DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment zip and myo2

DIOPT Version :9

Sequence 1:	NP_523860.2	Gene:	zip / 38001	FlyBaseID:	FBgn0265434	Length:	2056	Species:	Drosophila melanogaster
Sequence 2:	NP_588114.1	Gene:	myo2 / 2539513	PomBaseID:	SPCC645.05c	Length:	1526	Species:	Schizosaccharomyces pombe

Alignment Length:	1812	Identity:	606/1812 - (33%)
Similarity:	889/1812 - (49%)	Gaps:	374/1812 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    79 KRLVWVPHENQGFVAASIKREHGDEVEVELAETGKRVMIL-RDDIQKMNPPKFDKVEDMAELTCL 142
            ||.||:......|..|.||.:..|:..|......:...|: .|:|..:||.|||:|.||||||.|
pombe    24 KRWVWISDPETAFTKAWIKEDLPDKKYVVRYNNSRDEKIVGEDEIDPVNPAKFDRVNDMAELTYL 88

  Fly   143 NEASVLHNIKDRYYSGLIYTYSGLFCVVVNPYKKLPIYTEKIMERYKGIKRHEVPPHVFAITDSA 207
            ||.:|.:|::.||.|..||||||||.|.||||..|||||:.|::.||...:....||||||.|.|
pombe    89 NEPAVTYNLEQRYLSDQIYTYSGLFLVAVNPYCGLPIYTKDIIQLYKDKTQERKLPHVFAIADLA 153

  Fly   208 YRNMLGDREDQSILCTGESGAGKTENTKKVIQFLAYVAASKPKGSGAVPHPAVLINFSVNTNKYI 272
            |.|:|.::|:||||.|||||||||||||::||:||.:|:|...||
pombe   154 YNNLLENKENQSILVTGESGAGKTENTKRIIQYLAAIASSTTVGS-------------------- 198

  Fly   273 KVKIMAQNQNQTIEVVNGLKMVEVNSNCQEGELEQQLLQANPILEAFGNAKTVKNDNSSRFGKFI 337
                                          .::|:|:::.||:||:||||:||:|:|||||||||
pombe   199 ------------------------------SQVEEQIIKTNPVLESFGNARTVRNNNSSRFGKFI 233

  Fly   338 RINFDASGFISGANIETYLLEKSRAIRQAKDERTFHIFYQLLAGATPEQREKFIL-DDVKSYAFL 401
            ::.|..||.||.|.||.|||||||.:.|.:.||.:|:|||||:||....:.|.:| |:...|.:|
pombe   234 KVEFSLSGEISNAAIEWYLLEKSRVVHQNEFERNYHVFYQLLSGADTALKNKLLLTDNCNDYRYL 298

  Fly   402 SNGSLPVPGVDDYAEFQATVKSMNIMGMTSEDFNSIFRIVSAVLLFGSMKFRQERNNDQATL-PD 465
            .:....:.||||..||:..:.:...:|...::...:|.|:|.:|..|::....:|:.....| ||
pombe   299 KDSVHIIDGVDDKEEFKTLLAAFKTLGFDDKENFDLFNILSIILHMGNIDVGADRSGIARLLNPD 363

  Fly   466 NTVAQKIAHLLGLSVTDMTRAFLTPRIKVGRDFVTKAQTKEQVEFAVEAIAKACYERMFKWLVNR 530
            .  ..|:.||||:|....::..:.||||.|.::|..|:::.||..::||:|||.|||.|.|||.|
pombe   364 E--IDKLCHLLGVSPELFSQNLVRPRIKAGHEWVISARSQTQVISSIEALAKAIYERNFGWLVKR 426

  Fly   531 INRSLDRTKRQGASFIGILDMAGFEIFELNSFEQLCINYTNEKLQQLFNHTMFILEQEEYQREGI 595
            :|.||:.:..| :.||||||:|||||||.|||||||||||||||||.|||.||:||||||.:|.|
pombe   427 LNTSLNHSNAQ-SYFIGILDIAGFEIFEKNSFEQLCINYTNEKLQQFFNHHMFVLEQEEYMKEEI 490

  Fly   596 EWKFIDFGLDLQPTIDLIDK--PGGIMALLDEECWFPKATDKTFVDKLVSA---HSMHPKFMKTD 655
            .|.|||||.|||||||||:|  |.||::.|||||..|||||.||..||.:.   .|:..|..|..
pombe   491 VWDFIDFGHDLQPTIDLIEKANPIGILSCLDEECVMPKATDATFTSKLDALWRNKSLKYKPFKFA 555

