DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment zip and Myh1

DIOPT Version :9

Sequence 1:	NP_523860.2	Gene:	zip / 38001	FlyBaseID:	FBgn0265434	Length:	2056	Species:	Drosophila melanogaster
Sequence 2:	NP_001128630.1	Gene:	Myh1 / 287408	RGDID:	735061	Length:	1942	Species:	Rattus norvegicus

Alignment Length:	1974	Identity:	774/1974 - (39%)
Similarity:	1198/1974 - (60%)	Gaps:	72/1974 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly    55 PELKYLSVERNQFNDPATQAEWTQKRLVWVPHENQGFVAASIKREHGDEVEVELAETGKRVMILR 119
            |.|:....||.:    |....:..|..|:|....:.||.|:::...|.:|..: .|.|..|.:..
  Rat    15 PYLRKSEKERIE----AQNKPFDAKSSVFVVDAKESFVKATVQSREGGKVTAK-TEGGATVTVKD 74

  Fly   120 DDIQKMNPPKFDKVEDMAELTCLNEASVLHNIKDRYYSGLIYTYSGLFCVVVNPYKKLPIYTEKI 184
            |.:..|||||:||:||||.:|.|:|.:||:|:|:||.:.:||||||||||.|||||.||:|..::
  Rat    75 DQVFPMNPPKYDKIEDMAMMTHLHEPAVLYNLKERYAAWMIYTYSGLFCVTVNPYKWLPVYNAEV 139

  Fly   185 MERYKGIKRHEVPPHVFAITDSAYRNMLGDREDQSILCTGESGAGKTENTKKVIQFLAYVAASKP 249
            :..|:|.||.|.|||:|:|:|:||:.||.|||:||||.|||||||||.|||:|||:.|
  Rat   140 VAAYRGKKRQEAPPHIFSISDNAYQFMLTDRENQSILITGESGAGKTVNTKRVIQYFA------- 197

  Fly   250 KGSGAVPHPAVLINFSVNTNKYIKVKIMAQNQNQTIEVVNGLKMVEVNSNCQEGELEQQLLQANP 314
                                              ||.|....|..|..|...:|.||.|::.|||
  Rat   198 ----------------------------------TIAVTGEKKKEEAPSGKMQGTLEDQIISANP 228

  Fly   315 ILEAFGNAKTVKNDNSSRFGKFIRINFDASGFISGANIETYLLEKSRAIRQAKDERTFHIFYQLL 379
            :||||||||||:|||||||||||||:|..:|.::.|:||||||||||...|.|.||::|||||::
  Rat   229 LLEAFGNAKTVRNDNSSRFGKFIRIHFGTTGKLASADIETYLLEKSRVTFQLKAERSYHIFYQIM 293

  Fly   380 AGATPEQREKFIL-DDVKSYAFLSNGSLPVPGVDDYAEFQATVKSMNIMGMTSEDFNSIFRIVSA 443
            :...|:..|..:: .:...|||:|.|.:.||.:||..|..||..:::|:|.||::..||:::..|
  Rat   294 SNKKPDLIEMLLITTNPYDYAFVSQGEITVPSIDDQEELMATDSAIDILGFTSDERVSIYKLTGA 358

  Fly   444 VLLFGSMKFRQERNNDQATLPDNT-VAQKIAHLLGLSVTDMTRAFLTPRIKVGRDFVTKAQTKEQ 507
            |:.:|:|||:|::..:||. ||.| ||.|.|:|..|:..|:.:|...||:|||.::|||.||.:|
  Rat   359 VMHYGNMKFKQKQREEQAE-PDGTEVADKAAYLQNLNSADLLKALCYPRVKVGNEYVTKGQTVQQ 422

  Fly   508 VEFAVEAIAKACYERMFKWLVNRINRSLDRTKRQGASFIGILDMAGFEIFELNSFEQLCINYTNE 572
            |..||.|:|||.||:||.|:|.|||:.|| ||:....|||:||:||||||:.||.||||||:|||
  Rat   423 VYNAVGALAKAVYEKMFLWMVTRINQQLD-TKQPRQYFIGVLDIAGFEIFDFNSLEQLCINFTNE 486

  Fly   573 KLQQLFNHTMFILEQEEYQREGIEWKFIDFGLDLQPTIDLIDKPGGIMALLDEECWFPKATDKTF 637
            ||||.|||.||:||||||::|||||:|||||:||...|:||:||.||.::|:|||.||||||.:|
  Rat   487 KLQQFFNHHMFVLEQEEYKKEGIEWEFIDFGMDLAACIELIEKPMGIFSILEEECMFPKATDTSF 551

  Fly   638 VDKLVSAH------SMHPKFMKTDFRGVADFAIVHYAGRVDYSAAKWLMKNMDPLNENIVSLLQG 696
            .:||...|      ...||..|....  |.|::|||||.|||:.|.||.||.|||||.:|.|.|.
  Rat   552 KNKLYEQHLGKSNNFQKPKPAKGKVE--AHFSLVHYAGTVDYNIAGWLDKNKDPLNETVVGLYQK 614

