Protein Alignment zip and myo-2

DIOPT Version :9

• Sequence 1: NP_523860.2
• Gene: zip / 38001
• FlyBaseID: FBgn0265434
• Length: 2056
• Species: Drosophila melanogaster
• Sequence 2: NP_510092.2
• Gene: myo-2 / 181404
• WormBaseID: WBGene00003514
• Length: 1947
• Species: Caenorhabditis elegans
• Alignment Length: 1990
• Identity: 710/1990 - (35%)
• Similarity: 1121/1990 - (56%)
• Gaps: 83/1990 - (4%)

  Fly    53 NDPELKYLSVERNQFNDPATQAEWTQKRLVWVPHENQGFVAASIKREHGDEVEVELAETGKRVMI 117
            |||..|||...|.:.....::| :..|:.||:|....|::...|.:..||.|.|.:.: |....:
 Worm     5 NDPGWKYLRRSREEMLQDQSRA-YDSKKNVWIPDSEDGYIEGVITKTAGDNVTVSIGQ-GAEKTV 67

  Fly   118 LRDDIQKMNPPKFDKVEDMAELTCLNEASVLHNIKDRYYSGLIYTYSGLFCVVVNPYKKLPIYTE 182
            .:|.:|:||||||:|.|||:.||.||:||||:|:|.||.:.||||||||||||:||||:|||||:
 Worm    68 KKDVVQEMNPPKFEKTEDMSNLTFLNDASVLYNLKARYAAMLIYTYSGLFCVVINPYKRLPIYTD 132

  Fly   183 KIMERYKGIKRHEVPPHVFAITDSAYRNMLGDREDQSILCTGESGAGKTENTKKVIQFLAYVAAS 247
            .:...:.|.:|.|:|||:||::|.||||||.:.|:||:|.||||||||||||||||.:.|.|.|:
 Worm   133 SVARMFMGKRRTEMPPHLFAVSDEAYRNMLQNHENQSMLITGESGAGKTENTKKVISYFAAVGAA 197

  Fly   248 KPKGSGAVPHPAVLINFSVNTNKYIKVKIMAQNQNQTIEVVNGLKMVEVNSNCQEGELEQQLLQA 312
            :.:..||                    |..|               .|.:.|.::..||.|::|.
 Worm   198 QQETFGA--------------------KKAA---------------TEEDKNKKKVTLEDQIVQT 227

  Fly   313 NPILEAFGNAKTVKNDNSSRFGKFIRINFDASGFISGANIETYLLEKSRAIRQAKDERTFHIFYQ 377
            ||:||||||||||:|:|||||||||||:|...|.::..:||.|||||||.||||..||.:|||||
 Worm   228 NPVLEAFGNAKTVRNNNSSRFGKFIRIHFSKQGRVASCDIEHYLLEKSRVIRQAPGERCYHIFYQ 292

  Fly   378 LLAGATPEQREKFILD-DVKSYAFLSNGSLPVPGVDDYAEFQATVKSMNIMGMTSEDFNSIFRIV 441
            :.:...|..::..:|: .||.|.|::...|.:.|::|..|.|.|.::.:|:..|..:....:|:|
 Worm   293 VFSDYLPNLKKDLLLNKPVKDYWFIAQAELIIDGINDKEEHQLTDEAFDILKFTPTEKMECYRLV 357

  Fly   442 SAVLLFGSMKFRQERNNDQATLPDNT-VAQKIAHLLGLSVTDMTRAFLTPRIKVGRDFVTKAQTK 505
            :|::..|:|||:|....:||. ||.| .|::.|...|:...:..:|...||:|||.::|.|.|..
 Worm   358 AAMMHMGNMKFKQRPREEQAE-PDGTDDAERAAKCFGIDSEEFLKALTRPRVKVGNEWVNKGQNI 421

