DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment zip and Myo18b

DIOPT Version :9

Sequence 1:NP_523860.2 Gene:zip / 38001 FlyBaseID:FBgn0265434 Length:2056 Species:Drosophila melanogaster
Sequence 2:XP_006249639.1 Gene:Myo18b / 304551 RGDID:1594542 Length:2551 Species:Rattus norvegicus


Alignment Length:2334 Identity:537/2334 - (23%)
Similarity:951/2334 - (40%) Gaps:598/2334 - (25%)


- Green bases have known domain annotations that are detailed below.


  Fly    47 SEEVDRNDPELK----------------YLSVERNQF------------NDPATQAEWTQKRLVW 83
            :||||..:|:.:                ...:|..|.            :|.|.:..|.:.:.||
  Rat   445 TEEVDVTEPQAEGRRESVPETGMERPSMQKPMEEKQILQDPDRGGQSGDSDQAFEDRWYEAQKVW 509

  Fly    84 VPHENQGFVAASIKREHG---------------DEVEVELAETGKRVMILRDDIQKMNPPKFDKV 133
            :..:::..:|..:|.:.|               |....|:.|         :.:.:.||.:.|:.
  Rat   510 LVQKDRFTLATVLKPDEGTADLPAGRVRLCIDADRTVTEVDE---------EQVHRANPSELDQA 565

  Fly   134 EDMAELTCLNEASVLHNIKDRYYSGLIYTYSGLFCVVVNPYKKLPIYTEKIME-RYKGIKRHEVP 197
            ||:|.|..:||:|||:.:..||.:.|.:|.||...:.:.|.......:.|:.. |..|:     |
  Rat   566 EDLAFLVSVNESSVLNTLLKRYQAQLPHTCSGPDLIALQPQTTTVPSSGKVPRGRQDGL-----P 625

  Fly   198 PHVFAITDSAYRNMLGDREDQSILCTGESGAGKTENTKKVIQFLAYVAASKPKGSGAVPHPAVLI 262
            .||.::...||..:|..|.||||:..|.||||||...::|::.|..:|.|               
  Rat   626 AHVTSLAQRAYWALLSQRRDQSIVALGRSGAGKTTCCEQVLEHLVGMAGS--------------- 675

  Fly   263 NFSVNTNKYIKVKIMAQNQNQTIEVVNGLKMVEVNSNCQEGELEQQLLQANPILEAFGNAKTVKN 327
                                     |:|...||            :|.....:|:|||...|..:
  Rat   676 -------------------------VDGRVSVE------------KLRATFTVLQAFGCVSTSHS 703

  Fly   328 DNSSRFGKFIRINFDASGFISGANIETYLLEKSRAIRQAKDERTFHIFYQLLAGATPEQREKFIL 392
            ..::||...:.::|:|:|.::.|.:::.|||.||..||.:.|..|.:|.|||||...:.|.:..|
  Rat   704 RRATRFAMVMSLDFNATGRVTAAQLQSMLLENSRVARQPQGEGNFEVFSQLLAGLDVDLRTELNL 768

  Fly   393 DDV-KSYAF-LSNGSLPVPGVDDYAEFQATVKSMNIMGMTSEDFNSIFRIVSAVLLFGS------ 449
            ..: :|.|| :...|.|.........|.....:|.::|:...:..:|:|:::|:...|:      
  Rat   769 HQMAESSAFGMGLWSKPEDKQKAATAFSQLRGAMELLGILEGEQRAIWRVLAAIYHLGAAGACKV 833

  Fly   450 -----MKFRQERNNDQATLPD----NTVAQKIAHLLGLSVTDMTRAFLTPRIKVGRDFVTKAQTK 505
                 |:|....:..:|...|    ||...|  |.|...:..||..   |:.:..:|....:..|
  Rat   834 GRKQFMRFEWANHAAEALGCDYEELNTATFK--HHLRQIIEQMTSG---PQRQGLQDNEACSGLK 893

  Fly   506 EQVEFAVEAIAKACYERMFKWLVNRINRSLDRTKRQGASFIGILDMAGFEIFELN---------- 560
            ......||.:|...|:.:|..:|:.||||........|| |.::|..||:    |          
  Rat   894 MTGVECVEGMASGLYQELFVAVVSLINRSFSSQHLSMAS-IMVVDTPGFQ----NPRHQGKDRAA 953

