DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment zip and Myh6

DIOPT Version :9

Sequence 1:NP_523860.2 Gene:zip / 38001 FlyBaseID:FBgn0265434 Length:2056 Species:Drosophila melanogaster
Sequence 2:NP_058935.2 Gene:Myh6 / 29556 RGDID:62029 Length:1939 Species:Rattus norvegicus


Alignment Length:1951 Identity:763/1951 - (39%)
Similarity:1184/1951 - (60%) Gaps:76/1951 - (3%)


- Green bases have known domain annotations that are detailed below.


  Fly    83 WVPHENQGFVAASIKREHGDEVEVELAETGKRVMILRDDIQKMNPPKFDKVEDMAELTCLNEASV 147
            :||.:.:.:|.|.|....|.:|..| .|.||.|.:..|.:.:.|||||||:||||.||.|:|.:|
  Rat    38 FVPDDKEEYVKAKIVSREGGKVTAE-TENGKTVTVK
EDQVMQQNPPKFDKIEDMAMLTFLHEPAV 101

  Fly   148 LHNIKDRYYSGLIYTYSGLFCVVVNPYKKLPIYTEKIMERYKGIKRHEVPPHVFAITDSAYRNML 212
            |:|:|:||.:.:||||||||||.|||||.||:|..:::..|:|.||.|.|||:|:|:|:||:.||
  Rat   102 LYNLKERYAAWMIYTYSGLFCVTVNPYKWLPVYNAEVVAAYRGKKRSEAPPHIFSISDNAYQYML 166

  Fly   213 GDREDQSILCTGESGAGKTENTKKVIQFLAYVAASKPKGSGAVPHPAVLINFSVNTNKYIKVKIM 277
            .|||:||||.|||||||||.|||:|||:.|.:||.                              
  Rat   167 TDRENQSILITGESGAGKTVNTKRVIQYFASIAAI------------------------------ 201

  Fly   278 AQNQNQTIEVVNGLKMVEVNSNCQEGELEQQLLQANPILEAFGNAKTVKNDNSSRFGKFIRINFD 342
                        |.:..:.|.|..:|.||.|::||||.||||||||||:|||||||||||||:|.
  Rat   202 ------------GDRSKKDNPNANKGTLEDQIIQANPALEAFGNAKTVRNDNSSRFGKFIRIHFG 254

  Fly   343 ASGFISGANIETYLLEKSRAIRQAKDERTFHIFYQLLAGATPEQREKFIL-DDVKSYAFLSNGSL 406
            |:|.::.|:||||||||||.|.|.|.||.:|||||:|:...||..:..:: ::...|||:|.|.:
  Rat   255 ATGKLASADIETYLLEKSRVIFQLKAERNYHIFYQILSNKKPELLDMLLVTNNPYDYAFVSQGEV 319

  Fly   407 PVPGVDDYAEFQATVKSMNIMGMTSEDFNSIFRIVSAVLLFGSMKFRQERNNDQATLPDNTV-AQ 470
            .|..:||..|..||..:.:::|.|:|:...::::..|::.:|:|||:|::..:||. ||.|. |.
  Rat   320 SVASIDDSEELLATDSAFDVLGFTAEEKAGVYKLTGAIMHYGNMKFKQKQREEQAE-PDGTEDAD 383

  Fly   471 KIAHLLGLSVTDMTRAFLTPRIKVGRDFVTKAQTKEQVEFAVEAIAKACYERMFKWLVNRINRSL 535
            |.|:|:||:..|:.:....||:|||.::|||.|:.:||.:::.|:||:.||:||.|:|.|||.:|
  Rat   384 KSAYLMGLNSADLLKGLCHPRVKVGNEYVTKGQSVQQVYYSIGALAKSVYEKMFNWMVTRINATL 448

  Fly   536 DRTKRQGASFIGILDMAGFEIFELNSFEQLCINYTNEKLQQLFNHTMFILEQEEYQREGIEWKFI 600
            : ||:....|||:||:||||||:.|||||||||:|||||||.|||.||:||||||::|||||:||
  Rat   449 E-TKQPRQYFIGVLDIAGFEIFDFNSFEQLCINFTNEKLQQFFNHHMFVLEQEEYKKEGIEWEFI 512

  Fly   601 DFGLDLQPTIDLIDKPGGIMALLDEECWFPKATDKTFVDKLVSAH-SMHPKFMKTDFRGV----- 659
            |||:|||..||||:||.|||::|:|||.||||||.||..||...| .....|.|.  |.|     
  Rat   513 DFGMDLQACIDLIEKPMGIMSILEEECMFPKATDMTFKAKLYDNHLGKSNNFQKP--RNVKGKQE 575

  Fly   660 ADFAIVHYAGRVDYSAAKWLMKNMDPLNENIVSLLQGSQDPFVVNIWKDAEIVGMAQQALTDT-- 722
            |.|::|||||.|||:...||.||.|||||.:|.|.|.|....:..::        :..|..||  
  Rat   576 AHFSLVHYAGTVDYNILGWLEKNKDPLNETVVGLYQKSSLKLMATLF--------STYASADTGD 632

