DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment zip and myp2

DIOPT Version :9

Sequence 1:	NP_523860.2	Gene:	zip / 38001	FlyBaseID:	FBgn0265434	Length:	2056	Species:	Drosophila melanogaster
Sequence 2:	NP_593816.1	Gene:	myp2 / 2543576	PomBaseID:	SPAC4A8.05c	Length:	2104	Species:	Schizosaccharomyces pombe

Alignment Length:	2242	Identity:	647/2242 - (28%)
Similarity:	1077/2242 - (48%)	Gaps:	426/2242 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    51 DRNDPELKYLSVER--NQFNDPATQAEWTQKRLVWVPHENQGFVAASIKREHGDEVEVELAETGK 113
            |.|:...|.:..|:  |...|    |.:.::..:|:|...:.||.|.|..:.|::..|:|...|.
pombe    11 DNNNIIKKLVDAEKHCNAVKD----ASFDERTWIWIPDSKESFVKAWIVEDLGEKYRVKLERDGS 71

  Fly   114 RVMILRDDIQKMNPPKFDKVEDMAELTCLNEASVLHNIKDRYYSGLIYTYSGLFCVVVNPYKKLP 178
            ..::...|.:|:||||||.|:|||.||||||.||::|:..||...|||||||||.|.||||..||
pombe    72 ERIVDGFDAEKVNPPKFDMVDDMAALTCLNEPSVVNNLTQRYEKDLIYTYSGLFLVAVNPYCHLP 136

  Fly   179 IYTEKIMERYKGIKRHEVPPHVFAITDSAYRNMLGDREDQSILCTGESGAGKTENTKKVIQFLAY 243
            ||.:.::.:|:..:..|..||:|...|:|||::|..|.:||||.||||||||||.||||||:|..
pombe   137 IYGDDVVRKYQSKQFKETKPHIFGTADAAYRSLLERRINQSILVTGESGAGKTETTKKVIQYLTS 201

  Fly   244 VAASKPKGSGAVPHPAVLINFSVNTNKYIKVKIMAQNQNQTIEVVNGLKMVEVNSNCQEGELEQQ 308
            |..:                                                  |.....:||::
pombe   202 VTDA--------------------------------------------------STSDSQQLEKK 216

  Fly   309 LLQANPILEAFGNAKTVKNDNSSRFGKFIRINFDASGFISGANIETYLLEKSRAIRQAKDERTFH 373
            :|:.||:|||||||:||:|:|||||||||||.|..:|.|.|||::.|||||||.|..:.:||.:|
pombe   217 ILETNPVLEAFGNAQTVRNNNSSRFGKFIRIEFSNNGSIVGANLDWYLLEKSRVIHPSSNERNYH 281

  Fly   374 IFYQLLAGATPEQREKFILDD-VKSYAFLSNGSLPVPGVDDYAEFQATVKSMNIMGMTSEDFNSI 437
            :|||||.||.....|...||. |..|::|.||...:.||||..|||.....:..:|..:.:.:|:
pombe   282 VFYQLLRGADGSLLESLFLDRYVDHYSYLKNGLKHINGVDDGKEFQKLCFGLRTLGFDNNEIHSL 346

  Fly   438 FRIVSAVLLFGSMKFRQERNNDQATLPDNTVAQKIAHLLGLSVTDMTRAFLTPRIKVGRDFVTKA 502
            |.|::::|..|:::...:|:. ||..|..|...::.|||.:.|.....|.|.|:.|.||:::..|
pombe   347 FLIIASILHIGNIEVASDRSG-QARFPSLTQIDQLCHLLEIPVDGFVNAALHPKSKAGREWIVTA 410

  Fly   503 QTKEQVEFAVEAIAKACYERMFKWLVNRINRSLDRTKRQGASFIGILDMAGFEIFELNSFEQLCI 567
            :|:|||...::::||..|||.|..||.|:|:::..::.:...|||:||:||||||..||||||||
pombe   411 RTREQVVHTLQSLAKGLYERNFAHLVKRLNQTMYYSQSEHDGFIGVLDIAGFEIFTFNSFEQLCI 475

