Protein Alignment zip and hum-2

DIOPT Version :10

• Sequence 1: NP_523860.2
• Gene: zip / 38001
• FlyBaseID: FBgn0287873
• Length: 2056
• Species: Drosophila melanogaster
• Sequence 2: NP_001317742.1
• Gene: hum-2 / 179321
• WormBaseID: WBGene00002036
• Length: 1811
• Species: Caenorhabditis elegans
• Alignment Length: 1994
• Identity: 530/1994 - (26%)
• Similarity: 880/1994 - (44%)
• Gaps: 433/1994 - (21%)

  Fly    81 LVWVP---HENQGFVAASIKREHGDEVEVELA-ETGKRVMILRDDIQKMNPPKFDKVEDMAELTC 141
            |||:.   .|:..|...:::....|:.|||.| ::..::..||      ||......:|:..|:.
 Worm    31 LVWIGATLEEDITFQTRNVRIRLEDDTEVEYAIKSLDQLPFLR------NPAFLVGKDDLTLLSY 89

  Fly   142 LNEASVLHNIKDRYYSG-LIYTYSGLFCVVVNPYKKLP-IYTEKIMERYKGIKR--HEVPPHVFA 202
            |:|.:||||::.|:..| .||||.|:..|.:|||.... ||.|:|::.|:|..:  .|:.||:||
 Worm    90 LHEPAVLHNLQVRFVKGSSIYTYCGIVLVAINPYADCSHIYGEEIIQVYRGAGKSAREMDPHIFA 154

  Fly   203 ITDSAYRNMLGDREDQSILCTGESGAGKTENTKKVIQFLAYVAASKPKGSGAVPHPAVLINFSVN 267
            :.:.|:.:|....:.|||:.:||||||||.:.|.|:::||.|||||.:..|..
 Worm   155 VAEEAHFDMGAFGKSQSIIVSGESGAGKTVSAKFVMRYLASVAASKTRNGGTT------------ 207

  Fly   268 TNKYIKVKIMAQNQNQTIEVVNGLKMVEVNSNCQEGELEQQLLQANPILEAFGNAKTVKNDNSSR 332
                                                .:|.::|.:|||:|:.|||||::||||||
 Worm   208 ------------------------------------SIEARVLASNPIMESIGNAKTIRNDNSSR 236

  Fly   333 FGKFIRINFDASG-FISGANIETYLLEKSRAIRQAKDERTFHIFYQLLAGATPEQREKFILDDVK 396
            |||||:|||...| .|.||.::||||||||.:.||..||.:||||||.|....:..:...|...:
 Worm   237 FGKFIQINFCERGRRIVGAEMKTYLLEKSRLVFQAPGERNYHIFYQLCAARNHQVLKDLHLGPCE 301

  Fly   397 SYAFLS-NGSLPVPGVDDYAEFQATVKSMNIMGMTSEDFNSIFRIVSAVLLFGSMKFRQERNNDQ 460
            ||::|: .|...:|||||.|:|:|.:|::.::|...:..:.:||:::.:||.|::.|   .|.:.
 Worm   302 SYSYLTQGGDSRIPGVDDKADFEALLKALQLLGFDEKQMSDVFRLLAGLLLLGNVHF---ENGEG 363

  Fly   461 ATLPDNTVAQKIAHLL----GLSVTDMTRAFLTPR-IKVGRDFVTKAQTKEQVEFAVEAIAKACY 520
            ::....:..|:|:.|.    .:|.:|: |.:||.| |:...:.|||..||.:...:.:|:.|..|
 Worm   364 SSAVSASSCQEISRLCREFWKISESDL-RIWLTRREIRAVNEIVTKPLTKNEAVRSRDALTKMLY 427

  Fly   521 ERMFKWLVNRINRSL-DRTKRQGAS-------FIGILDMAGFEIFELNSFEQLCINYTNEKLQQL 577
            ..:|.|||::||.:| ::.|..|.:       |||:||:.|||.|::|||||..|||.||||||.
 Worm   428 SHLFGWLVDKINEALNEKDKLDGTNQKKRPDRFIGVLDIYGFETFDVNSFEQFSINYANEKLQQQ 492

  Fly   578 FNHTMFILEQEEYQREGIEWKFIDFGLDLQPTIDLIDKPGGIMALLDEECWFPKATDKTFVDKLV 642
            ||..:|.||||||.||.|||..:||. |.||.||||:.|.|::.||||:|.....:|..::.:|.
 Worm   493 FNQHVFKLEQEEYIREEIEWVRVDFH-DNQPAIDLIEGPVGMINLLDEQCKRLNGSDADWLSQLQ 556

  Fly   643 SAHSM--HPKFMKTDFRGVADFAIVHYAGRVDYSAAKWLMKNMDPLNENIVSLLQGSQDPFVVNI 705
            ::..:  :|:......|. .||.:.|:|..|.||...::.||.|.:.|.::.::..|:.||:..:
 Worm   557 NSTELKRNPQLAFPKVRS-NDFIVRHFAADVTYSTDGFVEKNRDAIGEQLLDVVVASKFPFIRTV 620

