DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment zip and Myo7a

DIOPT Version :9

Sequence 1:NP_523860.2 Gene:zip / 38001 FlyBaseID:FBgn0265434 Length:2056 Species:Drosophila melanogaster
Sequence 2:XP_006229804.1 Gene:Myo7a / 266714 RGDID:628830 Length:2276 Species:Rattus norvegicus


Alignment Length:1761 Identity:480/1761 - (27%)
Similarity:759/1761 - (43%) Gaps:380/1761 - (21%)


- Green bases have known domain annotations that are detailed below.


  Fly    71 ATQAEWTQKRLVWVPHENQGFVAASIKREH-------GDEVE------VELAETGKRVMILRDD- 121
            |:...|   .|:...::|...:.:|.|.::       |.|.:      |:|.|:| ::.::.|: 
  Rat    44 ASAGAW---YLILFGYKNTEALPSSYKGDYVWMDLKSGQEFDVPIGAMVKLCESG-QIQVVDDEG 104

  Fly   122 ------------IQKMNPPKFDKVEDMAELTCLNEASVLHNIKDRYYSGLIYTYSGLFCVVVNPY 174
                        |:.|:|.....||||..|..||||.:|.|:..||...|||||:|...|.||||
  Rat   105 NEHWISPQNATHIKPMHPTSVHGVEDMIRLGDLNEAGILRNLLIRYRDHLIYTYTGSILVAVNPY 169

  Fly   175 KKLPIYTEKIMERYKGIKRHEVPPHVFAITDSAYRNMLGDREDQSILCTGESGAGKTENTKKVIQ 239
            :.|.||:.:.:.:|...|..|:|||:|||.|:.|.||..:..||..:.:|||||||||:||.::|
  Rat   170 QLLSIYSSEHIRQYTNKKIGEMPPHIFAIADNCYFNMKRNNRDQCCIISGESGAGKTESTKLILQ 234

  Fly   240 FLAYVAASKPKGSGAVPHPAVLINFSVNTNKYIKVKIMAQNQNQTIEVVNGLKMVEVNSNCQEGE 304
            |||.::.                                                      |...
  Rat   235 FLAAISG------------------------------------------------------QHSW 245

  Fly   305 LEQQLLQANPILEAFGNAKTVKNDNSSRFGKFIRINFDASGFISGANIETYLLEKSRAIRQAKDE 369
            :|||:|:|.|||||||||||::|||||||||:|.|:|:..|.|.||.||.|||||||..|||.||
  Rat   246 IEQQVLEATPILEAFGNAKTIRNDNSSRFGKYIDIHFNKRGAIEGAKIEQYLLEKSRVCRQAPDE 310

  Fly   370 RTFHIFYQLLAGATPEQREKFILDDVKSYAFLSNGS-LPVPGVDDYAEFQATVKSMNIMGMTSED 433
            |.:|:||.:|.|...|:::|..|.....|.:|:.|: :...|..|..|:.....:|.::..|..:
  Rat   311 RNYHVFYCMLEGMNEEEKKKLGLGQAADYNYLAMGNCITCEGRVDSQEYANIRSAMKVLMFTDTE 375

  Fly   434 FNSIFRIVSAVLLFGSMKF--RQERNNDQA-TLPDNTVAQKIAHLLGLSVTDMTRAFLTPRIKVG 495
            ...|.::::|:|..|::::  |...|.|.. .|...::|...:| |.::..|: .:.||.|..:.
  Rat   376 NWEILKLLAAILHMGNLQYEARTFENLDACEVLFSPSLATAASH-LEVNPPDL-MSCLTSRTLIT 438

  Fly   496 R-DFVTKAQTKEQVEFAVEAIAKACYERMFKWLVNRINRSLDRTKRQGAS----FIGILDMAGFE 555
            | :.|:...::||.....:|..|..|.|:|.|:|.:||.::.:...|..:    .||:||:.|||
  Rat   439 RGETVSTPLSREQALDVRDAFVKGIYGRLFVWIVEKINAAIYKPPSQEVTNSRRSIGLLDIFGFE 503

  Fly   556 IFELNSFEQLCINYTNEKLQQLFNHTMFILEQEEYQREGIEWKFIDFGLDLQPTIDLI-DKPGGI 619
            .|.:|||||||||:.||.|||.|...:|.||||||..|.|:|..|:| .|.|..:|:| ::|..:
  Rat   504 NFTVNSFEQLCINFANEHLQQFFVRHVFKLEQEEYDLESIDWLHIEF-TDNQEALDMIANRPMNV 567

