DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment zip and Myh7

DIOPT Version :9

Sequence 1:NP_523860.2 Gene:zip / 38001 FlyBaseID:FBgn0265434 Length:2056 Species:Drosophila melanogaster
Sequence 2:NP_058936.1 Gene:Myh7 / 29557 RGDID:62030 Length:1935 Species:Rattus norvegicus


Alignment Length:1963 Identity:780/1963 - (39%)
Similarity:1191/1963 - (60%) Gaps:84/1963 - (4%)


- Green bases have known domain annotations that are detailed below.


  Fly    79 KRLVWVPHENQGFVAASIKREHGDEVEVELAETGKRVMILRDDIQKMNPPKFDKVEDMAELTCLN 143
            |:.|:||.:.:.||.|.|....|.:|..| .|.||.|.:..|.:.:.|||||||:||||.||.|:
  Rat    34 KKDVFVPDDKEEFVKAKIVSREGGKVTAE-TENGKTVTVKEDQVMQQNPPKFDKIEDMAMLTFLH 97

  Fly   144 EASVLHNIKDRYYSGLIYTYSGLFCVVVNPYKKLPIYTEKIMERYKGIKRHEVPPHVFAITDSAY 208
            |.:||:|:|:||.|.:||||||||||.|||||.||:|..:::..|:|.||.|.|||:|:|:|:||
  Rat    98 EPAVLYNLKERYASWMIYTYSGLFCVTVNPYKWLPVYNAQVVAAYRGKKRSEAPPHIFSISDNAY 162

  Fly   209 RNMLGDREDQSILCTGESGAGKTENTKKVIQFLAYVAASKPKGSGAVPHPAVLINFSVNTNKYIK 273
            :.||.|||:||||.|||||||||.|||:|||:.|.:||...:                       
  Rat   163 QYMLTDRENQSILITGESGAGKTVNTKRVIQYFAVIAAIGDR----------------------- 204

  Fly   274 VKIMAQNQNQTIEVVNGLKMVEVNSNCQEGELEQQLLQANPILEAFGNAKTVKNDNSSRFGKFIR 338
                 ..::||               ..:|.||.|::||||.||||||||||:||||||||||||
  Rat   205 -----SKKDQT---------------PGKGTLEDQIIQANPALEAFGNAKTVRNDNSSRFGKFIR 249

  Fly   339 INFDASGFISGANIETYLLEKSRAIRQAKDERTFHIFYQLLAGATPEQREKFIL-DDVKSYAFLS 402
            |:|.|:|.::.|:||||||||||.|.|.|.||.:|||||:|:...||..:..:: ::...|||.|
  Rat   250 IHFGATGKLASADIETYLLEKSRVIFQLKAERDYHIFYQILSNKKPELLDMLLITNNPYDYAFFS 314

  Fly   403 NGSLPVPGVDDYAEFQATVKSMNIMGMTSEDFNSIFRIVSAVLLFGSMKFRQERNNDQATLPDNT 467
            .|...|..:||..|..||..:.:::|.|.|:.|||:::..|::.||:|||:|::..:||. ||.|
  Rat   315 QGETTVASIDDSEEHMATDSAFDVLGFTPEEKNSIYKLTGAIMHFGNMKFKQKQREEQAE-PDGT 378

  Fly   468 -VAQKIAHLLGLSVTDMTRAFLTPRIKVGRDFVTKAQTKEQVEFAVEAIAKACYERMFKWLVNRI 531
             .|.|.|:|:||:..|:.:....||:|||.::|||.|..:||.:|:.|:||:.||:||.|:|.||
  Rat   379 EEADKSAYLMGLNSADLLKGLCHPRVKVGNEYVTKGQNVQQVAYAIGALAKSVYEKMFNWMVTRI 443

