DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment zip and Myh14

DIOPT Version :9

Sequence 1:	NP_523860.2	Gene:	zip / 38001	FlyBaseID:	FBgn0265434	Length:	2056	Species:	Drosophila melanogaster
Sequence 2:	XP_038967907.1	Gene:	Myh14 / 308572	RGDID:	1306821	Length:	2041	Species:	Rattus norvegicus

Alignment Length:	1988	Identity:	1106/1988 - (55%)
Similarity:	1461/1988 - (73%)	Gaps:	85/1988 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly    73 QAEWTQKRLVWVPHENQGFVAASIKREHGDEVEVELAETGKRVMILRDDIQKMNPPKFDKVEDMA 137
            |.|||.:|:||||.|..||.||:::.|..:|.||||||:|:|:.:.||.||:||||||.|.||||
  Rat    43 QVEWTARRMVWVPSELHGFEAAALRDEGEEEAEVELAESGRRLRLPRDQIQRMNPPKFSKAEDMA 107

  Fly   138 ELTCLNEASVLHNIKDRYYSGLIYTYSGLFCVVVNPYKKLPIYTEKIMERYKGIKRHEVPPHVFA 202
            |||||||||||||:::|||||||||||||||||:||||:||||||.|:|.|:|.||||||||::|
  Rat   108 ELTCLNEASVLHNLRERYYSGLIYTYSGLFCVVINPYKQLPIYTEAIVEMYRGKKRHEVPPHIYA 172

  Fly   203 ITDSAYRNMLGDREDQSILCTGESGAGKTENTKKVIQFLAYVAASKPKGSGAVPHPAVLINFSVN 267
            :|:.|||:||.||||||||||||||||||||||||||:||:||:| |||......||     ||:
  Rat   173 VTEGAYRSMLQDREDQSILCTGESGAGKTENTKKVIQYLAHVASS-PKGRKEPGVPA-----SVS 231

  Fly   268 TNKYIKVKIMAQNQNQTIEVVNGLKMVEVNSNCQEGELEQQLLQANPILEAFGNAKTVKNDNSSR 332
            |..|                               ||||:|||||||||||||||||||||||||
  Rat   232 TMSY-------------------------------GELERQLLQANPILEAFGNAKTVKNDNSSR 265

  Fly   333 FGKFIRINFDASGFISGANIETYLLEKSRAIRQAKDERTFHIFYQLLAGATPEQREKFILDDVKS 397
            ||||||||||.:|:|.|||||||||||||||||||||.:||||||||.||..:.:...:|:....
  Rat   266 FGKFIRINFDIAGYIVGANIETYLLEKSRAIRQAKDECSFHIFYQLLGGAGEQLKADLLLEPYSH 330

  Fly   398 YAFLSNGSLPVPGVDDYAEFQATVKSMNIMGMTSEDFNSIFRIVSAVLLFGSMKFRQERNNDQAT 462
            |.||:||....|| .:...||.|::|:.::|:..|:..::.|.|||||.||::..::|||.||||
  Rat   331 YRFLTNGPSSSPG-QERELFQETLESLRVLGLLPEEITAMLRTVSAVLQFGNIVLKKERNTDQAT 394

  Fly   463 LPDNTVAQKIAHLLGLSVTDMTRAFLTPRIKVGRDFVTKAQTKEQVEFAVEAIAKACYERMFKWL 527
            :||||.|||:..||||.|||.:||.||||||||||:|.|||||||.:||:||:|||.|||:|:||
  Rat   395 MPDNTAAQKLCRLLGLGVTDFSRALLTPRIKVGRDYVQKAQTKEQADFALEALAKATYERLFRWL 459

  Fly   528 VNRINRSLDRTKRQGASFIGILDMAGFEIFELNSFEQLCINYTNEKLQQLFNHTMFILEQEEYQR 592
            |.|:||:|||:.||||||:||||:||||||:|||||||||||||||||||||||||:||||||||
  Rat   460 VLRLNRALDRSPRQGASFLGILDIAGFEIFQLNSFEQLCINYTNEKLQQLFNHTMFVLEQEEYQR 524

