DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment zip and myh7

DIOPT Version :9

Sequence 1:NP_523860.2 Gene:zip / 38001 FlyBaseID:FBgn0265434 Length:2056 Species:Drosophila melanogaster
Sequence 2:NP_001106204.1 Gene:myh7 / 30616 ZFINID:ZDB-GENE-991123-5 Length:1938 Species:Danio rerio


Alignment Length:1948 Identity:760/1948 - (39%)
Similarity:1184/1948 - (60%) Gaps:68/1948 - (3%)


- Green bases have known domain annotations that are detailed below.


  Fly    79 KRLVWVPHENQGFVAASIKREHGDEVEVELAETGKRVMILRDDIQKMNPPKFDKVEDMAELTCLN 143
            |:..:||..::.:|.|||....||:|.|: .|..|.|.:...||...|||||||:||||..|.|:
Zfish    34 KKECFVPDPDEEYVKASIVSREGDKVTVQ-TEKRKTVTVKEADIHPQNPPKFDKIEDMAMFTFLH 97

  Fly   144 EASVLHNIKDRYYSGLIYTYSGLFCVVVNPYKKLPIYTEKIMERYKGIKRHEVPPHVFAITDSAY 208
            |.:||.|:|:||.:.:||||||||||.|||||.||:|.::::..|:|.||.|.|||:|:|:|:||
Zfish    98 EPAVLFNLKERYAAWMIYTYSGLFCVTVNPYKWLPVYNQEVVVAYRGKKRSEAPPHIFSISDNAY 162

  Fly   209 RNMLGDREDQSILCTGESGAGKTENTKKVIQFLAYVAA-SKPKGSGAVPHPAVLINFSVNTNKYI 272
            :.||.|||:||||.|||||||||.|||:|||:.|.:|| ...|..||.                 
Zfish   163 QYMLTDRENQSILITGESGAGKTVNTKRVIQYFASIAAGGSAKKEGAE----------------- 210

  Fly   273 KVKIMAQNQNQTIEVVNGLKMVEVNSNCQEGELEQQLLQANPILEAFGNAKTVKNDNSSRFGKFI 337
                                        ::|.||.|::||||.|||||||||::|||||||||||
Zfish   211 ----------------------------KKGTLEDQIIQANPALEAFGNAKTIRNDNSSRFGKFI 247

  Fly   338 RINFDASGFISGANIETYLLEKSRAIRQAKDERTFHIFYQLLAGATPEQREKFIL-DDVKSYAFL 401
            ||:|.|||.::.|:||||||||||...|.|.||.:|||||:|:...||..|..:: ::...||::
Zfish   248 RIHFGASGKLASADIETYLLEKSRVTFQLKAERDYHIFYQILSQRKPELLEMLLITNNPYDYAYI 312

  Fly   402 SNGSLPVPGVDDYAEFQATVKSMNIMGMTSEDFNSIFRIVSAVLLFGSMKFRQERNNDQATLPDN 466
            |.|...|..::|..|..||.::.:::|.|.|:.|.|::::.|::.||:|||:|::..:||.....
Zfish   313 SQGETTVASINDGEELLATDEAFDVLGFTQEEKNGIYKLIGAIMHFGNMKFKQKQREEQAEADGT 377

  Fly   467 TVAQKIAHLLGLSVTDMTRAFLTPRIKVGRDFVTKAQTKEQVEFAVEAIAKACYERMFKWLVNRI 531
            ....|:|:|:||:..|:.:....||:|||.::|||.|..:||.:|:.|:||:.||:||.|:|.||
Zfish   378 EDGDKVAYLMGLNSADLIKGLCHPRVKVGNEWVTKGQNVQQVYYAIGALAKSVYEKMFLWMVVRI 442

