / 38001	FlyBaseID:	FBgn0265434	Length:	2056	Species:	Drosophila melanogaster
Sequence 2:	NP_001091647.2	Gene:	myh9a / 333938	ZFINID:	ZDB-GENE-030131-5870	Length:	1961	Species:	Danio rerio

Alignment Length:	2015	Identity:	1192/2015 - (59%)
Similarity:	1534/2015 - (76%)	Gaps:	73/2015 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly    53 NDPELKYLSVERNQFNDPATQAEWTQKRLVWVPHENQGFVAASIKREHGDEVEVELAETGKRVMI 117
            :|.| |:|..:||..|||..||:|..|:|||||.|..||.|.|||.|.|||..||||::||::.:
Zfish     2 SDAE-KFLYADRNTINDPLAQADWATKKLVWVPSEKLGFEAGSIKEETGDECLVELADSGKKIKV 65

  Fly   118 LRDDIQKMNPPKFDKVEDMAELTCLNEASVLHNIKDRYYSGLIYTYSGLFCVVVNPYKKLPIYTE 182
            .:|||||||||||.|||||||||||||||||||:::|||||||||||||||||:||||.||||||
Zfish    66 NKDDIQKMNPPKFSKVEDMAELTCLNEASVLHNLRERYYSGLIYTYSGLFCVVINPYKYLPIYTE 130

  Fly   183 KIMERYKGIKRHEVPPHVFAITDSAYRNMLGDREDQSILCTGESGAGKTENTKKVIQFLAYVAAS 247
            :|:|.|||.||||:|||::||||:|||:|:.||||||||||||||||||||||||||:|||||:|
Zfish   131 EIVEMYKGKKRHEMPPHIYAITDTAYRSMMQDREDQSILCTGESGAGKTENTKKVIQYLAYVASS 195

  Fly   248 ----KPKGSGAVPHPAVLINFSVNTNKYIKVKIMAQNQNQTIEVVNGLKMVEVNSNCQEGELEQQ 308
                |.:.|.|:.|                                             ||||:|
Zfish   196 FKTKKDQSSIALSH---------------------------------------------GELEKQ 215

  Fly   309 LLQANPILEAFGNAKTVKNDNSSRFGKFIRINFDASGFISGANIETYLLEKSRAIRQAKDERTFH 373
            ||||||||||||||||||||||||||||||||||.:|:|.||||||||||||||||||||||.||
Zfish   216 LLQANPILEAFGNAKTVKNDNSSRFGKFIRINFDVNGYIVGANIETYLLEKSRAIRQAKDERAFH 280

  Fly   374 IFYQLLAGATPEQREKFILDDVKSYAFLSNGSLPVPGVDDYAEFQATVKSMNIMGMTSEDFNSIF 438
            |||.||.||..:.|.:..|:|...|.|||||::.:||..|...|..|:.:..|||:..::...:.
Zfish   281 IFYYLLTGAGDKLRSELCLEDYNKYRFLSNGNVTIPGQQDRELFAETIDAFRIMGIPEDEQTGLL 345

  Fly   439 RIVSAVLLFGSMKFRQERNNDQATLPDNTVAQKIAHLLGLSVTDMTRAFLTPRIKVGRDFVTKAQ 503
            ::|||||..|:|.|::|||:|||::||:|.|||::||||::|||.|||.|:||||||||||.|||
Zfish   346 KVVSAVLQLGNMSFKKERNSDQASMPDDTAAQKVSHLLGMNVTDFTRAILSPRIKVGRDFVQKAQ 410

  Fly   504 TKEQVEFAVEAIAKACYERMFKWLVNRINRSLDRTKRQGASFIGILDMAGFEIFELNSFEQLCIN 568
            |:||.||||||:|||.|||:|:|||.|||::||:|||||||||||||:|||||||||||||||||
Zfish   411 TQEQAEFAVEALAKATYERLFRWLVMRINKALDKTKRQGASFIGILDIAGFEIFELNSFEQLCIN 475