  Fly   620 MALLDEECWFPKATDKTFVDKLVSAHSMHPKFMKTDFRGVADFAIVHYAGRVDYSAAKWLMKNMD 684
            ::|:|||..|||.||.|.:.||.|.|.::..::.........|.|.|:||.|.|.:..:|.||.|
  Rat   568 ISLIDEESKFPKGTDATMLHKLNSQHRLNANYVPPKNSHETQFGINHFAGIVYYESQGFLEKNRD 632

  Fly   685 PLNENIVSLLQGSQDPFVVNIWKDAEIVGMAQQALTDTQFGARTRKGMFRTVSHLYKEQLAKLMD 749
            .|:.:|:.|:..|::.||..|::            .|...||.||| ...|:|..:|..|..||.
  Rat   633 TLHGDIIQLVHSSRNKFVKQIFQ------------ADVAMGAETRK-RSPTLSSQFKRSLELLMR 684

  Fly   750 TLRNTNPNFVRCIIPNHEKRAGKIDAPLVLDQLRCNGVLEGIRICRQGFPNRIPFQEFRQRYELL 814
            ||....|.|||||.||..|:....|..|.:.|||.:|::|.|||...|:|.|..|.||.:||.:|
  Rat   685 TLGACQPFFVRCIKPNEFKKPMLFDRHLCVRQLRYSGMMETIRIRHAGYPIRYSFVEFVERYRVL 749

  Fly   815 TPNVIPKGFMDG-KKACEKMIQALELDSNLYRVGQSKIFFRAGVLAHLEEERDFKISDLIVNFQA 878
            .|.|.|....|. :..|::|.:|:....:.:::|::|||.:......||.|||..|:|.::..|.
  Rat   750 LPGVKPAYKQDDLQGTCQRMAEAVLGTHDDWQIGKTKIFLKDHHDMLLEVERDKAITDRVILLQK 814

  Fly   879 FCRGFLARRNYQKRLQQLNAIRIIQRNCAAYLKLRNWQWWRL-YTKVKPLLEVTKQEEKLVQKED 942
            ..|||..|.|:   |:..:|..:|||:...:...:|::..|| :.:::.|....|..        
  Rat   815 VIRGFKDRSNF---LRLKSAATLIQRHWRGHHCRKNYELIRLGFLRLQALHRSRKLH-------- 868

  Fly   943 ELKQVREKLDTLAKNTQEYERKYQQALVEKTTLAEQLQAEIELCAEAEESRSRLMARKQELEDMM 1007
              ||.|.....:.|    ::.:.:..||.: ....:|.|.|.:.|.|....:|.:.|:     :.
  Rat   869 --KQYRLARQRIIK----FQARCRAYLVRR-AFRHRLWAVITVQAYARGMIARRLHRR-----LR 921

  Fly  1008 QELETRIEEEEERVLALGGEKKKLELNIQDLEEQLEEEEAARQKLQLEKVQLDAKIKKYEEDLA- 1071
            .|...|:|.|..|                     |.|||..|:::..:|.:.:|: :|::|.|| 
  Rat   922 VEYWRRLEAERMR---------------------LAEEEKLRKEMSAKKAKEEAE-RKHQERLAQ 964

  Fly  1072 LTDDQNQKLLKEKKLLEERANDLSQTLAEEEEKAKHLAKLKAKHEATISELEERLHKDQQQRQES 1136
            |..:..::.||||:  |.|.   .:.|.::.|:|:|               |...|.|       
  Rat   965 LAREDAERELKEKE--EARR---KKELLQQMERARH---------------EPINHSD------- 1002

  Fly  1137 DRSKRKIETEVADLKEQLNERRVQVDEMQAQLAKREEELTQTLLRIDEESATKATAQKAQRELES 1201
                                   .||:|...|.                :::....|      |.
  Rat  1003 -----------------------MVDKMFGFLG----------------TSSGLPGQ------EG 1022

  Fly  1202 QLAEIQEDLEAEKAARAKAEKVRRDLSEELEALKNELLDSLDTTAAQQELRSKREQELATLKKSL 1266
            |.....||||     |.:.|.|..|:...| .|.:|  |..|.:          |.:.|....:.
  Rat  1023 QAPSGFEDLE-----RGRREMVEEDVDAAL-PLPDE--DEEDLS----------EYKFAKFAATY 1069

  Fly  1267 EEETVNHEGVLADMRHK---HSQELNSINDQLENLRKAKTVLEKAKGTLE-----------AENA 1317
            .:.|..|......::..   |..|    .|||..|....|:| :..|.|.           :|..
  Rat  1070 FQGTTTHSYTRRPLKQPLLYHDDE----GDQLAALAVWITIL-RFMGDLPEPKYHTAMSDGSEKI 1129

