DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment zip and Myh11

DIOPT Version :9

Sequence 1:	NP_523860.2	Gene:	zip / 38001	FlyBaseID:	FBgn0265434	Length:	2056	Species:	Drosophila melanogaster
Sequence 2:	XP_006245904.1	Gene:	Myh11 / 24582	RGDID:	3136	Length:	1979	Species:	Rattus norvegicus

Alignment Length:	2019	Identity:	1200/2019 - (59%)
Similarity:	1546/2019 - (76%)	Gaps:	59/2019 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly    46 MSEEVDRNDPELKYLSVERNQFNDPATQAEWTQKRLVWVPHENQGFVAASIKREHGDEVEVELAE 110
            |:::...:|.| |:|.|::|..|.|..||:|..|:|||||.|.|||.|||||.|.||||.|||.|
  Rat     1 MAQKGQLSDDE-KFLFVDKNFINSPMAQADWVAKKLVWVPSEKQGFEAASIKEEKGDEVVVELVE 64

  Fly   111 TGKRVMILRDDIQKMNPPKFDKVEDMAELTCLNEASVLHNIKDRYYSGLIYTYSGLFCVVVNPYK 175
            .||:|.:.:|||||||||||.|||||||||||||||||||:::||:|||||||||||||||||||
  Rat    65 NGKKVTVGKDDIQKMNPPKFSKVEDMAELTCLNEASVLHNLRERYFSGLIYTYSGLFCVVVNPYK 129

  Fly   176 KLPIYTEKIMERYKGIKRHEVPPHVFAITDSAYRNMLGDREDQSILCTGESGAGKTENTKKVIQF 240
            .||||:|||::.|||.||||:|||::||.|:|||:||.||||||||||||||||||||||||||:
  Rat   130 HLPIYSEKIVDMYKGKKRHEMPPHIYAIADTAYRSMLQDREDQSILCTGESGAGKTENTKKVIQY 194

  Fly   241 LAYVAASK--PKGSGAVPHPAVLINFSVNTNKYIKVKIMAQNQNQTIEVVNGLKMVEVNSNCQEG 303
            ||.||:|.  .|.|.....|:...                                        |
  Rat   195 LAVVASSHKGKKDSSITQGPSFAY----------------------------------------G 219

  Fly   304 ELEQQLLQANPILEAFGNAKTVKNDNSSRFGKFIRINFDASGFISGANIETYLLEKSRAIRQAKD 368
            |||:|||||||||||||||||||||||||||||||||||.:|:|.||||||||||||||||||:|
  Rat   220 ELEKQLLQANPILEAFGNAKTVKNDNSSRFGKFIRINFDVTGYIVGANIETYLLEKSRAIRQARD 284

  Fly   369 ERTFHIFYQLLAGATPEQREKFILDDVKSYAFLSNGSLPVPGVDDYAEFQATVKSMNIMGMTSED 433
            ||||||||.|:|||..:.|...:|:...||.|||||.:|:|...|...||.|:::|:|||.:.|:
  Rat   285 ERTFHIFYYLIAGAKEKMRNDLLLESFNSYTFLSNGFVPIPAAQDDEMFQETLEAMSIMGFSEEE 349

  Fly   434 FNSIFRIVSAVLLFGSMKFRQERNNDQATLPDNTVAQKIAHLLGLSVTDMTRAFLTPRIKVGRDF 498
            ..:|.::||:||..|::.|::|||.|||::||||.|||:.||:|::|||.|||.||||||||||.
  Rat   350 QLAILKVVSSVLQLGNIVFKKERNTDQASMPDNTAAQKVCHLVGINVTDFTRAILTPRIKVGRDV 414

  Fly   499 VTKAQTKEQVEFAVEAIAKACYERMFKWLVNRINRSLDRTKRQGASFIGILDMAGFEIFELNSFE 563
            |.|||||||.:||:||:|||.|||:|:|:::|:|::||:|.||||||:||||:|||||||:||||
  Rat   415 VQKAQTKEQADFAIEALAKATYERLFRWILSRVNKALDKTHRQGASFLGILDIAGFEIFEVNSFE 479