  Fly   697 SQDPFVVNIWKDAEIVGMAQQALTDTQFGARTRKGMFRTVSHLYKEQLAKLMDTLRNTNPNFVRC 761
            |....:..::..|.....|:......:.||:.:...|:|||.|::|.|.|||..||:|:|:||||
  Rat   615 SSMKTLAYLFSGAAAAAEAESGGGGGKKGAKKKGSSFQTVSALFRENLNKLMTNLRSTHPHFVRC 679

  Fly   762 IIPNHEKRAGKIDAPLVLDQLRCNGVLEGIRICRQGFPNRIPFQEFRQRYELLTPNVIPKG-FMD 825
            ||||..|..|.::..|||.|||||||||||||||:|||:||.:.:|:|||::|..:.||:| |:|
  Rat   680 IIPNETKTPGAMEHELVLHQLRCNGVLEGIRICRKGFPSRILYADFKQRYKVLNASAIPEGQFID 744

  Fly   826 GKKACEKMIQALELDSNLYRVGQSKIFFRAGVLAHLEEERDFKISDLIVNFQAFCRGFLARRNYQ 890
            .|||.||::.::::|...|:.|.:|:||:||:|..|||.||.|::.||...||.|||:|||..||
  Rat   745 SKKASEKLLGSIDIDHTQYKFGHTKVFFKAGLLGLLEEMRDDKLAQLITRTQAMCRGYLARVEYQ 809

  Fly   891 KRLQQLNAIRIIQRNCAAYLKLRNWQWWRLYTKVKPLLEVTKQEEKLVQKEDELKQVREKLDTLA 955
            |.:::..:|..||.|..|::.:::|.|.:||.|:||||:..:.|:::...::|.::.:|.|....
  Rat   810 KMVERRESIFCIQYNVRAFMNVKHWPWMKLYFKIKPLLKSAETEKEMANMKEEFEKTKENLAKAE 874

  Fly   956 KNTQEYERKYQQALVEKTTLAEQLQAEIELCAEAEESRSRLMARKQELEDMMQELETRIEEEEER 1020
            ...:|.|.|....:.||..|..|:|:|.:..|:|||...:|:..|.:||..::|:..|.|:|||.
  Rat   875 AKRKELEEKMVALMQEKNDLQLQVQSEADSLADAEERCDQLIKTKIQLEAKIKEVTERAEDEEEI 939

  Fly  1021 VLALGGEKKKLELNIQDLEEQLEEEEAARQKLQLEKVQLDAKIKKYEEDLALTDDQNQKLLKEKK 1085
            ...|..:|:|||....:|::.:::.|....|::.||...:.|:|...|::|..|:...||.||||
  Rat   940 NAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKK 1004

  Fly  1086 LLEERANDLSQTLAEEEEKAKHLAKLKAKHEATISELEERLHKDQQQRQESDRSKRKIETEVADL 1150
            .|:|........|..||:|...|.|.|.|.|..:.:||..|.::::.|.:.:|:|||:|   .||
  Rat  1005 ALQEAHQQTLDDLQAEEDKVNTLTKAKIKLEQQVDDLEGSLEQEKKIRMDLERAKRKLE---GDL 1066

  Fly  1151 K-EQLNERRVQVDEMQ--AQLAKREEELTQTLLRIDEESATKATAQKAQRELESQLAEIQEDLEA 1212
            | .|.:...|:.|:.|  .:|.|:|.|::....:|::|.|.....||..:||::::.|::|::||
  Rat  1067 KLAQESTMDVENDKQQLDEKLKKKEFEMSNLQSKIEDEQALGMQLQKKIKELQARIEELEEEIEA 1131

  Fly  1213 EKAARAKAEKVRRDLSEELEALKNELLDSLDTTAAQQELRSKREQELATLKKSLEEETVNHEGVL 1277
            |:|:||||||.|.|||.|||.:...|.::...|:||.|:..|||.|...:::.|||.|:.||...
  Rat  1132 ERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATA 1196

  Fly  1278 ADMRHKHSQELNSINDQLENLRKAKTVLEKAKGTLEAENADLATELRSVNSSRQENDRRRKQAES 1342
            |.:|.||:..:..:.:|::||::.|..|||.|..::.|..|||:.:..::.|:...::..:..|.
  Rat  1197 ATLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNMEVISKSKGNLEKMCRTLED 1261

  Fly  1343 QIAELQVKLAEIERARSELQEKCTKLQQEAENITNQLEEAELKASAAVKSASNMESQLTEAQQLL 1407
            |::||:.|..|.:|..:||..:..:||.|:...:.||:|.:...|...:.......|:.|.::.|
  Rat  1262 QVSELKTKEEEQQRLINELTAQRGRLQTESGEYSRQLDEKDSLVSQLSRGKQAFTQQIEELKRQL 1326

