Protein Alignment zip and Myo5c

DIOPT Version :10

• Sequence 1: NP_523860.2
• Gene: zip / 38001
• FlyBaseID: FBgn0287873
• Length: 2056
• Species: Drosophila melanogaster
• Sequence 2: XP_006243475.1
• Gene: Myo5c / 315820
• RGDID: 1309994
• Length: 1749
• Species: Rattus norvegicus
• Alignment Length: 1953
• Identity: 505/1953 - (25%)
• Similarity: 871/1953 - (44%)
• Gaps: 433/1953 - (22%)

  Fly    76 WTQKRLVWVPHENQGFVAASIKREH--GDEVEVELAETGKRVMI---------LRDDIQKMNPPK 129
            :.|...||:|...:.:.:|.|.:::  ||:|...|.|.|..:..         ||      ||..
  Rat     7 YAQYNRVWIPDPEEVWKSAEIAKDYRVGDQVLRLLLEDGTELDYPVDPGSLPPLR------NPDI 65

  Fly   130 FDKVEDMAELTCLNEASVLHNIKDRY-YSGLIYTYSGLFCVVVNPYKKLPIYTEKIMERYKGIKR 193
            .....|:..|:.|:|.:||||::.|: .|.|||||||:..|.:||||:||||.:.|:..|.|...
  Rat    66 LVGENDLTALSYLHEPAVLHNLRIRFAESKLIYTYSGIILVAMNPYKQLPIYGDAIIHAYSGQNM 130

  Fly   194 HEVPPHVFAITDSAYRNMLGDREDQSILCTGESGAGKTENTKKVIQFLAYVAASKPKGSGAVPHP 258
            .::.||:||:.:.||:.|..:..:|||:.:||||||||.:.:..:::.|.|:.|
  Rat   131 GDMDPHIFAVAEEAYKQMARNNRNQSIIVSGESGAGKTVSARYAMRYFATVSKS----------- 184

  Fly   259 AVLINFSVNTNKYIKVKIMAQNQNQTIEVVNGLKMVEVNSNCQEGELEQQLLQANPILEAFGNAK 323
                    ::|.:::.|::|                                 :|||.||.||||
  Rat   185 --------SSNAHVEEKVLA---------------------------------SNPITEAVGNAK 208

  Fly   324 TVKNDNSSRFGKFIRINFDASGFISGANIETYLLEKSRAIRQAKDERTFHIFYQLLAGATPEQRE 388
            |.:|||||||||:..|:||....|.|||:.||||||||.:.|:::||.:||||||.|.|...:.:
  Rat   209 TTRNDNSSRFGKYTEISFDERNQIIGANMRTYLLEKSRVVFQSENERNYHIFYQLCASAQQSEFK 273

  Fly   389 KFILDDVKSYAFL-SNGSLPVPGVDDYAEFQATVKSMNIMGMTSEDFNSIFRIVSAVLLFGSMKF 452
            ...|...:.:.:. ..|:..:.||||.|:...|.|:..::|...:....:|:|::|:|..|:::.
  Rat   274 HLKLGSAEEFNYTRMGGNTVIEGVDDRADMAETQKTFTLLGFKKDFQMDVFKILAAILHLGNVQV 338

  Fly   453 RQERNNDQATLPDNTVAQKIAHLLGLSVTDMTRAFLTPRIKVGRDFVTKAQTKEQVEFAVEAIAK 517
            ....|...|...|::..:....||||....:.:.....:|....:.|.|..|:.|...|.:|:||
  Rat   339 TTVGNERSAVSEDDSHLKVFCELLGLETIKVAQWLCNRKIVTSSETVVKPMTRPQAINARDALAK 403

  Fly   518 ACYERMFKWLVNRINRSLDRTKRQGASFIGILDMAGFEIFELNSFEQLCINYTNEKLQQLFNHTM 582
            ..|..:|.::|.:||::|..:.:| .:|||:||:.|||.|::|||||.||||.||||||.||..:
  Rat   404 KIYAHLFDFIVEQINQALHFSGKQ-HTFIGVLDIYGFETFDVNSFEQFCINYANEKLQQQFNLHV 467

  Fly   583 FILEQEEYQREGIEWKFIDFGLDLQPTIDLIDKPGGIMALLDEECWFPKATDKTFVDKL----VS 643
            |.||||||.:|.|.|..||| .|.||.||||:...||:.||||||..|..||:.::.||    |:
  Rat   468 FKLEQEEYMKEDIPWTLIDF-YDNQPVIDLIEAKMGILELLDEECLLPHGTDENWLQKLYNNFVN 531