  Fly   564 QLCINYTNEKLQQLFNHTMFILEQEEYQREGIEWKFIDFGLDLQPTIDLIDKPG---GIMALLDE 625
            ||||||||||||||||||||||||||||||||||.||||||||||.|:||::|.   |::|||||
  Rat   480 QLCINYTNEKLQQLFNHTMFILEQEEYQREGIEWNFIDFGLDLQPCIELIERPNNPPGVLALLDE 544

  Fly   626 ECWFPKATDKTFVDKLVSAHSMHPKFMK-TDFRGVADFAIVHYAGRVDYSAAKWLMKNMDPLNEN 689
            ||||||||||:||:||.|....||||.| ...:...:|:|:||||:|||:|:.||.|||||||:|
  Rat   545 ECWFPKATDKSFVEKLCSEQGNHPKFQKPKQLKDKTEFSIIHYAGKVDYNASAWLTKNMDPLNDN 609

  Fly   690 IVSLLQGSQDPFVVNIWKDAE-IVGMAQQA-LTDTQF--GARTRKGMFRTVSHLYKEQLAKLMDT 750
            :.|||..|.|.||.::|||.: |||:.|.| :|::..  .::|:|||||||..||||||.|||.|
  Rat   610 VTSLLNASSDKFVADLWKDVDRIVGLDQMAKMTESSLPSASKTKKGMFRTVGQLYKEQLGKLMTT 674

  Fly   751 LRNTNPNFVRCIIPNHEKRAGKIDAPLVLDQLRCNGVLEGIRICRQGFPNRIPFQEFRQRYELLT 815
            ||||.||||||||||||||:||:||.|||:||||||||||||||||||||||.|||||||||:|.
  Rat   675 LRNTTPNFVRCIIPNHEKRSGKLDAFLVLEQLRCNGVLEGIRICRQGFPNRIVFQEFRQRYEILA 739

  Fly   816 PNVIPKGFMDGKKACEKMIQALELDSNLYRVGQSKIFFRAGVLAHLEEERDFKISDLIVNFQAFC 880
            .|.|||||||||:||..||:|||||.||||:||||||||.|||||||||||.||:|:|:.|||.|
  Rat   740 ANAIPKGFMDGKQACILMIKALELDPNLYRIGQSKIFFRTGVLAHLEEERDLKITDVIMAFQAMC 804

  Fly   881 RGFLARRNYQKRLQQLNAIRIIQRNCAAYLKLRNWQWWRLYTKVKPLLEVTKQEEKLVQKEDELK 945
            ||:|||:.:.||.|||.|:::|||||||||||||||||||:|||||||:||:|||::..||:|::
  Rat   805 RGYLARKAFTKRQQQLTAMKVIQRNCAAYLKLRNWQWWRLFTKVKPLLQVTRQEEEMQAKEEEMQ 869

  Fly   946 QVREKLDTLAKNTQEYERKYQQALVEKTTLAEQLQAEIELCAEAEESRSRLMARKQELEDMMQEL 1010
            :::|:........:|.|:::.|...|||.|.||||||.||.|||||.|.||.|:|||||:::.|:
  Rat   870 KIKERQQKAESELKELEQRHTQLAEEKTLLQEQLQAETELYAEAEEMRVRLAAKKQELEEILHEM 934

  Fly  1011 ETRIEEEEERVLALGGEKKKLELNIQDLEEQLEEEEAARQKLQLEKVQLDAKIKKYEEDLALTDD 1075
            |.|:||||:|...|..|:||:...:.|||||||||||||||||||||..:|||||.|:|:.:.||
  Rat   935 EARLEEEEDRSQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDDILVMDD 999