  Fly   706 WKDAEIVGMAQQALTDTQFGARTRKGMFRTVSHLYKEQLAKLMDTLRNTNPNFVRCIIPNHEKRA 770
            ........::..:.:.|. |.||.|   :||:..:::.|.:||..|.:|.|::||||.||..|.:
 Worm   621 IGSTAPTSVSSSSSSSTP-GKRTIK---KTVASQFRDSLKELMSVLCSTRPHYVRCIKPNDSKIS 681

  Fly   771 GKIDAPLVLDQLRCNGVLEGIRICRQGFPNRIPFQEFRQRYELLTPNVI------PKGFMDGKKA 829
            ...:....:.|||..||||.:||...|||:|.|::||.:||.::.....      ||.|  .:.|
 Worm   682 FDFEPKRAIQQLRACGVLETVRISAAGFPSRYPYEEFARRYRVIYTKEAALWRDKPKQF--AELA 744

  Fly   830 CEKMIQALELDSNLYRVGQSKIFFRAGVLAHLEEERDFKISDLIVNFQAFCRGFLARRNYQKRLQ 894
            |::.     |:...|.||::|||.|.|.:|.||..|...::......|...:||||||.|:...:
 Worm   745 CQQC-----LEEGKYAVGKTKIFLRTGQVAVLERVRLDTLAAAATVIQKMWKGFLARRKYETMRR 804

  Fly   895 QLNAIRIIQRNCAAYLKLRNWQWWRLY-------TKVKPLLEVTKQEE--------KLVQKEDEL 944
            .|   .|:|.:..|:|..|..::.:::       :.|:..||..|.|:        :.:.|.:.:
 Worm   805 SL---LIVQASLKAFLAFRRIKYLQMHRAVIVMQSAVRGYLERRKYEQIRDSIIGIQAMFKANRV 866

  Fly   945 KQVREKLDTLAKNTQEYERKYQQALVEKTTLAEQLQAEIELCAEAE-ESRSRLMARKQELEDM-- 1006
            ::..||| ...|:....:..::..|..:..:|.:.:..:..||..: .::.||...|.|...:
 Worm   867 RRYVEKL-RYEKSAITIQAAWRGYLARREQIANRKKVVMVQCAVRKWLAKRRLRELKIEARSVGH 930

  Fly  1007 MQELETRIEEEEERVLALGGEKKKLELNIQ-DLEEQLEEEEAARQKLQLEKVQLDAK-IKKYEED 1069
            :|:|.|            |.|.|.:||.:: |:..       ||.|.:.||....:| ::|.:.|
 Worm   931 LQKLNT------------GLENKIIELQMRLDIAN-------ARTKEEAEKFATASKNLQKTKAD 976

  Fly  1070 LALTDDQNQKLLKEKKLLEERANDLSQTLAEEEEKAKHLAKLKAKHEATISELEERLHKDQQQRQ 1134
            ||:.:.:...||:.:..:|        .|.||.|:.:....||
 Worm   977 LAMMEAERLTLLEARNRVE--------VLQEEVERLETECDLK---------------------- 1011

  Fly  1135 ESDRSKRKIETEVADLKEQLNERRVQVDEMQAQLAKREEELTQTLLRIDEESATKATAQKAQREL 1199
            |:.|.  .:||::.:|:.:|       |:.|.|     .|..||::.:.|: ..||.|.:...:.
 Worm  1012 EAQRG--GMETKMVELQSRL-------DQFQMQ-----SESGQTIVELTEQ-LEKAKADRVLWDE 1061

  Fly  1200 ESQLAEIQEDLEAEKAARAKAEKVRRDLSEELEALKNELLDSLD---TTAAQQELRSKREQE--- 1258
            |.|  .::..|..|::|       |..|..|:.|::.:|:.::|   ::..|:....|:.::
 Worm  1062 ERQ--RMEAALNTERSA-------RNALDAEMAAMREQLMKNVDLFESSTFQKRPSQKKNRDDDS 1117

  Fly  1259 -------LATLKKSLEEETVN--HE------GVLADMRHKHSQELNSINDQLENLRKAKTVLEKA 1308
                   |:.|..|...||:|  |.      .||.|......::|..|||..:.....:...|:.
 Worm  1118 CSRTTSNLSQLTGSFTAETINGVHSTSRGSPEVLLDNMASTFEQLRMINDLRQRNEHCQRETERM 1182

  Fly  1309 KGTLEA----ENADLATELRSVNSSRQENDRRRKQAESQIAELQVKLAEIERARSELQEKCTKLQ 1369
            |..:||    |..|..|.|::..|                    :::.|:|.|.:.|:....:|.
 Worm  1183 KAIIEASTLIETLDKKTSLKAFES--------------------IRVGELEGAYNRLKNDMERLV 1227