  Fly   644 AHSMHPKFMKTDFRGVADFAIVHYAGRVDYSAAKWLMKNMDPLNENIVSLLQGSQDPFVVNIWKD 708
            .:|:..|...::    :.|.|.|:|.:|:|....:|.||.|.:.:.:|.:|:.|:.......:::
  Rat   532 KNSLFEKPRMSN----SSFIIQHFADKVEYQCEGFLEKNRDTVYDMLVEVLRASKFHLCAAFFQE 592

  Fly   709 AEI----------VGMAQQALTDTQFGARTRKGMFRTVSHLYKEQLAKLMDTLRNTNPNFVRCII 763
            :.:          |..|:|.:.......||      ||.:.::..|..||:||..|.|::||||.
  Rat   593 SPVPSSPFGAMITVKSAKQVIKPNTKHFRT------TVGNKFRSSLFLLMETLNATTPHYVRCIK 651

  Fly   764 PNHEKRAGKIDAPLVLDQLRCNGVLEGIRICRQGFPNRIPFQEFRQRY-ELLTPNVIPKGFMDGK 827
            ||.||...:.|:..::.|||..||||.|||..|.:|:|..:.||..|| .|:|...:  ...|.|
  Rat   652 PNDEKLPFEFDSKRIVQQLRACGVLETIRISAQSYPSRWTYLEFYSRYGVLMTQQEL--SLSDKK 714

  Fly   828 KACEKMIQALELDSNLYRVGQSKIFFRAGVLAHLEEERDFKISDLIVNFQAFCRGFLARRNYQKR 892
            :.|:.::..|..|||.|:.|::|||||||.:|:||:.|..|:....:..|...||:|.|:.:.:.
  Rat   715 EVCKVVLHRLIQDSNQYQFGRTKIFFRAGQVAYLEKLRLDKLRQGCIVIQKHVRGWLQRKKFLRE 779

  Fly   893 -------------------------LQQLNAIRIIQRNCAAYLKLRNWQWWRLYTKVKPLLEVTK 932
                                     |::..|..|:|::|..|| :||     ||
  Rat   780 RRAALTIQQYFRGQQTVRKAITATALKEAWAAIILQKHCRGYL-VRN-----LY----------- 827

  Fly   933 QEEKLVQKEDELKQVREKLDTLAKNTQEY--ERKYQQALVEKTTLAEQLQAEIELCAEAEESRSR 995
                        :.:|....|:..:|:.:  .|:|::.|.|...:..|..|...|.....::..|
  Rat   828 ------------QLIRVATITIQAHTRGFLARRRYRKLLQEHKAVILQKYARAWLARRRFQNIRR 880

  Fly   996 LMARKQELEDMMQELETRIEEEE-------ERVLALGGEKKKLELNIQDLEEQLEEEEAARQKLQ 1053
            .:...| |...:|.|:.::|::.       |::.:|..      |.:.|| |:::..||..:|..
  Rat   881 FVLNIQ-LTYRVQRLQKKLEDQNRENHGLVEKLTSLAA------LRVGDL-EKVQRLEAELEKAA 937

  Fly  1054 LEKVQLDAKIKKYEEDLALTDDQNQKLLKEKKLLEERANDLSQTLAEEEEKAKHLAKLKAKHEAT 1118
            ..:...:.|.::|.:.:   :::..||.|....||.:.....|:|.|..|      :||.|.:..
  Rat   938 THRHSYEEKGRRYRDSM---EERLSKLQKHNAELESQRERAEQSLQERTE------ELKEKMDQL 993

  Fly  1119 ISELEERLHKDQQQRQESDRS--------KRKIET---EVADLKE-------QLNERRVQVDEMQ 1165
            ..:|.:.:.|::|||...::|        :::||:   |:..||:       ||.|.||..|.::
  Rat   994 TRQLFDDVQKEEQQRLLLEKSFELKTQAYEKEIESLREEIKALKDERTQLHHQLEEGRVTSDSLK 1058

  Fly  1166 AQLAKREEELTQTLLRIDEESATKATAQKAQRELESQLAEIQEDLEAEKAARAKAEKVRRDLSEE 1230
            .::|           |:.:::.|.:..:|....|::|..::::.::::|          |::.|.
  Rat  1059 GEVA-----------RLSKQAKTISEFEKEIELLQAQKIDVEKHVQSQK----------REMRER 1102

  Fly  1231 LEALKNELLDSLDTTAAQQELRSK----------REQELATLKKSLEEETVNHEGVLADMRHKHS 1285
            :..:..:||:|.|.    :::||:          .:.||....:.|::.|...|......:..:.
  Rat  1103 MSEVTKQLLESYDI----EDVRSRLSVEDLEHLNEDGELWFAYEGLKKATRVLESHFQSQKDCYE 1163