  Fly   506 EQVEFAVEAIAKACYERMFKWLVNRINRSLDRTKRQGASFIGILDMAGFEIFELNSFEQLCINYT 570
            |||.:||.|:||..|.|:|.|||.:.|::||:.......|||:||:||||||:.||||||.||:.
 Worm   422 EQVNWAVGAMAKGLYSRIFNWLVKKCNQTLDQKGISRDHFIGVLDIAGFEIFDFNSFEQLWINFV 486

  Fly   571 NEKLQQLFNHTMFILEQEEYQREGIEWKFIDFGLDLQPTIDLIDKPGGIMALLDEECWFPKATDK 635
            ||||||.|||.||:||||||.||||:|.|||||||||..|:||:||.||:|:|||||..|||||.
 Worm   487 NEKLQQFFNHHMFVLEQEEYAREGIQWTFIDFGLDLQACIELIEKPLGIIAMLDEECIVPKATDL 551

  Fly   636 TFVDKLVSAH-SMHPKFMK----TDFRGVADFAIVHYAGRVDYSAAKWLMKNMDPLNENIVSLLQ 695
            |...||:..| ..||.|.|    ...:..|.||:.||||.|.|:...||.||.||||:.:|::::
 Worm   552 TLAQKLIDQHLGKHPNFEKPKPPKGKQAEAHFAMRHYAGTVRYNCLNWLEKNKDPLNDTVVTVMK 616

  Fly   696 GSQD-PFVVNIWKDAEIVGMAQQALTDTQFGART--RKGMFRTVSHLYKEQLAKLMDTLRNTNPN 757
            .|:: ..:|.:|:|......|..|......||:.  :.|.|.|||.||:|.|.|||..|.:|:|:
 Worm   617 ASKEHALIVEVWQDYTTQEEAAAAAAKGTAGAKKKGKSGSFMTVSMLYRESLNKLMTMLHSTHPH 681

  Fly   758 FVRCIIPNHEKRAGKIDAPLVLDQLRCNGVLEGIRICRQGFPNRIPFQEFRQRYELLTPNVIPKG 822
            |:||||||.:|.:|.|||.|||:||.||||||||||||:|||||....:|.|||.||..:....|
 Worm   682 FIRCIIPNEKKASGVIDAGLVLNQLTCNGVLEGIRICRKGFPNRTLHPDFVQRYALLAADESIIG 746

  Fly   823 FMDGKKACEKMIQAL----ELDSNLYRVGQSKIFFRAGVLAHLEEERDFKISDLIVNFQAFCRGF 883
            ..|.||....|:..|    :|:...:|||.:|:||:||::||||:.||..::.||...||..|.:
 Worm   747 KTDAKKGSALMLARLVKEKKLEEENFRVGLTKVFFKAGIVAHLEDLRDQSLAQLITGLQAQIRWY 811

  Fly   884 LARRNYQKRLQQLNAIRIIQRNCAAYLKLRNWQWWRLYTKVKPLL---EVTKQEEKL-------- 937
            ......::|::::.|::|||||..::.:||.|.|::||.|||||:   ::..|.|||
 Worm   812 YQTIERKRRVEKITALKIIQRNIRSWAELRTWVWFKLYGKVKPLVNSGKIEAQYEKLQETVATLK 876

  Fly   938 ---VQKEDELKQVREKLDTLAKNTQEYERKYQQALVEKTTLAEQLQAEIELCAEAEESRSRLMAR 999
               ||:|::.:|::|..:.|.|.|.:              |..||:|......|.||..:.:..:
 Worm   877 DTVVQEEEKKRQLQEGAERLNKETAD--------------LLAQLEASKGSTREVEERMTAMNEQ 927

  Fly  1000 KQELEDMMQELETRIEEEEERVLALGGEKKKLELNIQDLEEQLEEEEAARQKLQLEKVQLDAKIK 1064
            |..||..:.:...::|.||.|.:.:..:||.:|....||::..::.:.:.:|::.||...:.:|:
 Worm   928 KVALEGKLADASKKLEVEEARAVEINKQKKLVEAECADLKKNCQDVDLSLRKVEAEKNAKEHQIR 992