  Fly   532 NRSLDRTKRQGASFIGILDMAGFEIFELNSFEQLCINYTNEKLQQLFNHTMFILEQEEYQREGIE 596
            |:||| ||:....|||:||:||||||:.|:|||||||:|||||||.|||.||:||||||::||||
Zfish   443 NQSLD-TKQPRQYFIGVLDIAGFEIFDFNTFEQLCINFTNEKLQQFFNHHMFVLEQEEYKKEGIE 506

  Fly   597 WKFIDFGLDLQPTIDLIDKPGGIMALLDEECWFPKATDKTFVDKLVSAH------SMHPKFMKTD 655
            |:|||||:|||..||||:||.|||::|:|||.||||:|.||..||...|      ...|:.:|. 
Zfish   507 WEFIDFGMDLQACIDLIEKPMGIMSILEEECMFPKASDSTFKAKLYDNHLGKSNNFQKPRAIKG- 570

  Fly   656 FRGVADFAIVHYAGRVDYSAAKWLMKNMDPLNENIVSLLQGSQDPFVVNIWKDAEIVGMAQQALT 720
             :..:.|::|||||.|||:...||:||.|||||.:|.|.|.|....:..::  |...|.......
Zfish   571 -KPESHFSLVHYAGTVDYNINNWLVKNKDPLNETVVGLFQKSTVKLLSMLF--ANYAGTESDNGK 632

  Fly   721 DTQFGARTRKG-MFRTVSHLYKEQLAKLMDTLRNTNPNFVRCIIPNHEKRAGKIDAPLVLDQLRC 784
            ..:.|...:|| .|:|||.|::|.|.|||..||:|:|:||||||||..|..|.::.|||:.||||
Zfish   633 GGKGGGSKKKGSSFQTVSALHRENLNKLMTNLRSTHPHFVRCIIPNETKTPGAMENPLVMHQLRC 697

  Fly   785 NGVLEGIRICRQGFPNRIPFQEFRQRYELLTPNVIPKG-FMDGKKACEKMIQALELDSNLYRVGQ 848
            |||||||||||:||||||.:.:|:|||.:|.|..||:| |:|.:|..||::.:|::|.|.|:.|.
Zfish   698 NGVLEGIRICRKGFPNRILYGDFKQRYRILNPAAIPEGQFIDSRKGAEKLLGSLDIDHNQYKFGH 762

  Fly   849 SKIFFRAGVLAHLEEERDFKISDLIVNFQAFCRGFLARRNYQKRLQQLNAIRIIQRNCAAYLKLR 913
            :|:||:||:|..|||.||.::|.:|...||..||.|||..:||.:::.:|:.:||.|..|::.::
Zfish   763 TKVFFKAGLLGQLEEMRDDRLSLIISGIQARSRGLLARVEFQKIVERRDALLVIQWNVRAFMGVK 827

  Fly   914 NWQWWRLYTKVKPLLEVTKQEEKLVQKEDELKQVREKLDTLAKNTQEYERKYQQALVEKTTLAEQ 978
            ||.|.:|:.|:||||:..:.|:::...:||..:::|.........:|.|.|....|.||..|..|
Zfish   828 NWPWMKLFFKIKPLLKSAEAEKEMANMKDEFAKLKEAYAKSEARRKELEEKMVSLLQEKNDLQLQ 892

  Fly   979 LQAEIELCAEAEESRSRLMARKQELEDMMQELETRIEEEEERVLALGGEKKKLELNIQDLEEQLE 1043
            :|||.:...:|||...:|:..|.:||...:||..|:|:|||....|..:|:|||....:|::.::
Zfish   893 VQAEQDNLCDAEERCDQLIKNKIQLEAKAKELTERLEDEEEMNAELTAKKRKLEDECSELKKDID 957

  Fly  1044 EEEAARQKLQLEKVQLDAKIKKYEEDLALTDDQNQKLLKEKKLLEERANDLSQTLAEEEEKAKHL 1108
            :.|....|::.||...:.|:|...|::|..||...||.||||.|:|........|..||:|...|
Zfish   958 DLELTLAKVEKEKHATENKVKNLTEEMAALDDIIAKLTKEKKALQEAHQQTLDDLQSEEDKVNTL 1022

