DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment zip and hum-6

DIOPT Version :9

Sequence 1:NP_523860.2 Gene:zip / 38001 FlyBaseID:FBgn0265434 Length:2056 Species:Drosophila melanogaster
Sequence 2:NP_508420.1 Gene:hum-6 / 180539 WormBaseID:WBGene00002039 Length:2098 Species:Caenorhabditis elegans


Alignment Length:2079 Identity:509/2079 - (24%)
Similarity:857/2079 - (41%) Gaps:408/2079 - (19%)


- Green bases have known domain annotations that are detailed below.


  Fly    82 VWV-PHENQGFV---AASIKREHGDEVEVELAETGKRVMILRD-DIQKMNPPKFDKVEDMAELTC 141
            :|: |.:.:|.:   |..|.::|| .::| :.:.|....:..| .::.|:|.....||||.:|..
 Worm    10 IWIEPGKTEGSIPIGARVIDQDHG-RLKV-IDDLGNEQWLSADRRVRLMHPTSVQGVEDMCQLGD 72

  Fly   142 LNEASVLHNIKDRYYSGLIYTYSGLFCVVVNPYKKLPIYTEKIMERYKGIKRHEVPPHVFAITDS 206
            .:|:::|.|:..||...|||.|:|...:.||||..:.|||...:..||..:..|:|||:|||.|:
 Worm    73 FHESAILRNLFIRYREKLIYAYTGSILIAVNPYMDIAIYTADEIRMYKRKRIGELPPHIFAIADN 137

  Fly   207 AYRNMLGDREDQSILCTGESGAGKTENTKKVIQFLAYVAASKPKGSGAVPHPAVLINFSVNTNKY 271
            ||.||..::::||::.:|||||||||:||.|:||||.::.                         
 Worm   138 AYTNMRREKKNQSVIISGESGAGKTESTKLVLQFLATISG------------------------- 177

  Fly   272 IKVKIMAQNQNQTIEVVNGLKMVEVNSNCQEGELEQQLLQANPILEAFGNAKTVKNDNSSRFGKF 336
                                         |...:|||:|:|||:|||||||||::|||||||||:
 Worm   178 -----------------------------QHSWIEQQVLEANPVLEAFGNAKTIRNDNSSRFGKY 213

  Fly   337 IRINFDASGFISGANIETYLLEKSRAIRQAKDERTFHIFYQLLAGATPEQREKFILDDVKSYAFL 401
            |.::|:.||.|.||.||.|||||||.:.|:::||.:||||.||||.:.|::.:..|.....|.:|
 Worm   214 IDVHFNESGSIEGAKIEQYLLEKSRIVTQSENERNYHIFYCLLAGLSREEKSELELGTAADYYYL 278

  Fly   402 SNG-SLPVPGVDDYAEFQATVKSMNIMGMTSEDFNSIFRIVSAVLLFGSMKFRQERNN--DQATL 463
            ..| :|...|.||.|:......:|.::.:..::..|||::::::|..|:::|||..|:  :...:
 Worm   279 IQGKTLTAEGRDDAADLAEIRSAMRVLMINEQEIGSIFKLLASLLHIGNIRFRQNTNDNMESVDV 343

  Fly   464 PDNTVAQKIAHLLGLSVTDMTRAFLTPRIKVGRDFVTKAQTKEQVEFAVEAIAKACYERMFKWLV 528
            .|.:...:||.||.|...::..|..|..:....:.|......:|...|.:|:|||.|.::|..:|
 Worm   344 ADPSTLVRIAKLLQLHEQNLLDAITTKSLVTREERVISRLNGQQAVDARDALAKAIYGKLFIHIV 408

  Fly   529 NRINRSLDRTKRQGASFIGILDMAGFEIFELNSFEQLCINYTNEKLQQLFNHTMFILEQEEYQRE 593
            .|:|.::.:..:...:.|||||:.|||.||.|||||||||:.||.|||.|.|.:|.:||:||..|
 Worm   409 RRVNDAIYKPSQSRRTSIGILDIFGFENFESNSFEQLCINFANETLQQFFVHHVFKMEQKEYDEE 473

