DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment zip and Myo15

DIOPT Version :9

Sequence 1:	NP_523860.2	Gene:	zip / 38001	FlyBaseID:	FBgn0265434	Length:	2056	Species:	Drosophila melanogaster
Sequence 2:	NP_034992.2	Gene:	Myo15 / 17910	MGIID:	1261811	Length:	3511	Species:	Mus musculus

Alignment Length:	1016	Identity:	341/1016 - (33%)
Similarity:	499/1016 - (49%)	Gaps:	193/1016 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 LKSKSALHPKSEYPVSNIHYPKAANYRQTRNYLEIAAKMSEEVDRNDPELKYLSVERNQFNDPAT 72
            ::..|:..||...||....:|.                       .|||           ..||.
Mouse  1102 VRGVSSFRPKGPAPVQPPEHPD-----------------------QDPE-----------QGPAP 1132

  Fly    73 QA---EWTQKRLVWVPHEN-------QGFVAASIKREHGDEVEVELAETGK------RVMILRD- 120
            ||   .|.:   :|.|.:.       :.:.:.|..|.||.:....|.:..:      ::..:|:
Mouse  1133 QACSLRWPR---LWPPTDAHCLWSRIRTYSSQSHLRGHGGDCHKSLWKKTRPQSWQNKMHSIRNL 1194

  Fly   121 -DIQKMNPPKFDKVEDMAELTCLNEASVLHNIKDRYYSGLIYTYSGLFCVVVNPYKKLPIYTEKI 184
             .::.....:.|.||||.:|..|.|.:||.|:|.|:...|||||.|...|.||||:...||..:.
Mouse  1195 PSMRSREQHREDGVEDMTQLEDLQETTVLANLKTRFERNLIYTYIGSILVSVNPYRMFAIYGPEQ 1259

  Fly   185 MERYKGIKRHEVPPHVFAITDSAYRNMLGDREDQSILCTGESGAGKTENTKKVIQFLAYVAASKP 249
            :::|.|....|.|||:|||.:.|:..||..:::|.::.:||||:||||.||.:::.||
Mouse  1260 VQQYSGRALGENPPHLFAIANLAFAKMLDAKQNQCVIISGESGSGKTEATKLILRCLA------- 1317

  Fly   250 KGSGAVPHPAVLINFSVNTNKYIKVKIMAQNQNQTIEVVNGLKMVEVNSNCQEGELEQQLLQANP 314
                                        |.||.:  :|:..:|                :|:|.|
Mouse  1318 ----------------------------AMNQRR--DVMQQIK----------------ILEATP 1336

  Fly   315 ILEAFGNAKTVKNDNSSRFGKFIRINFDASGFISGANIETYLLEKSRAIRQAKDERTFHIFYQLL 379
            :||||||||||:||||||||||:.| |...|.|.||....|||||||.:.|||:||.:||||:||
Mouse  1337 LLEAFGNAKTVRNDNSSRFGKFVEI-FLEGGVICGAITSQYLLEKSRIVFQAKNERNYHIFYELL 1400

  Fly   380 AGATPEQREKFILDDVKSYAFLS-NGSLPVPGVDDYAEFQATVKSMNIMGMTSEDFNSIFRIVSA 443
            ||...:.|:.|.|.:.::|.:|: .|:..:.|..|..:|:..:.:|.::|.||||.:|||||:::
Mouse  1401 AGLPAQLRQAFSLQEAETYYYLNQGGNCEIAGKSDADDFRRLLAAMEVLGFTSEDQDSIFRILAS 1465

  Fly   444 VLLFGSMKFRQERNNDQ--ATLPDNTVAQKIAHLLGLSVTDMTRAFLTPRIKVGRDFVTKAQTKE 506
            :|..|::.|.:...:.|  |::......|.:|.||.:|...:.:|.   ..||......|..|..
Mouse  1466 ILHLGNVYFEKHETDAQEVASVVSAREIQAVAELLQVSPEGLQKAI---TFKVTETIREKIFTPL 1527

  Fly   507 QVEFAV---EAIAKACYERMFKWLVNRINRSLDRTKRQGASFIGILDMAGFEIFELNSFEQLCIN 568
            .||.||   :||||..|..:|.||:.|:|..:  :.:|....|.|||:.|||....|||||||||
Mouse  1528 TVESAVDARDAIAKVLYALLFGWLITRVNALV--SPKQDTLSIAILDIYGFEDLSFNSFEQLCIN 1590