  Fly   561 SFEQLCINYTNEKLQQLFNHTMFILEQEEYQREGIEWKFIDFGL-DLQP--TIDLIDK------- 615
            :||:||.||..|:||.||.|..|:...|.|:.|||.   :.|.| :..|  |:.::|:       
  Rat   954 TFEELCYNYAQERLQLLFYHRTFVSTLERYREEGIP---VPFDLPESSPGTTVAVVDQNPSQVHL 1015

  Fly   616 --------PGGIMALLDEECWFPKATDKTFVDKL------VSAHSMHPKFMKTDFRGVADFAIVH 666
                    ..|:..:||||.....::|...:::|      .::.:..|..|:|..:.: :..:.|
  Rat  1016 TAGRGIEDAAGLFWVLDEEVRVEGSSDSVVLERLHAGFEKKASGAEEPPSMRTCEQPL-NCELFH 1079

  Fly   667 YAGR--VDYSAAKWLMK---NMDPL----------NENIVSLLQ--GSQDPFVVNIWKDAEIVGM 714
            ..||  |.|....||.:   |:..|          .|.:.||.|  ....|..:.:   |.:.|.
  Rat  1080 QLGRDPVRYDLTGWLRRAKPNLSALEAPQILQQSKREELQSLFQARAKLPPVCLMV---AGLEGT 1141

  Fly   715 AQQALTDTQFGARTRKGMFRTVSHL--------YKEQLAKLMDTLRNTNPNFVRCIIPNH-EKRA 770
            :||||   ..|...|:....:::.:        .|.|:..|:..||.:..:|:.|::|.. |.:|
  Rat  1142 SQQAL---HRGRVVRRAFASSLAAVKRKAPCAQIKLQMDALISLLRRSQLHFIHCLVPTTVETKA 1203

  Fly   771 GK--------------------IDAPLVLDQLRCNGVLEGIRICRQGFPNRIPFQEFRQRYELLT 815
            |:                    .|.|.:..||..:.:||.:|:.|.|:...:...:||:|::.|.
  Rat  1204 GQGTPTPSQPGGDQGGANEPPAPDIPALRVQLAGSHILEALRLHRAGYAEHMGLAQFRRRFQALD 1268

  Fly   816 PNVIPK------GFMDGKKACEKMIQALELDSNLYRVGQSKIFFRAGVLAHLEEERDFKISDLIV 874
            |.::.:      | :|.:||.|:::|.|:|:.....||.|::|.:|||::.||.:|:..:|..||
  Rat  1269 PALLKRLDLTSEG-LDERKAVEELLQTLDLEKKAVAVGHSQVFLKAGVVSRLERQREKLVSRNIV 1332

  Fly   875 NFQAFCRGFLARRNYQK-RLQQLNAIRIIQRNCAAYLKLRNWQWWRLYTKVKPLLEVTKQEEKLV 938
            .|||.|||||:|:.|:| ::::|.|: .||:|...:||:::|.||.|...::|||..|...|:|.
  Rat  1333 LFQAACRGFLSRQEYKKLKIRRLAAL-CIQKNLTVFLKVKDWPWWGLLASLRPLLSSTLSTEQLR 1396

  Fly   939 QKEDELKQVREKLDTLAKNTQEYERKYQQALVEK-----TTLA-EQLQAEIELCAEAEESRSRLM 997
            .||:||..:|:||.. ::|::...|:....|..|     :.|| |:.:.::...|...|...||.
  Rat  1397 AKEEELTLLRQKLQN-SENSRSELRQSADLLESKIADLTSELADERFKGDVACQALESERAERLQ 1460

  Fly   998 ARKQELEDMMQELETRIEEEEERVLALGGEKKKLELNIQDLE-EQLEEEE---AARQKLQLEKVQ 1058
            |.::     :|||:.:.::.::   ||||.:|:||...|.:: ..|||:.   |...:::|:..|
  Rat  1461 ALRE-----VQELKAKYQQVQD---ALGGVQKQLEEAQQRIQTANLEEKPTGGADEWQMRLDCAQ 1517

