DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment zip and Myo5c

DIOPT Version :9

Sequence 1:NP_523860.2 Gene:zip / 38001 FlyBaseID:FBgn0265434 Length:2056 Species:Drosophila melanogaster
Sequence 2:XP_006243475.1 Gene:Myo5c / 315820 RGDID:1309994 Length:1749 Species:Rattus norvegicus


Alignment Length:1953 Identity:505/1953 - (25%)
Similarity:871/1953 - (44%) Gaps:433/1953 - (22%)


- Green bases have known domain annotations that are detailed below.


  Fly    76 WTQKRLVWVPHENQGFVAASIKREH--GDEVEVELAETGKRVMI---------LRDDIQKMNPPK 129
            :.|...||:|...:.:.:|.|.:::  ||:|...|.|.|..:..         ||      ||..
  Rat     7 YAQYNRVWIPDPEEVWKSAEIAKDYRVGDQVLRLLLEDGTELDYPVDPGSLPPLR------NPDI 65

  Fly   130 FDKVEDMAELTCLNEASVLHNIKDRY-YSGLIYTYSGLFCVVVNPYKKLPIYTEKIMERYKGIKR 193
            .....|:..|:.|:|.:||||::.|: .|.|||||||:..|.:||||:||||.:.|:..|.|...
  Rat    66 LVGENDLTALSYLHEPAVLHNLRIRFAESKLIYTYSGIILVAMNPYKQLPIYGDAIIHAYSGQNM 130

  Fly   194 HEVPPHVFAITDSAYRNMLGDREDQSILCTGESGAGKTENTKKVIQFLAYVAASKPKGSGAVPHP 258
            .::.||:||:.:.||:.|..:..:|||:.:||||||||.:.:..:::.|.|:.|           
  Rat   131 GDMDPHIFAVAEEAYKQMARNNRNQSIIVSGESGAGKTVSARYAMRYFATVSKS----------- 184

  Fly   259 AVLINFSVNTNKYIKVKIMAQNQNQTIEVVNGLKMVEVNSNCQEGELEQQLLQANPILEAFGNAK 323
                    ::|.:::.|::|                                 :|||.||.||||
  Rat   185 --------SSNAHVEEKVLA---------------------------------SNPITEAVGNAK 208

  Fly   324 TVKNDNSSRFGKFIRINFDASGFISGANIETYLLEKSRAIRQAKDERTFHIFYQLLAGATPEQRE 388
            |.:|||||||||:..|:||....|.|||:.||||||||.:.|:::||.:||||||.|.|...:.:
  Rat   209 TTRNDNSSRFGKYTEISFDERNQIIGANMRTYLLEKSRVVFQSENERNYHIFYQLCASAQQSEFK 273

  Fly   389 KFILDDVKSYAFL-SNGSLPVPGVDDYAEFQATVKSMNIMGMTSEDFNSIFRIVSAVLLFGSMKF 452
            ...|...:.:.:. ..|:..:.||||.|:...|.|:..::|...:....:|:|::|:|..|:::.
  Rat   274 HLKLGSAEEFNYTRMGGNTVIEGVDDRADMAETQKTFTLLGFKKDFQMDVFKILAAILHLGNVQV 338

  Fly   453 RQERNNDQATLPDNTVAQKIAHLLGLSVTDMTRAFLTPRIKVGRDFVTKAQTKEQVEFAVEAIAK 517
            ....|...|...|::..:....||||....:.:.....:|....:.|.|..|:.|...|.:|:||
  Rat   339 TTVGNERSAVSEDDSHLKVFCELLGLETIKVAQWLCNRKIVTSSETVVKPMTRPQAINARDALAK 403

  Fly   518 ACYERMFKWLVNRINRSLDRTKRQGASFIGILDMAGFEIFELNSFEQLCINYTNEKLQQLFNHTM 582
            ..|..:|.::|.:||::|..:.:| .:|||:||:.|||.|::|||||.||||.||||||.||..:
  Rat   404 KIYAHLFDFIVEQINQALHFSGKQ-HTFIGVLDIYGFETFDVNSFEQFCINYANEKLQQQFNLHV 467

  Fly   583 FILEQEEYQREGIEWKFIDFGLDLQPTIDLIDKPGGIMALLDEECWFPKATDKTFVDKL----VS 643
            |.||||||.:|.|.|..||| .|.||.||||:...||:.||||||..|..||:.::.||    |:
  Rat   468 FKLEQEEYMKEDIPWTLIDF-YDNQPVIDLIEAKMGILELLDEECLLPHGTDENWLQKLYNNFVN 531

  Fly   644 AHSMHPKFMKTDFRGVADFAIVHYAGRVDYSAAKWLMKNMDPLNENIVSLLQGSQDPFVVNIWKD 708
            .:|:..|...::    :.|.|.|:|.:|:|....:|.||.|.:.:.:|.:|:.|:.......:::
  Rat   532 KNSLFEKPRMSN----SSFIIQHFADKVEYQCEGFLEKNRDTVYDMLVEVLRASKFHLCAAFFQE 592