  Fly   594 GIEWKFIDFGLDLQPTIDLI-DKPGGIMALLDEECWFPKATDKTFVDKLVSAHSMHPKFMKTDFR 657
            .|.|:.|.| :|.|.|:||| .:|..|::|:|||..|||.||||.:.||.|.|..:..:::....
 Worm   474 HINWRHIKF-VDNQATVDLIAQRPLNILSLIDEESIFPKGTDKTMLLKLHSTHGRNELYLQPKSE 537

  Fly   658 GVADFAIVHYAGRVDYSAAKWLMKNMDPLNENIVSLLQGSQDPFVVNIWKDAEIVGMAQQALTDT 722
            ....|.:.|:||.|.|:...:|.||.|..:.::..|:..|:.||:..::.|.|            
 Worm   538 LQRAFGVTHFAGNVFYNTRGFLEKNRDSFSADLSVLISSSKMPFLARLFDDIE------------ 590

  Fly   723 QFGARTRKGMFRTVSHLYKEQLAKLMDTLRNTNPNFVRCIIPNHEKRAGKIDAPLVLDQLRCNGV 787
             :...:||.:  ||.:.::..|.:||..|..|:|.|:|||.||..|||..:|..|||.|||.:|:
 Worm   591 -YDTSSRKKV--TVGNQFRRSLEQLMSQLTQTHPFFIRCIKPNEMKRALVMDRDLVLRQLRYSGM 652

  Fly   788 LEGIRICRQGFPNRIPFQEFRQRYELLTPNVI-PKGFMD----GKKACEKMIQALELDSNLYRVG 847
            :|.|:|.|.|:|.|..:..|..||.:|..::. |...:|    .||.|. ||.....|   |::|
 Worm   653 METIKIRRSGYPIRHDYYPFVFRYRVLVSSIQGPVNRIDLHDAAKKICH-MILGTNAD---YQLG 713

  Fly   848 QSKIFFRAGVLAHLEEERDFKISDLIVNFQAFCRGFLARRNYQKRLQQLNAIRIIQRNCAAYLKL 912
            ::|:|.:......||:|....:.|..:..|...|.:|.|::::|           ||..|..::.
 Worm   714 KTKVFLKDKHDLVLEQEYYRILKDKAIVIQKNVRRWLVRKDFEK-----------QRQAAVTIQT 767

  Fly   913 RNWQWWRLYTKVKPLLEVTKQEEKLVQKEDELKQVREKLDTLAKNTQEYERKYQQALVEKTTLAE 977
            .    ||.:.:.|...::.....:| |.....:|:.....||.|...:::...:.:||.:     
 Worm   768 A----WRGFDQRKRYRQIISGFSRL-QAVLRSRQLVSHYQTLRKTIIQFQAVCRGSLVRR----- 822

  Fly   978 QLQAEIELCAEAEESRSRLMARKQELEDMMQELETRIEEEEERVLALGGEKKKLELNIQDLEEQL 1042
                      :..|.|.|  ..|..|.::........:..||.|   |.....|..:.:|...:.
 Worm   823 ----------QVGEKRKR--GEKAPLTEVSSTASVISDSHEELV---GHLFDFLPSDGKDSGNEN 872

  Fly  1043 EEEEAARQ----KLQLEKVQLDAKIKK----YEEDL--------ALTDDQNQKLLKEKKLLEERA 1091
            :..:::|:    :|....|...|.|.:    .:|||        |.|..|.|......|      
 Worm   873 DSADSSRRGSYSRLHTSPVMPPANIPRVDSYVDEDLSKYQFGKYAATFFQAQATATHVK------ 931

  Fly  1092 NDLSQTLAEEEEKAKHLAKLKAKHEATISELEERLHKDQQQRQESDRSKRKIETEVADLK----- 1151
            ..|...|....|.:..||.|.|  ..||                     .:...::||:|     
 Worm   932 KPLKTALLTHTEPSAQLAALTA--WTTI---------------------LRFMGDLADVKPGSTN 973