  Fly   568 NYTNEKLQQLFNHTMFILEQEEYQREGIEWKFIDFGLDLQPTIDLIDK--PGGIMALLDEECWFP 630
            |:|||||||.|||.||:||||||.:|.|||.|||:|.|||||||.|:|  |.||.:.|||:|..|
pombe   476 NFTNEKLQQFFNHYMFVLEQEEYTQERIEWDFIDYGNDLQPTIDAIEKSEPIGIFSCLDEDCVMP 540

  Fly   631 KATDKTFVDKLVSAHSMHPKFMKTDFRGVAD-----------FAIVHYAGRVDYSAAKWLMKNMD 684
            .|||.||.:||   |.:        |:|.:|           |.:.||||.|:|....||.||.|
pombe   541 MATDATFTEKL---HLL--------FKGKSDIYRPKKFSSEGFVLKHYAGDVEYDTKDWLEKNKD 594

  Fly   685 PLNENIVSLLQGSQDPFVVNIWKDAEIVGMAQQALTDTQFGARTRKGMFRTVSHLYKEQLAKLMD 749
            |||..:.:|:..|.:..|.:::.|.......:..:        .:||:|||||..::.||:.||.
pombe   595 PLNACLAALMFKSTNSHVSSLFDDYSSNASGRDNI--------EKKGIFRTVSQRHRRQLSSLMH 651

  Fly   750 TLRNTNPNFVRCIIPNHEKRAGKIDAPLVLDQLRCNGVLEGIRICRQGFPNRIPFQEFRQRYELL 814
            .|..|.|:||||||||:.|:...:|..|||.|||||||||||||.:.||||::.:.|||.||.:|
pombe   652 QLEATQPHFVRCIIPNNLKQPHNLDKSLVLHQLRCNGVLEGIRIAQTGFPNKLFYTEFRARYGIL 716

  Fly   815 TPNVIPKGFMDGKKACEKMIQALELDSNLYRVGQSKIFFRAGVLAHLEEERDFKISDLIVNFQAF 879
            :.: :.:|:::.|||...:|..|:|.|.:||:|::|:||:|.||..||:.|:..:..:..:|.|.
pombe   717 SQS-LKRGYVEAKKATITIINELKLPSTVYRLGETKVFFKASVLGSLEDRRNALLRVIFNSFSAR 780

  Fly   880 CRGFLARRNYQKRLQQLNAIRIIQRNCAAYLKLRNWQWWRLYTKVKPLLEVTKQEEKLVQKE--- 941
            .||||.||...:...:.:|..::|.|......|:...||.|:..:||||..|:.:|.|.:|:
pombe   781 IRGFLTRRRLYRFNHRQDAAILLQHNLRQLKLLKPHPWWNLFLHLKPLLGTTQTDEYLRRKDALI 845

  Fly   942 --------------DELKQVREKLDTLAKNTQEYERKYQQALV-EKTTLAEQLQAEIELCAE--- 988
                          :||...:|::..|..:.||     :|||. ||..|.|:..:.:|:..|
pombe   846 NNLQNQLESTKEVANELTITKERVLQLTNDLQE-----EQALAHEKDILVERANSRVEVVHERLS 905

  Fly   989 --------AEESRSRLMARKQELE--------------DMMQELETR---IEEEEERVLALGGEK 1028
                    |:|....|.|.||.:|              |:...||.:   |:::|:.:.:...|.
pombe   906 SLENQVTIADEKYEFLYAEKQSIEEDLANKQTEISYLSDLSSTLEKKLSSIKKDEQTISSKYKEL 970

  Fly  1029 KKLELNI----QDLEEQLEEEEAARQKLQLEKVQLDAKIKKYEEDLALTDDQNQKLLKEKKLLEE 1089
            :|..|||    |...:.|...|.|..:..|...:|:.|:.:.:::|.|  .|.....|.::|.||
pombe   971 EKDYLNIMADYQHSSQHLSNLEKAINEKNLNIRELNEKLMRLDDELLL--KQRSYDTKVQELREE 1033

  Fly  1090 RANDLSQTLAEEEEKAKHLAKLKAKHEATISELEERLHKDQQQRQESDRSKRKIE-----TEVAD 1149
            .|:...|....|.:    ||.|.:|:..|.|||                :|::.|     .|:.:
pombe  1034 NASLKDQCRTYESQ----LASLVSKYSETESEL----------------NKKEAELVIFQKEITE 1078