  Fly   723 ---QFGARTRKGMFRTVSHLYKEQLAKLMDTLRNTNPNFVRCIIPNHEKRAGKIDAPLVLDQLRC 784
               ..|.:.:...|:|||.|::|.|.|||..||.|:|:||||||||..|..|.:|.|||:.||||
  Rat   633 SGKGKGGKKKGSSFQTVSALHRENLNKLMTNLRTTHPHFVRCIIPNERKAPGVMDNPLVMHQLRC 697

  Fly   785 NGVLEGIRICRQGFPNRIPFQEFRQRYELLTPNVIPKG-FMDGKKACEKMIQALELDSNLYRVGQ 848
            |||||||||||:||||||.:.:|||||.:|.|..||:| |:|.:|..||::.:|::|.|.|:.|.
  Rat   698 NGVLEGIRICRKGFPNRILYGDFRQRYRILNPAAIPEGQFIDSRKGAEKLLGSLDIDHNQYKFGH 762

  Fly   849 SKIFFRAGVLAHLEEERDFKISDLIVNFQAFCRGFLARRNYQKRLQQLNAIRIIQRNCAAYLKLR 913
            :|:||:||:|..|||.||.::|.:|...||..||.|.|..::|.:::.:|:.:||.|..|::.::
  Rat   763 TKVFFKAGLLGLLEEMRDERLSRIITRIQAQARGQLMRIEFKKMVERRDALLVIQWNIRAFMGVK 827

  Fly   914 NWQWWRLYTKVKPLLEVTKQEEKLVQKEDELKQVREKLDTLAKNTQEYERKYQQALVEKTTLAEQ 978
            ||.|.:||.|:||||:..:.|:::...::|..:|::.|:......:|.|.|....|.||..|..|
  Rat   828 NWPWMKLYFKIKPLLKSAETEKEMANMKEEFGRVKDALEKSEARRKELEEKMVSLLQEKNDLQLQ 892

  Fly   979 LQAEIELCAEAEESRSRLMARKQELEDMMQELETRIEEEEERVLALGGEKKKLELNIQDLEEQLE 1043
            :|||.:..|:|||...:|:..|.:||..::|:..|:|:|||....|..:|:|||....:|::.::
  Rat   893 VQAEQDNLADAEERCDQLIKNKIQLEAKVKEMTERLEDEEEMNAELTAKKRKLEDECSELKKDID 957

  Fly  1044 EEEAARQKLQLEKVQLDAKIKKYEEDLALTDDQNQKLLKEKKLLEERANDLSQTLAEEEEKAKHL 1108
            :.|....|::.||...:.|:|...|::|..|:...||.||||.|:|........|..||:|...|
  Rat   958 DLELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQALDDLQAEEDKVNTL 1022

  Fly  1109 AKLKAKHEATISELEERLHKDQQQRQESDRSKRKIETEVADLKEQLNERRVQVDEMQAQLAKREE 1173
            .|.|.|.|..:.:||..|.::::.|.:.:|:|||:|.::...:|.:.:......:::.:|.|:|.
  Rat  1023 IKSKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQESIMDLENDKLQLEEKLKKKEF 1087

  Fly  1174 ELTQTLLRIDEESATKATAQKAQRELESQLAEIQEDLEAEKAARAKAEKVRRDLSEELEALKNEL 1238
            :::|...:|::|.|.....||..:|.::::.|::|:||||:.||||.||:|.||:.|||.:...|
  Rat  1088 DISQQNSKIEDEQALALQLQKKLKENQARIEELEEELEAERTARAKVEKLRSDLTRELEEISERL 1152

  Fly  1239 LDSLDTTAAQQELRSKREQELATLKKSLEEETVNHEGVLADMRHKHSQELNSINDQLENLRKAKT 1303
            .::...|:.|.|:..|||.|...:::.|||.|:.||...|.:|.||:..:..:.:|::||::.|.
  Rat  1153 EEAGGATSVQIEMNKKREAEFQKMRRDLEEATLQHEATAAALRKKHADSVAELGEQIDNLQRVKQ 1217

  Fly  1304 VLEKAKGTLEAENADLATELRSVNSSRQENDRRRKQAESQIAELQVKLAEIERARSELQEKCTKL 1368
            .|||.|...:.|..|:.:.:..:..::...::..:..|.|..|.:|||.|.:|:.::...:..||
  Rat  1218 KLEKEKSEFKLELDDVTSNMEQIIKAKANLEKVSRTLEDQANEYRVKLEEAQRSLNDFTTQRAKL 1282

  Fly  1369 QQEAENITNQLEEAELKASAAVKSASNMESQLTEAQQLLEEETRQKLGLSSKLRQIESEKEALQE 1433
            |.|...:..||||.|...|...:...:...|:.:.::.||||.:.|..|:..|:....:.:.|:|
  Rat  1283 QTENGELARQLEEKEALISQLTRGKLSYTQQMEDLKRQLEEEGKAKNALAHALQSARHDCDLLRE 1347

