Protein Alignment zip and MYO1H

DIOPT Version :9

• Sequence 1: NP_523860.2
• Gene: zip / 38001
• FlyBaseID: FBgn0265434
• Length: 2056
• Species: Drosophila melanogaster
• Sequence 2: XP_011536525.1
• Gene: MYO1H / 283446
• HGNCID: 13879
• Length: 1044
• Species: Homo sapiens
• Alignment Length: 1076
• Identity: 325/1076 - (30%)
• Similarity: 513/1076 - (47%)
• Gaps: 180/1076 - (16%)

  Fly   131 DK--VEDMAELTC-LNEASVLHNIKDRYYSGLIYTYSGLFCVVVNPYKKLPIYTEKIMERYKGIK 192
            ||  |:|...|.. .:|::.:.|::.|:...|||||.|...|.||||::|.|||...||.|:|:.
Human     9 DKVGVQDFVLLDAYTSESAFVDNLRKRFSENLIYTYIGTLLVSVNPYQELGIYTVSQMELYQGVN 73

  Fly   193 RHEVPPHVFAITDSAYRNMLGDREDQSILCTGESGAGKTENTKKVIQFLAYVAASKPKGSGAVPH 257
            ..|:||||:||.|:|||.|..:..:..||.:|||||||||.:||:::   |.|.:.|
Human    74 FFELPPHVYAIADNAYRMMCAELNNHFILISGESGAGKTEASKKILE---YFAVTCP-------- 127

  Fly   258 PAVLINFSVNTNKYIKVKIMAQNQNQTIEVVNGLKMVEVNSNCQEGELEQQLLQANPILEAFGNA 322
                                   ..|::::.                 ..:||.:||:|||||||
Human   128 -----------------------MTQSLQIA-----------------RDRLLFSNPVLEAFGNA 152

  Fly   323 KTVKNDNSSRFGKFIRINFDASGFISGANIETYLLEKSRAIRQAKDERTFHIFYQLLAGATPEQR 387
            :|::|||||||||::.|.||..|...|.:|.:||:||||.:.|.:.||.||||||||||...|:.
Human   153 RTLRNDNSSRFGKYMDIQFDFQGIPVGGHIISYLIEKSRVVYQNEGERNFHIFYQLLAGGEEERL 217

  Fly   388 EKFILD-DVKSYAFLSNG-SLPVPGVDDYAEFQATVKSMNIMGMTSEDFNSIFRIVSAVLLFGSM 450
            ....|: |.:.|.:||.| ......:.|..:::....:.:::..|..|..::|.|:::||..|::
Human   218 SYLGLERDPQLYKYLSQGHCAKESSISDKNDWKTVSNAFSVIDFTEADLENLFGIIASVLHLGNI 282

  Fly   451 KFRQERNNDQ--ATLPDNTVAQKIAHLLGLSVTDMTRAFLTPRIKVGRDFVTKAQTKEQVEFAVE 513
            .|.::   ||  ||:||....:.||.|||:..:.:..|....:|:...:.|....|.|...:|.:
Human   283 GFEED---DQGCATIPDTHEIKWIAKLLGVHPSVLLEALTHRKIEAKTEEVICPLTLELSVYARD 344

  Fly   514 AIAKACYERMFKWLVNRINRSL---DRTKRQGASFIGILDMAGFEIFELNSFEQLCINYTNEKLQ 575
            |:|||.|.|.|.||||:||.||   |.|::   :.||:||:.|||:|:.|.|||.||||.|||||
Human   345 AMAKAVYGRTFTWLVNKINSSLVNKDFTRK---TVIGLLDIYGFEVFDKNGFEQFCINYCNEKLQ 406

  Fly   576 QLFNHTMFILEQEEYQREGIEWKFIDFGLDLQPTIDLI-DKPGGIMALLDEECWFP-KATDKTFV 638
            ||........||.||:.|||||:.|.: .:.:...||: ::..||:::|||||..| .|||.:|:
Human   407 QLLIERTLKAEQAEYEMEGIEWEPIKY-FNNKIICDLVEERHKGIISILDEECIRPGPATDLSFL 470