  Fly  1150 LKEQLN------ERRVQVDEMQAQLAKREEEL----TQTLLRIDEESATKATAQKAQRELESQLA 1204
            .::||:      |:...::::::.....:|.:    :.||..:.:....|:...|...:|..::.
pombe  1079 YRDQLHKAFQNPEKTHNINDVKSGPLNSDENIYSTSSTTLSILKDVQELKSLHTKEANQLSERIK 1143

  Fly  1205 EIQEDLEAEKAARAKAEKVRRDLSEELEALKNEL--------------LDSLDTTAAQ------- 1248
            ||.|.||...|...|..:...:|.:.:||||.::              ||..||....
pombe  1144 EISEMLEQSIATEEKLRRKNSELCDIIEALKYQIQDQETEIISLNADNLDLKDTNGVLEKNASDF 1208

  Fly  1249 ---QELRSKREQELATLKKSLEEE-------------------TVNHEGVLADMRHKHS----QE 1287
               |.::|:.|.:::.|...|::|                   |::..........|||    :.
pombe  1209 IDFQGIKSRYEHKISDLLNQLQKERCKVGLLKQKTENRSVTQHTLDGNSPHPSFEEKHSGDPLKR 1273

  Fly  1288 LNSIND--QLENLRKAKTV---LEKAKGTLEAENADLAT-----ELRSVNSSRQENDRRRKQAES 1342
            ::..||  :::| :..||:   |:..:.|:|.|.::|.:     ....::.....:.|:.::..|
pombe  1274 IDGNNDDRKIDN-KLLKTISKSLDALQLTVEEELSNLYSLSKDLSFTDISGHIPNSIRKLEKGLS 1337

  Fly  1343 QIAELQVKL--AEIERARSELQEKCTKLQQEAENITNQLEEAEL-KASAAVKSASNMESQLTEAQ 1404
            .::||:.:|  :..:|...::.:....:....:.::|...:|:. ..|:..|...|.||.:
pombe  1338 TLSELKERLNASNSDRPSPDIFKDTQAIMNSRKLLSNPNSDAQSGLISSLQKKLYNPESNM---- 1398

  Fly  1405 QLLEEETRQKLGLSSKLRQIESEKEALQEQLEEDDEAK-RNYERKLA----EVTTQMQEIKKKAE 1464
                |.|..|....||:..:.|.:.....:.....||. ||:::..:    .:..|...:.:...
pombe  1399 ----EFTGLKPLSPSKISNLPSSQPGSPSKRSGKMEALIRNFDQNSSIPDPFIVNQRNSVLQTEF 1459

  Fly  1465 EDADLAKELEEGKKR---LNKDIEALERQVKELIAQNDRL-----------DK------------ 1503
            |..:|  :|:|..|.   .|||:......::.|:.:|:.|           ||
pombe  1460 EKINL--KLKEATKSGILDNKDLSKFSELIQSLLKENEELKNLTTSNLGSDDKMLDFAPLLEDVP 1522

  Fly  1504 --SKKKIQSELEDATIELEAQRTKVLELEKKQKNFDKILAEEKAISEQIAQERD----------- 1555
              ::.:|:..:|.|.    :.:..:.:|....:  :|:.:.|||:.| |.:|||
pombe  1523 NNTRNQIKGFVEKAI----SSKRAIAKLYSASE--EKLFSTEKALRE-ITKERDRLLHGLQGPSV 1580

  Fly  1556 --------TAER------------EAREKETKVLSVSRELDEAFDKIEDLENKRKTLQNELDDLA 1600
                    ||.:            .:.|:||:.|  ..|::  ..||::|.:.....:.:|..:.
pombe  1581 PTSPLKAPTASQLIIPNFDGSITNYSGEEETEWL--QEEVN--IMKIKELTSTVNKYREQLAMVQ 1641

  Fly  1601 NTQGTADKNVHELEKAKRALESQLAELKAQNEELEDDLQLTEDAKLRLEVNMQALRSQFERDLLA 1665
            :....|:.::.:.|::|..|..:|.|:    |||....| |.:|.|:.|: ..|:..|.|.::|.
pombe  1642 SLNEHAESSLSKAERSKNYLTGRLQEV----EELARGFQ-TTNADLQNEL-ADAVVKQKEYEVLY 1700