  Fly   569 YTNEKLQQLFNHTMFILEQEEYQREGIEWKFIDFGLDLQPTIDLIDKPG---GIMALLDEECWFP 630
            |||||||||||||||||||||||||||||.||||||||||.|:||:||.   ||:||||||||||
Zfish   476 YTNEKLQQLFNHTMFILEQEEYQREGIEWSFIDFGLDLQPCIELIEKPNGPPGILALLDEECWFP 540

  Fly   631 KATDKTFVDKLVSAHSMHPKFMK-TDFRGVADFAIVHYAGRVDYSAAKWLMKNMDPLNENIVSLL 694
            |||||:||:|:|.....:|||.| ...:..|||.|:||||:|||.|.:||||||||||:|:.:||
Zfish   541 KATDKSFVEKVVQELGNNPKFQKPKKLKDDADFCIIHYAGKVDYKANEWLMKNMDPLNDNVATLL 605

  Fly   695 QGSQDPFVVNIWKDAE-IVGMAQQA-LTDTQFGA-RTRKGMFRTVSHLYKEQLAKLMDTLRNTNP 756
            ..|.|.||..:|||.: |||:.:.| :.::..|| :|||||||||..||||||..||.|||||||
Zfish   606 NQSVDKFVSELWKDVDRIVGLDKVAGMGESLHGAVKTRKGMFRTVGQLYKEQLMNLMTTLRNTNP 670

  Fly   757 NFVRCIIPNHEKRAGKIDAPLVLDQLRCNGVLEGIRICRQGFPNRIPFQEFRQRYELLTPNVIPK 821
            ||||||||||||:|||:...||||||||||||||||||||||||||.|||||||||:||||.|||
Zfish   671 NFVRCIIPNHEKKAGKLAHHLVLDQLRCNGVLEGIRICRQGFPNRIVFQEFRQRYEILTPNAIPK 735

  Fly   822 GFMDGKKACEKMIQALELDSNLYRVGQSKIFFRAGVLAHLEEERDFKISDLIVNFQAFCRGFLAR 886
            ||||||:||..|::||||||||||:||||:|||||||||||||||.||:|:|:||||:|||::||
Zfish   736 GFMDGKQACVLMVKALELDSNLYRIGQSKVFFRAGVLAHLEEERDMKITDVIINFQAWCRGYVAR 800

  Fly   887 RNYQKRLQQLNAIRIIQRNCAAYLKLRNWQWWRLYTKVKPLLEVTKQEEKLVQKEDELKQVREKL 951
            |.:.||.|||.|:|:|||||||||||||||||||:|||||||:||:|||::|.||:||.:::|:.
Zfish   801 RAFAKRQQQLTAMRVIQRNCAAYLKLRNWQWWRLFTKVKPLLQVTRQEEEMVAKEEELVKMKERQ 865

  Fly   952 DTLAKNTQEYERKYQQALVEKTTLAEQLQAEIELCAEAEESRSRLMARKQELEDMMQELETRIEE 1016
            .......:|.|.|.:|...||..|.||||||.|||.||||.||||.||.||:|:::.|||:|:||
Zfish   866 QQAEDQLKESEAKQKQLNAEKLALQEQLQAETELCQEAEEMRSRLTARMQEMEEVLHELESRLEE 930

  Fly  1017 EEERVLALGGEKKKLELNIQDLEEQLEEEEAARQKLQLEKVQLDAKIKKYEEDLALTDDQNQKLL 1081
            |||||.....||||::.||.|||:||:||||||||||||||.:|||:||.||||.:.:|||.||.
Zfish   931 EEERVAQFQSEKKKMQQNIGDLEQQLDEEEAARQKLQLEKVTMDAKLKKIEEDLMVIEDQNAKLS 995

  Fly  1082 KEKKLLEERANDLSQTLAEEEEKAKHLAKLKAKHEATISELEERLHKDQQQRQESDRSKRKIETE 1146
            ||||.:|||.::.:..|||||||:|.|.|||.|||..|::||:||.|:::.|||.::::||:|.:
Zfish   996 KEKKQMEERISEFTTNLAEEEEKSKSLQKLKTKHETMITDLEDRLRKEEKMRQELEKNRRKLEGD 1060