  Fly  1059 LDAKIKKYEEDLALTDDQNQKLLKEKKLLEERANDLSQTLAEEEEKAKHLAKLKAKHEATISELE 1123
            |                :|..|.|..:..|||.:                :::||:     :|||
  Rat  1518 L----------------ENDFLRKRLQQCEERLD----------------SEMKAR-----TELE 1545

  Fly  1124 ERLHKDQQQRQESDRSKRKIETEVADLKEQLNERRVQVDEMQAQ---LAKREEELTQTLLR-IDE 1184
            ::|.:.|...:|:.::..::..:...|...|.:.||.::..|::   |.||:::....|.: :.|
  Rat  1546 QKLGELQSAYEEAKKTAHQLRRKCHHLTWDLEDTRVLLENQQSRNHDLEKRQKKFDLQLAQALGE 1610

  Fly  1185 ESATKATAQKAQRE---LESQLAEIQEDLEAEKAARAKAEKVRRDLSEELEALKNELLD------ 1240
            ....|:..:|..||   :..:|.::|:.||.::   .:|.|::.:: |.|:..|.|||:      
  Rat  1611 SMFEKSLREKVSRENSGVRWELGQLQQQLEQKE---QEASKLKEEV-ERLQGQKRELLNCASVGN 1671

  Fly  1241 -----------SLDTTAAQQE---------------LRSKREQELATLKKSLEEETVNHEGVLAD 1279
                       .|::.|.:||               ||.:.|.|:..:|:..:::..:.|..|.|
  Rat  1672 QGVASLKERVWELESNALEQEKVRSQQENTIKQLEQLRQRFELEIERMKQMHQKDREDQEEELED 1736

  Fly  1280 MRHKHSQELNSINDQLENLRKAKTV-------LEKAKGTL--EAENADLATELRSVNSSRQENDR 1335
            :|....:.|..:..|||...:.|..       ||...|||  :..:.|...|      .|...|.
  Rat  1737 VRQSCQKRLRQLEMQLEQEYEEKQAALHEKHDLEGLIGTLCDQIGHRDFDVE------KRLRRDL 1795

  Fly  1336 RRKQAESQIAELQVKLAEIERARSELQEKCTKLQQEAENITNQLEEAELKASAAVKSASNMESQL 1400
            ||..|  .::::|:.||.||.:::.:.      ::|.|.:.:|||::|.|...|:|:...:.:.|
  Rat  1796 RRTHA--LLSDVQLLLATIEDSKTSIS------KEELEKVHSQLEQSEAKCEDALKTQKVLTADL 1852

  Fly  1401 TEAQQLLEEETRQKLGLSSKLRQIESEKEALQEQLEEDDEAKRNYERK----LAEVTTQMQEIKK 1461
            ......||..||.|..:..:|.:::.|:..|.::::||.:......:|    :|:....:.:|: 
  Rat  1853 ESMHSELENVTRSKSLVDEQLYRLQFERADLLKRIDEDQDDLNGLMQKHKDLIAQSAADIGQIQ- 1916

  Fly  1462 KAEEDADLAKELEEGKKRLNKDIEALERQVKELIAQNDRLDKSKKKIQSELEDATIE---LEAQR 1523
                  :|..:|||.||...|..|.|  ||.:|            :|| .||.:|:|   :..|.
  Rat  1917 ------ELQLQLEEAKKEKQKLWEQL--QVAQL------------RIQ-YLEQSTVERAIVSRQE 1960

  Fly  1524 TKVLELEKKQKNFDKILAEEKAISEQIAQERDTAEREARE--KETKVLSVSRELDEAFDKIEDLE 1586
            ..:.:||.|.: |.|:  :.|.....:.:.||:..:...|  :..|..:..||..:.:      :
  Rat  1961 AIICDLESKTE-FQKV--QMKRFEVLVIRLRDSMIKMGEELSRAVKAEAQQRENSQYY------Q 2016

  Fly  1587 NKRKTLQNELDDLANTQGTADKNVHELEKAKRALESQLAELKAQNEELEDDLQLTEDAKLRLEVN 1651
            .:.:.|:.|:.:|...:..|.:...|:||       .:.||.|..:.|:.||    :..:|...:
  Rat  2017 QRLEELKAEMQELVQREEEASRRCMEMEK-------YVEELAAVRQTLQTDL----ETSIRRIAD 2070