  Fly   656 FRGVADFAIVHYAGRVDYSAAKWLMKNMDPLNENIVSLLQGSQDPFVVNIWKDAEIVGMAQQALT 720
            .:|   |.:.|||..|.||...||.||.||||||:..||..|.:..|..::.|      .|:..|
pombe   556 DQG---FILTHYAADVPYSTEGWLEKNTDPLNENVAKLLAQSTNKHVATLFSD------YQETET 611

  Fly   721 DTQFGARTRKGMFRTVSHLYKEQLAKLMDTLRNTNPNFVRCIIPNHEKRAGKIDAPLVLDQLRCN 785
            .|..| ||:||:||||:..:||||.:||:...:|.|:|:|||:||.||:....:.||||.|||||
pombe   612 KTVRG-RTKKGLFRTVAQRHKEQLNQLMNQFNSTQPHFIRCIVPNEEKKMHTFNRPLVLGQLRCN 675

  Fly   786 GVLEGIRICRQGFPNRIPFQEFRQRYELLTPNVIPKG-FMDGKKACEKMIQALELDSNLYRVGQS 849
            ||||||||.|.|||||:||.:||.|||::..  :|.| :::.::|...:::.|::|...||:|.|
pombe   676 GVLEGIRITRAGFPNRLPFNDFRVRYEIMAH--LPTGTYVESRRASVMILEELKIDEASYRIGVS 738

  Fly   850 KIFFRAGVLAHLEEERDFKISDLIVNFQAFCRGFLARRNYQKRLQQLNAIRIIQRNCAAYLKLRN 914
            ||||:|||||.|||.|...:..|:...|...||||.|:.:||||:.:.||:::|.|...|.:.|.
pombe   739 KIFFKAGVLAELEERRVATLQRLMTMLQTRIRGFLQRKIFQKRLKDIQAIKLLQANLQVYNEFRT 803

  Fly   915 WQWWRLYTKVKPLLEVTKQEEKLVQKEDELKQVREKLDTLAKNTQEYERKYQQALVEKTTLAEQL 979
            :.|.:|:..::|||..|:.:::|.:::.|:.:::.:|.....:..|.||...:.....|.:...|
pombe   804 FPWAKLFFNLRPLLSSTQNDKQLKKRDAEIIELKYELKKQQNSKSEVERDLVETNNSLTAVENLL 868

  Fly   980 QAEIELCAEAEESRSRLMARKQELEDMMQELETRIEEEEERVLALGGEKKKLELNIQDLEEQLEE 1044
            ..|..:..:.||...|...|...:||...|.:.:                         .|.|:.
pombe   869 TTERAIALDKEEILRRTQERLANIEDSFSETKQQ-------------------------NENLQR 908

  Fly  1045 EEAARQKL--QLEKVQLDAKIKKYEEDLALTDDQNQKLLKEKKLLEERANDLSQTLAEEEEKAKH 1107
            |.|:.:::  :||...|: |..|.|   .|..:||:  ||||..|||:  ||..|..|.|...::
pombe   909 ESASLKQINNELESELLE-KTSKVE---TLLSEQNE--LKEKLSLEEK--DLLDTKGELESLREN 965

  Fly  1108 LAKLKAKHEATISELEERLHKDQQQRQESDRSKRKIETEVADLKEQLNERRVQVDEMQAQLAKRE 1172
            .|.:.::.    :|..|:....|:.....|....|:...::|.|.::.|.|:...:|..:..::|
pombe   966 NATVLSEK----AEFNEQCKSLQETIVTKDAELDKLTKYISDYKTEIQEMRLTNQKMNEKSIQQE 1026

  Fly  1173 EELTQTLLRIDEESATKATAQKAQRELESQLAEIQEDLEAEKAARAKAEKVRRDLSEELEALKNE 1237
            ..|:::|.|:          :|.:||..:.::::               .:.:...|||..||.
pombe  1027 GSLSESLKRV----------KKLERENSTLISDV---------------SILKQQKEELSVLKG- 1065

  Fly  1238 LLDSLDTTAAQQELRSKREQELATLKKSLEEETVNHEGVLADMRH--KHSQELNSIN--DQLENL 1298
                              .|||..  .:|||: ||:  :.||::.  |..:||.|:|  |||..|
pombe  1066 ------------------VQELTI--NNLEEK-VNY--LEADVKQLPKLKKELESLNDKDQLYQL 1107

  Fly  1299 RKAKTVLEKAKGTLEAENADLATELRSVNSSRQENDRRRKQAESQIAELQVKLAEIERARSELQE 1363
            :..|                                  .|:.|:::.|....:..:.:.....:|
pombe  1108 QATK----------------------------------NKELEAKVKECLNNIKSLTKELENKEE 1138