  Fly   593 EGIEWKFIDFGLDLQPTIDLIDKPG---GIMALLDEECWFPKATDKTFVDKLVSAHSMHPKFMK- 653
            |||.|.|:||||||||.||||::|.   |::|||||||||||||||:||:|:......||||.:
  Rat   525 EGIPWTFLDFGLDLQPCIDLIERPANPPGLLALLDEECWFPKATDKSFVEKVAQEQGSHPKFQRP 589

  Fly   654 TDFRGVADFAIVHYAGRVDYSAAKWLMKNMDPLNENIVSLLQGSQDPFVVNIWKDAE-------- 710
            .:.|..|||:::||||:|||.|.:||||||||||:|:.:||..|.|.....||||.:
  Rat   590 RNLRDQADFSVLHYAGKVDYKANEWLMKNMDPLNDNVAALLHQSTDRLTAEIWKDEQGGLQQFTF 654

  Fly   711 ----------------------------------IVGMAQ-QALTDTQFGARTRKGMFRTVSHLY 740
                                              |||:.| .:|.|...|.|.|:||||||..||
  Rat   655 LGSFPSPSPGPAGGLSSGASPPGLGSLCAPTVEGIVGLEQVSSLGDGPPGGRPRRGMFRTVGQLY 719

  Fly   741 KEQLAKLMDTLRNTNPNFVRCIIPNHEKRAGKIDAPLVLDQLRCNGVLEGIRICRQGFPNRIPFQ 805
            ||.|::||.||.||||:|||||:|||||||||::..||||||||||||||||||||||||||.||
  Rat   720 KESLSRLMATLSNTNPSFVRCIVPNHEKRAGKLEPRLVLDQLRCNGVLEGIRICRQGFPNRILFQ 784

  Fly   806 EFRQRYELLTPNVIPKGFMDGKKACEKMIQALELDSNLYRVGQSKIFFRAGVLAHLEEERDFKIS 870
            |||||||:||||.|||||||||:||||||||||||.||||||||||||||||||.||||||.|::
  Rat   785 EFRQRYEILTPNAIPKGFMDGKQACEKMIQALELDPNLYRVGQSKIFFRAGVLAQLEEERDLKVT 849

  Fly   871 DLIVNFQAFCRGFLARRNYQKRLQQLNAIRIIQRNCAAYLKLRNWQWWRLYTKVKPLLEVTKQEE 935
            |:||:|||..||:||||.:|:|.||.:|:|::||||||||||||||||||:.||||||:||:|:|
  Rat   850 DIIVSFQAAARGYLARRAFQRRQQQQSALRVMQRNCAAYLKLRNWQWWRLFIKVKPLLQVTRQDE 914

  Fly   936 KLVQKEDELKQVREKLDTLAKNTQEYERKYQQALVEKTTLAEQLQAEIELCAEAEESRSRLMARK 1000
            .|..:..||::|:|.....|:...|.:.:..|...|:..|||||:||.|||:||||:|:||.|||
  Rat   915 VLQARAQELQKVQELQQQSAREVGELQGRVAQLEEERARLAEQLRAEAELCSEAEETRARLAARK 979

  Fly  1001 QELEDMMQELETRIEEEEERVLALGGEKKKLELNIQDLEEQLEEEEAARQKLQLEKVQLDAKIKK 1065
            ||||.::.|||.|:.||||....|..|||:|:.:||:||..||.||.||||||||||..:||:||
  Rat   980 QELELVVTELEARVGEEEECSRQLQSEKKRLQQHIQELETHLEAEEGARQKLQLEKVTTEAKMKK 1044