  Fly  1076 QNQKLLKEKKLLEERANDLSQTLAEEEEKAKHLAKLKAKHEATISELEERLHKDQQQRQESDRSK 1140
            ||.||.||:||||||.:||:..|||||||||:|.|||:|||:.|||||.||.|:::.|||.::.|
  Rat  1000 QNNKLSKERKLLEERVSDLTTNLAEEEEKAKNLTKLKSKHESMISELEVRLKKEEKSRQELEKLK 1064

  Fly  1141 RKIETEVADLKEQLNERRVQVDEMQAQLAKREEELTQTLLRIDEESATKATAQKAQRELESQLAE 1205
            ||:|.:.:|..||:.:.:.|:.|::.||||:||||...|.|:|||...|..|.|..||||..:::
  Rat  1065 RKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDEEITQKNNALKKIRELEGHVSD 1129

  Fly  1206 IQEDLEAEKAARAKAEKVRRDLSEELEALKNELLDSLDTTAAQQELRSKREQELATLKKSLEEET 1270
            :||||::|:|||.||||.:|||.|||||||.||.|:||:||.|||||:|||||:..|||:|:|||
  Rat  1130 LQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTMLKKALDEET 1194

  Fly  1271 VNHEGVLADMRHKHSQELNSINDQLENLRKAKTVLEKAKGTLEAENADLATELRSVNSSRQENDR 1335
            .:||..:.:||.||:|.:..:.:|||..::||..|:|:|.|||.||||||.|||.:..::||.:.
  Rat  1195 RSHEAQVQEMRQKHTQAVEELTEQLEQFKRAKANLDKSKQTLEKENADLAGELRVLGQAKQEVEH 1259

  Fly  1336 RRKQAESQIAELQVKLAEIERARSELQEKCTKLQQEAENITNQLEEAELKASAAVKSASNMESQL 1400
            ::|:.|.|:.|||.|.::.||||:||.:|..|||.|.|::|..|.|||.||....|..:::.|||
  Rat  1260 KKKKLEGQLQELQSKCSDGERARTELSDKVHKLQNEVESVTGMLNEAEGKAIKLAKEVASLGSQL 1324

  Fly  1401 TEAQQLLEEETRQKLGLSSKLRQIESEKEALQEQLEEDDEAKRNYERKLAEVTTQMQEIKKKAEE 1465
            .:.|:||:|||||||.:|:||||:|.|:.:||:||:|:.|||:|.||.::.:..|:.:.|||.::
  Rat  1325 QDTQELLQEETRQKLNVSTKLRQLEDERNSLQDQLDEEMEAKQNLERHVSTLNIQLSDSKKKLQD 1389

  Fly  1466 DADLAKELEEGKKRLNKDIEALERQVKELIAQNDRLDKSKKKIQSELEDATIELEAQRTKVLELE 1530
            .|...:.:|||||||.|::|.|.:|.:|..|..|:|:|:|.::|.||:|..::|:.||..|..||
  Rat  1390 LASTIEVMEEGKKRLQKEMEGLGQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLE 1454

  Fly  1531 KKQKNFDKILAEEKAISEQIAQERDTAEREAREKETKVLSVSRELDEAFDKIEDLENKRKTLQNE 1595
            ||||.||::|||||.||.:.|.|||.||.||||||||.||::|.|:||.:..|:||...|.|:.|
  Rat  1455 KKQKKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAE 1519

  Fly  1596 LDDLANTQGTADKNVHELEKAKRALESQLAELKAQNEELEDDLQLTEDAKLRLEVNMQALRSQFE 1660
            ::||.:::....||||||||:|||||:|:.|::.|.|||||:||.|||||||||||||||:.|||
  Rat  1520 MEDLVSSKDDVGKNVHELEKSKRALETQMEEMRTQLEELEDELQATEDAKLRLEVNMQALKGQFE 1584

