DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment zip and Myo95E

DIOPT Version :9

Sequence 1:	NP_523860.2	Gene:	zip / 38001	FlyBaseID:	FBgn0265434	Length:	2056	Species:	Drosophila melanogaster
Sequence 2:	NP_001027208.1	Gene:	Myo95E / 2768680	FlyBaseID:	FBgn0039157	Length:	1288	Species:	Drosophila melanogaster

Alignment Length:	1084	Identity:	278/1084 - (25%)
Similarity:	438/1084 - (40%)	Gaps:	307/1084 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   135 DMAELTCLNEASVLHNIKDRYYSGLIYTYSGLFCVVVNPYKKLPIYTEKIMERY--KGIKRHEVP 197
            |...|..|:|.|.::||..||....||||.|...|.:|||..:..::...:..|  |||  .::|
  Fly     9 DSVLLENLSEDSFINNIHQRYKRDHIYTYIGTSVVALNPYHHISEHSLDNVRNYGDKGI--FQLP 71

  Fly   198 PHVFAITDSAYRNMLGDREDQSILCTGESGAGKTENTKKVIQFLAYV---------------AAS 247
            ||::.:|:.||:::....|||.:|.||||||||||..|.::.||.::               .:|
  Fly    72 PHIYGLTNLAYQSLKDQSEDQCVLLTGESGAGKTETFKMIVNFLTHIQDRSHCPPTPNVLRKQSS 136

  Fly   248 KPKGSGAVPHPAVLINFSVN-TNKYIKVKIMAQNQNQTI-------------------------- 285
            ....||.|.|.....:.|.: |..:|..|..|:|.:.::
  Fly   137 TSSASGLVMHAHRRASSSCSGTANFIICKNRAENPSGSVSRRQSPSPGPSQRSRTRAESIERQSR 201

  Fly   286 ------------------EVVNGL----------------------------------------- 291
                              |.::||
  Fly   202 RHMREKIVDFDFSHHKSSENISGLPESHAHHMHPTKSCFKHQQTQVSACTAMPAAAKGSPKYAVP 266

  Fly   292 ------------KMVEV------------NSNCQ------------------------------- 301
                        |.|..            .|||:
  Fly   267 TVYGGCRQCGHSKCVRAQSLEKEERDDLRGSNCRLSTIATATTNPAHPHRGSCSNLMRQHSTESQ 331

  Fly   302 -EGELEQQLLQ------------------------------------------------------ 311
             |.|.::..|.
  Fly   332 PERERDRSSLMGSTQRISLYDAHKLSKVLGDLPPPPPSSVSPTPSASSSLHRRHKSPTQRMRECV 396

  Fly   312 --ANPILEAFGNAKTVKNDNSSRFGKFIRINFDASGFISGANIETYLLEKSRAIRQAKDERTFHI 374
              |:..|||.|||.|:||:||||:||...|..|..|...|.:|..|:|||:|.......||.|||
  Fly   397 TCADVFLEAMGNACTLKNNNSSRYGKLFDIEIDFKGDPMGVHITHYMLEKTRITDPIIGERNFHI 461

  Fly   375 FYQLLAGATPEQREKF-ILDDVKSYAFLSNGSLPVPGVDDYAEFQATVKSMNIMGMTSEDFNSIF 438
            |||||.||..:..:.. :..:|:.|..|.|.:..   .:|...|..|.:|::::|::.|:.||||
  Fly   462 FYQLLLGADLQLLKSLKLYRNVEKYELLRNTTAM---EEDRMNFHYTKRSLDVLGLSCEESNSIF 523

  Fly   439 RIVSAVLLFGSMKFRQERNND--QATLPDNTV-AQKIAHLLGLS----VTDMTRAFLTPRIK--V 494
            |:::.||..|:..|....|.|  :.....|.. .|:.|.||.:.    :..:|||..|...:  |
  Fly   524 RVIAVVLKLGNFIFVPITNIDGTEGCQVSNVYEVQETAQLLNMEAQILINCLTRANSTNSAQEDV 588