  Fly  1364 KCTKLQQEAENITNQLEEAELKASAAVKSASNMESQLTEAQQLLEEETRQKLGLSSKLRQIESEK 1428
            ||           ..|.:|.||              ..|.|::.|       .|..|:..:|:.|
pombe  1139 KC-----------QNLSDASLK--------------YIELQEIHE-------NLLLKVSDLENYK 1171

  Fly  1429 ---EALQEQLEEDDEAKRNYERKLAEVTTQMQEIKKKAEEDADLAKELEEGKKRLNKDIEALERQ 1490
               |.||..||           .|.:|.|..||:.||..:              |..:.|:|.||
pombe  1172 KKYEGLQLDLE-----------GLKDVDTNFQELSKKHRD--------------LTFNHESLLRQ 1211

  Fly  1491 -----VKELIAQNDRLDKSKKKIQSELEDATIELEAQRTKVLELEKKQKNFDKILAEEKAISEQI 1550
                 .|..:|.::..|.|.|  .|.|.....||..:.:||.|||:|..|          :..:.
pombe  1212 SASYKEKLSLASSENKDLSNK--VSSLTKQVNELSPKASKVPELERKITN----------LMHEY 1264

  Fly  1551 AQERDTAEREAREKETKVLSVSRELDEAFDKIEDLENKRKTLQNELDDLANTQGTADKNVHELEK 1615
            :|...|.|.|.|    |.|..||:.:|......:||:|||
pombe  1265 SQLGKTFEDEKR----KALIASRDNEELRSLKSELESKRK------------------------- 1300

  Fly  1616 AKRALESQLAELKAQNEELEDDLQLTEDAKLRLEVNMQALRSQFERDLLAKEEGAEEKRRGLVKQ 1680
                       |:.:.:::.::::.|.  .||.||.:.       |:.:|..|....|
pombe  1301 -----------LEVEYQKVLEEVKTTR--SLRSEVTLL-------RNKVADHESIRSK------- 1338

  Fly  1681 LRDLETELDEERKQRTAAVASKKKLEGD---LKEIETTMEMHN----KVKEDALKHAKKL----- 1733
            |.::|.:|.:.||:..:|:.|.||.|.:   |||...:.:.:|    |..|..||:..:.
pombe  1339 LSEVEMKLVDTRKELNSALDSCKKREAEIHRLKEHRPSGKENNIPAVKTTEPVLKNIPQRKTIFD 1403

  Fly  1734 -------QAQVKDALRDAEEAKAAKEELQALSKEAE-------------RKVKALEAEVLQLTED 1778
                   ||..::..||.:.....|..|:....|.:             :.|....|..|:..:|
pombe  1404 LQQRNANQALYENLKRDYDRLNLEKHNLEKQVNELKGAEVSPQPTGQSLQHVNLAHAIELKALKD 1468

  Fly  1779 LASSERARRAA-----ETERDELAEEIAN--NANKGSLMIDEKRRLEARIATLEEEL 1828
            ..:||:|:..:     |....||.:.||:  ..||.||:  :.|.|..|||:||:||
pombe  1469 QINSEKAKMFSVQVQYEKREQELQKRIASLEKVNKDSLI--DVRALRDRIASLEDEL 1523

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
zip	NP_523860.2	Myosin_N	80..117	CDD:280832	9/36 (25%)
		Myosin_head	133..854	CDD:278492	346/728 (48%)
		MYSc_Myh2_insects_mollusks	145..854	CDD:276876	336/716 (47%)
		Myosin_tail_1	931..2011	CDD:279860	210/951 (22%)
		Prefoldin	1431..1515	CDD:298833	23/88 (26%)
		FAM76	<1847..1926	CDD:292665
myo2	NP_588114.1	COG5022	6..1516	CDD:227355	599/1803 (33%)
		Myosin_N	25..>48	CDD:280832	7/22 (32%)
		MYSc_class_II	91..743	CDD:276951	336/716 (47%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	621	1.000	Domainoid score	I26
eggNOG	1	0.900	-	-		E2759_KOG0161
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	794	1.000	Inparanoid score	I68
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000014
OrthoInspector	1	1.000	-	-		mtm9311
orthoMCL	1	0.900	-	-		OOG6_100110
Panther	1	1.100	-	-	LDO	PTHR45615
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R786
SonicParanoid	1	1.000	-	-		X58
TreeFam	0	0.000	Not matched by this tool.
	11	10.890