  Fly  1661 RDLLAKEEGAEEKRRGLVKQLRDLETELDEERKQRTAAVASKKKLEGDLKEIETTMEMHNKVKED 1725
            |||.|::|..|||||.|.:||.:.||||::|||||..|.|:|||||||||::|...:...|.:|:
  Rat  1585 RDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAVKGREE 1649

  Fly  1726 ALKHAKKLQAQVKDALRDAEEAKAAKEELQALSKEAERKVKALEAEVLQLTEDLASSERARRAAE 1790
            |:|..:|||||:||..|:.::|:|:::|:.|.|||.|:|.|:||||::||.||||::||||:.|:
  Rat  1650 AIKQLRKLQAQMKDFQRELDDARASRDEIFATSKENEKKAKSLEAELMQLQEDLAAAERARKQAD 1714

  Fly  1791 TERDELAEEIANNANKGSLMIDEKRRLEARIATLEEELEEEQSNSEVLLDRSRKAQLQIEQLTTE 1855
            .|::|||||:|::.:..:.:.|||||||||||.|||||||||.|.|.:.||.|||.||.|||:.|
  Rat  1715 LEKEELAEELASSLSGRNTLQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATLQAEQLSNE 1779

  Fly  1856 LANEKSNSQKNENGRALLERQNKELKAKLAEIETAQRTKVKATIATLEAKIANLEEQLENEGKER 1920
            |..|:|.:||||:.|..||||||||::||.|:|.|.:.|:|:|:|.|||||..||||:|.|.:|:
  Rat  1780 LVTERSAAQKNESARQQLERQNKELRSKLQEVEGAVKAKLKSTVAALEAKIVQLEEQIEQEAREK 1844

  Fly  1921 LLQQKANRKMDKKIKELTMNIEDERRHVDQHKEQMDKLNSRIKLLKRNLDETEEELQKEKTQKRK 1985
            ....|..::.|||:||:.:.:||||:.|:|:|||.:|.|:::|.|||.|:|.|||.|:....:||
  Rat  1845 QAATKLLKQKDKKLKEVLLQVEDERKMVEQYKEQAEKGNTKVKQLKRQLEEAEEESQRINANRRK 1909

  Fly  1986 YQRECEDMIESQEAMNREINSLKTKLRRTGGIGLSSSRLTGTPSSKRAGGGGGGDDSSVQDESLD 2050
            .|||.::..||.|||.||:|:||:||||    |..:|.:    .|:||||....:::...:|.:|
  Rat  1910 LQRELDEATESNEAMGREVNALKSKLRR----GNEASFV----PSRRAGGRRVIENTDGSEEEMD 1966

  Fly  2051 GEDS 2054
            ..||
  Rat  1967 ARDS 1970

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
zip	NP_523860.2	Myosin_N	80..117	CDD:280832	26/36 (72%)
		Myosin_head	133..854	CDD:278492	489/730 (67%)
		MYSc_Myh2_insects_mollusks	145..854	CDD:276876	477/718 (66%)
		Myosin_tail_1	931..2011	CDD:279860	586/1079 (54%)
		Prefoldin	1431..1515	CDD:298833	36/83 (43%)
		FAM76	<1847..1926	CDD:292665	43/78 (55%)
Myh11	XP_006245904.1	Myosin_N	34..71	CDD:280832	26/36 (72%)
		Myosin_head	87..778	CDD:278492	489/730 (67%)
		MYSc_class_II	99..778	CDD:276951	477/718 (66%)
		Myosin_tail_1	855..1935	CDD:279860	586/1079 (54%)
		FAM76	<997..1089	CDD:292665	52/91 (57%)
		UBAN	1049..1163	CDD:301588	58/113 (51%)
		BAR	<1166..>1295	CDD:299863	67/128 (52%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	990	1.000	Domainoid score	I27
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D40305at33208
OrthoFinder	1	1.000	-	-		FOG0000014
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100110
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X58
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.820