DRSC/TRiP Functional Genomics Resources

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Protein Alignment zip and MYO16

DIOPT Version :9

Sequence 1:NP_523860.2 Gene:zip / 38001 FlyBaseID:FBgn0265434 Length:2056 Species:Drosophila melanogaster
Sequence 2:NP_001185879.1 Gene:MYO16 / 23026 HGNCID:29822 Length:1880 Species:Homo sapiens


Alignment Length:1112 Identity:278/1112 - (25%)
Similarity:480/1112 - (43%) Gaps:271/1112 - (24%)


- Green bases have known domain annotations that are detailed below.


  Fly     6 LALKSKSALHPKSEYPVSNIHYPKAANYRQTRNYLEI-------AAKMSE---EVDRNDPELKYL 60
            :.||::.|...|.:.|:|      |:...|...|.||       ::|:|.   .:.:.|..|   
Human   325 MLLKAEIAWEEKMKEPLS------ASTLAQEEPYEEIIHDLPVLSSKLSPLVLPIAKQDSLL--- 380

  Fly    61 SVERNQFNDPATQAEWTQKRLVWVPHENQGFVAASIKREHGDEVEVELAETGKRVMILRDDIQKM 125
              |::.....||:....|:....:| ||. .::.|.|.|.                      .|:
Human   381 --EKDIMFKDATKGLCKQQSQDSIP-ENP-MMSGSTKPEQ----------------------VKL 419

  Fly   126 NPPKFDKVEDMAELTCLNEASVLHNIKDRYYSGLIYTYSGLFCVVVNPYKKLPIYTEKIMERY-- 188
            .||..:  :|:|.|:.||:.|:|:.|:.|:.:..|||:.|...::|||||:||||:..:.:.|  
Human   420 MPPAPN--DDLATLSELNDGSLLYEIQKRFGNNQIYTFIGDILLLVNPYKELPIYSSMVSQLYFS 482

  Fly   189 -KGIKRHEVPPHVFAITDSAYRNMLGDREDQSILCTGESGAGKTENTKKVIQFLAYVAASKPKGS 252
             .|.....:|||:|:..:.|:..:..::..|..:.:||.|:||:|.:|::|:.|           
Human   483 SSGKLCSSLPPHLFSCVERAFHQLFREQRPQCFILSGERGSGKSEASKQIIRHL----------- 536

  Fly   253 GAVPHPAVLINFSVNTNKYIKVKIMAQNQNQTIEVVNGLKMVEVNSNCQEG----ELEQQLLQAN 313
                                                          .|:.|    .|:.:.....
Human   537 ----------------------------------------------TCRAGASRATLDSRFKHVV 555

  Fly   314 PILEAFGNAKTVKNDNSSRFGKFIRINF-DASGFISGANIETYLLEKSRAIRQAKDERTFHIFYQ 377
            .||||||:|||..||.||.|.|:..:.| :....::||.|.||||||||.:.|...:..|.|||.
Human   556 CILEAFGHAKTTLNDLSSCFIKYFELQFCERKQQLTGARIYTYLLEKSRLVSQPLGQSNFLIFYL 620

  Fly   378 LLAGATPEQREKFILDDVKSYAFLSNGSLPVPGVDDYAEFQATV---------KSMNIMGMTSED 433
            |:.|.:.|::....|:::.::.:| |.::.    ||.:..:.::         :::|::|.:|.:
Human   621 LMDGLSAEEKYGLHLNNLCAHRYL-NQTIQ----DDASTGERSLNREKLAVLKRALNVVGFSSLE 680

  Fly   434 FNSIFRIVSAVLLFGSMKFRQERNNDQATLPDNTVAQKIAHLLGLSVTDMTRAFLTPRIKVGRDF 498
            ..::|.|::|:|..|.::|......:.|.:.|..:.:::|.:|.:|..::..|..|.......|.
Human   681 VENLFVILAAILHLGDIRFTALNEGNSAFVSDLQLLEQVAGMLQVSTDELASALTTDIQYFKGDM 745

  Fly   499 VTKAQTKEQVEFAVEAIAKACYERMFKWLVNRIN---RSLDRTKRQGASFIGILDMAGFEIFELN 560
            :.:..|.:..||..:.:||:.|.|:|.:|||.:|   .|.|..|......|||||:.|||.|:.|
Human   746 IIRRHTIQIAEFFRDLLAKSLYSRLFSFLVNTMNSCLHSQDEQKSMQTLDIGILDIFGFEEFQKN 810