  Fly   495 G-----RDFVTKAQTKEQVEFAVEAIAKACYERMFKWLVNRINRSLDRTKRQGASFIGILDMAGF 554
            |     |...|...|          :.:..|.|:|.||||:||.||..|:|:  ..:.:||..||
  Fly   589 GCEMDARQAATNRNT----------LCRTLYSRLFTWLVNKINESLKSTQRE--KNLALLDFYGF 641

  Fly   555 EIFELNSFEQLCINYTNEKLQQLFNHTMFILEQEEYQREGIEWKFIDFGLDLQPTIDLIDKPG-G 618
            |..:.|||||..|||:.||:.|.|...:...|||.|.|||:||..||: .|.:...:|||||. |
  Fly   642 EALDHNSFEQFAINYSAEKIHQNFVFHVLRSEQELYIREGLEWSRIDY-FDNESICELIDKPSYG 705

  Fly   619 IMALLDEECWFPKA-TDKTFVDKLVSAHSMHPKFMKTDFRGVADFAIVHYAGRVDYSAAKWLMKN 682
            |::|::|    |.. ::...:.::....:.||.||.|....:. |.|.|||..|:||..::|.||
  Fly   706 ILSLINE----PHLNSNDALLLRVQQCCAGHPNFMTTGSNSMC-FQIRHYASVVNYSIHRFLEKN 765

  Fly   683 MDPLNENIVSLLQGSQDPFVVNIWKDAEIVGMAQQALTDTQFGARTRKGMFRTVSHLYKEQLAKL 747
            .|.|.:.|.:....|:...|.:::.:    |..::.:|...          .|:|...:.||..|
  Fly   766 SDMLPKYISAAFYQSKLSLVQSLFPE----GNPRRQVTKKP----------STLSSNIRTQLQTL 816

  Fly   748 MDTLRNTNPNFVRCIIPNHEKRAGKIDAPLVLDQLRCNGVLEGIRICRQGFPNRIPFQEFRQRYE 812
            :..:::...::|.||.||..|:..:.|..||..|:|...::..:.:||.|....:...:|..||:
  Fly   817 LAIVKHRRSHYVFCIKPNEGKQPHQFDMALVQHQVRYMSLMPLVHLCRTGHCYHLLHVKFFHRYK 881

  Fly   813 LLTPNVIPKGFMDGK--KACEKMIQALELDSNLYRVGQSKIFFRA-GVLAHLEEERDFKISDLIV 874
            ||.....|. |..|.  :....:|:.|.|.|..:.:|...:|.|: ..:..||:.|..:||:|.|
  Fly   882 LLNSLTWPH-FHGGSQVEGIALIIRNLPLPSAEFTIGTKNVFVRSPRTVYELEQFRRLRISELAV 945

  Fly   875 NFQAFCRGFLARRNYQKRLQQLNAIRIIQRNCAAYLKLRNWQWWR-------------LYTKVKP 926
            ..|...|.:.||    ||.|::...::|..:.        |:.||             |::
  Fly   946 LIQTMFRMYHAR----KRFQRMRHSQMIISSA--------WRTWRECRFGIPFTGRRHLWS---- 994

  Fly   927 LLEVTKQEEKLVQKEDELKQVREKLDTLAKNTQEYERKYQQALV 970
            |..|.::|.:.::.:   :|||..:|.:.:..:::  |.:|.|:
  Fly   995 LYRVAREEYRSLKYK---RQVRWAIDIIGRYYRQW--KIRQFLL 1033

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
zip	NP_523860.2	Myosin_N	80..117	CDD:280832
		Myosin_head	133..854	CDD:278492	248/952 (26%)
		MYSc_Myh2_insects_mollusks	145..854	CDD:276876	244/942 (26%)
		Myosin_tail_1	931..2011	CDD:279860	8/40 (20%)
		Prefoldin	1431..1515	CDD:298833
		FAM76	<1847..1926	CDD:292665
Myo95E	NP_001027208.1	Motor_domain	19..>118	CDD:277568	41/100 (41%)
		Motor_domain	403..924	CDD:277568	180/556 (32%)
		Myosin_TH1	1092..1267	CDD:283635
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45466228
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.840