  Fly  1408 EEETRQKLGLSSKLRQIESEKEALQEQLEEDDEAKRNYERKLAEVTTQMQEIKKKAEEDA-DLAK 1471
            |||.:.|..|:..|:....:.:.|:||.||:.|||...:|.:::..:::.:.:.|.|.|| ...:
  Rat  1327 EEEVKAKSALAHALQSSRHDCDLLREQYEEEQEAKAELQRAMSKANSEVAQWRTKYETDAIQRTE 1391

  Fly  1472 ELEEGKKRLNKDIEALERQVKELIAQNDRLDKSKKKIQSELEDATIELEAQRTKVLELEKKQKNF 1536
            ||||.||:|.:.::..|..|:.:.|:...|:|:|:::|:|:||..|::|........|:|||:||
  Rat  1392 ELEEAKKKLAQRLQDAEEHVEAVNAKCASLEKTKQRLQNEVEDLMIDVERTNAACAALDKKQRNF 1456

  Fly  1537 DKILAEEKAISEQIAQERDTAEREAREKETKVLSVSRELDEAFDKIEDLENKRKTLQNELDDLAN 1601
            ||||||.|...|:...|.:.:::|:|...|::..:....:|:.|::|.|:.:.|.||.|:.||..
  Rat  1457 DKILAEWKQKYEETHAELEASQKESRSLSTELFKIKNAYEESLDQLETLKRENKNLQQEISDLTE 1521

  Fly  1602 TQGTADKNVHELEKAKRALESQLAELKAQNEELEDDLQLTEDAKLRLEVNMQALRSQFERDLLAK 1666
            ......|.:|||||.|:.:|.:.:||:|..||.|..|:..|...||:::.:..::|:.:|.:..|
  Rat  1522 QIAEGGKRIHELEKIKKQIEQEKSELQAALEEAEASLEHEEGKILRIQLELNQVKSEIDRKIAEK 1586

  Fly  1667 EEGAEEKRRGLVKQLRDLETELDEERKQRTAAVASKKKLEGDLKEIETTMEMHNKVKEDALKHAK 1731
            :|..::.:|..::.:..:::.||.|.:.|..|:..|||:||||.|:|..:...|::..:||::.:
  Rat  1587 DEEIDQLKRNHIRVVESMQSTLDAEIRSRNDAIRIKKKMEGDLNEMEIQLNHSNRMAAEALRNYR 1651

  Fly  1732 KLQAQVKDALRDAEEAKAAKEELQALSKEAERKVKALEAEVLQLTEDLASSERARRAAETERDEL 1796
            ..|..:||.....::|...:|:|:......||:...|:||:.:|...|..:||:|:.||.|..:.
  Rat  1652 NTQGILKDTQLHLDDALRGQEDLKEQLAMVERRANLLQAEIEELRATLEQTERSRKIAEQELLDA 1716

  Fly  1797 AEEIANNANKGSLMIDEKRRLEARIATLEEELE---EEQSNSEVLLDRSRKAQLQIEQLTTELAN 1858
            :|.:.....:.:.:|:.|::||..|:.::.|:|   :|..|:|   ::::||......:..||..
  Rat  1717 SERVQLLHTQNTSLINTKKKLETDISQIQGEMEDIVQEARNAE---EKAKKAITDAAMMAEELKK 1778

  Fly  1859 EKSNSQKNENGRALLERQNKELKAKLAEIETAQRTKVKATIATLEAKIANLEEQLENEGKERLLQ 1923
            |:..|...|..:..||:..|:|:.:|.|.|.......|..|..|||::..||.::|||.|..:..
  Rat  1779 EQDTSAHLERMKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQKLEARVRELEGEVENEQKRNVEA 1843

  Fly  1924 QKANRKMDKKIKELTMNIEDERRHVDQHKEQMDKLNSRIKLLKRNLDETEEELQKEKTQKRKYQR 1988
            .|..||.::::||||...|::|::|.:.::.:|||.|::|..||..:|.||:......:.||.|.
  Rat  1844 IKGLRKHERRVKELTYQTEEDRKNVLRLQDLVDKLQSKVKAYKRQAEEAEEQSNVNLAKFRKIQH 1908

  Fly  1989 ECEDMIESQEAMNREINSLKTKLR 2012
            |.|:..|..:....::|.|:.|.|
  Rat  1909 ELEEAEERADIAESQVNKLRVKSR 1932

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
zip	NP_523860.2	Myosin_N	80..117	CDD:280832	10/36 (28%)
		Myosin_head	133..854	CDD:278492	366/729 (50%)
		MYSc_Myh2_insects_mollusks	145..854	CDD:276876	359/717 (50%)
		Myosin_tail_1	931..2011	CDD:279860	345/1086 (32%)
		Prefoldin	1431..1515	CDD:298833	29/84 (35%)
		FAM76	<1847..1926	CDD:292665	23/78 (29%)
Myh1	NP_001128630.1	Myosin_N	35..73	CDD:397036	11/38 (29%)
		MYSc_Myh1_mammals	100..773	CDD:276875	359/717 (50%)
		Myosin_tail_1	853..1930	CDD:396244	345/1082 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0161
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D47111at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.910