  Fly  1434 QLEEDDEAKRNYERKLAEVTTQMQEIKKKAEEDA-DLAKELEEGKKRLNKDIEALERQVKELIAQ 1497
            |.||:.|||...:|.|::..:::.:.:.|.|.|| ...:||||.||:|.:.::..|..|:.:.|:
  Rat  1348 QYEEEMEAKAELQRVLSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDAEEAVEAVNAK 1412

  Fly  1498 NDRLDKSKKKIQSELEDATIELEAQRTKVLELEKKQKNFDKILAEEKAISEQIAQERDTAEREAR 1562
            ...|:|:|.::|:|:||..:::|........|:|||:||||||||.|...|:...|.:::::|||
  Rat  1413 CSSLEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQRNFDKILAEWKQKYEESQSELESSQKEAR 1477

  Fly  1563 EKETKVLSVSRELDEAFDKIEDLENKRKTLQNELDDLANTQGTADKNVHELEKAKRALESQLAEL 1627
            ...|::..:....:|:.:.:|..:.:.|.||.|:.||....|...||||||||.::.||.:..||
  Rat  1478 SLSTELFKLKNAYEESLEHLETFKRENKNLQEEISDLTEQLGEGGKNVHELEKIRKQLEVEKLEL 1542

  Fly  1628 KAQNEELEDDLQLTEDAKLRLEVNMQALRSQFERDLLAKEEGAEEKRRGLVKQLRDLETELDEER 1692
            ::..||.|..|:..|...||.::....::::.||.|..|:|..|:.:|..::.:..|:|.||.|.
  Rat  1543 QSALEEAEASLEHEEGKILRAQLEFNQIKAEIERKLAEKDEEMEQAKRNHLRVVDSLQTSLDAET 1607

  Fly  1693 KQRTAAVASKKKLEGDLKEIETTMEMHNKVKEDALKHAKKLQAQVKDALRDAEEAKAAKEELQAL 1757
            :.|..|:..|||:||||.|:|..:...|::..:|.||.|..||.:||.....::|..|.::|:..
  Rat  1608 RSRNEALRVKKKMEGDLNEMEIQLSQANRIASEAQKHLKNAQAHLKDTQLQLDDAVRANDDLKEN 1672

  Fly  1758 SKEAERKVKALEAEVLQLTEDLASSERARRAAETERDELAEEIANNANKGSLMIDEKRRLEARIA 1822
            ....||:...|:||:.:|...:..:||:|:.||.|..|.:|.:....::.:.:|::|::::|.::
  Rat  1673 IAIVERRNTLLQAELEELRAVVEQTERSRKLAEQELIETSERVQLLHSQNTSLINQKKKMDADLS 1737

  Fly  1823 TLEEELEE---EQSNSEVLLDRSRKAQLQIEQLTTELANEKSNSQKNENGRALLERQNKELKAKL 1884
            .|:.|:||   |..|:|   ::::||......:..||..|:..|...|..:..:|:..|:|:.:|
  Rat  1738 QLQTEVEEAVQECRNAE---EKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTIKDLQHRL 1799

  Fly  1885 AEIETAQRTKVKATIATLEAKIANLEEQLENEGKERLLQQKANRKMDKKIKELTMNIEDERRHVD 1949
            .|.|.......|..:..|||::..||.:||.|.|......|..||.:::|||||...|::::::.
  Rat  1800 DEAEQIALKGGKKQLQKLEARVRELENELEAEQKRNAESVKGMRKSERRIKELTYQTEEDKKNLV 1864

  Fly  1950 QHKEQMDKLNSRIKLLKRNLDETEEELQKEKTQKRKYQRECEDMIESQEAMNREINSLKTKLRRT 2014
            :.::.:|||..::|..||..:|.||:.....::.||.|.|.::..|..:....::|.|:.|.|..
  Rat  1865 RLQDLVDKLQLKVKAYKRQAEEAEEQANTNLSKFRKVQHELDEAEERADIAESQVNKLRAKSRDI 1929

  Fly  2015 G 2015
            |
  Rat  1930 G 1930

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
zipNP_523860.2 Myosin_N 80..117 CDD:280832 12/33 (36%)
Myosin_head 133..854 CDD:278492 368/734 (50%)
MYSc_Myh2_insects_mollusks 145..854 CDD:276876 360/722 (50%)
Myosin_tail_1 931..2011 CDD:279860 339/1083 (31%)
Prefoldin 1431..1515 CDD:298833 30/84 (36%)
FAM76 <1847..1926 CDD:292665 21/78 (27%)
Myh6NP_058935.2 Myosin_N 34..72 CDD:397036 12/34 (35%)
MYSc_class_II 99..768 CDD:276951 360/722 (50%)
Actin-binding 657..679 15/21 (71%)
Actin-binding 759..773 6/13 (46%)
Calmodulin-binding. /evidence=ECO:0000250 790..807 7/16 (44%)
Calmodulin-binding. /evidence=ECO:0000250 816..833 7/16 (44%)
Myosin_tail_1 848..1925 CDD:396244 339/1079 (31%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1908..1939 6/23 (26%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG0161
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D47111at2759
OrthoFinder 1 1.000 - - FOG0000014
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100110
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 1 1.000 - - X58
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
76.720

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