  Fly  1066 YEEDLALTDDQNQKLLKEKKLLEERANDLSQTLAEEEEKAKHLAKLKAKHEATISELEERLHKDQ 1130
            :||||.|.:|||.||.||::|||||..:.|...||||||.|.|.||:.|:||||:::|:||.|::
  Rat  1045 FEEDLLLLEDQNSKLSKERRLLEERLAEFSSQAAEEEEKVKSLNKLRVKYEATIADMEDRLKKEE 1109

  Fly  1131 QQRQESDRSKRKIETEVADLKEQLNERRVQVDEMQAQLAKREEELTQTLLRIDEESATKATAQKA 1195
            :.|||.::.||:::.|.::|:||:.|::.:.:|:..||.::||||...|:|.:||...:|...|:
  Rat  1110 KGRQELEKLKRRLDGESSELQEQMMEQKQRAEELLIQLGRKEEELQSALVRAEEEGGARAQLLKS 1174

  Fly  1196 QRELESQLAEIQEDLEAEKAARAKAEKVRRDLSEELEALKNELLDSLDTTAAQQELRSKREQELA 1260
            .||.::.|||.|||||||:.|||||||.||||.||||||:.||.|:||:|.||||||||||||:.
  Rat  1175 LREAQAGLAEAQEDLEAERVARAKAEKQRRDLGEELEALRGELEDTLDSTNAQQELRSKREQEVT 1239

  Fly  1261 TLKKSLEEETVNHEGVLADMRHKHSQELNSINDQLENLRKAKTVLEKAKGTLEAENADLATELRS 1325
            .|||:||||...||..:.::|.:|||.|..:.:|||..|:.|:|.||.:.:||||.::|.|||.|
  Rat  1240 ELKKTLEEEARTHEVAMQELRQRHSQALVELTEQLEQARRGKSVWEKTRLSLEAEVSELKTELSS 1304

  Fly  1326 VNSSRQENDRRRKQAESQIAELQVKLAEIERARSELQEKCTKLQQEAENITNQLEEAELKASAAV 1390
            :.:||||.:::|::.|||:.|:|.:.::.||||:|..||..:.|.|.|:::..|.|||.||....
  Rat  1305 LQTSRQEGEQKRRRLESQLQEVQGRSSDSERARAEAAEKLQRAQVELESVSTALSEAESKAIRLS 1369

  Fly  1391 KSASNMESQLTEAQQLLEEETRQKLGLSSKLRQIESEKEALQEQLEEDDEAKRNYERKLAEVTTQ 1455
            |..|:.||||.:.|:||:||||.||.|.|::|.:|:|...|:||:||:..|:....|:|.....|
  Rat  1370 KELSSAESQLHDTQELLQEETRAKLALGSRVRALEAEAAGLREQMEEEVVARERAGRELQTTQAQ 1434

  Fly  1456 MQEIKKKAEEDADLAKELEEGKKRLNKDIEALERQVKELIAQNDRLDKSKKKIQSELEDATIELE 1520
            :.|.:::.||:|.:.:..||.::|..::.|.|.:::.|.....:||:::::::|.||:|||::|.
  Rat  1435 LSEWRRRQEEEAAVLEAGEEARRRAAREAETLAQRLAEKTEAVERLERARRRLQQELDDATVDLG 1499

  Fly  1521 AQRTKVLELEKKQKNFDKILAEEKAISEQIAQERDTAEREAREKETKVLSVSRELDEAFDKIEDL 1585
            .|:..:..|||||:.||::||||||...:..::|:..|.|.||:|.:.||::|.|:|..:..|:|
  Rat  1500 QQKQLLSTLEKKQRKFDQLLAEEKAAVLRAVEDRERVEAEGREREARALSLTRALEEEQEAREEL 1564

  Fly  1586 ENKRKTLQNELDDLANTQGTADKNVHELEKAKRALESQLAELKAQNEELEDDLQLTEDAKLRLEV 1650
            |.:.:.|:.||:.|.:::....|||||||:|:|..|...::|:.|..||||:|...|||||||||
  Rat  1565 ERQNRALRAELEALLSSKDDVGKNVHELERARRVAEQAASDLRTQVTELEDELTAAEDAKLRLEV 1629