  Fly   639 DKLVSAHSMHPKFMKTDFRGV--------ADFAIVHYAGRVDYSAAKWLMKNMDPLNENIVSLLQ 695
            :||......|..|......|.        .:|.::||||.|.|....:|.||.|.|..::..:|.
Human   471 EKLEEKVGKHAHFETRKLAGPKGRKRIGWMEFRLLHYAGEVTYCTKGFLEKNNDLLYRHLKEVLC 535

  Fly   696 GSQDPFVVNIWKDAEIVGMAQQALTDTQFGARTRKGMFRTVSHLYKEQLAKLMDTLRNTNPNFVR 760
            .|::..:...:..||:....:.....|||                |..|:.|::||.:..|:::|
Human   536 KSKNIILRECFLLAELENRRRPPTVGTQF----------------KNSLSSLLETLISKEPSYIR 584

  Fly   761 CIIPNHEKRAGKIDAPLVLDQLRCNGVLEGIRICRQGFPNRIPFQEFRQRY---EL--------- 813
            ||.||..|...|.|..|:..|::..|::|.:|:.|.||..|..::.|.|||   ||
Human   585 CIKPNDRKEPSKFDDFLIRHQIKYLGLMEHLRVRRAGFAYRRKYEHFLQRYLGVELSHWVERLMM 649

  Fly   814 ----------LTPNVIPKGFMDGKKACEKMIQALELDSNLYRVGQSKIFFR-AGVLAHLEEERDF 867
                      |.|:..|.......:..|::|:.:......|::|::|||.| ...|...|:..:|
Human   650 SLFYKDRYKSLCPDTWPHWHGPPAEGVERLIKYIGYKPEEYKLGKTKIFIRFPRTLFATEDAFEF 714

  Fly   868 KISDLIVNFQAFCRGFLARRNYQKRLQQLNAIRIIQRNCAAYLKLRNWQW-WRLYTKV------- 924
            ....|:...||..:..|.||.|.|:.|....:....|...|...::..:| .|:..|.
Human   715 SKHQLVARIQATYKRCLGRREYVKKRQAAIKLEAHWRGALARKAIQRRKWAVRIIRKFIKGFISR 779

  Fly   925 -KPLLEVTKQEEKLVQKEDEL-------KQVREKL----DTLAKNTQEYERKY-QQALVEKTTLA 976
             |||....::....|:|...|       |.|.:|.    ..:.:|..:..||. .:.||:|
Human   780 NKPLCPDNEEFIVFVRKNYILNLRYHLPKTVLDKSWLRPPGILENASDLLRKMCVRNLVQK---- 840

  Fly   977 EQLQAEIELCAEAEESRSRLMARKQELEDMMQELETRIEEEEERVLALGGEKKKLELNIQDLEEQ 1041
                    .|......|..:|.:|....::.:..:....|               .||...:..:
Human   841 --------YCRGITAERKAMMQQKVVTSEIFRGRKDGYTE---------------SLNQPFVNSR 882

  Fly  1042 LEEEEAARQKLQL---EKVQLDAKIKKYEEDLALTDDQNQKLLKEKKLLEERANDLSQTLAEEEE 1103
            ::|.:...:.|||   ||:|....:.||       |.:..|..:.:.:|.::|..:.: ||:.::
Human   883 IDEGDINPKVLQLISHEKIQYGVPVIKY-------DRKGFKARQRQLILTQKAAYVVE-LAKIKQ 939

  Fly  1104 KAKHLAKLKAKHEATISELEERLH---KDQQQRQES 1136
            |.::.| ||....:.:|:....:|   :|.:|:.::
Human   940 KIEYSA-LKGVSTSNLSDGILVIHVSPEDSKQKGDA 974

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
zip	NP_523860.2	Myosin_N	80..117	CDD:280832
		Myosin_head	133..854	CDD:278492	260/760 (34%)
		MYSc_Myh2_insects_mollusks	145..854	CDD:276876	256/747 (34%)
		Myosin_tail_1	931..2011	CDD:279860	42/224 (19%)
		Prefoldin	1431..1515	CDD:298833
		FAM76	<1847..1926	CDD:292665
MYO1H	XP_011536525.1	MYSc	8..711	CDD:214580	265/775 (34%)
		MYSc_Myo1	26..700	CDD:276829	256/747 (34%)
		Myosin_TH1	856..1019	CDD:283635	27/143 (19%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910