  Fly  1666 KEEGAE-----------------------------EKRRGLV-----KQLRDLETELDEERKQRT 1696
            .|:..:                             ||:..|:     |:|...:.:|:|||::..
pombe  1701 VEKSNDYNTLLLQKEKLMKQIDEFHVIRVQDLEEREKKDQLLFQRYQKELNGFKVQLEEEREKNL 1765

  Fly  1697 AAVASKKKLEGDLKEIET-----TMEMHNKVKEDALKHAKKLQAQVKDALRDAEEAKAAKEELQA 1756
            ......:.:..::.:|.|     .:|..|.:||:::     |||.::...|....:..|::..|:
pombe  1766 RIRQDNRHMHAEIGDIRTKFDELVLEKTNLLKENSI-----LQADLQSLSRVNNSSSTAQQNAQS 1825

  Fly  1757 --LSKEAERKVKALEAEVLQLTEDLASSE----RARRAAETERDELAEEIANNANKGSLMIDEKR 1815
              ||..|:.:      ||.:..:.|...:    |..|..|.:..|::|::....:..:...|| .
pombe  1826 QLLSLTAQLQ------EVREANQTLRKDQDTLLRENRNLERKLHEVSEQLNKKFDSSARPFDE-I 1883

  Fly  1816 RLEARIATLEEELEEEQSNSEVLLDRSRKAQLQIEQLTTELANEKSNSQKNENGR-----ALLER 1875
            .:|..:.||:..|.::......|::|.:  |:::..|.|:   :.||:.:.||.:     .:|::
pombe  1884 EMEKEVLTLKSNLAQKDDLLSSLVERIK--QIEMFALKTQ---KDSNNHREENLQLHRQLGVLQK 1943

  Fly  1876 QNKELKAKLAEIETAQRTKVKAT---IATLEAKIANLEEQLENEGKERLLQQKANRKMDKKIKEL 1937
            :.|:|:.||.:::.  :|...:|   :..|:.:|::||........||:......|..|:.|::|
pombe  1944 EKKDLELKLFDLDL--KTYPISTSKDVRMLQKQISDLEASFAASDIERIKGIDECRNRDRTIRQL 2006

  Fly  1938 TMNI---EDERRHVDQHKEQMDKLNSRIKLLKRNLDETEEELQKEKTQKRKYQRECEDMIESQEA 1999
            ...|   :|:::.:.....::::.|::   |:..|    |::|..:||.:...|..|..::.:
pombe  2007 EAQISKFDDDKKRIQSSVSRLEERNAQ---LRNQL----EDVQASETQWKFALRRTEHALQEE-- 2062

  Fly  2000 MNREINSLKT------KLRRTGGIGLSSSRLT 2025
             ...:.||:|      .|.....:..|.|||:
pombe  2063 -RERVKSLETDFDKYRSLLEGQRVKRSESRLS 2093

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
zip	NP_523860.2	Myosin_N	80..117	CDD:280832	10/36 (28%)
		Myosin_head	133..854	CDD:278492	324/734 (44%)
		MYSc_Myh2_insects_mollusks	145..854	CDD:276876	314/722 (43%)
		Myosin_tail_1	931..2011	CDD:279860	267/1330 (20%)
		Prefoldin	1431..1515	CDD:298833	20/116 (17%)
		FAM76	<1847..1926	CDD:292665	19/86 (22%)
myp2	NP_593816.1	COG5022	17..1607	CDD:227355	534/1709 (31%)
		Myosin_N	38..76	CDD:280832	10/37 (27%)
		MYSc_class_II	103..755	CDD:276951	314/722 (43%)
		Tup_N	1684..1759	CDD:285748	12/75 (16%)
		RILP-like	<1997..2072	CDD:304877	17/84 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	621	1.000	Domainoid score	I26
eggNOG	1	0.900	-	-		E2759_KOG0161
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	794	1.000	Inparanoid score	I68
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000014
OrthoInspector	1	1.000	-	-		mtm9311
orthoMCL	1	0.900	-	-		OOG6_100110
Panther	1	1.100	-	-	O	PTHR45615
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X58
TreeFam	1	0.960	-	-
	11	10.820