  Fly   561 SFEQLCINYTNEKLQQLFNHTMFILEQEEYQREGIEWK----------FIDFGLDLQPTIDLIDK 615
            .|||||:|.||||:....|..:|:.||.|..:||:..:          .:||         ...|
Human   811 EFEQLCVNMTNEKMHHYINEVLFLHEQVECVQEGVTMETAYSPGNQNGVLDF---------FFQK 866

  Fly   616 PGGIMALLDEECWFPKATDKTFVDKLVS------AHSMHPKFMKTDFRGVA------DFAIVHYA 668
            |.|.:.|||||.....:.:..|..||.|      .::::.. ||.....||      .|.|:|||
Human   867 PSGFLTLLDEESQMIWSVESNFPKKLQSLLESSNTNAVYSP-MKDGNGNVALKDHGTAFTIMHYA 930

  Fly   669 GRVDYSAAKWLMKNMDPLNENIVSLLQGSQDPFVVNIWKD------------------------- 708
            |||.|.....:.||.|.|::|::.:::.|::..:.::::.                         
Human   931 GRVMYDVVGAIEKNKDSLSQNLLFVMKTSENVVINHLFQSKLSQTGSLVSAYPSFKFRGHKSALL 995

  Fly   709 ------AEIVGMAQQAL----------TDTQFGARTRKGMFRTVSHLYKEQLAKLMDTLRNTNPN 757
                  :.|:|..:..|          |.| |..|..:|...|::...::.|..::..|:...|:
Human   996 SKKMTASSIIGENKNYLELSKLLKKKGTST-FLQRLERGDPVTIASQLRKSLMDIIGKLQKCTPH 1059

  Fly   758 FVRCIIPNHEKRAGKIDAPLVLDQLRCNGVLEGIRICRQGFPNRIPFQEFRQRYELLTPNVI-PK 821
            |:.||.||:.|.....|...|..||:..||||.::|.|.|:|.|:.|.:|..||:.|....: .|
Human  1060 FIHCIRPNNSKLPDTFDNFYVSAQLQYIGVLEMVKIFRYGYPVRLSFSDFLSRYKPLADTFLREK 1124

  Fly   822 GFMDGKKACEKMIQALELDSNLYRVGQSKIFFRAGVLAHLEEERD--FKISDLIVNFQAFCRGFL 884
            ......:.|..::|..:|..  :::|..|:|.:   ..|.::..|  .::...|:..|...||||
Human  1125 KEQSAAERCRLVLQQCKLQG--WQMGVRKVFLK---YWHADQLNDLCLQLQRKIITCQKVIRGFL 1184

  Fly   885 ARRNYQKRLQQLNAIRIIQRNCAAYLKLRNWQWWRLYTKVKPLLEVTKQEEKLVQKEDELKQVRE 949
            ||::..:|      |.|.|:                        |||                  
Human  1185 ARQHLLQR------ISIRQQ------------------------EVT------------------ 1201

  Fly   950 KLDTLAKNTQEYERKYQQALVEKTTLAEQLQAEIELCAEAEESRSRLMA----RKQELEDMMQEL 1010
            .:::..:||::...|...|||        :|...::..|.:..||.:.|    .|.|:.:|.:|.
Human  1202 SINSFLQNTEDMGLKTYDALV--------IQNASDIARENDRLRSEMNAPYHKEKLEVRNMQEEG 1258

  Fly  1011 ETRIEEE 1017
            ..|.:::
Human  1259 SKRTDDK 1265

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
zipNP_523860.2 Myosin_N 80..117 CDD:280832 6/36 (17%)
Myosin_head 133..854 CDD:278492 217/804 (27%)
MYSc_Myh2_insects_mollusks 145..854 CDD:276876 212/792 (27%)
Myosin_tail_1 931..2011 CDD:279860 17/91 (19%)
Prefoldin 1431..1515 CDD:298833
FAM76 <1847..1926 CDD:292665
MYO16NP_001185879.1 ANKYR 81..332 CDD:223738 2/6 (33%)
ANK repeat 86..112 CDD:293786
ANK 89..190 CDD:238125
ANK repeat 114..145 CDD:293786
ANK 142..297 CDD:238125
ANK repeat 147..178 CDD:293786
ANK repeat 180..210 CDD:293786
ANK repeat 243..274 CDD:293786
ANK repeat 276..307 CDD:293786
ANK repeat 309..335 CDD:293786 3/9 (33%)
MYSc 426..1165 CDD:214580 218/816 (27%)
MYSc_Myo16 437..1155 CDD:276844 212/792 (27%)
NYAP_N 1253..1590 CDD:292079 3/13 (23%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG0161
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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