  Fly   569 YTNEKLQQLFNHTMFILEQEEYQREGIEWKFIDFGLDLQPTIDLID-KPGGIMALLDEECWFPKA 632
            |.||.||.|||..:|..|||||.||.::|:.|.|. |.||.|:||. ||.||:.:||::|.||:|
Mouse  1591 YANENLQYLFNKIVFQEEQEEYIREQMDWREIAFA-DNQPCINLISLKPYGILRILDDQCCFPQA 1654

  Fly   633 TDKTFVDKLVSAHSMHPKFMKTDFRGVADFAIVHYAGRVDYSAAKWLMKNMDPLNENIVSLLQGS 697
            ||.||:.|....|..:|.:.|... .:.:|.|.||||:|.|...|:|.||.|.:.::::.|...|
Mouse  1655 TDHTFLQKCHYHHGANPLYSKPKM-PLPEFTIKHYAGKVTYQVHKFLDKNHDQVRQDVLDLFVHS 1718

  Fly   698 QDPFVVNIWKDAEIVGMAQQALTDTQFGARTRKGMFRTVSHLYK---------EQLAKLMDTLRN 753
            :...|.:::.       :..|.|     |..|.|...:::.|||         :.|..|::.:..
Mouse  1719 RTRVVAHLFS-------SHAAQT-----APPRLGKSSSITRLYKAHTVAAKFQQSLLDLVEKMER 1771

  Fly   754 TNPNFVRCIIPNHEKRAGKIDAPLVLDQLRCNGVLEGIRICRQGFPNRIPFQEFRQRYELLTP-- 816
            .||.||||:.|||:|..|..:..:::.|||.:||||.:||.::|||.|:|||.|..||..|..
Mouse  1772 CNPLFVRCLKPNHKKEPGLFEPDVMMAQLRYSGVLETVRIRKEGFPVRLPFQVFIDRYRCLVALK 1836

  Fly   817 -NVIPKGFMDGKKACEKMIQAL-ELDSNLYRVGQSKIFFRAGVLAHLEE---------------- 863
             ||...|.|     |..::..| .:..::||||.||:|.:..:...||.
Mouse  1837 LNVPADGDM-----CVSLLSRLCTVTPDMYRVGISKLFLKEHLHQLLESMRERVQNRAALTLQRY 1896

  Fly   864 ------ERDFK-ISDLIVNFQAFCRGFLARRNYQKRLQQLNAIRIIQR---NCAAYLKLRNWQ-- 916
                  :|.|: :...|:..|:..||||||:.||:..|.|...|.:..   |...|||||..|
Mouse  1897 LRGFFIQRHFRSLRRKIILLQSRARGFLARQRYQQMRQSLLKFRSLVHTYVNRRRYLKLRAEQRR 1961

  Fly   917 -----WWR-----LYTKVKPL--LEVTKQEEKLVQKEDELK 945
                 |.|     ...:|.|:  |||..:...|:|....||
Mouse  1962 RAQEAWLREQEELSKREVVPVRHLEVPAEVAGLLQAAAGLK 2002

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
zip	NP_523860.2	Myosin_N	80..117	CDD:280832	7/49 (14%)
		Myosin_head	133..854	CDD:278492	283/740 (38%)
		MYSc_Myh2_insects_mollusks	145..854	CDD:276876	276/728 (38%)
		Myosin_tail_1	931..2011	CDD:279860	4/15 (27%)
		Prefoldin	1431..1515	CDD:298833
		FAM76	<1847..1926	CDD:292665
Myo15	NP_034992.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..44
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	574..690
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	712..1030
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1105..1135		12/63 (19%)
		MYSc	1201..1883	CDD:214580	286/759 (38%)
		MYSc_Myo15	1220..1871	CDD:276838	276/728 (38%)
		Actin-binding. /evidence=ECO:0000255	1776..1783		4/6 (67%)
		FliJ	1870..1960	CDD:280262	23/89 (26%)
		Neck or regulatory domain	1872..2013		35/131 (27%)
		Tail	2014..3511
		MyTH4	2049..2195	CDD:214535
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2330..2359
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2392..2425
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2460..2509
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2565..2584
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2629..2648
		SH3	2852..2931	CDD:302595
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2964..2984
		MyTH4	3031..3185	CDD:214535
		B41	3195..3400	CDD:214604
		FERM_B-lobe	3290..3390	CDD:271216
		FERM_C_MyoXV	3396..3497	CDD:270022
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000014
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.000