  Fly  1065 KYEEDLALTDDQNQKLLKEKKLLEERANDLSQTLAEEEEKAKHLAKLKAKHEATISELEERLHKD 1129
            ..::::...|:...||.||:|..||:...|::.|...||:.....|||||...::.:.|:.:.::
 Worm   993 ALQDEMRQQDENISKLNKERKNQEEQNKKLTEDLQAAEEQNLAANKLKAKLMQSLEDSEQTMERE 1057

  Fly  1130 QQQRQESDRSKRKIETEVADLKEQLNERRVQVDEMQAQLAKREEELTQTLLRIDEESATKATAQK 1194
            ::.|.:.|::|||.|.|:...:|.|.|......:.:..|.::|.||....:::::|.|..|..||
 Worm  1058 KRNRADMDKNKRKAEGELKIAQETLEELNKSKSDAENALRRKETELHTLGMKLEDEQAAVAKLQK 1122

  Fly  1195 AQRELESQLAEIQEDLEAEKAARAKAEKVRRDLSEELEALKNELLDSLDTTAAQQELRSKREQEL 1259
            ..::.|:::.::.:.|..||.||.:|::.|.|...|.:.|..:|.|....||||.||..|::.||
 Worm  1123 GIQQDEARVKDLHDQLADEKDARQRADRSRADQQAEYDELTEQLEDQARATAAQIELGKKKDAEL 1187

  Fly  1260 ATLKKSLEEETVNHEGVLADMRHKHSQELNSINDQLENLRKAKTVLEKAKGTLEAENADLATELR 1324
            ..|::.|||..:.....|..::.|.|..:..::||:|.|:|.|..:||.||.::.|..:.:..|.
 Worm  1188 TKLRRDLEESGLKFGEQLTVLKKKGSDAIQELSDQIEQLQKQKGRIEKEKGHMQREFDESSAALD 1252

  Fly  1325 SVNSSRQENDRRRKQAESQIAELQVKLAEIERARSELQEKCTKLQQEAENITNQLEEAELKASAA 1389
            .....|.:.:|..|..|.::.||::|..|..|...:......:|..|..::..|:||.|.|..||
 Worm  1253 QEAKLRADQERIAKGYEVRLLELRLKADEQSRQLQDFVSSKGRLNSENSDLARQVEELEAKIQAA 1317

  Fly  1390 VKSASNMESQLTEAQQLLEEETRQKLGLSSKLRQIESEKEALQEQLEEDDEAKRNYERKLAEVTT 1454
            .:......::|..|::..|||:|::..||:..:.:..|.|.|:|.:|::...|....|:|::.:.
 Worm  1318 NRLKLQFSNELDHAKRQAEEESRERQNLSNLSKNLARELEQLKESIEDEVAGKNEASRQLSKASV 1382

  Fly  1455 QMQEIKKKAEEDADL-AKELEEGKKRLNKDIEALERQVKELIAQNDRLDKSKKKIQSELEDATIE 1518
            ::.:.:.|.|.:..: |.|.:|.|||.|:....::..:....|:...|:.::.::.:|.:...:|
 Worm  1383 ELDQWRTKFETEGLIGADEFDEVKKRQNQKTSEIQDALDACNAKIVALENARSRLTAEADANRLE 1447

  Fly  1519 LEAQRTKVLELEKKQKNFDKILAEEKAISEQIAQERDTAEREAREKETKVLSVSRELDEAFDKIE 1583
            .|.....|..||||||.|||::.|.|...:.:..|.|.|:|:||:...:...:..:.|...|::|
 Worm  1448 AEHHAQAVSSLEKKQKAFDKVIDEWKKKVDDLYLELDGAQRDARQLSGEAHKLRGQHDTLADQVE 1512