  Fly  1147 VADLKEQLNERRVQVDEMQAQLAKREEELTQTLLRIDEESATKATAQKAQRELESQLAEIQEDLE 1211
            ..:|.:|:.|.:.|:.|::|||||:||||...|.||:||:|.|..|||:.||:|:|::|:|||||
Zfish  1061 STELHDQIAELQAQIAELRAQLAKKEEELQAALARIEEEAALKNAAQKSIREMEAQISELQEDLE 1125

  Fly  1212 AEKAARAKAEKVRRDLSEELEALKNELLDSLDTTAAQQELRSKREQELATLKKSLEEETVNHEGV 1276
            .|||||.||||.||||.|||||||.||.|:||:||||||||:|||.|:..|||:||:|...||.:
Zfish  1126 LEKAARNKAEKQRRDLGEELEALKTELEDTLDSTAAQQELRAKRETEVTQLKKTLEDEARAHEQM 1190

  Fly  1277 LADMRHKHSQELNSINDQLENLRKAKTVLEKAKGTLEAENADLATELRSVNSSRQENDRRRKQAE 1341
            |:::|.||:|....:|:|||..:::|..::|||..||:|..:|..||:|::.|:.:::.|||:||
Zfish  1191 LSEVRQKHNQAFEELNEQLEQSKRSKASVDKAKQALESERNELQIELKSLSQSKNDSENRRKKAE 1255

  Fly  1342 SQIAELQVKLAEIERARSELQEKCTKLQQEAENITNQLEEAELKASAAVKSASNMESQLTEAQQL 1406
            ||:.|||||..|.||.:.||.:|.:|:|.|.|::...:.:.|.|:..|.|..|.:||||.:||.|
Zfish  1256 SQLQELQVKHTESERQKHELLDKVSKMQAELESLQGTVTKVESKSIKAAKDCSAVESQLKDAQAL 1320

  Fly  1407 LEEETRQKLGLSSKLRQIESEKEALQEQLEEDDEAKRNYERKLAEVTTQMQEIKKKAEEDADLAK 1471
            |||||||||.:|::|||:|.|:..|:|.|||::|:|:|.|::|.....|:.|:|||.|::|...:
Zfish  1321 LEEETRQKLAISTRLRQLEDEQNNLKEMLEEEEESKKNVEKQLHTAQAQLAEMKKKIEQEAQSLE 1385

  Fly  1472 ELEEGKKRLNKDIEALERQVKELIAQNDRLDKSKKKIQSELEDATIELEAQRTKVLELEKKQKNF 1536
            .:|:|||:|.:::|::.:|::|..|..|:|||:|.::|.||:|..::....|..|.|||:|||.|
Zfish  1386 SMEDGKKKLQREVESVLQQLEERNASYDKLDKTKTRLQRELDDVLVDQGHLRQTVQELERKQKKF 1450

  Fly  1537 DKILAEEKAISEQIAQERDTAEREAREKETKVLSVSRELDEAFDKIEDLENKRKTLQNELDDLAN 1601
            |::|||||:||.:.|:|||.||.||||||||.|:::|||:...|...:||...|.|:.|::||.:
Zfish  1451 DQMLAEEKSISTKYAEERDRAEAEAREKETKSLTLARELEAMTDLKNELERVNKQLKTEMEDLVS 1515

  Fly  1602 TQGTADKNVHELEKAKRALESQLAELKAQNEELEDDLQLTEDAKLRLEVNMQALRSQFERDLLAK 1666
            ::..|.|:|||||:|||.:|.||.|:|.|.|||||:||||||||||||||||||::||||||.::
Zfish  1516 SKDDAGKSVHELERAKRGMEQQLEEMKTQLEELEDELQLTEDAKLRLEVNMQALKAQFERDLQSR 1580