  Fly  1370 QEAENITNQ-----LEEAELKASAAVKSASNMESQLTEAQQLLEEETRQKLGLSSKLRQ------ 1423
            ......|:.     :||.|.....||:..|.:.|..          .:|.:..||..|:
 Worm  1228 SGENGATHSVFERIMEENERLREEAVELRSMLSSHF----------EKQSVAGSSGYRRSPRPDS 1282

  Fly  1424 -----IESEKEALQEQLEED--DEAKRNYERKLAE-----VTTQMQEIKKKAEE----------- 1465
                 .:||..:....||||  .|.:..:.:.|||     :|.|..||::..::
 Worm  1283 GHCSGADSEDGSSGADLEEDLCIERQCRHLKNLAENLTKMLTNQNLEIERLQQQLRFSESQTVFR 1347

  Fly  1466 DADLAKELEEGKKRLNKDIEALERQVKELIAQNDRLDKSKKKIQSELEDATIEL----------E 1520
            .:|.:  |:|..:..:|..:.|.:|..:|   ||:|.:..:    ||.:|..:|          .
 Worm  1348 PSDCS--LDEAVRGAHKQTQLLAQQNMDL---NDKLTRQSE----ELAEARAQLRGYSGPLGLEN 1403

  Fly  1521 AQRTKVLELEKKQKNFDK----------------ILAEEKAISEQIAQERDTA--------EREA 1561
            |...:::.||..:|...|                |:.|.|....::..:...|        ..:.
 Worm  1404 ASDEEIIRLEAFEKGSIKHSGFLEVYNVPEFARIIVCELKPTLARLLTKNLPAYLLVAAFRNHDE 1468

  Fly  1562 REKETKVL----SVSRELDEAFDKIEDLENKRKTLQN--ELDDLANTQGTADKNVHELEKAKRAL 1620
            :..||.:.    ||...|.:...:..||:.....|.|  .|.:|.......|...
 Worm  1469 KRDETALTGLFSSVHLVLKDTISRSHDLDLLSLWLVNLWRLFNLLRQYSGEDSQP---------- 1523

  Fly  1621 ESQLAELKAQNE---ELEDDLQLTEDAKLRLEVNMQALRSQFERDLLA--------KEEGAEEKR 1674
            |..:|..:.||.   :..|...:.:..|||:|....:|..:....:|:        :.|.:.
 Worm  1524 EWHVANTETQNSYRFKAYDVAPIRDQLKLRIEECYTSLMKKAIEHVLSPKIVPGILQHESSS--- 1585

  Fly  1675 RGLVKQLRDLETELDEERKQRTAAVASKKKLEGDLKEIETTME-MHNKVK----EDALKHAKKLQ 1734
                    ||.|...|.|.:.:.:|.|::|...||.:.   || :|.|:.    :|.:
 Worm  1586 --------DLMTAGQERRDRNSGSVESQRKSLDDLLQF---MEIVHTKLTTYGGDDIV------- 1632

  Fly  1735 AQVKDALRDAEEAKAAKEELQALSKEAERKVKALEAEVLQLTEDLASSERARRAAETERDELAEE 1799
              ||                |.:.:.| |.:.||....:....:|.:.|:|.:....     ..:
 Worm  1633 --VK----------------QVIGQMA-RWMCALALNYMMFRRELCNFEKAIQIKHN-----VTQ 1673

  Fly  1800 IANNANKGSLM--------------IDEKRRLEARIATLEEELEEEQSNSEVLLDRSRKAQLQIE 1850
            |.|..|...|.              :.:.|:..:.:.||..|:.......:|:      |.||..
 Worm  1674 IQNWLNAKGLSDCRDHFEPLVQACHLLQSRKDPSNLDTLCGEMTSRLKPRQVV------AILQHY 1732

  Fly  1851 QLTTELANEKS-----NSQKNENGRALLERQNKELKAKLAEIET 1889
            ..:.|:.:..|     ..||..|.||:......|.|.||..:.|
 Worm  1733 DPSDEMEDGLSPEFLVQIQKKLNERAIANNDPIEDKDKLIMLGT 1776

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
zip	NP_523860.2	Myosin_N	79..122	CDD:460670	12/44 (27%)
		MYSc_Myh2_insects_mollusks	145..854	CDD:276876	267/735 (36%)
		Myosin_tail_1	931..2011	CDD:460256	222/1106 (20%)
hum-2	NP_001317742.1	MYSc_Myo5	93..764	CDD:276831	267/735 (36%)
		IQ	779..799	CDD:197470	7/19 (37%)
		IQ	826..847	CDD:197470	3/20 (15%)
		CCDC158	<864..1473	CDD:464943	146/721 (20%)
		Myo5_CBD	1429..1803	CDD:271254	77/409 (19%)