  Fly  1584 DLENKRKTLQNELDDLANTQGTADKNVHELEKAKRALESQLAELKAQNEELEDDLQLTEDAKLRL 1648
            .|..:.|:|.:|..||..:.....:..|.|.|..|.||.:..||:...:|.|..|:..|...||.
 Worm  1513 GLRRENKSLSDETRDLTESLSEGGRATHALSKNLRRLEMEKEELQRGLDEAEAALESEESKALRC 1577

  Fly  1649 EVNMQALRSQFERDLLAKEEGAEEKRRGLVKQLRDLETELDEERKQRTAAVASKKKLEGDLKEIE 1713
            ::.:..:|::.|:.:..|||..|..|:...:.:..::..||.|.|.::.....|||||.|:.|:|
 Worm  1578 QIEVSQIRAEIEKRIAEKEEEFENHRKVHQQTIDSIQATLDSETKAKSELFRVKKKLEADINELE 1642

  Fly  1714 TTMEMHNKVKEDALKHAKKLQAQVKDALRDAEEAKAAKEELQALSKEAERKVKALEAEVLQLTED 1778
            ..::..||..|||.|:.::...|:::..:..:|.:..:||.:.....||||:...:.|..:|...
 Worm  1643 IALDHANKANEDAQKNIRRYLDQIRELQQTVDEEQKRREEFREHLLAAERKLAVAKQEQEELIVK 1707

  Fly  1779 LASSERARRAAETERDELAEEIANNANKGSL-MIDEKRRLEARIATLEEELEEEQSNSEVLLDRS 1842
            |.:.|||||..|:...| .:|..|..|..:: :...|.:|:..||.|..::.|..:......||.
 Worm  1708 LEALERARRVVESSVKE-HQEHNNELNSQNVALAAAKSQLDNEIALLNSDIAEAHTELSASEDRG 1771

  Fly  1843 RKAQLQIEQLTTELANEKSNSQKNENGRALLERQNKELKAKLAEIETAQRTKVKATIATLEAKIA 1907
            |:|.....:|..:|.:|:..||:.|..:..||...|:|:.:....|.|........|...|.::.
 Worm  1772 RRAASDAAKLAEDLRHEQEQSQQLERFKKQLESAVKDLQERADAAEAAVMKGGAKAIQKAEQRLK 1836

  Fly  1908 NLEEQLENEGKERLLQQKANRKMDKKIKELTMNIEDERRHVDQHKEQMDKLNSRIKLLKRNLDET 1972
            ..:..||.|.:......|...:.|:|::|....:.:::::.|:.:|.::||.:::||.|:.|:|.
 Worm  1837 AFQSDLETESRRAGEASKTLARADRKVREFEFQVAEDKKNYDKLQELVEKLTAKLKLQKKQLEEA 1901

  Fly  1973 EEELQKEKTQKRKYQRECEDMIESQEAMNREINSLKTKLR 2012
            ||:.....::.|..|...|...|..::..:.:..::::.|
 Worm  1902 EEQANSHLSKYRTVQLSLETAEERADSAEQCLVRIRSRTR 1941

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
zip	NP_523860.2	Myosin_N	80..117	CDD:280832	10/36 (28%)
		Myosin_head	133..854	CDD:278492	355/734 (48%)
		MYSc_Myh2_insects_mollusks	145..854	CDD:276876	348/722 (48%)
		Myosin_tail_1	931..2011	CDD:279860	294/1092 (27%)
		Prefoldin	1431..1515	CDD:298833	18/84 (21%)
		FAM76	<1847..1926	CDD:292665	17/78 (22%)
myo-2	NP_510092.2	Myosin_N	31..68	CDD:280832	10/37 (27%)
		Myosin_head	83..782	CDD:278492	355/734 (48%)
		MYSc_class_II	95..782	CDD:276951	348/722 (48%)
		Myosin_tail_1	876..1939	CDD:279860	290/1077 (27%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0161
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D47111at2759
OrthoFinder	1	1.000	-	-		FOG0000014
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100110
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X58
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.720