DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment zip and MYH15

DIOPT Version :9

Sequence 1:NP_523860.2 Gene:zip / 38001 FlyBaseID:FBgn0265434 Length:2056 Species:Drosophila melanogaster
Sequence 2:XP_011510861.1 Gene:MYH15 / 22989 HGNCID:31073 Length:1946 Species:Homo sapiens


Alignment Length:1965 Identity:718/1965 - (36%)
Similarity:1120/1965 - (56%) Gaps:103/1965 - (5%)


- Green bases have known domain annotations that are detailed below.


  Fly    79 KRLVWVPHENQGFVAASIKREHGD-EVEVELAETGKRVMILRDDIQKMNPPKFDKVEDMAELTCL 142
            |:..|:|.....::.|.:|....| .|.||.|: |:.:.|..|.||:||||:|:.:||||.||.|
Human    51 KKKCWIPDGENAYIEAEVKGSEDDGTVIVETAD-GESLSIKEDKIQQMNPPEFEMIEDMAMLTHL 114

  Fly   143 NEASVLHNIKDRYYSGLIYTYSGLFCVVVNPYKKLPIYTEKIMERYKGIKRHEVPPHVFAITDSA 207
            |||||||.:|.||...:||||||||||.:||||.||:|.:::|..|||.:|.|.|||:||:.::|
Human   115 NEASVLHTLKRRYGQWMIYTYSGLFCVTINPYKWLPVYQKEVMAAYKGKRRSEAPPHIFAVANNA 179

  Fly   208 YRNMLGDREDQSILCTGESGAGKTENTKKVIQFLAYVAASKPKGSGAVPHPAVLINFSVNTNKYI 272
            :::||.:||:||||.|||||||||.|:|.:||:.|.:||                          
Human   180 FQDMLHNRENQSILFTGESGAGKTVNSKHIIQYFATIAA-------------------------- 218

  Fly   273 KVKIMAQNQNQTIEVVNGLKMVEVNSNCQEGELEQQLLQANPILEAFGNAKTVKNDNSSRFGKFI 337
                                |:|  |..::|.||.|::|||.||||||||||::|||||||||||
Human   219 --------------------MIE--SRKKQGALEDQIMQANTILEAFGNAKTLRNDNSSRFGKFI 261

  Fly   338 RINFDASGFISGANIETYLLEKSRAIRQAKDERTFHIFYQLLAGATPEQREKFILDDV------- 395
            |::|.|.|.:|..:|:.|||||||.|.|...||.:|||||:|:|    |:|   |.|:       
Human   262 RMHFGARGMLSSVDIDIYLLEKSRVIFQQAGERNYHIFYQILSG----QKE---LHDLLLVSANP 319

  Fly   396 KSYAFLSNGSLPVPGVDDYAEFQATVKSMNIMGMTSEDFNSIFRIVSAVLLFGSMKFRQERNNDQ 460
            ..:.|.|.|::.|..:||..|..||.::|:|:|...::....:::..|::.||:|||:|:...:|
Human   320 SDFHFCSCGAVTVESLDDAEELLATEQAMDILGFLPDEKYGCYKLTGAIMHFGNMKFKQKPREEQ 384

  Fly   461 ATLPDNTVAQKIAHLLGLSVTDMTRAFLTPRIKVGRDFVTKAQTKEQVEFAVEAIAKACYERMFK 525
            ........|.|.|.|:|::.:::.:..:.||||||.::||:.||.|||..||.|::|:.||||||
Human   385 LEADGTENADKAAFLMGINSSELVKCLIHPRIKVGNEYVTRGQTIEQVTCAVGALSKSMYERMFK 449

  Fly   526 WLVNRINRSLD-RTKRQGASFIGILDMAGFEIFELNSFEQLCINYTNEKLQQLFNHTMFILEQEE 589
            |||.||||:|| :..||  .||||||:.||||.|.||.||||||:|||||||.||..||:|||||
Human   450 WLVARINRALDAKLSRQ--FFIGILDITGFEILEYNSLEQLCINFTNEKLQQFFNWHMFVLEQEE 512