  Fly  1152 -EQLNERRVQVDEMQAQLAKR--EEELTQTLLRIDEESATKATAQKAQRELESQLAEIQEDLEAE 1213
             .::.::...:.::.|.|.|:  ..:|.:.:|. .|....|...:...|:|.|...:.:..:...
 Worm   974 GSEVYDKTPVMIKLYATLGKKFSAHDLEEAMLS-SEYGGAKTLKKGMGRKLISMTLKRKGKINGS 1037

  Fly  1214 KAARAKAEKVRRDLSEELEALKNELLDSLDTTAAQQELRSKREQELATLKKSLEEETVNHEGVLA 1278
            ..:...::.|....:..||......||.|.....           |..|::.|.:|.        
 Worm  1038 DTSSISSDSVYSSFNAMLENKPMTSLDKLHYIIG-----------LGILREDLRDEI-------- 1083

  Fly  1279 DMRHKHSQELNSINDQLENLRKAK--TVLEKAKGTLE-------------AENADLATELRSVNS 1328
                 :.|....:::....|..|:  .:|....|...             .|.....|     ..
 Worm  1084 -----YCQLCKQLSNNPSKLSAARGWILLSLCVGCFAPSERFIKYLFCFIRERGPAGT-----GY 1138

  Fly  1329 SRQENDRRRKQAESQIAELQVKLAEIERARSE-------------LQEKCTKLQQEAENITNQL- 1379
            |:...||.|:...:..........|::..:|:             ::..|......|..:..|| 
 Worm  1139 SKYIEDRLRRTQVNGTRHQPPSYVELQANKSQKPVVLAVTFMDGSVKTLCADSATTAAELCKQLA 1203

  Fly  1380 EEAEL--------------KASAAVKSASNMESQLTEAQQLLEEETRQKLGLSSKL---RQIESE 1427
            |:..|              |.|:......::...:::.:|..:|:.||:.....:|   ::|.|.
 Worm  1204 EKVGLTNSFGFSLYIALFDKVSSLGSGTDHVMDAISQCEQYAKEQGRQERNAPWRLFFRKEIFSP 1268

  Fly  1428 KEALQEQLEEDDEAKRN--YERKLAEVTTQMQEIKKKAEEDADLAKE--LEEGKKRLNK------ 1482
            ...     ..||....|  |::.:..:........|..|..|..|::  ::||...:||      
 Worm  1269 WHD-----PRDDPVSTNLIYQQVIRGIKYGEYRCDKDEELAAICAQQYYIDEGTMDVNKLENNLP 1328

  Fly  1483 ----DIE------ALERQVKELIAQNDRLDKSKKKIQSELEDATIELEAQRTKVLELEKKQKNFD 1537
                |.|      |||:..:.::.|..:  |...::.|::|.....:...:||...|..:.....
 Worm  1329 SYLPDFEMSGKEMALEKWTQTIMHQYRK--KFTGRLPSQIEVKENVVSVAKTKWPLLFSRFYEAL 1391

  Fly  1538 KILAEEKAISEQIAQERDTAEREAREKETKVLSVSRELDEAFDKIEDL---ENKRKTLQN----- 1594
            |........:|.|.....|......::|..:|..|      |.:|...   :.||.|...     
 Worm  1392 KFAGPPLPKNEVIIAVNWTGVYVVDDREHVMLEFS------FPEISTAYYGKGKRSTTDTCTVRT 1450

  Fly  1595 -----------ELDDLAN-----TQGTADKNVHELEKAKRALESQLAELKAQNEELEDDLQLTED 1643
                       ..||:.|     .:|        |:|..|    .|..:|:|..:.:::....|.
 Worm  1451 VVGDEYTFQSPNADDITNLIVMFLEG--------LKKRSR----YLVAIKSQKGDEKNNFLEFEK 1503