  Fly  1651 NMQALRSQFERDLLAKEEGAEEKRRGLVKQLRDLETELDEERKQRTAAVASKKKLEGDLKEIETT 1715
            .:|||::|.||||..:::..||:||.|.|||||.|.|.|||||||..|:|::||||.:|:|::..
  Rat  1630 TVQALKAQHERDLQGRDDAGEERRRQLAKQLRDAEVERDEERKQRALAMAARKKLELELEELKAQ 1694

  Fly  1716 MEMHNKVKEDALKHAKKLQAQVKDALRDAEEAKAAKEELQALSKEAERKVKALEAEVLQLTEDLA 1780
            .....:.||:|:|..||:|||:|:..|:.||.::::||:..||:|:|:::|.||||||:|.|:||
  Rat  1695 TSAAGQGKEEAVKQLKKMQAQMKELWREVEETRSSREEMFTLSRESEKRLKGLEAEVLRLQEELA 1759

  Fly  1781 SSERARRAAETERDELAEEIANNANKGSLMIDEKRRLEARIATLEEELEEEQSNSEVLLDRSRKA 1845
            :|:||||.|:.:|||:|||:|:.....:..::|||:||.|:..|||||||||:|||:|.|..||.
  Rat  1760 ASDRARRQAQQDRDEMAEEVASGNLSKAATLEEKRQLEGRLGQLEEELEEEQNNSELLKDHYRKL 1824

  Fly  1846 QLQIEQLTTELANEKSNSQKNENGRALLERQNKELKAKLAEIETAQRTKVKATIATLEAKIANLE 1910
            .||:|.|||||:.|:|.|.|.|:||..||||.:||:|:|.|.:...|.:.|..||.||:|:|..|
  Rat  1825 VLQVETLTTELSAERSFSAKAESGRQQLERQIQELRARLGEEDAGARARQKMLIAALESKLAQAE 1889

  Fly  1911 EQLENEGKERLLQQKANRKMDKKIKELTMNIEDERRHVDQHKEQMDKLNSRIKLLKRNLDETEEE 1975
            ||||.|.:||:|..|..|:.:|::||:.:.:::|||..||.::|::|.|.|:|.|||.|:|.|||
  Rat  1890 EQLEQESRERILSGKLVRRAEKRLKEVVLQVDEERRVADQLRDQLEKSNLRLKQLKRQLEEAEEE 1954

  Fly  1976 LQKEKTQKRKYQRECEDMIESQEAMNREINSLKTKLRR 2013
            ..:.:..:|:.|||.||:.||.|:||||:.:|:.:|||
  Rat  1955 ASRAQAGRRRLQRELEDVTESAESMNREVTTLRNRLRR 1992

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
zip	NP_523860.2	Myosin_N	80..117	CDD:280832	20/36 (56%)
		Myosin_head	133..854	CDD:278492	492/767 (64%)
		MYSc_Myh2_insects_mollusks	145..854	CDD:276876	481/755 (64%)
		Myosin_tail_1	931..2011	CDD:279860	519/1079 (48%)
		Prefoldin	1431..1515	CDD:298833	24/83 (29%)
		FAM76	<1847..1926	CDD:292665	41/78 (53%)
Myh14	XP_038967907.1	Motor_domain	115..833	CDD:419868	481/755 (64%)
Myh14	XP_038967907.1	Myosin_tail_1	910..1990	CDD:396244	519/1079 (48%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	990	1.000	Domainoid score	I27
eggNOG	1	0.900	-	-		E2759_KOG0161
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	2335	1.000	Inparanoid score	I31
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D40305at33208
OrthoFinder	1	1.000	-	-		FOG0000014
OrthoInspector	1	1.000	-	-		otm46459
orthoMCL	1	0.900	-	-		OOG6_100110
Panther	1	1.100	-	-	O	PTHR45615
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X58
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	11	10.870