  Fly  1318 DLATELRSV---NSSRQENDRRRKQAESQIAELQVKLAEIERARSELQEKCTKLQQEAENITNQL 1379
            .:.|::...   .:.::|....:.:.|:|::|.|.|.:...:......:|.:||.:|   :|.:|
  Rat  1130 PVMTKIYETLGKKTYKRELQALQGEGEAQLSEGQKKTSVKHKLVHLTLKKKSKLTEE---VTKRL 1191

  Fly  1380 EEAELKASAAVKSASNMESQLTEAQQLLEEETRQKLGLSSKLRQIESE---KEALQEQLE----- 1436
            .:.|               .:.:...:||:.....|   .||..|...   :.||::::.     
  Rat  1192 HDGE---------------SMVQGNSMLEDRPTSNL---EKLHFIIGNGILRPALRDEIYCQISK 1238

  Fly  1437 --EDDEAKRNYERKLAEVTTQMQEIKKKAEEDADLAKELEEGKKRLNKDIEA--------LERQV 1491
              ..:.:|.:|.|....|:..:           ......|:..|.|...|..        .|.::
  Rat  1239 QLTHNPSKSSYARGWILVSLCV-----------GCFAPSEKFVKYLRNFIHGGPPGYAPYCEERL 1292

  Fly  1492 KELIAQNDRLD----------KSKKKIQSELE--DATIELEAQRTKVLELEKKQKNFDKILAEEK 1544
            :.......|..          ||||.|...:.  |.|     .:|.:.:.....|.....||::.
  Rat  1293 RRTFVNGTRTQPPSWLELQATKSKKPIMLPVTFMDGT-----TKTLLADSATTAKELCNALADKI 1352

  Fly  1545 AISEQIAQERDTAEREAREKETKVLSVSRELDEAFDKIEDLENKRKTLQNELDDLANTQGTADKN 1609
            ::.::.......|..:      ||.|:....|...|.|           ::.:..|..||..::|
  Rat  1353 SLKDRFGFSLYIALFD------KVSSLGSGSDHVMDAI-----------SQCEQYAKEQGAQERN 1400

  Fly  1610 VHELEKAKRALESQLAELKAQNEELEDDL--QLTEDAKLRLEVNMQALRSQFERDL--LAKEE-- 1668
                  |...|..:.......:...||::  .|.....:| .|.....|.:.|.||  ||.::  
  Rat  1401 ------APWRLFFRKEVFTPWHNPSEDNVATNLIYQQVVR-GVKFGEYRCEKEDDLAELASQQYF 1458

  Fly  1669 ---GAE---EKRRGLV-KQLRDLE-TELDEERKQRTAAVASKKKLEGDLKEIETTMEMHNKVKED 1725
               |:|   |:...|| ..:.|.| |.|....|....|:|:.||  |...:..|..:   |||:|
  Rat  1459 VDYGSEMILERLLSLVPTYIPDREITPLKNLEKWAQLAIAAHKK--GIYAQRRTDAQ---KVKQD 1518

  Fly  1726 ALKHAK 1731
            .:.:|:
  Rat  1519 VVNYAR 1524

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
zipNP_523860.2 Myosin_N 80..117 CDD:280832 10/49 (20%)
Myosin_head 133..854 CDD:278492 275/731 (38%)
MYSc_Myh2_insects_mollusks 145..854 CDD:276876 267/719 (37%)
Myosin_tail_1 931..2011 CDD:279860 167/863 (19%)
Prefoldin 1431..1515 CDD:298833 16/110 (15%)
FAM76 <1847..1926 CDD:292665
Myo7aXP_006229804.1 MYSc 121..802 CDD:214580 279/750 (37%)
MYSc_Myo7 140..790 CDD:276832 267/719 (37%)
IQ 827..848 CDD:197470 4/20 (20%)
MAP7 <918..996 CDD:283355 28/124 (23%)
eIF3_subunit 936..>991 CDD:285763 18/60 (30%)
MyTH4 1078..1314 CDD:214535 43/272 (16%)
B41 1320..1535 CDD:214604 51/239 (21%)
FERM_N 1323..>1362 CDD:286467 6/43 (14%)
FERM_B-lobe 1424..1524 CDD:271216 29/105 (28%)
FERM_C1_MyoVII 1529..1665 CDD:270019
SH3_MYO7A 1666..1730 CDD:212814
MyTH4 1808..1957 CDD:214535
B41 1964..2176 CDD:214604
FERM_M 2074..2176 CDD:278785
FERM_C2_MyoVII 2172..2267 CDD:270020
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
11.000

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