  Fly   590 YQREGIEWKFIDFGLDLQPTIDLIDKPGGIMALLDEECWFPKATDKTFVDKLVSAH---SMH--- 648
            |::|.|||..|.||||||..||||:||.||:::|:|||.||||||.||..||...|   |:|   
Human   513 YKKESIEWVSIGFGLDLQACIDLIEKPMGILSILEEECMFPKATDLTFKTKLFDNHFGKSVHLQK 577

  Fly   649 PKFMKTDFRGVADFAIVHYAGRVDYSAAKWLMKNMDPLNENIVSLLQGSQDPFVVNIWKDAEIVG 713
            ||..|..|.  |.|.:|||||.|.|:.:.||.||.|.|||.:|::.|.|.:..:.:::::     
Human   578 PKPDKKKFE--AHFELVHYAGVVPYNISGWLEKNKDLLNETVVAVFQKSSNRLLASLFEN----- 635

  Fly   714 MAQQALTDT--QFGARTRK--GMFRTVSHLYKEQLAKLMDTLRNTNPNFVRCIIPNHEKRAGKID 774
               ...||:  .||.:.||  ..|:||:.|:||.|.|||..|::|.|:|||||.||..|..|.:|
Human   636 ---YMSTDSAIPFGEKKRKKGASFQTVASLHKENLNKLMTNLKSTAPHFVRCINPNVNKIPGILD 697

  Fly   775 APLVLDQLRCNGVLEGIRICRQGFPNRIPFQEFRQRYELLTPNVIPKG-FMDGKKACEKMIQALE 838
            ..|||.||||||||||.||||:|||||:.:.:|:|||.:|.|...||. |:..:||.|:::.:||
Human   698 PYLVLQQLRCNGVLEGTRICREGFPNRLQYADFKQRYCILNPRTFPKSKFVSSRKAAEELLGSLE 762

  Fly   839 LDSNLYRVGQSKIFFRAGVLAHLEEERDFKISDLIVNFQAFCRGFLARRNYQKRLQQLNAIRIIQ 903
            :|...||.|.:|:||:||.|..||..||.::|.:...|||..:|.|.|..:||.|::.:|:.:||
Human   763 IDHTQYRFGITKVFFKAGFLGQLEAIRDERLSKVFTLFQARAQGKLMRIKFQKILEERDALILIQ 827

  Fly   904 RNCAAYLKLRNWQWWRLYTKVKPLLEVTKQEEKLVQKEDELKQVREKLDTLAKNTQEYERKYQQA 968
            .|..|::.::||.|.||:.|:|||::.::..|::...::|..|:::.|:......:|.:.|....
Human   828 WNIRAFMAVKNWPWMRLFFKIKPLVKSSEVGEEVAGLKEECAQLQKALEKSEFQREELKAKQVSL 892

  Fly   969 LVEKTTLAEQLQAEIELCAEAEESRSRLMARKQELEDMMQELETRIEEEEERVLALGGEKKKLEL 1033
            ..||..|..|||||.|..|..||....|:..|.:||..::||..|:|||||....|....:|||.
Human   893 TQEKNDLILQLQAEQETLANVEEQCEWLIKSKIQLEARVKELSERVEEEEEINSELTARGRKLED 957

  Fly  1034 NIQDLEEQLEEEEAARQKLQLEKVQLDAKIKKYEEDLALTDDQNQKLLKEKKLLEERANDLSQTL 1098
            ...:|::::::.|....|.:.||...:.|:|...|::...::...||.:..|:::|........|
Human   958 ECFELKKEIDDLETMLVKSEKEKRTTEHKVKNLTEEVEFLNEDISKLNRAAKVVQEAHQQTLDDL 1022