  Fly  1109 AKLKAKHEATISELEERLHKDQQQRQESDRSKRKIETEVADLKEQLNERRVQVDEMQAQLAKREE 1173
            .|.|||.|..:.:||..|.::::.|.:.:|:|||:|.::...:|.|.:......:::.:|.|::.
Zfish  1023 TKAKAKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLTQESLMDLENDKQQLEERLKKKDF 1087

  Fly  1174 ELTQTLLRIDEESATKATAQKAQRELESQLAEIQEDLEAEKAARAKAEKVRRDLSEELEALKNEL 1238
            |::|...:|::|.......||..:||::::.|::|:||||:|||||.||.|.||:.|||.:...|
Zfish  1088 EISQLNGKIEDEQTICIQLQKKLKELQARIEELEEELEAERAARAKVEKQRADLARELEEISERL 1152

  Fly  1239 LDSLDTTAAQQELRSKREQELATLKKSLEEETVNHEGVLADMRHKHSQELNSINDQLENLRKAKT 1303
            .::...||||.|:..|||.|...|::.|||.|:.||...|.:|.|.:..:..:.:|::||::.|.
Zfish  1153 EEAGGATAAQIEMNKKREAEFQKLRRDLEEATLQHEATAATLRKKQADSVAELGEQIDNLQRVKQ 1217

  Fly  1304 VLEKAKGTLEAENADLATELRSVNSSRQENDRRRKQAESQIAELQVKLAEIERARSELQEKCTKL 1368
            .|||.|..|..|..|:.:.:..|..::...::..:..|.|:.|.:.|..|.:|..::...:.:||
Zfish  1218 KLEKEKSELRLELDDVVSNMEHVVKTKANLEKMTRSLEDQMNEYKTKYEEGQRCINDFTMQKSKL 1282

  Fly  1369 QQEAENITNQLEEAELKASAAVKSASNMESQLTEAQQLLEEETRQKLGLSSKLRQIESEKEALQE 1433
            |.|...::.||||.:...|...:|..:...|:.:.::.|||||:.|..|:..::....:.:.|:|
Zfish  1283 QSENGELSRQLEEKDSLVSQLTRSKMSYTQQIEDLKRQLEEETKAKSALAHAVQSARHDTDLLRE 1347

  Fly  1434 QLEEDDEAKRNYERKLAEVTTQMQEIKKKAEEDA-DLAKELEEGKKRLNKDIEALERQVKELIAQ 1497
            |.||:.|||...:|.:::..:::.:.:.|.|.|| ...:||||.||:|.:.::..|..|:.:.|:
Zfish  1348 QYEEEQEAKAELQRGMSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQETEEAVEAVNAK 1412

  Fly  1498 NDRLDKSKKKIQSELEDATIELEAQRTKVLELEKKQKNFDKILAEEKAISEQIAQERDTAEREAR 1562
            ...|:|:|.::|:|:||..::||........|:|||:||||:|:|.|...|:...|.:::::|||
Zfish  1413 CSSLEKTKHRLQNEIEDLMVDLERSNAAAAALDKKQRNFDKVLSEWKQKFEESQAELESSQKEAR 1477

  Fly  1563 EKETKVLSVSRELDEAFDKIEDLENKRKTLQNELDDLANTQGTADKNVHELEKAKRALESQLAEL 1627
            ...|::..:....:||.|.:|.::.:.|.||.|:.||....|...|::|||||.::.||.:.:|:
Zfish  1478 CLSTELFKLKNSYEEALDHLETMKRENKNLQEEISDLTEQLGEGGKSIHELEKMRKQLEQEKSEI 1542

  Fly  1628 KAQNEELEDDLQLTEDAKLRLEVNMQALRSQFERDLLAKEEGAEEKRRGLVKQLRDLETELDEER 1692
            ::..||.|..|:..|...||.::....:::..||.|..|:|..|:.:|.|.:.:..|::.|:.|.
Zfish  1543 QSALEEAEASLEHEEGKILRAQLEFSQIKADIERKLAEKDEEMEQSKRNLQRTIDTLQSSLESET 1607