  Fly  1286 QELNSINDQLENLRKAKTVLEKAKGTLEAENADLATELRSVNSSRQENDRRRKQAESQIAELQVK 1350
            :|:..:|.::.:|.:....|:|           |..|...:|.|.:....|.......|.:.:.:
  Rat  1164 KEIEGLNFKVVHLSQEINHLQK-----------LFREETDINESIRHEVTRLTSENMMIPDFKQQ 1217

  Fly  1351 LAEIERARSELQEKCTKLQQEAENITNQLEEAELKASAAVKSASNMESQLTEAQQLLEEETRQKL 1415
            ::|:||.:.:|:   ::|:::||.:..:.||                 ..:...:.||||.||..
  Rat  1218 ISELERQKQDLE---SRLKEQAEKMEGKQEE-----------------PFSHLNRGLEEEGRQGK 1262

  Fly  1416 GLSSKLRQIESEKEALQEQLEEDDEAKRNYERKLAEVTTQMQEIKKKAEEDADLAKELEEGKKRL 1480
            .....||.:|:       |.|...|.|.....|:.|....::..||:||.:.::...|.:...||
  Rat  1263 APRPFLRAVEA-------QSETHPEGKERLVGKIQEPQEAIKFPKKQAEAEEEVESILRQEASRL 1320

  Fly  1481 ---NKDIEALERQVKELIAQNDRLDKSKKKIQSELEDATIELEAQRTKVLELEKKQKNFDKILAE 1542
               |:|:|      :||    |..|:..:|:|.:::..|..:|  :...:.|....:.:..:|..
  Rat  1321 SLENRDLE------EEL----DMKDRMIRKLQDQVKTLTRTIE--KANSVPLPSGSREYLGMLEY 1373

  Fly  1543 EKAISEQIAQERDTAEREAREKETKVLSVSRELD-----------------------EAFDKIED 1584
            :|                  |.|||::. :..||                       ...|.:.|
  Rat  1374 KK------------------EDETKLIQ-NLILDLKPRGVVVNMIPGLPAHILFMCVRYADSLND 1419

  Fly  1585 LENKRKTLQN------------ELDDLANTQGTADKNVHELEKAKR-ALESQLAELKA--QNEEL 1634
             .|..|:|.|            ..:||...........|.|...|: :.|.:..:..:  ||:..
  Rat  1420 -ANMLKSLMNSAINGIKHVVKEHFEDLEMLSFWLSNTCHFLNCLKQYSGEEEFMKCNSPQQNKNC 1483

  Fly  1635 EDDLQLTE------DAKLR--------LEVNMQAL--RSQFERDLLAKEEGAE----EKR----- 1674
            .::..|||      |..:|        :|.|:|.:  ....|.:.|....|.:    .||
  Rat  1484 LNNFDLTEYRQILSDVAIRIYHQFILVMENNLQPIIVPGMLEYESLQGISGLKPTGFRKRSSSID 1548

  Fly  1675 -------RGLVKQL---------RDLETELDEERKQRT-----AAVASKKKLEGDLKEIETTMEM 1718
                   ..:::||         ..|:.|:..:..::.     |...:...|..|:......|::
  Rat  1549 DTDAYTMTSILQQLSYFYSTMCQNGLDPEIVRQAVKQLFYLIGAVTLNSLLLRKDMCSCRKGMQI 1613

  Fly  1719 HNKVK--EDALKHAKKLQAQVKDALRDAEEAKAAKEELQALSKEAERKVKALEAEVLQLTEDLAS 1781
            ...:.  |:.||. |.||..:            |||.|:.||:         .|.:||:
  Rat  1614 RCNISFLEEWLKD-KNLQNSL------------AKETLEPLSQ---------AAWLLQV------ 1650

  Fly  1782 SERARRAAETERDELAE--------EIANNANKGSLMID-EKRRLEARIATLEEELEEEQSNSEV 1837
                ::..:::..|:::        :|....|..:.:.| |||...:.:..::..|.....:|::
  Rat  1651 ----KKTTDSDAKEISQCCTSLSAVQIIKILNSYTPIDDFEKRVNPSFVRKVQALLNNRGDSSQL 1711

  Fly  1838 LLD 1840
            :||
  Rat  1712 MLD 1714

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
zip	NP_523860.2	Myosin_N	79..122	CDD:460670	13/53 (25%)
		MYSc_Myh2_insects_mollusks	145..854	CDD:276876	261/725 (36%)
		Myosin_tail_1	931..2011	CDD:460256	199/1045 (19%)
Myo5c	XP_006243475.1	MYSc_Myo5	81..741	CDD:276831	261/725 (36%)
		IQ	755..776	CDD:197470	6/20 (30%)
		IQ	831..851	CDD:459869	4/19 (21%)
		SMC_prok_B	<850..>1385	CDD:274008	132/645 (20%)
		Myo5c_CBD	1376..1743	CDD:271260	67/373 (18%)