  Fly   532 NRSLDRTKRQGASFIGILDMAGFEIFELNSFEQLCINYTNEKLQQLFNHTMFILEQEEYQREGIE 596
            |.:|: ||:....|||:||:||||||:.|||||||||:|||||||.|||.||:||||||::||||
  Rat   444 NATLE-TKQPRQYFIGVLDIAGFEIFDFNSFEQLCINFTNEKLQQFFNHHMFVLEQEEYKKEGIE 507

  Fly   597 WKFIDFGLDLQPTIDLIDKPGGIMALLDEECWFPKATDKTFVDKLVSAH-SMHPKFMK-TDFRG- 658
            |.|||||:|||..||||:||.|||::|:|||.||||||.||..||...| .....|.| .:.:| 
  Rat   508 WTFIDFGMDLQACIDLIEKPMGIMSILEEECMFPKATDMTFKAKLYDNHLGKSNNFQKPRNIKGK 572

  Fly   659 -VADFAIVHYAGRVDYSAAKWLMKNMDPLNENIVSLLQGSQDPFVVNIWKDAEIVGMAQQALTDT 722
             .|.|:::||||.|||:...||.||.|||||.:|.|.|.|....:.|::  |...|  ..|..|.
  Rat   573 QEAHFSLIHYAGTVDYNILGWLQKNKDPLNETVVGLYQKSSLKLLSNLF--ANYAG--ADAPVDK 633

  Fly   723 QFGARTRKGMFRTVSHLYKEQLAKLMDTLRNTNPNFVRCIIPNHEKRAGKIDAPLVLDQLRCNGV 787
            ..|...:...|:|||.|::|.|.|||..||:|:|:||||||||..|..|.:|.|||:.|||||||
  Rat   634 GKGKAKKGSSFQTVSALHRENLNKLMTNLRSTHPHFVRCIIPNETKSPGVMDNPLVMHQLRCNGV 698

  Fly   788 LEGIRICRQGFPNRIPFQEFRQRYELLTPNVIPKG-FMDGKKACEKMIQALELDSNLYRVGQSKI 851
            ||||||||:||||||.:.:|||||.:|.|..||:| |:|.:|..||::.:|::|.|.|:.|.:|:
  Rat   699 LEGIRICRKGFPNRILYGDFRQRYRILNPAAIPEGQFIDSRKGAEKLLGSLDIDHNQYKFGHTKV 763

  Fly   852 FFRAGVLAHLEEERDFKISDLIVNFQAFCRGFLARRNYQKRLQQLNAIRIIQRNCAAYLKLRNWQ 916
            ||:||:|..|||.||.::|.:|...||..||.|:|..::|.|::.:::.|||.|..|::.::||.
  Rat   764 FFKAGLLGLLEEMRDERLSRIITRIQAQSRGVLSRMEFKKLLERRDSLLIIQWNIRAFMGVKNWP 828

  Fly   917 WWRLYTKVKPLLEVTKQEEKLVQKEDELKQVREKLDTLAKNTQEYERKYQQALVEKTTLAEQLQA 981
            |.:||.|:||||:..:.|:::...::|..:|::.|:......:|.|.|....|.||..|..|:||
  Rat   829 WMKLYFKIKPLLKSAETEKEMANMKEEFGRVKDALEKSEARRKELEEKMVSLLQEKNDLQLQVQA 893

  Fly   982 EIELCAEAEESRSRLMARKQELEDMMQELETRIEEEEERVLALGGEKKKLELNIQDLEEQLEEEE 1046
            |.:..|:|||...:|:..|.:||..::|:..|:|:|||....|..:|:|||....:|:..:::.|
  Rat   894 EQDNLADAEERCDQLIKNKIQLEAKVKEMTERLEDEEEMNAELTAKKRKLEDECSELKRDIDDLE 958

  Fly  1047 AARQKLQLEKVQLDAKIKKYEEDLALTDDQNQKLLKEKKLLEERANDLSQTLAEEEEKAKHLAKL 1111
            ....|::.||...:.|:|...|::|..|:...||.||||.|:|........|..||:|...|.|.
  Rat   959 LTLAKVEKEKHATENKVKNLTEEMAGLDEIIVKLTKEKKALQEAHQQALDDLQAEEDKVNTLTKA 1023

