DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment zip and Myo5b

DIOPT Version :9

Sequence 1:	NP_523860.2	Gene:	zip / 38001	FlyBaseID:	FBgn0265434	Length:	2056	Species:	Drosophila melanogaster
Sequence 2:	XP_006525777.1	Gene:	Myo5b / 17919	MGIID:	106598	Length:	1849	Species:	Mus musculus

Alignment Length:	1760	Identity:	501/1760 - (28%)
Similarity:	804/1760 - (45%)	Gaps:	373/1760 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    76 WTQKRLVWVPHENQGFVAASIKREH--GDEVEVELAETGKRVMILRDDIQK------MNPPKFDK 132
            :|:...||:|..::.:.:|.:.:::  ||: .::|......::....|:|.      .||.....
Mouse     7 YTRYTRVWIPDPDEVWRSAELTKDYKEGDK-SLQLRLEDDTILEYPVDVQNNQVPFLRNPDILVG 70

  Fly   133 VEDMAELTCLNEASVLHNIKDRYY-SGLIYTYSGLFCVVVNPYKKLPIYTEKIMERYKGIKRHEV 196
            ..|:..|:.|:|.:||||:|.|:. |..||||.|:..|.:|||::||||.:.::..|.|....::
Mouse    71 ENDLTALSHLHEPAVLHNLKVRFLESNHIYTYCGIVLVAINPYEQLPIYGQDVIYAYSGQNMGDM 135

  Fly   197 PPHVFAITDSAYRNMLGDREDQSILCTGESGAGKTENTKKVIQFLAYVAASKPKGSGAVPHPAVL 261
            .||:||:.:.||:.|..|.::|||:.:||||||||.:.|..:::.|.|..|
Mouse   136 DPHIFAVAEEAYKQMARDEKNQSIIVSGESGAGKTVSAKYAMRYFATVGGS-------------- 186

  Fly   262 INFSVNTNKYIKVKIMAQNQNQTIEVVNGLKMVEVNSNCQEGELEQQLLQANPILEAFGNAKTVK 326
               :.:||                                   :|:::|.::||:||.|||||.:
Mouse   187 ---ASDTN-----------------------------------IEEKVLASSPIMEAIGNAKTTR 213

  Fly   327 NDNSSRFGKFIRINFDASGFISGANIETYLLEKSRAIRQAKDERTFHIFYQLLAGATPEQREKFI 391
            |||||||||||.|.||....|.|||:.||||||||.:.||.|||.:||||||.|.|:..:.::..
Mouse   214 NDNSSRFGKFIEIGFDKKYHIIGANMRTYLLEKSRVVFQADDERNYHIFYQLCAAASLPEFKELA 278

  Fly   392 LDDVKSYAFLSN-GSLPVPGVDDYAEFQATVKSMNIMGMTSEDFNSIFRIVSAVLLFGSMKFRQE 455
            |...:.:.:.:: |:..:.||:|..:|:.|.:::.::|:......|||:|::::|..||::.:.|
Mouse   279 LTCAEDFFYTAHGGNTTIEGVNDADDFEKTRQALTLLGVRDSHQISIFKIIASILHLGSVEIQSE 343

  Fly   456 RNNDQATL-PDNTVAQKIAHLLGLSVTDMTRAFLTPRIKVGRDFVTKAQTKEQVEFAVEAIAKAC 519
            |:.|..:: |.:........|||:..:.|.......::....:...|..:.:||..|.:|:||..
Mouse   344 RDGDSCSISPQDEHLSNFCSLLGIEHSQMEHWLCHRKLVTTSETYVKTMSLQQVVNARDALAKHI 408

  Fly   520 YERMFKWLVNRINRSLDRTKRQGASFIGILDMAGFEIFELNSFEQLCINYTNEKLQQLFNHTMFI 584
            |.::|.|:|..||::|..:.:| .||||:||:.|||.||:|||||.||||.||||||.||..:|.
Mouse   409 YAQLFSWIVEHINKALHTSLKQ-HSFIGVLDIYGFETFEINSFEQFCINYANEKLQQQFNSHVFK 472

  Fly   585 LEQEEYQREGIEWKFIDFGLDLQPTIDLIDKPGGIMALLDEECWFPKATDKTFVDKLVSAHSMHP 649
            ||||||.:|.|.|..||| .|.||.||||:...||:.||||||..||.||:.:..||...||...
Mouse   473 LEQEEYMKEQIPWTLIDF-YDNQPCIDLIEAKLGILDLLDEECKVPKGTDQNWAQKLYERHSNSQ 536