  Fly  1667 EEGAEEKRRGLVKQLRDLETELDEERKQRTAAVASKKKLEGDLKEIETTMEMHNKVKEDALKHAK 1731
            :|..||||:.||||:|::|.||::|||||..||:.:||||.||.|:...:::.||.:::|||..|
Zfish  1581 DEQGEEKRKQLVKQVREMEMELEDERKQRAQAVSVRKKLELDLSELAAQIDLANKARDEALKQLK 1645

  Fly  1732 KLQAQVKDALRDAEEAKAAKEELQALSKEAERKVKALEAEVLQLTEDLASSERARRAAETERDEL 1796
            |||||:|:.:|:.|:.:.:::|....:||.|||:|::|||::||.||||:::||:|..:.|||||
Zfish  1646 KLQAQMKEQMREFEDLRLSRDESLNQAKENERKIKSMEAEIMQLHEDLAAADRAKRQIQQERDEL 1710

  Fly  1797 AEEIANNANKGSLMIDEKRRLEARIATLEEELEEEQSNSEVLLDRSRKAQLQIEQLTTELANEKS 1861
            .:||.:...|.||..||:||||||||.||||||||..:.|::.||.:||.||.||:|.||..|:|
Zfish  1711 QDEINSQNAKNSLSSDERRRLEARIAQLEEELEEEHLSVELVNDRLKKASLQAEQVTVELTAERS 1775

  Fly  1862 NSQKNENGRALLERQNKELKAKLAEIETAQRTKVKATIATLEAKIANLEEQLENEGKERLLQQKA 1926
            |||:.|..|:.|:||||::|.||.|:|.|.::|.|:||..||.||..|||||::|.|||....|.
Zfish  1776 NSQRLEGLRSQLDRQNKDMKQKLQELEGAVKSKYKSTITALETKIQQLEEQLDSEMKERQQSTKQ 1840

  Fly  1927 NRKMDKKIKELTMNIEDERRHVDQHKEQMDKLNSRIKLLKRNLDETEEELQKEKTQKRKYQRECE 1991
            .|:::||:||:.:.:|||||:.||.|.:.:|.|.|:|.:||.|:|||||..:.....||.:||.|
Zfish  1841 VRRVEKKLKEVLLQVEDERRNADQSKTETEKANIRLKQMKRQLEETEEEAARANASCRKLRRELE 1905

  Fly  1992 DMIESQEAMNREINSLKTKLRR---TGGIGLSSSRLTGTPSSKRAGGGGGGDDSSVQDESLDGED 2053
            |..||..|||||:::||.||||   ||.:             :||.|..|.:.....|...:|.:
Zfish  1906 DATESASAMNREVSTLKNKLRRGDFTGNV-------------RRAIGRTGVESDDENDLKSEGSE 1957

Fly 2054 2053
Zfish 1958 1957

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
zip	NP_523860.2	Myosin_N	80..117	CDD:280832	22/36 (61%)
		Myosin_head	133..854	CDD:278492	500/731 (68%)
		MYSc_Myh2_insects_mollusks	145..854	CDD:276876	488/719 (68%)
		Myosin_tail_1	931..2011	CDD:279860	571/1079 (53%)
		Prefoldin	1431..1515	CDD:298833	34/83 (41%)
		FAM76	<1847..1926	CDD:292665	42/78 (54%)
myh9a	NP_001091647.2	Myosin_N	28..66	CDD:280832	22/37 (59%)
		Myosin_head	81..768	CDD:278492	500/731 (68%)
		MYSc_Myh18	93..768	CDD:276895	488/719 (68%)
		Myosin_tail_1	845..1925	CDD:279860	571/1079 (53%)
		crotonase-like	1067..>1101	CDD:304874	18/33 (55%)
		DUF2570	1777..1878	CDD:305162	49/100 (49%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	1019	1.000	Domainoid score	I28
eggNOG	1	0.900	-	-		E2759_KOG0161
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D40305at33208
OrthoFinder	1	1.000	-	-		FOG0000014
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100110
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X58
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	9	8.680