  Fly  1644 AKLRLEVNMQALRSQFERDLLAKEE--GAEEKRRGLVKQLRDLETELDEERKQRTAAVASKKKLE 1706
            ..|.:.||      :|..:.|..|.  ..|..|..|...:|     .:......|....||..|:
 Worm  1504 GDLLILVN------EFTGNTLLTESVVKGENSRTCLFGLIR-----AENVYVLPTLVKPSKNTLQ 1557

  Fly  1707 GDLKEIETTMEMHNKVKE----DALKHAKKLQAQVKDALRDAEEAKAAKEELQAL-SKEAERKVK 1766
            ...|:::.::::.|..|:    |.......|:...:|......:...::..|..| .||::.:..
 Worm  1558 IFPKDMDLSLDLFNNNKQVTVVDYNAEPYTLENFAEDNFNSQVKRVGSQISLMTLRKKESQIECW 1622

  Fly  1767 ALEAEVLQ--LTEDLASSERARRAA----ETERDELAEEIANNANKGSLMIDEKRRLEARIATLE 1825
            ....|.:.  |.:.|...|.|.|.|    ......:.:|.:..:..|:.:.|...:|...:..|.
 Worm  1623 RFSREHIDQPLLKKLNGREDACRGAIEIFAAIMKYMGDEPSKRSRLGTHLTDHIFKLPISMEALR 1687

  Fly  1826 EEL-----EEEQSNSEVLLDRSRKAQLQIEQLTT-------ELANEKSNSQKNENGRALLERQNK 1878
            :||     ::...|..::   |.:...::..:.|       .||.|.|:..|:......|:.||:
 Worm  1688 DELYCQLVKQLTLNPSIM---SEERGWELLWMATGLFAPSAALAKEISHFLKSRPHPIALDCQNR 1749

  Fly  1879 ELK-AK---------LAEIETAQRTKVKATIATLEAKI---ANLEEQLENEGKERL--------- 1921
            ..| ||         |.|:|..|.   |.|  .:..|:   .|.:|.:|.:...|.         
 Worm  1750 MQKLAKGGSRKYPPHLVEVEAIQH---KTT--QIFHKVFFPDNTDEAIEVDSATRARDFCHKIGY 1809

  Fly  1922 ---LQQKANRKMDKKIKELTMNIEDER---------------RHVDQHKEQMDKLNSRIKLLKR 1967
               |:......:..|||:..:.:.:..               .|..|....|..:|.::..:::
 Worm  1810 RLGLKSSDGFSLFVKIKDKVLAVPESEFFFDYVRSLSDWVHTNHATQKDATMIPINYQVYFMRK 1873

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
zipNP_523860.2 Myosin_N 80..117 CDD:280832 9/38 (24%)
Myosin_head 133..854 CDD:278492 272/729 (37%)
MYSc_Myh2_insects_mollusks 145..854 CDD:276876 266/717 (37%)
Myosin_tail_1 931..2011 CDD:279860 210/1216 (17%)
Prefoldin 1431..1515 CDD:298833 21/103 (20%)
FAM76 <1847..1926 CDD:292665 24/110 (22%)
hum-6NP_508420.1 MYSc 57..731 CDD:214580 275/747 (37%)
MYSc_Myo7 76..720 CDD:276832 266/717 (37%)
IQ 757..779 CDD:197470 7/36 (19%)
MyTH4 929..1168 CDD:214535 45/297 (15%)
B41 1174..1388 CDD:214604 39/220 (18%)
FERM_B-lobe 1278..1378 CDD:271216 19/101 (19%)
FERM_C1_MyoVII 1382..1480 CDD:270019 18/111 (16%)
SH3 1481..1544 CDD:302595 15/77 (19%)
MyTH4 1624..1772 CDD:214535 31/150 (21%)
B41 1779..1993 CDD:214604 13/95 (14%)
FERM_B-lobe 1890..1985 CDD:271216
FERM_C2_MyoVII 1989..2087 CDD:270020
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
21.910

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