  Fly  1652 MQALRSQFERDLLAKEEGAEEKRRGLVKQLRDLETELDEERKQRTAAVASKKKLEGDLKEIETTM 1716
            :||          |.||.|              .::.|.|..|.....:|:...|||        
  Rat  2071 LQA----------ALEEVA--------------SSDSDTESVQTAVDCSSRSGKEGD-------- 2103

  Fly  1717 EMHNKVKEDALKHAKKLQAQVKDALRDAEEAKAAKEELQALSKEAERKVKALEAEVLQLTEDLAS 1781
                .|...:.:....||:.:..:|..|.::........|:|......         :::|:...
  Rat  2104 ----NVSVISSQPESSLQSWMSCSLSLATDSVRIPSRQSAISSSLHSP---------RVSEEAGD 2155

  Fly  1782 SERARRAA-------ETERDEL--------------------AEEIANNANK-----GSLMIDEK 1814
            |||.|.|:       :..||..                    .|..|.:...     |||.....
  Rat  2156 SERPRPASTVLHGDWDAPRDTAGAGSVSLHPVLPQKPYHLGDGEGFAVHRKSTPERPGSLSSSPT 2220

  Fly  1815 RR------LEARIATLEEELEEEQSNSEVLLDRSRKAQ-----------LQIEQLTTELANEKSN 1862
            .|      |.:..|.|.|.:||.:..      |:::.|           ..|.|.|...:..:..
  Rat  2221 SRSEVVSPLPSPSAALSEFVEELRRK------RAQRGQGSTLHLGDGPVFPIFQTTGAFSLRRGR 2279

  Fly  1863 SQKNENGRALLERQNKELKAK------------------------------------------LA 1885
            :..:|...:|..|....|.|:                                          |.
  Rat  2280 ASSDEGDLSLRTRVKSPLGAEGNAGATGGLSRSTSLKCITSEGAEGITRLPDKQKTRFGSCESLL 2344

  Fly  1886 EIETAQRTKVKATIA----TLEAKIANLEEQLENE-----GKERLLQQKANRKMDKKIKELTMNI 1941
            |...:.|.|:.:..|    ||..:...||..:::.     |||.|:.|  ||:..        ::
  Rat  2345 ESGPSTRRKLSSPTALLSPTLRPRRPCLESSVDDAACLDLGKEPLVFQ--NRQFS--------HL 2399

  Fly  1942 EDERRHVDQHKEQMDKLNSRIKLLKRNLDETEEELQKEKTQKRKYQRECEDM-------IESQEA 1999
            .:|....|....::..||.| :..|.:.|:....::|.........::.::.       .|..||
  Rat  2400 MEETPDSDPFSWKLPSLNYR-RQTKVDFDDFLPAIKKPDVALSGASKDGKEASKHPGVHFEMGEA 2463

  Fly  2000 MNRE-INSLKTKLRR-----------------TGGI--GLSSSRLTGTPSSKRAGGGGG 2038
            .:|. ::.:||.|::                 :|.|  ..|:..:.|.|...|..|.||
  Rat  2464 ADRSFLSGIKTILKKNPEAKEDPAHLSDSSSSSGSILSFKSTDGMRGGPRVPRLQGDGG 2522

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
zipNP_523860.2 Myosin_N 80..117 CDD:280832 8/51 (16%)
Myosin_head 133..854 CDD:278492 209/824 (25%)
MYSc_Myh2_insects_mollusks 145..854 CDD:276876 203/812 (25%)
Myosin_tail_1 931..2011 CDD:279860 263/1254 (21%)
Prefoldin 1431..1515 CDD:298833 22/87 (25%)
FAM76 <1847..1926 CDD:292665 22/129 (17%)
Myo18bXP_006249639.1 MYSc 558..1324 CDD:214580 217/843 (26%)
MYSc_Myo18 577..1312 CDD:276837 203/812 (25%)
KASH_CCD 1390..1579 CDD:291334 55/234 (24%)
GBP_C <1683..1766 CDD:303769 18/82 (22%)
coiled coil 1737..1751 CDD:293879 2/13 (15%)
Rab5-bind 1788..2082 CDD:286404 85/373 (23%)
DUF3585 <1889..2033 CDD:304905 39/174 (22%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG0161
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
32.810

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