  Fly  1693 KQRTAAVASKKKLEGDLKEIETTMEMHNKVKEDALKHAKKLQAQVKDALRDAEEAKAAKEELQAL 1757
            :.|..|:..|||:||||.|:|..:...|:...:|.|..|.:.|.:|||....:::....|:|:..
Zfish  1608 RSRNEALRIKKKMEGDLNEMEIQLSQANRQAAEAQKQLKSVHAHMKDAQLQLDDSLRTNEDLKEN 1672

  Fly  1758 SKEAERKVKALEAEVLQLTEDLASSERARRAAETERDELAEEIANNANKGSLMIDEKRRLEARIA 1822
            :...||:...|:||:.:|...|..:||.|:.||.|..:.:|.:....::.:.::::|::||..|:
Zfish  1673 TAIVERRNNLLQAELEELRAALEQTERGRKLAEQELLDTSERVQLLHSQNTSLLNQKKKLETDIS 1737

  Fly  1823 TLEEELEE---EQSNSEVLLDRSRKAQLQIEQLTTELANEKSNSQKNENGRALLERQNKELKAKL 1884
            .|:.|:||   |..|:|   ::::||......:..||..|:..|...|..:..:|:..|:|:.:|
Zfish  1738 QLQTEVEEAVQECRNAE---EKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTIKDLQHRL 1799

  Fly  1885 AEIETAQRTKVKATIATLEAKIANLEEQLENEGKERLLQQKANRKMDKKIKELTMNIEDERRHVD 1949
            .|.|.......|..:..|||::..||.::|:|.|:.....|..||.:::|||||...|::|:::.
Zfish  1800 DEAEQIAMKGGKKQVQKLEARVRELESEVESEQKKSSEAVKGIRKYERRIKELTYQTEEDRKNLA 1864

  Fly  1950 QHKEQMDKLNSRIKLLKRNLDETEEELQKEKTQKRKYQRECEDMIESQEAMNREINSLKTKLR 2012
            :.::.:|||..::|..||..:|.||:.....::.||.|.|.::..|..:....::|.|:.|.|
Zfish  1865 RLQDLVDKLQLKVKAYKRAAEEAEEQANTNLSKFRKIQHELDEAEERADIAESQVNKLRAKSR 1927

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
zipNP_523860.2 Myosin_N 80..117 CDD:280832 13/36 (36%)
Myosin_head 133..854 CDD:278492 361/730 (49%)
MYSc_Myh2_insects_mollusks 145..854 CDD:276876 354/718 (49%)
Myosin_tail_1 931..2011 CDD:279860 340/1083 (31%)
Prefoldin 1431..1515 CDD:298833 29/84 (35%)
FAM76 <1847..1926 CDD:292665 20/78 (26%)
myh7NP_001106204.1 Myosin_N 35..72 CDD:280832 13/37 (35%)
Myosin_head 87..768 CDD:278492 361/730 (49%)
MYSc_class_II 99..768 CDD:276951 354/718 (49%)
MIT_CorA-like 780..>991 CDD:294313 71/210 (34%)
Myosin_tail_1 848..1925 CDD:279860 340/1079 (32%)
RILP-like 963..1096 CDD:304877 42/132 (32%)
MIT_CorA-like <1297..>1409 CDD:294313 32/111 (29%)
COG6 1374..>1536 CDD:303003 57/161 (35%)
GBP_C 1563..1825 CDD:303769 74/264 (28%)
TMPIT 1742..>1832 CDD:285135 26/92 (28%)
coiled coil 1795..1805 CDD:293879 4/9 (44%)
coiled coil 1814..1825 CDD:293879 3/10 (30%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG0161
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D47111at2759
OrthoFinder 1 1.000 - - FOG0000014
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100110
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X58
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
65.720

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