  Fly  1112 KAKHEATISELEERLHKDQQQRQESDRSKRKIETE-------VADL---KEQLNERRVQVDEMQA 1166
            |.|.|..:.:||..|.:|::.|.:.:|:|||:|.:       :.||   |:||:||         
  Rat  1024 KVKLEQQVDDLEGSLDQDKKVRMDLERAKRKLEGDLKLTQESIMDLENDKQQLDER--------- 1079

  Fly  1167 QLAKREEELTQTLLRIDEESATKATAQKAQRELESQLAEIQEDLEAEKAARAKAEKVRRDLSEEL 1231
             |.|::.||.....||::|.|..:..||..:||::::.|::|:||||:.||||.||:|.|||.||
  Rat  1080 -LKKKDFELNALNARIEDEQALGSQLQKKLKELQARIEELEEELEAERTARAKVEKLRSDLSREL 1143

  Fly  1232 EALKNELLDSLDTTAAQQELRSKREQELATLKKSLEEETVNHEGVLADMRHKHSQELNSINDQLE 1296
            |.:...|.::...|:.|.|:..|||.|...:::.|||.|:.||...|.:|.||:..:..:.:|::
  Rat  1144 EEISERLEEAGGATSVQIEMNKKREAEFQKMRRDLEEATLQHEATAAALRKKHADSVAELGEQID 1208

  Fly  1297 NLRKAKTVLEKAKGTLEAENADLATELRSVNSSRQENDRRRKQAESQIAELQVKLAEIERARSEL 1361
            ||::.|..|||.|...:.|..|:.:.:..:..::...::..:..|.|:.|.:.|..|.:|:.::|
  Rat  1209 NLQRVKQKLEKEKSEFKLELDDVTSNMEQIIKAKANLEKMCRTLEDQMNEHRSKAEETQRSVNDL 1273

  Fly  1362 QEKCTKLQQEAENITNQLEEAELKASAAVKSASNMESQLTEAQQLLEEETRQKLGLSSKLRQIES 1426
            ..:..|||.|...::.||:|.|...|...:.......||.:.::.||||.:.|..|:..|:....
  Rat  1274 TRQRAKLQTENGELSRQLDEKEALISQLTRGKLTYTQQLEDLKRQLEEEVKAKNALAHALQSARH 1338

  Fly  1427 EKEALQEQLEEDDEAKRNYERKLAEVTTQMQEIKKKAEEDA-DLAKELEEGKKRLNKDIEALERQ 1490
            :.:.|:||.||:.|||...:|.|::..:::.:.:.|.|.|| ...:||||.||:|.:.::..|..
  Rat  1339 DCDLLREQYEEETEAKAELQRVLSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDAEEA 1403

  Fly  1491 VKELIAQNDRLDKSKKKIQSELEDATIELEAQRTKVLELEKKQKNFDKILAEEKAISEQIAQERD 1555
            |:.:.|:...|:|:|.::|:|:||..:::|........|:|||:||||||.|.|...|:...|.:
  Rat  1404 VEAVNAKCSSLEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQRNFDKILVEWKQKYEESQSELE 1468

  Fly  1556 TAEREAREKETKVLSVSRELDEAFDKIEDLENKRKTLQNELDDLANTQGTADKNVHELEKAKRAL 1620
            ::::|||...|::..:....:|:.:.:|..:.:.|.||.|:.||....|:..|::|||||.::.|
  Rat  1469 SSQKEARSLSTELFKLKNAYEESLEHLETFKRENKNLQEEISDLTEQLGSTGKSIHELEKIRKQL 1533

  Fly  1621 ESQLAELKAQNEELEDDLQLTEDAKLRLEVNMQALRSQFERDLLAKEEGAEEKRRGLVKQLRDLE 1685
            |::..||::..||.|..|:..|...||.::....::::.||.|..|:|..|:.:|..::.:..|:
  Rat  1534 EAEKLELQSALEEAEASLEHEEGKILRAQLEFNQIKAEIERKLAEKDEEMEQAKRNHLRVVDSLQ 1598