  Fly  1099 AEEEEKAKHLAKLKAKHEATISELEERLHKDQQQRQESDRSKRKIETEVADLKEQLNERRVQVDE 1163
            ..||||...|:|...|.|..:.|||..|.::::.|...:|...|:|..:...:|.:.........
Human  1023 HMEEEKLSSLSKANLKLEQQVDELEGALEQERKARMNCERELHKLEGNLKLNRESMENLESSQRH 1087

  Fly  1164 MQAQLAKREEELTQTLLRIDEESATKATAQKAQRELESQLAEIQEDLEAEKAARAKAEKVRRDLS 1228
            :..:|.|:|.||:|...:::.|....|..||..:||::|:.:::|.||||:..|||.|:.|.||:
Human  1088 LAEELRKKELELSQMNSKVENEKGLVAQLQKTVKELQTQIKDLKEKLEAERTTRAKMERERADLT 1152

  Fly  1229 EELEALKNELLDSLDTTAAQQELRSKREQELATLKKSLEEETVNHEGVLADMRHKHSQELNSIND 1293
            ::|..|...|.:...::.||.|:..|:|.:...|.:.:||.|::.|...|.::.:|:..|..:..
Human  1153 QDLADLNERLEEVGGSSLAQLEITKKQETKFQKLHRDMEEATLHFETTSASLKKRHADSLAELEG 1217

  Fly  1294 QLENLRKAKTVLEKAKGTLEAENADLATELRSVNSSRQENDRRRKQAESQIAELQVKLAEIERAR 1358
            |:|||::.|..|||.|..|:.|..||.|.:..:..::...::.....|.::.|...||.::.:..
Human  1218 QVENLQQVKQKLEKDKSDLQLEVDDLLTRVEQMTRAKANAEKLCTLYEERLHEATAKLDKVTQLA 1282

  Fly  1359 SELQEKCTKLQQEAENITNQLEEAELKASAAVKSASNMESQLTEAQQLLEEETRQKLGLSSKLRQ 1423
            ::|..:.|||..|:.....:|||.|...:...:..||...|:.:.:..||:||:.:..|:..|::
Human  1283 NDLAAQKTKLWSESGEFLRRLEEKEALINQLSREKSNFTRQIEDLRGQLEKETKSQSALAHALQK 1347

  Fly  1424 IESEKEALQEQLEEDDEAKRNYERKLAEVTTQMQEIKKKAEEDA-DLAKELEEGKKRLNKDIEAL 1487
            .:.:.:.|:||.||:.|.|....|.|::|..:|.:.:.|.|.:. ...::||:.||.|...::..
Human  1348 AQRDCDLLREQYEEEQEVKAELHRTLSKVNAEMVQWRMKYENNVIQRTEDLEDAKKELAIRLQEA 1412

  Fly  1488 ERQVKELIAQNDRLDKSKKKIQSELEDATIELEAQRTKVLELEKKQKNFDKILAEEKAISEQIAQ 1552
            ...:....|:|..|::::.::|.||.||..:|...|:....|::||....|.||:.|...|:...
Human  1413 AEAMGVANARNASLERARHQLQLELGDALSDLGKVRSAAARLDQKQLQSGKALADWKQKHEESQA 1477

  Fly  1553 ERDTAEREAREKETKVLSVSRELDEAFDKIEDLENKRKTLQNELDDLANTQGTADKNVHELEKAK 1617
            ..|.:::|.:...|::|.:....:|:....|.|..:.|.||.|:.:|.|......||:.|:||.|
Human  1478 LLDASQKEVQALSTELLKLKNTYEESIVGQETLRRENKNLQEEISNLTNQVREGTKNLTEMEKVK 1542