  Fly   650 KFMKTDFRGVADFAIVHYAGRVDYSAAKWLMKNMDPLNENIVSLLQGSQDPFVVNIW---KDAEI 711
            .|.|......| |.:.|:|.:|:|.:..:|.||.|.:.|..:::|:.|:.|.|.:::   ||:..
Mouse   537 HFQKPRMSNTA-FIVNHFADKVEYLSDGFLEKNRDTVYEEQINILKASKFPLVADLFHDDKDSAP 600

  Fly   712 VGMAQQALTDTQFGARTRKGMF--------RTVSHLYKEQLAKLMDTLRNTNPNFVRCIIPNHEK 768
            .....:..:.::...|:.:.:.        ::|.:.::..|..||:||..|.|::||||.||.||
Mouse   601 ATNTAKNRSSSKINVRSSRPLIKVPNKEHKKSVGYQFRTSLNLLMETLNATTPHYVRCIKPNDEK 665

  Fly   769 RAGKIDAPLVLDQLRCNGVLEGIRICRQGFPNRIPFQEFRQRYELLTPNVIPKGFM---DGKKAC 830
            .....|....:.|||..||||.|||...|:|:|..:.:|..||.:|    :.|..:   |.|..|
Mouse   666 LPFHFDPKRAVQQLRACGVLETIRISAAGYPSRWTYHDFFNRYRVL----MKKRELTNTDKKNIC 726

  Fly   831 EKMIQALELDSNLYRVGQSKIFFRAGVLAHLEEERDFKISDLIVNFQAFCRGFLARRNYQKRLQQ 895
            :.::::|..|.:.::.|::|||||||.:|:||:.|..|..:..:..|...||:|.|..| :||:.
Mouse   727 KSVLESLIKDPDKFQFGRTKIFFRAGQVAYLEKLRADKFREATIMIQKSVRGWLQRVKY-RRLRA 790

  Fly   896 LNAIRIIQRNCAAYLKLRNWQWWRLYTKVKPLLEVTKQEEKLV--QKEDELKQVREKLDTLAKNT 958
              |...:||.|..||..|             |.|..::....:  ||:..:.:.|.....:.:.|
Mouse   791 --ATLSLQRFCRGYLARR-------------LAEHLRRTRAAIVFQKQYRMLKARRAYRRVCRAT 840

  Fly   959 ---QEY------ERKYQQALVE----------------KTTLAEQLQAEIELCAEAEESRSRLMA 998
               |.:      .|.|:|.|:|                |..|.|:..|.:..||     ..||.|
Mouse   841 VIIQSFTRAMFVRRNYRQVLMEHKATIIQKYARGWMARKRFLRERDAAIVIQCA-----FRRLKA 900

  Fly   999 RKQELEDMMQELETRIEEEEERVLALGGEKKKLELNIQDLEEQLEEEEAARQKLQLEKVQLDAKI 1063
            | |||:.:  ::|.|..|..:| |.:|.|.|                          .|||..||
Mouse   901 R-QELKAL--KIEARSAEHLKR-LNVGMENK--------------------------VVQLQRKI 935

  Fly  1064 KKYEEDLALTDDQNQKLLKEKKLLEERANDLSQTLAEEEEKAKHLAKLKAKHEATISELEERLHK 1128
                      ||||    ||.|.|.|:.:.::.:.|.|.||.|                :|..|
Mouse   936 ----------DDQN----KEFKTLSEQLSAVTSSHAVEVEKLK----------------KELAH- 969

  Fly  1129 DQQQRQESDRSKRKIETEVADLKEQL----NERRVQVDEMQAQLAKREEELTQTLLRIDEESATK 1189
             .||.||:|.| .:::.||..|:.:|    :||||..|
Mouse   970 -YQQNQEADTS-LQLQEEVQSLRTELQKAHSERRVLED--------------------------- 1005

  Fly  1190 ATAQKAQRELESQLAEIQEDLEAEKAARAKAEKVRRDLSEELEALKNELLDSLDTTAAQQELRSK 1254
             ...|...||..::|    |||.|.|.          |.:|.|.|.|::|......::|..:
Mouse  1006 -AHNKENGELRKRVA----DLEHENAL----------LKDEKEYLNNQILCQSKAESSQSSV--- 1052