  Fly   709 AEI----------VGMAQQALTDTQFGARTRKGMFRTVSHLYKEQLAKLMDTLRNTNPNFVRCII 763
            :.:          |..|:|.:.......||      ||.:.::..|..||:||..|.|::||||.
  Rat   593 SPVPSSPFGAMITVKSAKQVIKPNTKHFRT------TVGNKFRSSLFLLMETLNATTPHYVRCIK 651

  Fly   764 PNHEKRAGKIDAPLVLDQLRCNGVLEGIRICRQGFPNRIPFQEFRQRY-ELLTPNVIPKGFMDGK 827
            ||.||...:.|:..::.|||..||||.|||..|.:|:|..:.||..|| .|:|...:  ...|.|
  Rat   652 PNDEKLPFEFDSKRIVQQLRACGVLETIRISAQSYPSRWTYLEFYSRYGVLMTQQEL--SLSDKK 714

  Fly   828 KACEKMIQALELDSNLYRVGQSKIFFRAGVLAHLEEERDFKISDLIVNFQAFCRGFLARRNYQKR 892
            :.|:.::..|..|||.|:.|::|||||||.:|:||:.|..|:....:..|...||:|.|:.:.:.
  Rat   715 EVCKVVLHRLIQDSNQYQFGRTKIFFRAGQVAYLEKLRLDKLRQGCIVIQKHVRGWLQRKKFLRE 779

  Fly   893 -------------------------LQQLNAIRIIQRNCAAYLKLRNWQWWRLYTKVKPLLEVTK 932
                                     |::..|..|:|::|..|| :||     ||           
  Rat   780 RRAALTIQQYFRGQQTVRKAITATALKEAWAAIILQKHCRGYL-VRN-----LY----------- 827

  Fly   933 QEEKLVQKEDELKQVREKLDTLAKNTQEY--ERKYQQALVEKTTLAEQLQAEIELCAEAEESRSR 995
                        :.:|....|:..:|:.:  .|:|::.|.|...:..|..|...|.....::..|
  Rat   828 ------------QLIRVATITIQAHTRGFLARRRYRKLLQEHKAVILQKYARAWLARRRFQNIRR 880

  Fly   996 LMARKQELEDMMQELETRIEEEE-------ERVLALGGEKKKLELNIQDLEEQLEEEEAARQKLQ 1053
            .:...| |...:|.|:.::|::.       |::.:|..      |.:.|| |:::..||..:|..
  Rat   881 FVLNIQ-LTYRVQRLQKKLEDQNRENHGLVEKLTSLAA------LRVGDL-EKVQRLEAELEKAA 937

  Fly  1054 LEKVQLDAKIKKYEEDLALTDDQNQKLLKEKKLLEERANDLSQTLAEEEEKAKHLAKLKAKHEAT 1118
            ..:...:.|.::|.:.:   :::..||.|....||.:.....|:|.|..|      :||.|.:..
  Rat   938 THRHSYEEKGRRYRDSM---EERLSKLQKHNAELESQRERAEQSLQERTE------ELKEKMDQL 993

  Fly  1119 ISELEERLHKDQQQRQESDRS--------KRKIET---EVADLKE-------QLNERRVQVDEMQ 1165
            ..:|.:.:.|::|||...::|        :::||:   |:..||:       ||.|.||..|.::
  Rat   994 TRQLFDDVQKEEQQRLLLEKSFELKTQAYEKEIESLREEIKALKDERTQLHHQLEEGRVTSDSLK 1058

  Fly  1166 AQLAKREEELTQTLLRIDEESATKATAQKAQRELESQLAEIQEDLEAEKAARAKAEKVRRDLSEE 1230
            .::|           |:.:::.|.:..:|....|::|..::::.::::|          |::.|.
  Rat  1059 GEVA-----------RLSKQAKTISEFEKEIELLQAQKIDVEKHVQSQK----------REMRER 1102

  Fly  1231 LEALKNELLDSLDTTAAQQELRSK----------REQELATLKKSLEEETVNHEGVLADMRHKHS 1285
            :..:..:||:|.|.    :::||:          .:.||....:.|::.|...|......:..:.
  Rat  1103 MSEVTKQLLESYDI----EDVRSRLSVEDLEHLNEDGELWFAYEGLKKATRVLESHFQSQKDCYE 1163

  Fly  1286 QELNSINDQLENLRKAKTVLEKAKGTLEAENADLATELRSVNSSRQENDRRRKQAESQIAELQVK 1350
            :|:..:|.::.:|.:....|:|           |..|...:|.|.:....|.......|.:.:.:
  Rat  1164 KEIEGLNFKVVHLSQEINHLQK-----------LFREETDINESIRHEVTRLTSENMMIPDFKQQ 1217