  Fly  1618 RALESQLAELKAQNEELEDDLQLTEDAKLRLEVNMQALRSQFERDLLAKEEGAEEKRRGLVKQLR 1682
            :.:|.:..|::...||.|..|:..|...|..::.:...:::.||.|..|:|..|..||.....:.
Human  1543 KLIEEEKTEVQVTLEETEGALERNESKILHFQLELLEAKAELERKLSEKDEEIENFRRKQQCTID 1607

  Fly  1683 DLETELDEERKQRTAAVASKKKLEGDLKEIETTMEMHNKVKEDALKHAKKLQAQVKDALRDAEEA 1747
            .|::.||.|.|.|......|||:|.||.|:|..:...|:...:|.|...:||.|:||.....:::
Human  1608 SLQSSLDSEAKSRIEVTRLKKKMEEDLNEMELQLSCANRQVSEATKSLGQLQIQIKDLQMQLDDS 1672

  Fly  1748 KAAKEELQALSKEAERKVKALEAEVLQLTEDLAS----SERARRAAETERDELAEEIANNANKGS 1808
            .....:|:.....|||:...|::|:    |||.|    :||.||.:|.|..|..|.|.....:.:
Human  1673 TQLNSDLKEQVAVAERRNSLLQSEL----EDLRSLQEQTERGRRLSEEELLEATERINLFYTQNT 1733

  Fly  1809 LMIDEKRRLEARIATLEEELEE---EQSNSEVLLDRSRKAQLQIEQLTTELANEKSNSQKNENGR 1870
            .::.:|::|||.:|.:::|.||   |..|:|   ::::||.::...|:.||..::......|..|
Human  1734 SLLSQKKKLEADVARMQKEAEEVVQECQNAE---EKAKKAAIEAANLSEELKKKQDTIAHLERTR 1795

  Fly  1871 ALLERQNKELKAKLAEIETAQRTKVKATIATLEAKIANLEEQLENEGKERLLQQKANRKMDKKIK 1935
            ..:|:...:|:.:|||.|.......:..|..||:::..||.:||.|.:.....|:..|::::.||
Human  1796 ENMEQTITDLQKRLAEAEQMALMGSRKQIQKLESRVRELEGELEGEIRRSAEAQRGARRLERCIK 1860

  Fly  1936 ELTMNIEDERRHVDQHKEQMDKLNSRIKLLKRNLDETEEELQKEKTQKRKYQRECEDMIESQEAM 2000
            |||...|::::::.:.:.|||||..:::..|:.::..|.:..:..::.:|.|.|..::.|..|..
Human  1861 ELTYQAEEDKKNLSRMQTQMDKLQLKVQNYKQQVEVAETQANQYLSKYKKQQHELNEVKERAEVA 1925

  Fly  2001 NREINSLKTKLRRTG 2015
            ..::|.||.|.|..|
Human  1926 ESQVNKLKIKAREFG 1940

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
zipNP_523860.2 Myosin_N 80..117 CDD:280832 10/37 (27%)
Myosin_head 133..854 CDD:278492 355/739 (48%)
MYSc_Myh2_insects_mollusks 145..854 CDD:276876 346/727 (48%)
Myosin_tail_1 931..2011 CDD:279860 308/1087 (28%)
Prefoldin 1431..1515 CDD:298833 24/84 (29%)
FAM76 <1847..1926 CDD:292665 20/78 (26%)
MYH15XP_011510861.1 Myosin_N 52..90 CDD:280832 10/38 (26%)
Myosin_head 105..778 CDD:278492 355/739 (48%)
MYSc_Myh15_mammals 117..778 CDD:276892 346/727 (48%)
Myosin_tail_1 859..1935 CDD:279860 308/1082 (28%)
CENP-Q 1017..1164 CDD:289839 46/146 (32%)
DUF2317 <1487..1600 CDD:302887 31/112 (28%)
DUF4337 <1864..>1940 CDD:290935 18/75 (24%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG0161
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D47111at2759
OrthoFinder 1 1.000 - - FOG0000014
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100110
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X58
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
65.720

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