  Fly  1255 REQELATLKKSLEEETVNHEGVLADMRHKHSQELNSINDQLENLRKAKTVLEKAKGTLEAENADL 1319
              :|...:||.||||...::.::        :|.:.:..:.||||...|:|::..|
Mouse  1053 --EENLLMKKELEEERSRYQNLV--------KEYSQLEQRYENLRDEVTILKQTPG--------- 1098

  Fly  1320 ATELRSVNSSRQENDRRRKQAESQIAELQVKLAEIERARSELQEKCTKLQQEAENITNQLEEAEL 1384
                      .::|...:...||......:..:||               .:.|:...|:||..:
Mouse  1099 ----------HRKNPSNQSSLESDSNYPSISTSEI---------------GDTEDALQQVEEIGI 1138

  Fly  1385 KASAAVKSASNMESQLTEAQQLLEEETRQKLGLSSKLRQIESEKEALQEQLEEDDEAKRNYERKL 1449
            :     |:|.:|...|.               |..::|::|.|::.||.|||     |...:.|.
Mouse  1139 E-----KAAMDMTVFLK---------------LQKRVRELEQERKKLQAQLE-----KGQQDSKK 1178

  Fly  1450 AEVTTQMQEIKKKAEEDADLA------KELEEGKKRLNKDIEALERQVKELIAQNDRLDKSKKK- 1507
            .:|..|...:  ..::|||:|      :|||...|:|..|:..|.:.|.:...|::....|...
Mouse  1179 GQVEQQNNGL--DVDQDADIAYNSLKRQELESENKKLKNDLNELRKAVADQAMQDNSTHSSPDSY 1241

  Fly  1508 --IQSELEDATIELEAQRTKVLELEKKQKNFDKILAEEKAI------------SEQIAQERDTAE 1558
              :.::|:.|..|||.::.:||.|..:..|.|:.....|.:            ||:...:.|..|
Mouse  1242 SLLLNQLKLANEELEVRKEEVLILRTQIMNADQRRLSGKNMEPNINARTSWPNSEKHVDQEDAIE 1306

  Fly  1559 -------REAREKETKVLSVSRELDEAFDKIEDLENKRKTLQNELDDLANTQGTADKNVHELEKA 1616
                   ..::.::...|:...||..|:   :.|:...:.|:.:|      |..:.::..|:|..
Mouse  1307 AYHGVCQTNSQTEDWGYLNEDGELGLAY---QGLKQVARLLEAQL------QAQSLEHEEEVEHL 1362

  Fly  1617 KRALESQLAELKAQNEELEDDLQLTEDAKLRLEVNMQALRSQFER-DLLAKEEGAEEKRRGLVKQ 1680
            |..:|:...|:..|.:.....|.|:.:|::...|..:..|...|. |.....|..|:..|.|.||
Mouse  1363 KAQVEALKEEMDKQQQTFCQTLLLSPEAQVEFGVQQEISRLTNENLDFKELVEKLEKNERKLKKQ 1427

  Fly  1681 LR-------DLE-----TELDEERKQRTAAVASKKKLEGDLKEIETTMEMHNKVKEDALKHAKKL 1733
            |:       |||     .:.|....:.|..|..::|    .|:.:..:|.|   |||.....:.|
Mouse  1428 LKIYMKKVQDLEAAQALAQSDRRHHELTRQVTVQRK----EKDFQGMLEYH---KEDEALLIRNL 1485

  Fly  1734 QAQVK 1738
            ...:|
Mouse  1486 VTDLK 1490

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
zip	NP_523860.2	Myosin_N	80..117	CDD:280832	7/38 (18%)
		Myosin_head	133..854	CDD:278492	267/737 (36%)
		MYSc_Myh2_insects_mollusks	145..854	CDD:276876	263/725 (36%)
		Myosin_tail_1	931..2011	CDD:279860	196/880 (22%)
		Prefoldin	1431..1515	CDD:298833	24/92 (26%)
		FAM76	<1847..1926	CDD:292665
Myo5b	XP_006525777.1	COG5022	11..>1268	CDD:227355	450/1516 (30%)
		MYSc_Myo5	83..750	CDD:276831	263/725 (36%)
		EnvC	1136..>1449	CDD:227278	77/348 (22%)
		Myo5b_CBD	1475..1846	CDD:271261	5/16 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000014
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.000