  Fly  1686 TELDEERKQRTAAVASKKKLEGDLKEIETTMEMHNKVKEDALKHAKKLQAQVKDALRDAEEAKAA 1750
            |.||.|.:.|..|:..|||:||||.|:|..:...|::..:|.|..|.||:.:||.....::|..|
  Rat  1599 TSLDAETRSRNEALRVKKKMEGDLNEMEIQLSHANRMAAEAQKQVKSLQSLLKDTQIQLDDAVRA 1663

  Fly  1751 KEELQALSKEAERKVKALEAEVLQLTEDLASSERARRAAETERDELAEEIANNANKGSLMIDEKR 1815
            .::|:......||:...|:||:.:|...:..:||:|:.||.|..|.:|.:....::.:.:|::|:
  Rat  1664 NDDLKENIAIVERRNNLLQAELEELRAVVEQTERSRKLAEQELIETSERVQLLHSQNTSLINQKK 1728

  Fly  1816 RLEARIATLEEELEE---EQSNSEVLLDRSRKAQLQIEQLTTELANEKSNSQKNENGRALLERQN 1877
            :::|.::.|:.|:||   |..|:|   ::::||......:..||..|:..|...|..:..:|:..
  Rat  1729 KMDADLSQLQTEVEEAVQECRNAE---EKAKKAITDAAMMAEELKKEQDTSAHLERMKNNMEQTI 1790

  Fly  1878 KELKAKLAEIETAQRTKVKATIATLEAKIANLEEQLENEGKERLLQQKANRKMDKKIKELTMNIE 1942
            |:|:.:|.|.|.......|..:..|||::..||.:||.|.|......|..||.:::|||||...|
  Rat  1791 KDLQHRLDEAEQIALKGGKKQLQKLEARVRELENELEAEQKRNAESVKGMRKSERRIKELTYQTE 1855

  Fly  1943 DERRHVDQHKEQMDKLNSRIKLLKRNLDETEEELQKEKTQKRKYQRECEDMIESQEAMNREINSL 2007
            ::|:::.:.::.:|||..::|..||..:|.||:.....::.||.|.|.::..|..:....::|.|
  Rat  1856 EDRKNLLRLQDLVDKLQLKVKAYKRQAEEAEEQANTNLSKFRKVQHELDEAEERADIAESQVNKL 1920

  Fly  2008 KTKLRRTGGIGLS 2020
            :.|.|..|..||:
  Rat  1921 RAKSRDIGAKGLN 1933

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
zipNP_523860.2 Myosin_N 80..117 CDD:280832 14/36 (39%)
Myosin_head 133..854 CDD:278492 373/727 (51%)
MYSc_Myh2_insects_mollusks 145..854 CDD:276876 365/715 (51%)
Myosin_tail_1 931..2011 CDD:279860 345/1093 (32%)
Prefoldin 1431..1515 CDD:298833 30/84 (36%)
FAM76 <1847..1926 CDD:292665 21/78 (27%)
Myh7NP_058936.1 Myosin_N 35..72 CDD:280832 14/37 (38%)
Myosin_head 87..766 CDD:278492 373/727 (51%)
MYSc_class_II 99..766 CDD:276951 365/715 (51%)
Actin-binding 655..677 15/21 (71%)
Actin-binding 757..771 6/13 (46%)
Myosin_tail_1 846..1923 CDD:279860 345/1089 (32%)
MM_CoA_mutase <1132..1293 CDD:294532 50/160 (31%)
BAR 1232..1424 CDD:299863 53/191 (28%)
TMPIT 1740..>1830 CDD:285135 27/92 (29%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1915..1935 7/19 (37%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG0161
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D47111at2759
OrthoFinder 1 1.000 - - FOG0000014
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100110
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 1 1.000 - - X58
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
76.720

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