  Fly  1351 LAEIERARSELQEKCTKLQQEAENITNQLEEAELKASAAVKSASNMESQLTEAQQLLEEETRQKL 1415
            ::|:||.:.:|:   ::|:::||.:..:.||                 ..:...:.||||.||..
  Rat  1218 ISELERQKQDLE---SRLKEQAEKMEGKQEE-----------------PFSHLNRGLEEEGRQGK 1262

  Fly  1416 GLSSKLRQIESEKEALQEQLEEDDEAKRNYERKLAEVTTQMQEIKKKAEEDADLAKELEEGKKRL 1480
            .....||.:|:       |.|...|.|.....|:.|....::..||:||.:.::...|.:...||
  Rat  1263 APRPFLRAVEA-------QSETHPEGKERLVGKIQEPQEAIKFPKKQAEAEEEVESILRQEASRL 1320

  Fly  1481 ---NKDIEALERQVKELIAQNDRLDKSKKKIQSELEDATIELEAQRTKVLELEKKQKNFDKILAE 1542
               |:|:|      :||    |..|:..:|:|.:::..|..:|  :...:.|....:.:..:|..
  Rat  1321 SLENRDLE------EEL----DMKDRMIRKLQDQVKTLTRTIE--KANSVPLPSGSREYLGMLEY 1373

  Fly  1543 EKAISEQIAQERDTAEREAREKETKVLSVSRELD-----------------------EAFDKIED 1584
            :|                  |.|||::. :..||                       ...|.:.|
  Rat  1374 KK------------------EDETKLIQ-NLILDLKPRGVVVNMIPGLPAHILFMCVRYADSLND 1419

  Fly  1585 LENKRKTLQN------------ELDDLANTQGTADKNVHELEKAKR-ALESQLAELKA--QNEEL 1634
             .|..|:|.|            ..:||...........|.|...|: :.|.:..:..:  ||:..
  Rat  1420 -ANMLKSLMNSAINGIKHVVKEHFEDLEMLSFWLSNTCHFLNCLKQYSGEEEFMKCNSPQQNKNC 1483

  Fly  1635 EDDLQLTE------DAKLR--------LEVNMQAL--RSQFERDLLAKEEGAE----EKR----- 1674
            .::..|||      |..:|        :|.|:|.:  ....|.:.|....|.:    .||     
  Rat  1484 LNNFDLTEYRQILSDVAIRIYHQFILVMENNLQPIIVPGMLEYESLQGISGLKPTGFRKRSSSID 1548

  Fly  1675 -------RGLVKQL---------RDLETELDEERKQRT-----AAVASKKKLEGDLKEIETTMEM 1718
                   ..:::||         ..|:.|:..:..::.     |...:...|..|:......|::
  Rat  1549 DTDAYTMTSILQQLSYFYSTMCQNGLDPEIVRQAVKQLFYLIGAVTLNSLLLRKDMCSCRKGMQI 1613

  Fly  1719 HNKVK--EDALKHAKKLQAQVKDALRDAEEAKAAKEELQALSKEAERKVKALEAEVLQLTEDLAS 1781
            ...:.  |:.||. |.||..:            |||.|:.||:         .|.:||:      
  Rat  1614 RCNISFLEEWLKD-KNLQNSL------------AKETLEPLSQ---------AAWLLQV------ 1650

  Fly  1782 SERARRAAETERDELAE--------EIANNANKGSLMID-EKRRLEARIATLEEELEEEQSNSEV 1837
                ::..:::..|:::        :|....|..:.:.| |||...:.:..::..|.....:|::
  Rat  1651 ----KKTTDSDAKEISQCCTSLSAVQIIKILNSYTPIDDFEKRVNPSFVRKVQALLNNRGDSSQL 1711

  Fly  1838 LLD 1840
            :||
  Rat  1712 MLD 1714

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
zipNP_523860.2 Myosin_N 80..117 CDD:280832 11/38 (29%)
Myosin_head 133..854 CDD:278492 265/737 (36%)
MYSc_Myh2_insects_mollusks 145..854 CDD:276876 261/725 (36%)
Myosin_tail_1 931..2011 CDD:279860 199/1045 (19%)
Prefoldin 1431..1515 CDD:298833 22/86 (26%)
FAM76 <1847..1926 CDD:292665
Myo5cXP_006243475.1 Myosin_N 12..48 CDD:280832 11/35 (31%)
MYSc 62..752 CDD:214580 274/755 (36%)
MYSc_Myo5 81..741 CDD:276831 261/725 (36%)
IQ 755..776 CDD:197470 6/20 (30%)
IQ 830..851 CDD:197470 4/20 (20%)
COG1340 890..1150 CDD:224259 62/300 (21%)
GBP_C <929..1030 CDD:303769 25/109 (23%)
RILP-like <977..1096 CDD:304877 30/135 (22%)
coiled coil 1001..1010 CDD:293879 4/8 (50%)
coiled coil 1019..1030 CDD:293879 2/10 (20%)
Myo5c_CBD 1376..1743 CDD:271260 67/373 (18%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0000014
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
22.000

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